Shay Whey M Koh

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Corneal endothelial autocrine trophic factor VIP in a mechanism-based strategy to enhance human donor cornea preservation for transplantation
    Shay Whey Margaret Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Exp Eye Res 95:48-53. 2012
  2. pmc Corneal endothelial autocrine VIP enhances its integrity in stored human donor corneoscleral explant
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 10 S Pine Street, Baltimore, MD 21201, USA
    Invest Ophthalmol Vis Sci 52:5632-40. 2011
  3. pmc VIP down-regulates the inflammatory potential and promotes survival of dying (neural crest-derived) corneal endothelial cells ex vivo: necrosis to apoptosis switch and up-regulation of Bcl-2 and N-cadherin
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurochem 109:792-806. 2009
  4. doi request reprint Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 50:1801-7. 2009
  5. pmc VIP and VIP gene silencing modulation of differentiation marker N-cadherin and cell shape of corneal endothelium in human corneas ex vivo
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Invest Ophthalmol Vis Sci 49:3491-8. 2008
  6. pmc Vasoactive intestinal peptide induction by ciliary neurotrophic factor in donor human corneal endothelium in situ
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, United States
    Neurosci Lett 423:89-94. 2007
  7. ncbi request reprint VIP immunoreactivity in human aqueous humor
    Shay Whey Koh
    Department of Ophthalmology, University of Maryland, Baltimore, Maryland 21201, USA
    Curr Eye Res 30:189-94. 2005
  8. ncbi request reprint Antiglaucoma eye drop pulses--increased interleukin-6 secretion by Tenon's capsule fibroblast cultures
    Shay Whey M Koh
    Department of Ophthalmology, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    J Glaucoma 13:200-9. 2004
  9. ncbi request reprint Ciliary neurotrophic factor released by corneal endothelium surviving oxidative stress ex vivo
    Shay Whey M Koh
    Department of Ophthalmology, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 43:2887-96. 2002
  10. ncbi request reprint VIP stimulation of cAMP production in corneal endothelial cells in tissue and organ cultures
    Shay Whey M Koh
    Department of Ophthalmology, University of Maryland, Baltimore, Maryland 21201, USA
    Cornea 21:270-4. 2002

Research Grants

Detail Information

Publications12

  1. pmc Corneal endothelial autocrine trophic factor VIP in a mechanism-based strategy to enhance human donor cornea preservation for transplantation
    Shay Whey Margaret Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Exp Eye Res 95:48-53. 2012
    ....
  2. pmc Corneal endothelial autocrine VIP enhances its integrity in stored human donor corneoscleral explant
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 10 S Pine Street, Baltimore, MD 21201, USA
    Invest Ophthalmol Vis Sci 52:5632-40. 2011
    ..To demonstrate corneal endothelial (CE) integrity enhanced during eye banking by a brief treatment of human donor corneoscleral explant (explant) with CE autocrine trophic factor vasoactive intestinal peptide (VIP)...
  3. pmc VIP down-regulates the inflammatory potential and promotes survival of dying (neural crest-derived) corneal endothelial cells ex vivo: necrosis to apoptosis switch and up-regulation of Bcl-2 and N-cadherin
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurochem 109:792-806. 2009
    ..02) and decreased glycogen level by 32% (p < 0.02). VPAC1 (not VPAC2) receptor was expressed in CE cells. Thus, CE cell VIP/VPAC1 signaling is both anti-inflammatory and protective in the corneal endothelium...
  4. doi request reprint Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 50:1801-7. 2009
    ..Here, the recombinant human (rh) CNTFRalpha was shown to restore functional CNTFRalpha in human corneal endothelial (CE) cells that lost endogenous CNTFRalpha during corneal storage..
  5. pmc VIP and VIP gene silencing modulation of differentiation marker N-cadherin and cell shape of corneal endothelium in human corneas ex vivo
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Invest Ophthalmol Vis Sci 49:3491-8. 2008
    ..This study demonstrated the role of CE cell VIP in maintaining the expression level of a CE differentiation marker, N-cadherin, and the hexagonal cell shape...
  6. pmc Vasoactive intestinal peptide induction by ciliary neurotrophic factor in donor human corneal endothelium in situ
    Shay Whey M Koh
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, United States
    Neurosci Lett 423:89-94. 2007
    ....
  7. ncbi request reprint VIP immunoreactivity in human aqueous humor
    Shay Whey Koh
    Department of Ophthalmology, University of Maryland, Baltimore, Maryland 21201, USA
    Curr Eye Res 30:189-94. 2005
    ....
  8. ncbi request reprint Antiglaucoma eye drop pulses--increased interleukin-6 secretion by Tenon's capsule fibroblast cultures
    Shay Whey M Koh
    Department of Ophthalmology, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    J Glaucoma 13:200-9. 2004
    ..The study tested the hypothesis that secretion of the proinflammatory cytokine interleukin (IL)-6 by wounded Tenon's capsule-fibroblasts is elevated by prior long-term antiglaucoma eye drop treatment...
  9. ncbi request reprint Ciliary neurotrophic factor released by corneal endothelium surviving oxidative stress ex vivo
    Shay Whey M Koh
    Department of Ophthalmology, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 43:2887-96. 2002
    ..To demonstrate that corneal endothelial (CE) cells that survive oxidative stress in corneas release ciliary neurotrophic factor (CNTF), which does not possess the secretion signal sequence...
  10. ncbi request reprint VIP stimulation of cAMP production in corneal endothelial cells in tissue and organ cultures
    Shay Whey M Koh
    Department of Ophthalmology, University of Maryland, Baltimore, Maryland 21201, USA
    Cornea 21:270-4. 2002
    ..To demonstrate that vasoactive intestinal peptide (VIP), an immunosuppressive factor found in the aqueous humor, is a modulator of the corneal endothelium (CE) stimulating its intracellular cAMP production...
  11. ncbi request reprint Corneal endothelial cell survival in organ cultures under acute oxidative stress: effect of VIP
    S W Koh
    Department of Ophthalmology, University of Maryland at Baltimore, USA
    Invest Ophthalmol Vis Sci 41:4085-92. 2000
    ....
  12. ncbi request reprint VIP enhances the differentiation of retinal pigment epithelium in culture: from cAMP and pp60(c-src) to melanogenesis and development of fluid transport capacity
    S M Koh
    Department of Ophthalmology, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    Prog Retin Eye Res 19:669-88. 2000
    ..Finally, identification of RPE differentiation factors may prove essential for the ultimate success of RPE transplantation, thus promoting the rescue of photoreceptor cells in retinal degeneration...

Research Grants10

  1. NEUROTROPHIC FACTOR MODULATION OF CORNEAL ENDOTHELIUM
    Shay Whey Koh; Fiscal Year: 2001
    ..3, CNTF and VIP help to maintain the viability, the barrier function, & the integrity of CEC cell-cell junction and cell-matrix attachment in stored human corneas and in human cornea organ cultures. ..
  2. NEUROTROPHIC FACTOR MODULATION OF CORNEAL ENDOTHELIUM
    Shay Whey Koh; Fiscal Year: 2009
    ..abstract_text> ..