Mitchell D Knutson

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, USA
    Nutr Rev 66:591-6. 2008
  2. pmc Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 102:1324-8. 2005
  3. ncbi request reprint Steap proteins: implications for iron and copper metabolism
    Mitchell D Knutson
    Food Science and Human Nutrition Department, PO Box 110370, University of Florida, Gainesville, FL 32611 0370, USA
    Nutr Rev 65:335-40. 2007
  4. doi request reprint Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    Nutr Rev 67:284-8. 2009
  5. ncbi request reprint Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy
    Jinze Xu
    Department of Aging and Geriatric Research, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida 32611, USA
    Exp Gerontol 47:100-8. 2012
  6. pmc Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
    Tim Hofer
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, USA
    Exp Gerontol 43:563-70. 2008
  7. pmc Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 103:13612-7. 2006
  8. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
  9. doi request reprint Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice
    Chia Yu Wang
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL
    Hepatology 58:788-98. 2013
  10. pmc Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels
    Supak Jenkitkasemwong
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    J Nutr 140:723-30. 2010

Research Grants

  1. Ferroportin and iron export from the macrophage
    Mitchell Knutson; Fiscal Year: 2007
  2. Ferroportin and iron export from the macrophage
    Mitchell Knutson; Fiscal Year: 2006

Collaborators

Detail Information

Publications30

  1. doi request reprint Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, USA
    Nutr Rev 66:591-6. 2008
    ..Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders...
  2. pmc Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 102:1324-8. 2005
    ..We conclude that FPN1 is directly involved in the export of iron during erythrocyte-iron recycling by macrophages...
  3. ncbi request reprint Steap proteins: implications for iron and copper metabolism
    Mitchell D Knutson
    Food Science and Human Nutrition Department, PO Box 110370, University of Florida, Gainesville, FL 32611 0370, USA
    Nutr Rev 65:335-40. 2007
    ..Further characterization of Steap3 and other Steap proteins reveals a possible greater role of Steap proteins in iron and copper metabolism...
  4. doi request reprint Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    Nutr Rev 67:284-8. 2009
    ..As a novel suppressor of hepcidin expression, matriptase-2 emerges as a possible candidate for therapeutic interventions aimed at treating disorders of iron metabolism...
  5. ncbi request reprint Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy
    Jinze Xu
    Department of Aging and Geriatric Research, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida 32611, USA
    Exp Gerontol 47:100-8. 2012
    ..In conclusion, advanced age is associated with disruption of muscle iron metabolism which is further perturbed by disuse and persists over a longer time period...
  6. pmc Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
    Tim Hofer
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, USA
    Exp Gerontol 43:563-70. 2008
    ..These results suggest that RNA oxidation, possibly mediated by increased non-heme iron, might contribute to muscle atrophy due to disuse particularly in aged muscle...
  7. pmc Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 103:13612-7. 2006
    ..Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases...
  8. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
    ..These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects...
  9. doi request reprint Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice
    Chia Yu Wang
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL
    Hepatology 58:788-98. 2013
    ..Although hepatocyte DMT1 is partially required for hepatic TBI uptake, hepatic iron levels were unaffected in Dmt1(liv/liv) mice, suggesting that this pathway is a minor contributor to the iron economy of the liver...
  10. pmc Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels
    Supak Jenkitkasemwong
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    J Nutr 140:723-30. 2010
    ..Diminished hepcidin expression in CuD rats was associated with lower levels of TfR2, but not BMP6. Our data suggest that holotransferrin and TfR2, rather than anemia or BMP6, are signals for hepcidin synthesis during copper deficiency...
  11. pmc ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders
    Hyeyoung Nam
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA
    Haematologica 98:1049-57. 2013
    ..Our results provide insight into the potential contributions of these transporters to tissue iron uptake during iron deficiency and overload...
  12. pmc Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages
    Fikret Aydemir
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    J Nutr 139:434-8. 2009
    ..Collectively, these data are consistent with the hypothesis that iron increases macrophage ferroportin mRNA levels by inducing transcription of the ferroportin gene...
  13. pmc ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin
    Ningning Zhao
    Department of Food Science and Human Nutrition, University of Florida, Gainesville, Florida 32611, USA
    J Biol Chem 285:32141-50. 2010
    ..These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism...
  14. pmc Metabolic crossroads of iron and copper
    James F Collins
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    Nutr Rev 68:133-47. 2010
    ..Many unanswered questions regarding the role of these metals and their interactions in health and disease emerge from this synopsis, highlighting extensive future research opportunities...
  15. doi request reprint Physiologic implications of metal-ion transport by ZIP14 and ZIP8
    Supak Jenkitkasemwong
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    Biometals 25:643-55. 2012
    ..We also discuss potential roles of these proteins in the metabolism of zinc, iron, manganese, and cadmium as well as recent associations with human diseases...
  16. pmc ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading
    Chia Yu Wang
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA
    J Biol Chem 287:34032-43. 2012
    ..Collectively, these data identify ZIP8 as an iron transport protein that may function in iron metabolism...
  17. doi request reprint Effect of dietary iron deficiency and overload on the expression of ZIP metal-ion transporters in rat liver
    Hyeyoung Nam
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    Biometals 25:115-24. 2012
    ..Overall, our data suggest that ZIP5, ZIP6, ZIP7, and ZIP10 are regulated by iron, indicating that they may play a role in hepatic iron/metal homeostasis during iron deficiency and overload...
  18. ncbi request reprint Iron-sensing proteins that regulate hepcidin and enteric iron absorption
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611 2710, USA
    Annu Rev Nutr 30:149-71. 2010
    ..Emphasis is placed on the proteins that directly sense iron and how they coordinate and fine-tune the molecular, cellular, and physiologic responses to iron deficiency and overload...
  19. pmc Mitochondrial iron accumulation with age and functional consequences
    Arnold Y Seo
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Aging Cell 7:706-16. 2008
    ..Overall, our data suggest that age-dependent accumulation of mitochondrial iron may increase mitochondrial dysfunction and oxidative damage,thereby enhancing the susceptibility to apoptosis...
  20. pmc Impaired iron status in aging research
    Jinze Xu
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Int J Mol Sci 13:2368-86. 2012
    ..This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models...
  21. pmc Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload
    Richard Coffey
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e86019. 2014
    ..Overall, these data raise the possibility that Reg expression may serve as a biomarker for iron-related pancreatic stress, and that iron deficiency may adversely affect the risk of developing diabetes through up-regulation of Alox15. ..
  22. pmc Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 102:6843-8. 2005
    ....
  23. ncbi request reprint Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages
    Mitchell D Knutson
    Harvard School of Public Health, Dept of Nutrition, Bldg 2, Rm 205, 665 Huntington Ave, Boston, MA 02115, USA
    Blood 102:4191-7. 2003
    ..The rapid and strong induction of FPN1 expression after erythrophagocytosis suggests that FPN1 plays a role in iron recycling...
  24. pmc The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica
    Sabine Chlosta
    Pediatric Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Infect Immun 74:3065-7. 2006
    ..Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance...
  25. pmc The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells
    Junwei Gao
    Department of Cell and Developmental Biology, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Biol Chem 283:21462-8. 2008
    ..Further analysis of protein turnover indicated that the half-life of Zip14 is lower in cells that express HFE. These results suggest that HFE decreases the stability of Zip14 and therefore reduces the iron loading in HepG2 cells...
  26. ncbi request reprint Iron and iron-responsive proteins in the cardiomyopathy of Friedreich's ataxia
    Susan Michael
    Research Service, Veterans Affairs Medical Center, Albany, New York, USA
    Cerebellum 5:257-67. 2006
    ..Progressive cardiomyopathy in FRDA is the likely result of iron-catalyzed mitochondrial damage followed by muscle fiber necrosis and a chronic reactive myocarditis...
  27. ncbi request reprint The dentate nucleus in Friedreich's ataxia: the role of iron-responsive proteins
    Arnulf H Koeppen
    Research, Veterans Affairs Medical Center, Albany, NY 12208, USA
    Acta Neuropathol 114:163-73. 2007
    ..Neuronal loss in the dentate nucleus is the likely result of trans-synaptic degeneration...
  28. pmc Effects of iron status on transpulmonary transport and tissue distribution of Mn and Fe
    Joseph D Brain
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 34:330-7. 2006
    ..Although lung DMT1 expression did not correlate with iron status, differences in pharmacokinetics of instilled metals suggest that their potential toxicity can be modified by iron status...
  29. doi request reprint Daily supplementation with iron increases lipid peroxidation in young women with low iron stores
    Sarah M King
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Exp Biol Med (Maywood) 233:701-7. 2008
    ..The increased indicators of lipid peroxidation with duration of supplementation and as iron status improved suggest that providing daily nearly 100 mg iron may not be a totally innocuous regimen for correcting iron depletion in women...
  30. pmc Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats
    Patrick B Walter
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:2264-9. 2002
    ..Untreated iron deficiency, as well as excessive-iron supplementation, are deleterious and emphasize the importance of maintaining optimal iron intake...

Research Grants3

  1. Ferroportin and iron export from the macrophage
    Mitchell Knutson; Fiscal Year: 2007
    ..abstract_text> ..
  2. Ferroportin and iron export from the macrophage
    Mitchell Knutson; Fiscal Year: 2006
    ..abstract_text> ..