P Kochunov

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study
    Peter Kochunov
    Research Imaging Institute, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Neuroreport 21:716-21. 2010
  2. pmc Mapping primary gyrogenesis during fetal development in primate brains: high-resolution in utero structural MRI of fetal brain development in pregnant baboons
    Peter Kochunov
    Research Imaging Institute, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    Front Neurosci 4:20. 2010
  3. pmc Fractional anisotropy of water diffusion in cerebral white matter across the lifespan
    P Kochunov
    Research Imaging Institute, University of Texas Health Science Center at San Antonio, TX 78284, United States
    Neurobiol Aging 33:9-20. 2012
  4. ncbi request reprint Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Neuroimage 35:478-87. 2007
  5. pmc Blood pressure and cerebral white matter share common genetic factors in Mexican Americans
    Peter Kochunov
    University of Texas Health Science Center at San Antonio, Research Imaging Institute, San Antonio, TX 78284, USA
    Hypertension 57:330-5. 2011
  6. pmc Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses
    Peter Kochunov
    Dip ABMP, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 41:2137-42. 2010
  7. pmc Can structural MRI indices of cerebral integrity track cognitive trends in executive control function during normal maturation and adulthood?
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Texas 78284, USA
    Hum Brain Mapp 30:2581-94. 2009
  8. pmc Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center, San Antonio, 78284, USA
    Neuroimage 45:17-28. 2009
  9. pmc Development of structural MR brain imaging protocols to study genetics and maturation
    Peter Kochunov
    Research Imaging Center, Univ Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Methods 50:136-46. 2010
  10. pmc Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging
    P Kochunov
    University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Neuroimage 49:1190-9. 2010

Research Grants

Detail Information

Publications33

  1. pmc Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study
    Peter Kochunov
    Research Imaging Institute, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    Neuroreport 21:716-21. 2010
    ..Our findings indicate that alcohol intoxication produces profound changes, which may detrimentally influence neurodevelopmental processes in the brain...
  2. pmc Mapping primary gyrogenesis during fetal development in primate brains: high-resolution in utero structural MRI of fetal brain development in pregnant baboons
    Peter Kochunov
    Research Imaging Institute, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    Front Neurosci 4:20. 2010
    ....
  3. pmc Fractional anisotropy of water diffusion in cerebral white matter across the lifespan
    P Kochunov
    Research Imaging Institute, University of Texas Health Science Center at San Antonio, TX 78284, United States
    Neurobiol Aging 33:9-20. 2012
    ..These findings carry multiple and diverse implications for both theoretical studies of the neurobiology of maturation and aging and for the clinical studies of neuropsychiatric disorders...
  4. ncbi request reprint Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Neuroimage 35:478-87. 2007
    ..These data are consistent with the hypothesis that late-myelinating regions of the brain bear the brunt of age-related degenerative changes...
  5. pmc Blood pressure and cerebral white matter share common genetic factors in Mexican Americans
    Peter Kochunov
    University of Texas Health Science Center at San Antonio, Research Imaging Institute, San Antonio, TX 78284, USA
    Hypertension 57:330-5. 2011
    ..The magnitude of this overlap appears to be influenced by phylogeny of WM development, suggesting a possible role for genotype-by-age interactions...
  6. pmc Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses
    Peter Kochunov
    Dip ABMP, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 41:2137-42. 2010
    ..Our aims were to localize novel quantitative trait loci acting pleiotropically on these phenotypes and to replicate previous genetic findings on whole brain HWM volume and BP measurements...
  7. pmc Can structural MRI indices of cerebral integrity track cognitive trends in executive control function during normal maturation and adulthood?
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Texas 78284, USA
    Hum Brain Mapp 30:2581-94. 2009
    ..A large fraction of the variability in ECF (62%) can be explained by variability in the structural indices from these two regions...
  8. pmc Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center, San Antonio, 78284, USA
    Neuroimage 45:17-28. 2009
    ..Specifically, age-related WM degradation in the thinly myelinated association tracts appears to track the decreases in global and regional rates of glucose uptake...
  9. pmc Development of structural MR brain imaging protocols to study genetics and maturation
    Peter Kochunov
    Research Imaging Center, Univ Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Methods 50:136-46. 2010
    ..Finally, recent findings in the genetics of cerebral gyrification and tracking of maturation trends in the fetal, newborn and adult brain are described...
  10. pmc Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging
    P Kochunov
    University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Neuroimage 49:1190-9. 2010
    ..A smaller proportion (20%) of variance in the PP-CPS could be explained by bilateral increases in frontal sulcal span and increases in HWM volumes...
  11. pmc Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Stroke 40:3685-90. 2009
    ....
  12. pmc Genetics of primary cerebral gyrification: Heritability of length, depth and area of primary sulci in an extended pedigree of Papio baboons
    P Kochunov
    Research Imaging Institute, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neuroimage 53:1126-34. 2010
    ..Our results imply that heritability of sulcal phenotypes may be regionally modulated by arcuate U-fiber systems. However, further research is necessary to unravel the complexity of genetic contributions to cortical morphology...
  13. pmc Genetics of microstructure of cerebral white matter using diffusion tensor imaging
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, TX 78284, USA
    Neuroimage 53:1109-16. 2010
    ....
  14. ncbi request reprint Relationship among neuroimaging indices of cerebral health during normal aging
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Texas 78284, USA
    Hum Brain Mapp 29:36-45. 2008
    ..34). These findings are of interest in designing quantitative measures of brain aging for monitoring individual patients and in large-scale clinical trials...
  15. ncbi request reprint Improvement in variability of the horizontal meridian of the primary visual area following high-resolution spatial normalization
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Hum Brain Mapp 18:123-34. 2003
    ..Thus, the proposed methodology provides an efficient, unbiased, and automated way to study structure-functional relationship in human brain...
  16. ncbi request reprint Localized morphological brain differences between English-speaking Caucasians and Chinese-speaking Asians: new evidence of anatomical plasticity
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284, USA
    Neuroreport 14:961-4. 2003
    ..While anatomical plasticity due to manual skill acquisition (e.g. in musicians) has been established, to our knowledge this is the first report of a brain anatomical difference attributable to a learned cognitive strategy...
  17. ncbi request reprint Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalization
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Hum Brain Mapp 24:325-31. 2005
    ..Regionally, the posterior portions of corpus callosum (posterior midbody, isthmus, and splenium), which contain heavily myelinated fibers, were found to be 25% smaller in the population with 18q-...
  18. ncbi request reprint Perfusion-weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIR-HASTE: comparison with H(2)(15)O PET measurements
    H L Liu
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78284-6240, USA
    Magn Reson Med 45:431-5. 2001
    ..A statistically significant correlation (r = 0.75, P < 0.05) was found between results acquired from these two modalities. Magn Reson Med 45:431-435, 2001...
  19. ncbi request reprint Regional spatial normalization: toward an optimal target
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA
    J Comput Assist Tomogr 25:805-16. 2001
    ..Warping to the MDT target was shown by an independent multiscale correlation method to produce superior results...
  20. pmc Cortical sulcal areas in baboons (Papio hamadryas spp.) with generalized interictal epileptic discharges on scalp EEG
    C A Szabo
    Department of Neurology, UTHSCSA, San Antonio, TX, USA
    Epilepsy Res 93:91-5. 2011
    ....
  21. ncbi request reprint An optimized individual target brain in the Talairach coordinate system
    P Kochunov
    Research Laboratory Center, University of Texas Health Science Center at San Antonio, 78284, USA
    Neuroimage 17:922-7. 2002
    ..05). An intended use of this processing is to create a digital volumetric atlas that represents anatomy of a normal adult brain by optimizing the HRBT to the group consisting of 100+ normal subjects...
  22. ncbi request reprint ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:155-64. 2005
    ..We then give an example of how comparisons of this sort may lead to advanced designs in future meta-analytic research...
  23. ncbi request reprint A comparison of label-based review and ALE meta-analysis in the Stroop task
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:6-21. 2005
    ....
  24. ncbi request reprint Intensity modulation of TMS-induced cortical excitation: primary motor cortex
    Peter T Fox
    Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284, USA
    Hum Brain Mapp 27:478-87. 2006
    ..Remote regions showed varying patterns of intensity response, which we interpret as reflecting varying levels of neuronal excitability and/or functional coupling in the conditions studied...
  25. ncbi request reprint Column-based model of electric field excitation of cerebral cortex
    Peter T Fox
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 22:1-14. 2004
    ..In addition, Rushton's cosine principle can used to model stimulation efficacy for an electrical field applied at any cortical site at any intensity and in any orientation...
  26. pmc Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract
    Addanki P Kumar
    Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Clin Cancer Res 13:2784-94. 2007
    ..In this study, we used the transgenic adenocarcinoma of mouse prostate (TRAMP) model to examine the ability of Nexrutine to protect TRAMP mice from developing prostate cancer...
  27. ncbi request reprint Age-related morphology trends of cortical sulci
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Hum Brain Mapp 26:210-20. 2005
    ..Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05)...
  28. ncbi request reprint Structural brain changes in bipolar disorder using deformation field morphometry
    Jair C Soares
    Division of Mood and Anxiety Disorders, South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, Texas, USA
    Neuroreport 16:541-4. 2005
    ..Our results are complementary to the findings of functional imaging and post-mortem studies that demonstrate abnormalities in the dorsolateral prefrontal cortex in bipolar patients...
  29. ncbi request reprint Retrospective motion correction protocol for high-resolution anatomical MRI
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Texas, USA
    Hum Brain Mapp 27:957-62. 2006
    ..RMC was tested on 35 subjects who were considered at high risk for head motion. Our results show that RMC provided better contrast-to-noise ratio and boundary detail when compared to nonmotion-corrected averaged images...
  30. pmc Transcriptomics of cortical gray matter thickness decline during normal aging
    P Kochunov
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA
    Neuroimage 82:273-83. 2013
    ....
  31. ncbi request reprint Multimodality Chamber for coregistered anatomical and molecular imaging of small animals
    Ali N Bahadur
    Greehey Children s Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX, USA
    Lab Anim (NY) 36:29-35. 2007
    ..The authors have developed and successfully tested a two-piece acrylic Multimodality Chamber that enables investigators to coregister images from two or more modalities, including microMR, microCT, microPET and optical imaging...
  32. ncbi request reprint Heritability of brain volume, surface area and shape: an MRI study in an extended pedigree of baboons
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Hum Brain Mapp 28:576-83. 2007
    ....
  33. ncbi request reprint Cortical sulci and bipolar disorder
    Thomas R Coyle
    Department of Psychology, University of Texas at San Antonio, Texas 78249, USA, and Service Hospitalier Frédéric Joliot, Commissariat a l Energie Atomique, Orsay Cedex, France
    Neuroreport 17:1739-42. 2006
    ..The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci...

Research Grants2

  1. COMBINING NEUROIMAGING AND GENETICS FOR HERITABILITY MEASUREMENTS
    Peter Kochunov; Fiscal Year: 2007
    ..In addition to generating valuable, new data, this project will allow Peter Kochunov to undertake rigorous training in analytical genomics and accumulate first hand experience in executing genomic studies. ..