Paulo Kofuji

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Molecular substrates of potassium spatial buffering in glial cells
    Paulo Kofuji
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Neurobiol 28:195-208. 2003
  2. pmc Potassium buffering in the central nervous system
    P Kofuji
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Neuroscience 129:1045-56. 2004
  3. ncbi request reprint Potassium channel Kir4.1 macromolecular complex in retinal glial cells
    Nathan C Connors
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Glia 53:124-31. 2006
  4. ncbi request reprint The potassium channel Kir4.1 associates with the dystrophin-glycoprotein complex via alpha-syntrophin in glia
    Nathan C Connors
    Department of Neuroscience, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Biol Chem 279:28387-92. 2004
  5. pmc Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis
    Xiaofang Tang
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Glia 57:1706-15. 2009
  6. pmc Functional and morphological differences among intrinsically photosensitive retinal ganglion cells
    Tiffany M Schmidt
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 29:476-82. 2009
  7. pmc Neurovascular coupling is not mediated by potassium siphoning from glial cells
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:2468-71. 2007
  8. pmc Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits
    Claudio E Perez-Leighton
    Department of Neuroscience, University of Minnesota, 321 Church St SE, 6 145 Jackson Hall, Minneapolis, MN, USA
    Eur J Neurosci 33:856-67. 2011
  9. ncbi request reprint Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering
    Paulo Kofuji
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    Glia 39:292-303. 2002
  10. ncbi request reprint Dystrophin Dp71 is critical for the clustered localization of potassium channels in retinal glial cells
    Nathan C Connors
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:4321-7. 2002

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Molecular substrates of potassium spatial buffering in glial cells
    Paulo Kofuji
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Neurobiol 28:195-208. 2003
    ..How such complexity fits into their proposed role in buffering [K+]o in retina is the main topic of this article...
  2. pmc Potassium buffering in the central nervous system
    P Kofuji
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Neuroscience 129:1045-56. 2004
    ..We also discuss intriguing new data that suggest a close physical and functional relationship between Kir and water channels in glial cells...
  3. ncbi request reprint Potassium channel Kir4.1 macromolecular complex in retinal glial cells
    Nathan C Connors
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Glia 53:124-31. 2006
    ..1, suggesting that both channels are tethered together by the DGC in Müller cells. This work further defines a subcellular localization mechanism in Müller cells that facilitates [K+]o buffering in the retina...
  4. ncbi request reprint The potassium channel Kir4.1 associates with the dystrophin-glycoprotein complex via alpha-syntrophin in glia
    Nathan C Connors
    Department of Neuroscience, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Biol Chem 279:28387-92. 2004
    ..These results suggest that Kir4.1 is localized in glial cells by its association with the DGC through a PDZ domain-mediated interaction with alpha-syntrophin and suggest an important role for the DGC in central nervous system physiology...
  5. pmc Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis
    Xiaofang Tang
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Glia 57:1706-15. 2009
    ..These results suggest differential expression of Kir4.1 in glia and that this channel likely underlies the resting K(+) conductance in passive and complex astrocytes...
  6. pmc Functional and morphological differences among intrinsically photosensitive retinal ganglion cells
    Tiffany M Schmidt
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 29:476-82. 2009
    ..These data indicate morphological and functional heterogeneity among ipRGCs...
  7. pmc Neurovascular coupling is not mediated by potassium siphoning from glial cells
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:2468-71. 2007
    ..1 knock-out and wild-type animals. Contrary to the hypothesis, the results demonstrate that glial K+ siphoning in the retina does not contribute significantly to neurovascular coupling...
  8. pmc Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits
    Claudio E Perez-Leighton
    Department of Neuroscience, University of Minnesota, 321 Church St SE, 6 145 Jackson Hall, Minneapolis, MN, USA
    Eur J Neurosci 33:856-67. 2011
    ..They also suggest that the melanopsin signaling pathway includes TRPC6-containing heteromeric channels in mature retinas...
  9. ncbi request reprint Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering
    Paulo Kofuji
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    Glia 39:292-303. 2002
    ..1). The expression of strongly rectifying Kir channels along the "cables" for spatial buffering currents may prevent an unwarranted outward leak of K(+), and, thus, avoid disturbances of neuronal information processing...
  10. ncbi request reprint Dystrophin Dp71 is critical for the clustered localization of potassium channels in retinal glial cells
    Nathan C Connors
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:4321-7. 2002
    ..In summary, our data indicate that Dp71 is critical for the clustering but not membrane expression of Kir4.1 in mouse Müller cells. These results point to a new role for dystrophin in glial cells...
  11. pmc Differential cone pathway influence on intrinsically photosensitive retinal ganglion cell subtypes
    Tiffany M Schmidt
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 30:16262-71. 2010
    ..These findings also suggest that ipRGC subtypes signal diverse photic information to various non-image-forming visual centers...
  12. pmc Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse
    Tiffany M Schmidt
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Comp Neurol 519:1492-504. 2011
    ..We report that M3 cells form a morphologically heterogeneous population but one that is physiologically homogeneous with properties similar to those of M2 cells...
  13. pmc Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia
    X Tang
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Neuroscience 166:397-407. 2010
    ..1 is the principal Kir channel type in SGCs. Therefore Kir4.1 emerges as a key regulator of SGC function and possibly neuronal excitability in sensory ganglia...
  14. pmc Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina
    P Kofuji
    Departments of Neuroscience and Physiology, University of Minnesota, Minneapolis 55455, USA
    J Neurosci 20:5733-40. 2000
    ..The highly regulated localization and the functional properties of Kir4.1 in Müller cells suggest the involvement of this channel in the regulation of extracellular K(+) in the mouse retina...
  15. pmc Diverse types of ganglion cell photoreceptors in the mammalian retina
    Andrea Sand
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Prog Retin Eye Res 31:287-302. 2012
    ..In this review, we summarize the evidence for the structural and functional diversity of melanopsin photoreceptor subtypes and current controversies in the field...
  16. pmc Intrinsic and extrinsic light responses in melanopsin-expressing ganglion cells during mouse development
    Tiffany M Schmidt
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurophysiol 100:371-84. 2008
    ..Collectively, these results demonstrate that ipRGCs make use of melanopsin for phototransduction before eye opening and that these cells further integrate signals derived from the outer retina as the retina matures...
  17. pmc Variable loss of Kir4.1 channel function in SeSAME syndrome mutations
    Xiaofang Tang
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 399:537-41. 2010
    ..These results indicate the differential loss of Kir channel function among SeSAME syndrome mutations...
  18. ncbi request reprint Connexin immunoreactivity in glial cells of the rat retina
    Kathleen R Zahs
    Department of Physiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Comp Neurol 455:531-46. 2003
    ....
  19. pmc Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus
    J P Clark
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    J Neurophysiol 103:3448-64. 2010
    ....
  20. pmc Contribution of Kir4.1 to the mouse electroretinogram
    Jiang Wu
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Vis 10:650-4. 2004
    ..The electroretinogram (ERG) represents the combination of several distinct cellular processes and conductances. Here, we define the contribution that K+ conductance through Kir4.1 channels makes to the mouse ERG...
  21. ncbi request reprint KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential
    Daniel C Marcus
    Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
    Am J Physiol Cell Physiol 282:C403-7. 2002
    ..KCNJ10 is also a limiting pathway for K(+) secretion...
  22. ncbi request reprint Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit
    Nora Rozengurt
    Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Hear Res 177:71-80. 2003
    ..in stria vascularis, Kir4.1 helps to generate the cochlear endolymph; and (2). in spiral and vestibular ganglia, Kir4.1 in surrounding glial cells helps to support the spiral and vestibular ganglion neurons and their projecting axons...