Thomas J Kodadek

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Synthetic molecules as antibody replacements
    Thomas Kodadek
    Center for Biomedical Inventions, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8573, USA
    Acc Chem Res 37:711-8. 2004
  2. pmc The proteasomal ATPase complex is required for stress-induced transcription in yeast
    Rita Sulahian
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8573, USA
    Nucleic Acids Res 34:1351-7. 2006
  3. ncbi request reprint Protein microarrays: prospects and problems
    T Kodadek
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Chem Biol 8:105-15. 2001
  4. ncbi request reprint Development of protein-detecting microarrays and related devices
    Thomas Kodadek
    Dept of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Trends Biochem Sci 27:295-300. 2002
  5. ncbi request reprint Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors
    Thomas Kodadek
    Departments of Internal Medicine and Molecular Biology, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Biopolymers 66:134-40. 2002
  6. ncbi request reprint Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads
    Thomas Kodadek
    Department of Internal Medicine, Division of Translational Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9185, USA
    Mol Biosyst 2:25-35. 2006
  7. ncbi request reprint Keeping transcriptional activators under control
    Thomas Kodadek
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, USA
    Cell 127:261-4. 2006
  8. pmc Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins
    William Renthal
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 62:335-48. 2009

Research Grants

  1. Development of Protein-Detecting Microarrays
    Thomas Kodadek; Fiscal Year: 2002

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Synthetic molecules as antibody replacements
    Thomas Kodadek
    Center for Biomedical Inventions, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8573, USA
    Acc Chem Res 37:711-8. 2004
    ..This article reviews efforts to overcome these limitations and to develop a facile, high-throughput methodology for the isolation of synthetic protein ligands with antibody-like binding characteristics...
  2. pmc The proteasomal ATPase complex is required for stress-induced transcription in yeast
    Rita Sulahian
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8573, USA
    Nucleic Acids Res 34:1351-7. 2006
    ..These data show that the non-proteolytic requirement for the proteasomal ATPases extends beyond the GAL genes in yeast and includes at least the heat and oxidative stress-responsive genes...
  3. ncbi request reprint Protein microarrays: prospects and problems
    T Kodadek
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Chem Biol 8:105-15. 2001
    ..These arrays will allow for expression profiling to be done at the protein level. In this article, some of the major technological challenges to the development of protein arrays are discussed, along with potential solutions...
  4. ncbi request reprint Development of protein-detecting microarrays and related devices
    Thomas Kodadek
    Dept of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Trends Biochem Sci 27:295-300. 2002
    ..Progress in these areas, and some of the challenges remaining, are reviewed in this article...
  5. ncbi request reprint Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors
    Thomas Kodadek
    Departments of Internal Medicine and Molecular Biology, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8573, USA
    Biopolymers 66:134-40. 2002
    ..Recent experimental progress toward this goal and a number of other potential solutions are discussed...
  6. ncbi request reprint Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads
    Thomas Kodadek
    Department of Internal Medicine, Division of Translational Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9185, USA
    Mol Biosyst 2:25-35. 2006
    ..This is a particularly convenient format for library screening for laboratories with limited budgets and modest robotics capabilities...
  7. ncbi request reprint Keeping transcriptional activators under control
    Thomas Kodadek
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, USA
    Cell 127:261-4. 2006
    ..Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process...
  8. pmc Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins
    William Renthal
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 62:335-48. 2009
    ....

Research Grants1

  1. Development of Protein-Detecting Microarrays
    Thomas Kodadek; Fiscal Year: 2002
    ..If successful, we will then move to apply these technologies to the creation and evaluation of functional PDMs. ..