H Koerber

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors
    Derek C Molliver
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Pain 7:13. 2011
  2. ncbi request reprint Comprehensive phenotyping of sensory neurons using an ex vivo somatosensory system
    H Richard Koerber
    Department of Neurobiology, School of Medicine, University of Pittsburgh, 15261, Pittsburgh PA, USA
    Physiol Behav 77:589-94. 2002
  3. pmc Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers
    H Richard Koerber
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Pain 6:58. 2010
  4. ncbi request reprint Synaptic plasticity in the adult spinal dorsal horn: the appearance of new functional connections following peripheral nerve regeneration
    H Richard Koerber
    Department of Neurobiology, University of Pittsburgh, School of Medicine, PA 15261, USA
    Exp Neurol 200:468-79. 2006
  5. ncbi request reprint Changes in skin levels of two neutotrophins (glial cell line derived neurotrohic factor and neurotrophin-3) cause alterations in cutaneous neuron responses to mechanical stimuli
    Jeffrey Lawson
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Sheng Li Xue Bao 60:584-96. 2008
  6. pmc Identity of myelinated cutaneous sensory neurons projecting to nocireceptive laminae following nerve injury in adult mice
    C Jeffery Woodbury
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Comp Neurol 508:500-9. 2008
  7. pmc Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors
    Kristofer K Rau
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:8612-9. 2009
  8. ncbi request reprint Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors
    Sabrina L McIlwrath
    Department of Neurobiology, School of Medicine, University of Pittsburgh, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Eur J Neurosci 26:1801-12. 2007
  9. pmc TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat
    Jeffrey J Lawson
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Pain 9:298-308. 2008
  10. ncbi request reprint Central and peripheral anatomy of slowly adapting type I low-threshold mechanoreceptors innervating trunk skin of neonatal mice
    C Jeffery Woodbury
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15281, USA
    J Comp Neurol 505:547-61. 2007

Collaborators

Detail Information

Publications24

  1. pmc The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors
    Derek C Molliver
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Pain 7:13. 2011
    ..These neurons represent the majority of epidermal afferents in hairy skin, and are predominantly C-fiber polymodal nociceptors (CPMs), responding to mechanical stimulation, heat and in some cases cold...
  2. ncbi request reprint Comprehensive phenotyping of sensory neurons using an ex vivo somatosensory system
    H Richard Koerber
    Department of Neurobiology, School of Medicine, University of Pittsburgh, 15261, Pittsburgh PA, USA
    Physiol Behav 77:589-94. 2002
    ....
  3. pmc Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers
    H Richard Koerber
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Pain 6:58. 2010
    ....
  4. ncbi request reprint Synaptic plasticity in the adult spinal dorsal horn: the appearance of new functional connections following peripheral nerve regeneration
    H Richard Koerber
    Department of Neurobiology, University of Pittsburgh, School of Medicine, PA 15261, USA
    Exp Neurol 200:468-79. 2006
    ..Although there was no obvious anatomical reorganization of afferent projections in the dorsal horn, the observed functional changes with time following transection show the formation of new functional central connections...
  5. ncbi request reprint Changes in skin levels of two neutotrophins (glial cell line derived neurotrohic factor and neurotrophin-3) cause alterations in cutaneous neuron responses to mechanical stimuli
    Jeffrey Lawson
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Sheng Li Xue Bao 60:584-96. 2008
    ..This data indicates that both neurotrophins play roles in determining mechanical thresholds of cutaneous HTMRs and LTMRs and that sensitivity changes involve the ASIC family of putative mechanoreceptive ion channels...
  6. pmc Identity of myelinated cutaneous sensory neurons projecting to nocireceptive laminae following nerve injury in adult mice
    C Jeffery Woodbury
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Comp Neurol 508:500-9. 2008
    ..We conclude that the previously undocumented central morphology of large, myelinated cutaneous nociceptors may very well account for the morphological findings previously thought to require sprouting of LTMRs...
  7. pmc Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors
    Kristofer K Rau
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:8612-9. 2009
    ..Our results demonstrate that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and thermal stimuli...
  8. ncbi request reprint Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors
    Sabrina L McIlwrath
    Department of Neurobiology, School of Medicine, University of Pittsburgh, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Eur J Neurosci 26:1801-12. 2007
    ..These results indicate that cutaneous NT3 overexpression alters the response properties of specific cutaneous sensory neurons, and that these changes may be due to the modulation of putative mechanosensitive ion channels...
  9. pmc TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat
    Jeffrey J Lawson
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Pain 9:298-308. 2008
    ..Therefore, these murine fibers provide a clinically relevant animal model for further study of this group of cutaneous nociceptors...
  10. ncbi request reprint Central and peripheral anatomy of slowly adapting type I low-threshold mechanoreceptors innervating trunk skin of neonatal mice
    C Jeffery Woodbury
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15281, USA
    J Comp Neurol 505:547-61. 2007
    ..These findings therefore provide the first direct confirmation of the functional morphology of this physiologically unique afferent class...
  11. ncbi request reprint Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo
    Sacha A Malin
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 26:8588-99. 2006
    ..These results indicate that GDNF family members regulate the sensitivity of thermal nociceptors and implicate artemin in particular as an important effector in inflammatory hyperalgesia...
  12. ncbi request reprint Phenotypic characterization of gastric sensory neurons in mice
    Klaus Bielefeldt
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 291:G987-97. 2006
    ..Using this novel technique, we identified TRPV1 immunoreactivity in only one-fourth of gastric mechanosensitive neurons, arguing against a major role of this ion channel in sensation of mechanical stimuli under physiological conditions...
  13. ncbi request reprint Glial cell-line-derived neurotrophic factor expression in skin alters the mechanical sensitivity of cutaneous nociceptors
    Kathryn M Albers
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 26:2981-90. 2006
    ..These data indicate that enhanced expression of GDNF in the skin can change mechanical sensitivity of IB4-positive nociceptive afferents and that this may occur through enhanced expression of specific types of channel proteins...
  14. ncbi request reprint Widespread projections from myelinated nociceptors throughout the substantia gelatinosa provide novel insights into neonatal hypersensitivity
    C Jeffery Woodbury
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 23:601-10. 2003
    ..This frequently overlooked population is in a position, therefore, to contribute substantially to paradoxical nocifensive behaviors in neonates and various pain states in adults...
  15. ncbi request reprint Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold
    Christopher M Elitt
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 26:8578-87. 2006
    ..These results indicate that the level of artemin in the skin modulates gene expression and response properties of afferents that project to the skin and that these changes lead to behavioral sensitivity to both hot and cold stimuli...
  16. pmc Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2
    Sacha A Malin
    Department of Medicine, University of Pittsburgh, Pittsburgh, S841 Scaife Hall, 3550 Terrace Avenue, PA 15261, USA
    Pain 138:484-96. 2008
    ..These results indicate that nucleotide signaling through P2Y(2) plays a key role in thermal nociception...
  17. pmc Sensitization of cutaneous nociceptors after nerve transection and regeneration: possible role of target-derived neurotrophic factor signaling
    Michael P Jankowski
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:1636-47. 2009
    ..These changes may underlie the functional alterations observed after nerve regeneration and may explain how nerve damage leads to chronic pain conditions...
  18. pmc Sox11 transcription factor modulates peripheral nerve regeneration in adult mice
    Michael P Jankowski
    Department of Neurobiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Brain Res 1256:43-54. 2009
    ..These anatomical and expression data support an intrinsic role for Sox11 in events that underlie successful regeneration following peripheral nerve injury...
  19. ncbi request reprint Nociceptors lacking TRPV1 and TRPV2 have normal heat responses
    C Jeffery Woodbury
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 24:6410-5. 2004
    ..Moreover, in TRPV1(-/-) mice, 82% of heat-responsive neurons did not express immunoreactivity for TRPV2, another putative noxious heat channel...
  20. pmc Overexpression of artemin in the tongue increases expression of TRPV1 and TRPA1 in trigeminal afferents and causes oral sensitivity to capsaicin and mustard oil
    Christopher M Elitt
    Department of Medicine, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Brain Res 1230:80-90. 2008
    ..These results suggest a potential role for artemin-responsive GFRalpha3/TRPV1/TRPA1 sensory afferents in mediating sensitivity associated with tissue injury, chemical sensitivity or disease states such as burning mouth syndrome...
  21. doi request reprint Heat detection without TRPV1
    H Richard Koerber
    J Pain 9:666. 2008
  22. ncbi request reprint From innervation density to tactile acuity: 1. Spatial representation
    Paul B Brown
    Department of Physiology, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Brain Res 1011:14-32. 2004
    ..The population receptive field representation therefore contains information sufficient for this discrimination...
  23. ncbi request reprint From innervation density to tactile acuity 2: embryonic and adult pre- and postsynaptic somatotopy in the dorsal horn
    Paul B Brown
    Department of Physiology, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Brain Res 1055:36-59. 2005
    ....
  24. ncbi request reprint Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse
    Melissa Zwick
    Department of Anatomy, University of Kentucky School of Medicine, Lexington, Kentucky 40536, USA
    J Neurosci 22:4057-65. 2002
    ....

Research Grants23

  1. PERIPHERAL NERVE REGENERATION AND DORSAL HORN SOMATOTOPY
    H Koerber; Fiscal Year: 1993
    ..Once identified, these processes can then be studied further to determine if certain manipulations could enhance their efficacy...
  2. Peripheral Nerve Regeneration and Dorsal Horn Plasticity
    H Koerber; Fiscal Year: 2007
    ..abstract_text> ..
  3. Primary and Secondary Nociceptors in Persistent Pain
    H Koerber; Fiscal Year: 2007
    ..By comparing the 3 groups, we hope to elucidate the specific populations of primary afferent and secondary nociceptive neurons crucial to this process. ..
  4. Primary and Secondary Nociceptors in Persistent Pain
    H Richard Koerber; Fiscal Year: 2010
    ..By comparing the three groups, we hope to elucidate the specific populations of primary afferent and secondary nociceptive neurons crucial to this process. ..
  5. PERIPHERAL NERVE REGENERATION AND DORSAL HORN SOMATOTOPY
    H Koerber; Fiscal Year: 2003
    ..abstract_text> ..
  6. Peripheral Nerve Regeneration and Sensory Neuron Plasticity
    H Richard Koerber; Fiscal Year: 2010
    ..Determination of these mechanisms could provide targets for new pharmaceutical therapies that could provide for improved functional recovery following regeneration as well as alleviation of the adverse syndromes. ..