James J Kobie
Affiliation: University of Rochester
- 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activityJames J Kobie
Division of Allergy, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 7:e35356. 2012..Our results suggest that the development of HIV BNAbs is not merely a consequence of a general breakdown in tolerance, but rather a more intricate expansion of selective autoreactive B cells and antibodies...
- T helper cytokine patterns: defined subsets, random expression, and external modulationTim R Mosmann
David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, NY 14642, USA
Immunol Res 45:173-84. 2009..Additional contributions to diversity may include new committed subsets, random expression of only part of the committed pattern, and modification of the expression patterns by cytokines and other mediators...
- Anti-idiotypic monobodies for immune response profilingMark A Sullivan
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Methods 58:62-8. 2012....
- 9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profilesDanielle C Alcena
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 8:e85098. 2013..Further studies of 9G4+ B cells may shed light on the regulation of B cell tolerance and interface between the generation of specific autoreactivities and the induction of antiviral immunity in persons living with HIV. ..
- Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Specific Human Monoclonal AntibodiesJames J Kobie
1 Division of Infectious Diseases, University of Rochester Medical Center, Rochester, New York
Monoclon Antib Immunodiagn Immunother 34:65-72. 2015..These results also bear significant implications for the development of immunogens. ..
- Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factorJames J Kobie
Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA
Arthritis Res Ther 13:R209. 2011..Therefore, we asked if short-term effector (d5-d10) and memory (1 month or later) B cell responses to antigen were compromised in RA patients treated with anti-TNF therapy...
- Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunizationJessica L Halliley
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 28:3582-7. 2010..The kinetics of this response and the relationship of circulating ASCs to protective antibody titers have not been completely explored...
- Human basophils express amphiregulin in response to T cell-derived IL-3Yilin Qi
David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Allergy Clin Immunol 126:1260-6.e4. 2010..Amphiregulin produced by mouse hematopoietic cells contributes to the elimination of a nematode infection by a type 2 effector response...
- Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsivenessShannon P Hilchey
James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 183:6157-66. 2009..In addition, these studies suggest that the A(2A/B) AR as well as CD39 are novel pharmacological targets for augmenting cancer immunotherapy...
- Characterization of cell seeding and specific capture of B cells in microbubble well arraysMeghan C Jones
Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA
Biomed Microdevices 15:453-63. 2013..These results emphasize the importance of using primary cells in technology development and suggest the need to utilize B cell capture agents that are insensitive to cell activation...