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Genomes and Genes | Paulo KofujiSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Molecular substrates of potassium spatial buffering in glial cellsPaulo Kofuji
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
Mol Neurobiol 28:195-208. 2003..How such complexity fits into their proposed role in buffering [K+]o in retina is the main topic of this article...
Potassium buffering in the central nervous systemP Kofuji
Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
Neuroscience 129:1045-56. 2004..We also discuss intriguing new data that suggest a close physical and functional relationship between Kir and water channels in glial cells...- Potassium channel Kir4.1 macromolecular complex in retinal glial cellsNathan C Connors
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Glia 53:124-31. 2006..1, suggesting that both channels are tethered together by the DGC in Müller cells. This work further defines a subcellular localization mechanism in Müller cells that facilitates [K+]o buffering in the retina... - The potassium channel Kir4.1 associates with the dystrophin-glycoprotein complex via alpha-syntrophin in gliaNathan C Connors
Department of Neuroscience, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
J Biol Chem 279:28387-92. 2004..These results suggest that Kir4.1 is localized in glial cells by its association with the DGC through a PDZ domain-mediated interaction with alpha-syntrophin and suggest an important role for the DGC in central nervous system physiology... - Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesisXiaofang Tang
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
Glia 57:1706-15. 2009..These results suggest differential expression of Kir4.1 in glia and that this channel likely underlies the resting K(+) conductance in passive and complex astrocytes... - Functional and morphological differences among intrinsically photosensitive retinal ganglion cellsTiffany M Schmidt
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 29:476-82. 2009..These data indicate morphological and functional heterogeneity among ipRGCs... - Neurovascular coupling is not mediated by potassium siphoning from glial cellsMonica R Metea
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 27:2468-71. 2007..1 knock-out and wild-type animals. Contrary to the hypothesis, the results demonstrate that glial K+ siphoning in the retina does not contribute significantly to neurovascular coupling... - Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunitsClaudio E Perez-Leighton
Department of Neuroscience, University of Minnesota, 321 Church St SE, 6 145 Jackson Hall, Minneapolis, MN, USA
Eur J Neurosci 33:856-67. 2011..They also suggest that the melanopsin signaling pathway includes TRPC6-containing heteromeric channels in mature retinas... - Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium bufferingPaulo Kofuji
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
Glia 39:292-303. 2002..1). The expression of strongly rectifying Kir channels along the "cables" for spatial buffering currents may prevent an unwarranted outward leak of K(+), and, thus, avoid disturbances of neuronal information processing... - Dystrophin Dp71 is critical for the clustered localization of potassium channels in retinal glial cellsNathan C Connors
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 22:4321-7. 2002..In summary, our data indicate that Dp71 is critical for the clustering but not membrane expression of Kir4.1 in mouse Müller cells. These results point to a new role for dystrophin in glial cells... - Differential cone pathway influence on intrinsically photosensitive retinal ganglion cell subtypesTiffany M Schmidt
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 30:16262-71. 2010..These findings also suggest that ipRGC subtypes signal diverse photic information to various non-image-forming visual centers... 
Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouseTiffany M Schmidt
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Comp Neurol 519:1492-504. 2011..We report that M3 cells form a morphologically heterogeneous population but one that is physiologically homogeneous with properties similar to those of M2 cells...- Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory gangliaX Tang
Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
Neuroscience 166:397-407. 2010..1 is the principal Kir channel type in SGCs. Therefore Kir4.1 emerges as a key regulator of SGC function and possibly neuronal excitability in sensory ganglia... - Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retinaP Kofuji
Departments of Neuroscience and Physiology, University of Minnesota, Minneapolis 55455, USA
J Neurosci 20:5733-40. 2000..The highly regulated localization and the functional properties of Kir4.1 in Müller cells suggest the involvement of this channel in the regulation of extracellular K(+) in the mouse retina... - Diverse types of ganglion cell photoreceptors in the mammalian retinaAndrea Sand
Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
Prog Retin Eye Res 31:287-302. 2012..In this review, we summarize the evidence for the structural and functional diversity of melanopsin photoreceptor subtypes and current controversies in the field... - Intrinsic and extrinsic light responses in melanopsin-expressing ganglion cells during mouse developmentTiffany M Schmidt
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurophysiol 100:371-84. 2008..Collectively, these results demonstrate that ipRGCs make use of melanopsin for phototransduction before eye opening and that these cells further integrate signals derived from the outer retina as the retina matures... - Variable loss of Kir4.1 channel function in SeSAME syndrome mutationsXiaofang Tang
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
Biochem Biophys Res Commun 399:537-41. 2010..These results indicate the differential loss of Kir channel function among SeSAME syndrome mutations... - Connexin immunoreactivity in glial cells of the rat retinaKathleen R Zahs
Department of Physiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Comp Neurol 455:531-46. 2003.... - Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleusJ P Clark
Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
J Neurophysiol 103:3448-64. 2010.... - Contribution of Kir4.1 to the mouse electroretinogramJiang Wu
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Mol Vis 10:650-4. 2004..The electroretinogram (ERG) represents the combination of several distinct cellular processes and conductances. Here, we define the contribution that K+ conductance through Kir4.1 channels makes to the mouse ERG... - KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potentialDaniel C Marcus
Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
Am J Physiol Cell Physiol 282:C403-7. 2002..KCNJ10 is also a limiting pathway for K(+) secretion... - Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunitNora Rozengurt
Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Hear Res 177:71-80. 2003..in stria vascularis, Kir4.1 helps to generate the cochlear endolymph; and (2). in spiral and vestibular ganglia, Kir4.1 in surrounding glial cells helps to support the spiral and vestibular ganglion neurons and their projecting axons...