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Species | Christian G KohlerSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Differences in facial expressions of four universal emotionsChristian G Kohler
Neuropsychiatry, Department of Psychiatry, 10th Floor Gates Bldg, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Psychiatry Res 128:235-44. 2004..Comparisons are made with previous studies that used different facial stimuli...- Emotional processing in schizophreniaChristian G Kohler
University of Pennsylvania, Philadelphia, PA 19104, USA
Cognit Neuropsychiatry 11:250-71. 2006..New treatment modalities and behavioural interventions offer possible improvements in quality of life and psychosocial functioning... - Postpsychotic depression in schizophrenia patientsChristian G Kohler
Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania Medical Center, 3400 Spruce Street, Gates Building 10th Floor, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 4:273-8. 2002..Various proposed causes, differential diagnosis, and issues regarding management of postpsychotic depression are discussed... - Association between facial emotion recognition and odor identification in schizophreniaChristian G Kohler
Schizophrenia Research Center, University of Pennsylvania, Department of Psychiatry, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Neuropsychiatry Clin Neurosci 19:128-31. 2007..Olfactory and emotion recognition abilities appear significantly linked in schizophrenia... - Emotion-discrimination deficits in mild Alzheimer diseaseChristian G Kohler
Department of Psychiatry, Univ of Pennsylvania, Philadelphia, PA, USA
Am J Geriatr Psychiatry 13:926-33. 2005..Mild Alzheimer disease (AD) preferentially affects temporal lobe regions, which represent important structures in memory and emotional processes. This study investigated emotion discrimination in people with mild AD, versus Caretakers... - No effect of donepezil on neurocognition and social cognition in young persons with stable schizophreniaChristian G Kohler
Schizophrenia Research Center, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA
Cogn Neuropsychiatry 12:412-21. 2007..Cognitive dysfunction is common in schizophrenia and linked with psychosocial dysfunction. We examined the possible effect of a 16-week trial of donepezil on cognition in young persons with stable schizophrenia... - Facial emotion recognition in schizophrenia: intensity effects and error patternChristian G Kohler
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 160:1768-74. 2003..The authors used color photographs of emotional and neutral expressions to investigate recognition patterns of five universal emotions in schizophrenia... 
Abnormal superior temporal connectivity during fear perception in schizophreniaDavid I Leitman
Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Schizophr Bull 34:673-8. 2008..Such abnormal integration may disrupt the evaluation of threat within fronto-cortical regions...- Dynamic evoked facial expressions of emotions in schizophreniaChristian G Kohler
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Schizophr Res 105:30-9. 2008..In this study, we examined facial expression differences based on duration and frequencies of emotion expressions... - Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophreniaDavid I Leitman
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Soc Cogn Affect Neurosci 6:66-73. 2011..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal... - Prognostic variables at intake and long-term level of function in schizophreniaSteven J Siegel
Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 163:433-41. 2006..This study assessed the relationship between symptoms and cognitive measures at intake and functional outcome 2-8 years later (average 3 years) in first-episode and previously treated schizophrenia patients... - Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measuresPaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Clin Exp Neuropsychol 28:1444-61. 2006.... 
Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophreniaTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 167:418-26. 2010..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...- Static posed and evoked facial expressions of emotions in schizophreniaChristian G Kohler
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Schizophr Res 105:49-60. 2008..This study examined static facial expressions of emotions for evidence of flattened and inappropriate affect in persons with stable schizophrenia... - Facial emotion perception in schizophrenia: a meta-analytic reviewChristian G Kohler
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Bull 36:1009-19. 2010..0 (Borenstein M, Hedges L, Higgins J and Rothstein H. Comprehensive Meta-analysis. 2. Englewood, NJ: Biostat; 2005)... - Brain activation during eye gaze discrimination in stable schizophreniaChristian G Kohler
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Schizophr Res 99:286-93. 2008..Earlier studies described gaze discrimination impairment in schizophrenia. The purpose of this study was to compare gaze discrimination abilities and associated brain activation in persons with stable schizophrenia and matched controls... - Flat affect in schizophrenia: relation to emotion processing and neurocognitive measuresRaquel E Gur
Department of Psychiatry, Neuropsychiatry Division, Schizophrenia Center, University of Pennsylvania, USA
Schizophr Bull 32:279-87. 2006..However, the 2 patient groups did not differ in the neurocognitive profile except for verbal memory. We conclude that flat affect is an important clinical feature of schizophrenia that exacerbates the course of illness... - Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performancePaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Schizophr Res 90:221-8. 2007..Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles... - Limbic activation associated with misidentification of fearful faces and flat affect in schizophreniaRaquel E Gur
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Arch Gen Psychiatry 64:1356-66. 2007..Deficits in emotion processing are prominent in schizophrenia, and flat affect is resistant to treatment and portends poor outcome. Investigation of the underlying neural circuitry can elucidate affective dysfunction... - Olfactory physiological impairment in first-degree relatives of schizophrenia patientsBruce I Turetsky
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Schizophr Res 102:220-9. 2008..It is unclear, however, whether these behavioral abnormalities reflect basic olfactory sensory processing deficits or nonspecific disruptions of attention and cognition... - Symptom and demographic profiles in first-episode schizophreniaEdward I Gelber
Schizophrenia Research Center, Neuropsychiatry Section, 10th Floor Gates Building HUP, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
Schizophr Res 67:185-94. 2004..The model showed that higher levels of anhedonia and hallucinations increased the odds of a final diagnosis of schizophrenia. This predictive model was validated in a smaller group of patients... - Profile of auditory information-processing deficits in schizophreniaBruce I Turetsky
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Psychiatry Res 165:27-37. 2009..Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia... - An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosisVidyulata Kamath
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Schizophr Res 138:280-4. 2012..Odor-detection thresholds to two odorants that differ in the degree to which they activate intracellular cAMP were assessed in clinical risk and low-risk participants... - Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicineFarzin Irani
Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 29:960-8. 2004..Thus, the study provides impetus for future work in this area... - Reduced posterior nasal cavity volume: a gender-specific neurodevelopmental abnormality in schizophreniaBruce I Turetsky
Schizophrenia Research Center, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA
Schizophr Res 93:237-44. 2007.... - Facial emotion recognition in schizophrenia: when and why does it go awry?Bruce I Turetsky
Neurophysiology and Brain Imaging Laboratory, Department of Psychiatry 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Res 94:253-63. 2007..This study examined event-related potential (ERP) responses to emotional faces in schizophrenia patients and controls to determine when, in the temporal processing stream, patient abnormalities occur... - Apolipoprotein E genotype and odor identification in schizophreniaPaul J Moberg
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Neuropsychiatry Clin Neurosci 18:231-3. 2006..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele... - Do we recognize facial expressions of emotions from persons with schizophrenia?Kristin M Healey
The Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Schizophr Res 122:144-50. 2010..This study examined how static facial expressions of posed and evoked emotions of patients and controls are recognized by naïve observers... - Automated Facial Action Coding System for dynamic analysis of facial expressions in neuropsychiatric disordersJihun Hamm
Department of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA 19104, USA
J Neurosci Methods 200:237-56. 2011..The quantitative measures of flatness and inappropriateness showed clear differences between patients and the controls, highlighting their potential in automatic and objective quantification of symptom severity... - Recognition of facial emotions in neuropsychiatric disordersChristian G Kohler
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
CNS Spectr 9:267-74. 2004..In addition, we review the recent literature on emotion recognition in psychiatric and neurologic disorders, and studies that compare different disorders... - Odor hedonic capacity and anhedonia in schizophrenia and unaffected first-degree relatives of schizophrenia patientsVidyulata Kamath
To whom correspondence should be addressed Neuropsychiatry Section, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, US tel 215 839 9193, fax 215 662 7903, E mail
Schizophr Bull 39:59-67. 2013..Normal responses in unaffected first-degree relatives suggest that this is an environmentally, rather than genetically, mediated abnormality denoting negative symptomatology... - Facial emotion perception in depression and bipolar disorder: a quantitative reviewChristian G Kohler
Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Psychiatry Res 188:303-9. 2011..Emotion perception impairment in bipolar disorder and major depressive disorder represents a moderate and stable deficit that appears to be moderated by a limited number of demographic and clinical factors... - Psychiatric manifestations of paraneoplastic disordersMatthew S Kayser
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 167:1039-50. 2010..They also discuss the broad behavioral findings that highlight the need for psychiatrists to be aware of initial presentations of paraneoplastic disorders... - Differential effect of catechol-O-methyltransferase Val158Met genotype on emotional recognition abilities in healthy men and womenElisabeth M Weiss
Department of General Psychiatry, Innsbruck Medical, Innsbruck, Austria
J Int Neuropsychol Soc 13:881-7. 2007..Additional research is needed to further define the neurocognitive phenotypes associated with COMT polymorphisms... - Gender differences in facial emotion recognition in persons with chronic schizophreniaElisabeth M Weiss
Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
Eur Psychiatry 22:116-22. 2007....