David Koelle

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
    D M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 101:1500-8. 1998
  2. pmc A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice
    Julie L Dutton
    Coridon Pty Ltd, Brisbane, Queensland, Australia
    PLoS ONE 8:e76407. 2013
  3. pmc Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes
    David M Koelle
    Department of Medicine, University of Washington, Seattle, USA
    J Virol 80:2863-72. 2006
  4. doi request reprint Herpes simplex: insights on pathogenesis and possible vaccines
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Annu Rev Med 59:381-95. 2008
  5. pmc Homing in on the cellular immune response to HSV-2 in humans
    David M Koelle
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Am J Reprod Immunol 53:172-81. 2005
  6. pmc Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:12899-904. 2003
  7. ncbi request reprint Expression cloning for the discovery of viral antigens and epitopes recognized by T cells
    David M Koelle
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Methods 29:213-26. 2003
  8. pmc Recent progress in herpes simplex virus immunobiology and vaccine research
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Microbiol Rev 16:96-113. 2003
  9. ncbi request reprint Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles
    David M Koelle
    Department of Medicine, University of Washington, Seattle, USA
    Blood 99:3844-7. 2002
  10. ncbi request reprint Vaccines for herpes simplex virus infections
    David M Koelle
    University of Washington, Harborview Medical Center, Seattle 98104, USA
    Curr Opin Investig Drugs 7:136-41. 2006

Research Grants

  1. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2003
  2. Vaccinia: T-cell immunity and homing to skin
    David Koelle; Fiscal Year: 2007
  3. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2007
  4. Vaccinia: T-cell immunity and homing to skin
    David Koelle; Fiscal Year: 2006
  5. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2006
  6. HSV Immunotherapeutic Vaccine
    David Koelle; Fiscal Year: 2005
  7. Intradermal vaccinia:T-cell specificity and skin homing
    David Koelle; Fiscal Year: 2005
  8. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2005
  9. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2004
  10. Vaccinia: T-cell immunity and homing to skin
    David Koelle; Fiscal Year: 2009

Collaborators

Detail Information

Publications51

  1. pmc Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
    D M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 101:1500-8. 1998
    ..The phenotypes of cells with HSV-specific cytotoxic responses varied between patients, having CD4+ and CD8+ components. Immunotherapeutic approaches to HSV should be directed at improving in vivo cytolytic activity to HSV...
  2. pmc A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice
    Julie L Dutton
    Coridon Pty Ltd, Brisbane, Queensland, Australia
    PLoS ONE 8:e76407. 2013
    ....
  3. pmc Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes
    David M Koelle
    Department of Medicine, University of Washington, Seattle, USA
    J Virol 80:2863-72. 2006
    ..These observations are consistent with cooperation between innate and acquired immunity to promote a pattern of homing receptor expression that is physiologically appropriate for trafficking to infected tissues...
  4. doi request reprint Herpes simplex: insights on pathogenesis and possible vaccines
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Annu Rev Med 59:381-95. 2008
    ....
  5. pmc Homing in on the cellular immune response to HSV-2 in humans
    David M Koelle
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Am J Reprod Immunol 53:172-81. 2005
    ..Vaccines have had activity in herpes simplex virus (HSV)-seronegative women only. Understanding how HSV-specific T cells traffic to infected sites may assist in vaccine design...
  6. pmc Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:12899-904. 2003
    ..We conclude that among circulating cells expressing a homing-associated receptor, during chronic herpes type 2 infection, the CD8 T cell response becomes quite focused despite the presence of many potential antigenic peptides...
  7. ncbi request reprint Expression cloning for the discovery of viral antigens and epitopes recognized by T cells
    David M Koelle
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Methods 29:213-26. 2003
    ..Alternative methods of antigen discovery are better suited for nonculturable viruses. Expression cloning methods are somewhat generic and are adaptable between infectious diseases, autoimmunity, and tumor immunology research projects...
  8. pmc Recent progress in herpes simplex virus immunobiology and vaccine research
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Microbiol Rev 16:96-113. 2003
    ..HSV vaccines have also been evaluated for the immunotherapy of established HSV infection...
  9. ncbi request reprint Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles
    David M Koelle
    Department of Medicine, University of Washington, Seattle, USA
    Blood 99:3844-7. 2002
    ..Given the prevalence of this viral infection and the HLA alleles involved, it is possible that this cross-reactivity may be involved in clinically significant events...
  10. ncbi request reprint Vaccines for herpes simplex virus infections
    David M Koelle
    University of Washington, Harborview Medical Center, Seattle 98104, USA
    Curr Opin Investig Drugs 7:136-41. 2006
    ..Other vaccine formats also in development include attenuated live or replication-incompetent HSV-2 strains and technologies that target virus-specific CD8 T-cell responses...
  11. ncbi request reprint Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection
    D M Koelle
    Allergy and Infectious Diseases, Harborview Medical Center, Seattle, WA 98104, USA
    J Infect Dis 182:662-70. 2000
    ..This local response may possibly assist in limiting the clinical consequences of secondary HSV-2 infection, whether due to endogenous reactivation or exogenous reinfection...
  12. pmc Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans
    D M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 74:10930-8. 2000
    ..Some clones had cytotoxic-T-lymphocyte activity. The diverse specificities and HLA-restricting alleles of local virus-specific T cells in HSK are consistent with their contribution to HSK by a proinflammatory effect...
  13. pmc CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins
    D M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98105, USA
    J Virol 74:11422-5. 2000
    ..Recognition of VP5 and tegument VP22 were similar to that of gB2 and gD2, currently under study as vaccines. These prevalence data suggest that HSV capsid and tegument proteins may also be candidate vaccine antigens...
  14. ncbi request reprint CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells
    D M Koelle
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:4049-58. 2001
    ..Tegument proteins, identified for the first time as Ags recognized by HSV-specific CD8 CTL, are rational candidate vaccine compounds...
  15. pmc APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98102, USA
    Sex Transm Infect 86:202-6. 2010
    ..Apolipoprotein E is polymorphic in the human population. APOE4 has previously been reported to correlate with symptomatic oral and genital herpes disease...
  16. pmc Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naïve and HSV-2-infected subjects
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Vaccine Immunol 15:773-82. 2008
    ..Modifications of the dose, adjuvant, route, schedule, or HSV antigen may be required to improve responses...
  17. pmc Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus
    David M Koelle
    Department of Medicine, Department of Laboratory Medicine, and Department of Pathobiology, University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 110:537-48. 2002
    ..The evaluation of vaccines for skin and mucosal pathogens should include study of the induction of appropriate tissue-specific homing molecules...
  18. doi request reprint One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection
    Joseph B Bavaro
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:383-6. 2008
    ..To evaluate the efficacy of a 1-day course of valacyclovir in reducing the duration and severity of genital herpes recurrences and to measure the frequency of viral shedding episodes subsequent to antiviral therapy...
  19. ncbi request reprint Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells
    Nancy A Danke
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Hum Immunol 66:777-87. 2005
    ....
  20. ncbi request reprint Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus
    Lichen Jing
    Department of Medicine, University of Washington, Seattle 98101, USA
    J Immunol 178:6374-86. 2007
    ..These findings are consistent with models in which exogenous Ag drives CD4 immunodominance, and provides tools to investigate the relationship between Ab and CD4 T cell specificity for complex pathogens...
  21. pmc Public TCR use by herpes simplex virus-2-specific human CD8 CTLs
    Lichun Dong
    Department of Medicine, University of Washington, Seattle, WA 98102, USA
    J Immunol 184:3063-71. 2010
    ..These data indicate that the CD8 response to a dominant alpha-herpesvirus epitope converges on preferred TCR sequences with relatively constant functional avidity...
  22. pmc Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009
    ..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition...
  23. pmc Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection
    William J Muller
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    J Gen Virol 90:1153-63. 2009
    ..Cellular responses to tegument protein epitopes were also detected after HSV-2 infection. Tegument proteins are rational candidates for further HSV-2 vaccine research...
  24. pmc Diversity in the acute CD8 T cell response to vaccinia virus in humans
    Lichen Jing
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 175:7550-9. 2005
    ....
  25. pmc Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2
    Julio C Gonzalez
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Infect Dis 191:243-54. 2005
    ..Short-term culture-expanded HSV-2-specific CD4(+) T lymphocytes also selectively express ESL. These findings have implications for the optimization of vaccines for HSV and other cutaneous pathogens...
  26. pmc Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2
    William J Muller
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Arch Virol 153:1165-9. 2008
    ..We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease...
  27. ncbi request reprint Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells
    Lidija Bosnjak
    Center for Virus Research, Westmead Millennium Institutem, Westmead Millennium Institute and Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Australia
    J Immunol 174:2220-7. 2005
    ..In this study we provide an explanation for this phenomenon, demonstrating that HSV-infected apoptotic DCs are readily phagocytosed by uninfected bystander DCs, which, in turn, stimulate virus-specific CD8+ T cell clones...
  28. ncbi request reprint Autoreactive T cells in healthy individuals
    Nancy A Danke
    Benaroya Research Institute, Virginia Mason, Seattle, WA 98101, USA
    J Immunol 172:5967-72. 2004
    ..These results show that autoreactive T cells are present in most healthy individuals and that Treg likely play an important role of keeping these autoreactive T cells in check...
  29. pmc Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes
    Nancy Hosken
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98109, USA
    J Virol 80:5509-15. 2006
    ..Whether this variability in the CD8(+) T-cell response within individuals is associated with the frequency of viral reactivation warrants further study...
  30. pmc ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humans
    Lichen Jing
    Department of Medicine, University of Washington, 1616 Eastlake Avenue East, Suite 251, Seattle, WA 98102, USA
    J Immunol Methods 347:36-45. 2009
    ....
  31. ncbi request reprint High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 185:20-7. 2002
    ..All ganR isolates contained a UL97 mutation. GanR CMV infection occurs in nearly 10% of lung transplant recipients, despite preemptive antiviral therapy, and is more common among D+/R- patients...
  32. pmc An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling
    Lichen Jing
    Department of Medicine, University of Washington, Seattle, Washington 98102, USA
    J Virol 82:7120-34. 2008
    ..Our results provide the first empirical whole-proteome data set regarding the global CD4 response to full-length proteins in a complex virus and are consistent with the theory that abundant structural proteins are immunodominant...
  33. pmc Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system
    Ashok Cattamanchi
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Clin Vaccine Immunol 15:1638-43. 2008
    ..A DNA-based vaccination strategy against HSV-2 appears to be safe and may generate a vaccine-specific cellular immune response, but high vaccine doses are likely needed to elicit an immune response in most vaccinees...
  34. ncbi request reprint T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
    J Immunol 170:4380-8. 2003
    ..Understanding the basis of these acquired immune responses may be critical in developing effective vaccines for genital herpes...
  35. ncbi request reprint Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 35:518-25. 2002
    ..For all assays, results did not differ between the group of twins with CFS and the healthy twins...
  36. pmc Evasion of the mucosal innate immune system by herpes simplex virus type 2
    Tao Peng
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 83:12559-68. 2009
    ..HSV-2's blockade of the innate immune system's production of type I IFN may be a major factor in allowing the virus to break through host mucosal defenses...
  37. ncbi request reprint Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome
    Daniel E Sabath
    Department of Laboratory Medicine, Chronic Fatigue Syndrome Cooperative Research Center, University of Washington, Seattle, Washington 98195 7110, USA
    J Infect Dis 185:828-32. 2002
    ..The monozygotic co-twin control design is of unique value because of its ability to control for genetic influences on CFS; however, additional studies will be required to further assess immune dysregulation in this illness...
  38. pmc A case of Ramsay Hunt-like syndrome caused by herpes simplex virus type 2
    George A Diaz
    Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 40:1545-7. 2005
    ..Clinical and laboratory-proven acyclovir resistance developed during therapy. Immunologic assays revealed normal reactivity to HSV-2...
  39. pmc Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    Joshua T Schiffer
    Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:18973-8. 2010
    ..The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host...
  40. pmc Human CD4+ CD25 high cells suppress proliferative memory lymphocyte responses to herpes simplex virus type 2
    George A Diaz
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 80:8271-3. 2006
    ..Regulatory T cells may modulate human CD4 memory responses to HSV-2 and influence their antiviral and inflammatory functions...
  41. pmc Longitudinal analysis of herpes simplex virus-specific CD4+ cell clonotypes in infected tissues and blood
    Serge Barcy
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109 8070, USA
    J Infect Dis 191:2012-21. 2005
    ..Genital infection by herpes simplex virus (HSV)-2 offers a unique model for study of the effects of a remitting and exacerbating infection on the survival and persistence of antigen-specific T cells...
  42. pmc Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    Jia Zhu
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:595-603. 2007
    ..These findings indicate that the frequency and clinical course of HSV-2 reactivation in humans is influenced by virus-specific CD8(+) T cells that persist in peripheral mucosa and genital skin after resolution of herpes lesions...
  43. pmc Sequence-based methods for identifying epidemiologically linked herpes simplex virus type 2 strains
    Emily Toth Martin
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 600 Broadway, Suite 400, Seattle, WA 98122, USA
    J Clin Microbiol 44:2541-6. 2006
    ..Our results suggest that a multilocus assay based on several DNA sequences has the potential to be an informative tool for identifying epidemiologically related HSV-2 strains...
  44. pmc Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman
    Todd Czartoski
    Molecular Virology Laboratory, University of Washington, 960 Republican St, Seattle, WA 98195, USA
    J Clin Microbiol 44:1584-6. 2006
    ..She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2...
  45. ncbi request reprint Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA
    J Infect Dis 196:505-9. 2007
    ..02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection...
  46. ncbi request reprint HHV-8 infection: a model for reactivation and transmission
    Lawrence Corey
    Department of Medicine, Laboratory Medicine and Epidemiology, University of Washington, Seattle, WA, USA
    Rev Med Virol 12:47-63. 2002
    ..Hopefully continued study will address many of the critical questions that exist today regarding how this infection is transmitted and acquired...
  47. pmc A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition
    Whitney A Macdonald
    Dept of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 198:679-91. 2003
    ..The findings suggest that these closely related class I genes are maintained in diverse human populations through their differential impact on the selection of peptide ligands and the T cell repertoire...
  48. ncbi request reprint Doctor, why is my herpes so bad? The search continues
    David M Koelle
    J Infect Dis 197:331-4. 2008
  49. ncbi request reprint Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcoma
    Louise E Kimball
    Department of Pathobiology, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, 98109, USA
    J Infect Dis 189:2016-22. 2004
    ..The data from the present study suggest that NAb may play a role in the control of KSHV infection and the prevention of progression of KSHV infection to KS...
  50. ncbi request reprint Prospects for developing an effective vaccine against ocular herpes simplex virus infection
    David M Koelle
    Department of Medicine, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Curr Eye Res 30:929-42. 2005
    ....
  51. ncbi request reprint Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 193:698-702. 2006
    ..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1...

Research Grants11

  1. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2003
    ....
  2. Vaccinia: T-cell immunity and homing to skin
    David Koelle; Fiscal Year: 2007
    ..Our data will assist in evaluating the immunogenicity of these constructs. ..
  3. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2007
    ....
  4. Vaccinia: T-cell immunity and homing to skin
    David Koelle; Fiscal Year: 2006
    ..Our data will assist in evaluating the immunogenicity of these constructs. ..
  5. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2006
    ....
  6. HSV Immunotherapeutic Vaccine
    David Koelle; Fiscal Year: 2005
    ....
  7. Intradermal vaccinia:T-cell specificity and skin homing
    David Koelle; Fiscal Year: 2005
    ..2) Measure E-selectin binding by vaccinia-specific CD8 cells, and 2.3) Compare CLA and E-selectin binding by vaccinia-specific T-cells in recent and distant vaccines. ..
  8. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2005
    ....
  9. Immune Correlates of HSV-2 Disease Severity
    David Koelle; Fiscal Year: 2004
    ....
  10. Vaccinia: T-cell immunity and homing to skin
    David Koelle; Fiscal Year: 2009
    ..Our data will assist in evaluating the immunogenicity of these constructs. ..