Christian G Kohler

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Facial emotion perception differs in young persons at genetic and clinical high-risk for psychosis
    Christian G Kohler
    University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, United States Electronic address
    Psychiatry Res 216:206-12. 2014
  2. doi request reprint Is prevention a realistic goal for schizophrenia?
    Christian Kohler
    Schizophrenia Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce Street, Philadelphia, PA, 19104, USA
    Curr Psychiatry Rep 16:439. 2014
  3. pmc Brain activation during eye gaze discrimination in stable schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 99:286-93. 2008
  4. doi request reprint Static posed and evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:49-60. 2008
  5. pmc Dynamic evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:30-9. 2008
  6. pmc Facial emotion perception in schizophrenia: a meta-analytic review
    Christian G Kohler
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 36:1009-19. 2010
  7. doi request reprint Facial emotion perception in depression and bipolar disorder: a quantitative review
    Christian G Kohler
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 188:303-9. 2011
  8. pmc Abnormal superior temporal connectivity during fear perception in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Schizophr Bull 34:673-8. 2008
  9. pmc Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophrenia
    David I Leitman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Soc Cogn Affect Neurosci 6:66-73. 2011
  10. ncbi request reprint Prognostic variables at intake and long-term level of function in schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:433-41. 2006

Detail Information

Publications39

  1. doi request reprint Facial emotion perception differs in young persons at genetic and clinical high-risk for psychosis
    Christian G Kohler
    University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, United States Electronic address
    Psychiatry Res 216:206-12. 2014
    ..Preliminary results with clinical high-risk participants, when considered along findings in genetic risk relatives, suggest social cognition abilities to reflect pathophysiological processes involved in risk of schizophrenia. ..
  2. doi request reprint Is prevention a realistic goal for schizophrenia?
    Christian Kohler
    Schizophrenia Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce Street, Philadelphia, PA, 19104, USA
    Curr Psychiatry Rep 16:439. 2014
    ..The article places these recent studies within the context of prior research and the concept of potential measures to prevent or ameliorate the onset of psychosis. ..
  3. pmc Brain activation during eye gaze discrimination in stable schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 99:286-93. 2008
    ..Earlier studies described gaze discrimination impairment in schizophrenia. The purpose of this study was to compare gaze discrimination abilities and associated brain activation in persons with stable schizophrenia and matched controls...
  4. doi request reprint Static posed and evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:49-60. 2008
    ..This study examined static facial expressions of emotions for evidence of flattened and inappropriate affect in persons with stable schizophrenia...
  5. pmc Dynamic evoked facial expressions of emotions in schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 105:30-9. 2008
    ..In this study, we examined facial expression differences based on duration and frequencies of emotion expressions...
  6. pmc Facial emotion perception in schizophrenia: a meta-analytic review
    Christian G Kohler
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 36:1009-19. 2010
    ..0 (Borenstein M, Hedges L, Higgins J and Rothstein H. Comprehensive Meta-analysis. 2. Englewood, NJ: Biostat; 2005)...
  7. doi request reprint Facial emotion perception in depression and bipolar disorder: a quantitative review
    Christian G Kohler
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 188:303-9. 2011
    ..Emotion perception impairment in bipolar disorder and major depressive disorder represents a moderate and stable deficit that appears to be moderated by a limited number of demographic and clinical factors...
  8. pmc Abnormal superior temporal connectivity during fear perception in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Schizophr Bull 34:673-8. 2008
    ..Such abnormal integration may disrupt the evaluation of threat within fronto-cortical regions...
  9. pmc Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophrenia
    David I Leitman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Soc Cogn Affect Neurosci 6:66-73. 2011
    ..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal...
  10. ncbi request reprint Prognostic variables at intake and long-term level of function in schizophrenia
    Steven J Siegel
    Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 163:433-41. 2006
    ..This study assessed the relationship between symptoms and cognitive measures at intake and functional outcome 2-8 years later (average 3 years) in first-episode and previously treated schizophrenia patients...
  11. doi request reprint Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:418-26. 2010
    ..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...
  12. ncbi request reprint Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 64:1356-66. 2007
    ..Deficits in emotion processing are prominent in schizophrenia, and flat affect is resistant to treatment and portends poor outcome. Investigation of the underlying neural circuitry can elucidate affective dysfunction...
  13. ncbi request reprint Association between facial emotion recognition and odor identification in schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, University of Pennsylvania, Department of Psychiatry, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 19:128-31. 2007
    ..Olfactory and emotion recognition abilities appear significantly linked in schizophrenia...
  14. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  15. pmc Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 90:221-8. 2007
    ..Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles...
  16. pmc Olfactory physiological impairment in first-degree relatives of schizophrenia patients
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Schizophr Res 102:220-9. 2008
    ..It is unclear, however, whether these behavioral abnormalities reflect basic olfactory sensory processing deficits or nonspecific disruptions of attention and cognition...
  17. ncbi request reprint No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cogn Neuropsychiatry 12:412-21. 2007
    ..Cognitive dysfunction is common in schizophrenia and linked with psychosocial dysfunction. We examined the possible effect of a 16-week trial of donepezil on cognition in young persons with stable schizophrenia...
  18. ncbi request reprint Symptom and demographic profiles in first-episode schizophrenia
    Edward I Gelber
    Schizophrenia Research Center, Neuropsychiatry Section, 10th Floor Gates Building HUP, Department of Psychiatry, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Schizophr Res 67:185-94. 2004
    ..The model showed that higher levels of anhedonia and hallucinations increased the odds of a final diagnosis of schizophrenia. This predictive model was validated in a smaller group of patients...
  19. pmc An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosis
    Vidyulata Kamath
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Schizophr Res 138:280-4. 2012
    ..Odor-detection thresholds to two odorants that differ in the degree to which they activate intracellular cAMP were assessed in clinical risk and low-risk participants...
  20. pmc Odor hedonic capacity and anhedonia in schizophrenia and unaffected first-degree relatives of schizophrenia patients
    Vidyulata Kamath
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Schizophr Bull 39:59-67. 2013
    ..We also examine odor valence processing unirhinally, rather than birhinally, to probe possible lateralized differences in patients' hedonic processing deficits...
  21. doi request reprint Do we recognize facial expressions of emotions from persons with schizophrenia?
    Kristin M Healey
    The Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 122:144-50. 2010
    ..This study examined how static facial expressions of posed and evoked emotions of patients and controls are recognized by naïve observers...
  22. ncbi request reprint Differences in facial expressions of four universal emotions
    Christian G Kohler
    Neuropsychiatry, Department of Psychiatry, 10th Floor Gates Bldg, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Psychiatry Res 128:235-44. 2004
    ..Comparisons are made with previous studies that used different facial stimuli...
  23. pmc Profile of auditory information-processing deficits in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychiatry Res 165:27-37. 2009
    ..Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia...
  24. pmc Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures
    Raquel E Gur
    Department of Psychiatry, Neuropsychiatry Division, Schizophrenia Center, University of Pennsylvania, USA
    Schizophr Bull 32:279-87. 2006
    ..However, the 2 patient groups did not differ in the neurocognitive profile except for verbal memory. We conclude that flat affect is an important clinical feature of schizophrenia that exacerbates the course of illness...
  25. pmc Facial emotion recognition in schizophrenia: when and why does it go awry?
    Bruce I Turetsky
    Neurophysiology and Brain Imaging Laboratory, Department of Psychiatry 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Res 94:253-63. 2007
    ..This study examined event-related potential (ERP) responses to emotional faces in schizophrenia patients and controls to determine when, in the temporal processing stream, patient abnormalities occur...
  26. doi request reprint The effect of odor valence on olfactory performance in schizophrenia patients, unaffected relatives and at-risk youth
    Vidyulata Kamath
    Neuropsychiatry Section, Department of Psychiatry, Philadelphia, PA, USA Smell and Taste Center, Department of Otorhinolaryngology Head and Neck Surgery, Perelman School of Medicine, Philadelphia, PA, USA Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    J Psychiatr Res 47:1636-41. 2013
    ..Further research examining the utility of odor valence measures as markers for psychosis risk is warranted. ..
  27. ncbi request reprint Facial emotion recognition in schizophrenia: intensity effects and error pattern
    Christian G Kohler
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 160:1768-74. 2003
    ..The authors used color photographs of emotional and neutral expressions to investigate recognition patterns of five universal emotions in schizophrenia...
  28. pmc Reduced posterior nasal cavity volume: a gender-specific neurodevelopmental abnormality in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA
    Schizophr Res 93:237-44. 2007
    ....
  29. pmc Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis
    Paul J Moberg
    To whom correspondence should be addressed 10 Gates, HUP, 3400 Spruce Street, Philadelphia, PA 19104, US tel 215 615 3608, fax 215 662 7903, E mail
    Schizophr Bull 40:50-9. 2014
    ..Thus, the current meta-analysis was undertaken to incorporate additional studies, risk cohorts, olfactory test domains, and moderator variable analyses...
  30. ncbi request reprint Emotion-discrimination deficits in mild Alzheimer disease
    Christian G Kohler
    Department of Psychiatry, Univ of Pennsylvania, Philadelphia, PA, USA
    Am J Geriatr Psychiatry 13:926-33. 2005
    ..Mild Alzheimer disease (AD) preferentially affects temporal lobe regions, which represent important structures in memory and emotional processes. This study investigated emotion discrimination in people with mild AD, versus Caretakers...
  31. ncbi request reprint Apolipoprotein E genotype and odor identification in schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropsychiatry Clin Neurosci 18:231-3. 2006
    ..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele...
  32. ncbi request reprint Emotional processing in schizophrenia
    Christian G Kohler
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Cogn Neuropsychiatry 11:250-71. 2006
    ..Persons with schizophrenia have impaired emotional processing, involving experience, expression, and recognition of emotions...
  33. ncbi request reprint Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine
    Farzin Irani
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:960-8. 2004
    ..Thus, the study provides impetus for future work in this area...
  34. pmc Automated Facial Action Coding System for dynamic analysis of facial expressions in neuropsychiatric disorders
    Jihun Hamm
    Department of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neurosci Methods 200:237-56. 2011
    ..The quantitative measures of flatness and inappropriateness showed clear differences between patients and the controls, highlighting their potential in automatic and objective quantification of symptom severity...
  35. ncbi request reprint Recognition of facial emotions in neuropsychiatric disorders
    Christian G Kohler
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    CNS Spectr 9:267-74. 2004
    ..In addition, we review the recent literature on emotion recognition in psychiatric and neurologic disorders, and studies that compare different disorders...
  36. doi request reprint Psychiatric manifestations of paraneoplastic disorders
    Matthew S Kayser
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:1039-50. 2010
    ..They also discuss the broad behavioral findings that highlight the need for psychiatrists to be aware of initial presentations of paraneoplastic disorders...
  37. ncbi request reprint Postpsychotic depression in schizophrenia patients
    Christian G Kohler
    Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania Medical Center, 3400 Spruce Street, Gates Building 10th Floor, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 4:273-8. 2002
    ..Various proposed causes, differential diagnosis, and issues regarding management of postpsychotic depression are discussed...
  38. ncbi request reprint Differential effect of catechol-O-methyltransferase Val158Met genotype on emotional recognition abilities in healthy men and women
    Elisabeth M Weiss
    Department of General Psychiatry, Innsbruck Medical, Innsbruck, Austria
    J Int Neuropsychol Soc 13:881-7. 2007
    ..Additional research is needed to further define the neurocognitive phenotypes associated with COMT polymorphisms...
  39. ncbi request reprint Gender differences in facial emotion recognition in persons with chronic schizophrenia
    Elisabeth M Weiss
    Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur Psychiatry 22:116-22. 2007
    ....