Affiliation: University of Pittsburgh
Jackson T, Kotermanski S, Kochanek P, Jackson E. Oxidative Stress Induces Release of 2'-AMP from Microglia. Brain Res. 2018;: pubmed publisher
..The 2',3'-cAMP/2'-AMP/adenosine pathway mechanism may serve to prevent over-activation of microglia in response to oxidative stress. ..
Santarsieri M, Kumar R, Kochanek P, Berga S, Wagner A. Variable neuroendocrine-immune dysfunction in individuals with unfavorable outcome after severe traumatic brain injury. Brain Behav Immun. 2015;45:15-27 pubmed publisher
..These results present a novel biomarker-based index from which to discriminate outcome and emphasize the need for evaluating tailored treatments targeting inflammation early after injury. ..
ANEJA R, Alcamo A, Cummings J, Vagni V, Janesko Feldman K, Wang Q, et al
. Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability or Cognitive Outcome in Global, Inducible HMGB1 Knockout Mice despite Tissue Sparing after Experimental Traumatic Brain Injury. J Neurotrauma. 2018;: pubmed publisher
..Given the pleiotropic actions of extracellular and intracellular HMGB1, when evaluating the potential use of therapies targeting HMGB1, effects on long-term cognitive outcome should be carefully evaluated. ..
Kochanek P. Pediatric traumatic brain injury: quo vadis?. Dev Neurosci. 2006;28:244-55 pubmed
..Unique therapeutic targets and enhanced therapeutic opportunities, both in the acute phase after injury and in rehabilitation and regeneration, are suggested. ..
Kochanek P, Fink E, Bell M, Bayir H, Clark R. Therapeutic hypothermia: applications in pediatric cardiac arrest. J Neurotrauma. 2009;26:421-7 pubmed publisher
Newell E, Exo J, Verrier J, Jackson T, Gillespie D, Janesko Feldman K, et al
. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-Î± and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res. 2015;1594:27-35 pubmed publisher
..Adenosine and its precursors, via A2A receptors, likely suppress TNF-Î± and CXCL10 production by activated microglia in brain diseases. ..
Kochanek P, Bramlett H, Dietrich W, Dixon C, Hayes R, POVLISHOCK J, et al
. A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy. J Trauma. 2011;71:S15-24 pubmed publisher
Kochanek P, Vagni V, Janesko K, Washington C, Crumrine P, Garman R, et al
. Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2006;26:565-75 pubmed
..05) and SE was restricted to the ko mice (83% incidence). Our data suggest a critical endogenous anticonvulsant action of adenosine at A1 receptors early after experimental TBI. ..
Kochanek P, Wallisch J, Bayir H, Clark R. Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned. Childs Nerv Syst. 2017;33:1693-1701 pubmed publisher