Research Topics
Species | M D KnudtsonSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Location of lesions associated with age-related maculopathy over a 10-year period: the Beaver Dam Eye StudyMichael D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, 53726 2336, USA
Invest Ophthalmol Vis Sci 45:2135-42. 2004..To describe cumulative incidence and changes in retinal lesions associated with age-related maculopathy (ARM) by location over a 10-year period and to examine the relation of location of those lesions to progression of ARM...
Alcohol consumption and the 15-year cumulative incidence of age-related macular degenerationMichael D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Am J Ophthalmol 143:1026-9. 2007..To investigate alcohol consumption as a risk factor for the 15-year cumulative incidence and progression of age-related macular degeneration (AMD)...
Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye StudyM D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
Br J Ophthalmol 90:1461-3. 2006..Physical activity improves the cardiovascular risk profile; however, there have been few studies investigating a relationship between physical activity and the long-term incidence of AMD...
A longitudinal study of nonvitamin, nonmineral supplement use: prevalence, associations, and survival in an aging populationMichael D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53726 2336, USA
Ann Epidemiol 17:933-9. 2007..We sought to describe population and survival characteristics in nonvitamin, nonmineral (NVNM) supplement users in a population-based cohort study...
Biomarkers of aging and falling: the Beaver Dam eye studyMichael D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
Arch Gerontol Geriatr 49:22-6. 2009..33; 95% confidence interval=CI=1.13-1.57). We conclude that biomarkers of aging, including any of three measures of visual function, are associated with falls. Improvement in these functional measures may lead to decreased risk of falls...
Age-related eye disease, visual impairment, and survival: the Beaver Dam Eye StudyMichael D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53726 2336, USA
Arch Ophthalmol 124:243-9. 2006..To investigate the relationship of age-related maculopathy, cataract, glaucoma, visual impairment, and diabetic retinopathy to survival during a 14-year period...
Associations with weight loss and subsequent mortality riskMichael D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53726 2336, USA
Ann Epidemiol 15:483-91. 2005..Studies have shown a high prevalence of weight loss in older adults is associated with an increased risk of death. We investigated this in a population-based study...
Variation associated with measurement of retinal vessel diameters at different points in the pulse cycleM D Knudtson
UW Madison Department of Ophthalmology and Visual Sciences, University of Wisconsin, 610 N Walnut Street, 4th Floor WARF, Madison, WI 53726, USA
Br J Ophthalmol 88:57-61. 2004..To assess the variability in retinal vessel measurements at different points in the pulse cycle...
The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetesRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Ophthalmology 115:1859-68. 2008..To examine the 25-year cumulative progression and regression of diabetic retinopathy (DR) and its relation to various risk factors...
Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errorsTien Yin Wong
Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA
Ophthalmology 111:1183-90. 2004....
Clinically significant macular edema and survival in type 1 and type 2 diabetesFlavio E Hirai
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Madison, Wisconsin 53726, USA
Am J Ophthalmol 145:700-6. 2008..To investigate the association of clinically significant macular edema (CSME) and long-term survival in individuals with type 1 and type 2 diabetes...
Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin epidemiologic study of diabetic retinopathyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53726, USA
Arch Intern Med 164:1917-24. 2004..Retinal vascular characteristics were associated with these end points, but this association was confounded by nephropathy...
Associations of selected medications and visual function: the Beaver Dam Eye StudyB E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53726 2397, USA
Br J Ophthalmol 87:403-8. 2003..To investigate association of drug use and visual function...
Revised formulas for summarizing retinal vessel diametersMichael D Knudtson
Department of Ophthalmology, University of Wisconsin, Madison, WI 53726, USA
Curr Eye Res 27:143-9. 2003....
Retinopathy and survival in a population without diabetes: The Beaver Dam Eye StudyFlavio E Hirai
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726 2336, USA
Am J Epidemiol 166:724-30. 2007..05, 2.12) and ischemic heart disease (hazard ratio = 2.43, 95% confidence interval: 1.48, 4.01) mortality. Study results suggest that retinal changes have possible prognostic implications regarding survival of persons without diabetes...
Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye StudyB E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53726 2336, USA
Br J Ophthalmol 89:284-7. 2005..To investigate the relation between change in systemic blood pressures and change in intraocular pressure...
Relationship of measures of frailty to visual function: the Beaver Dam Eye StudyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA
Trans Am Ophthalmol Soc 101:191-6; discussion 196-9. 2003..Including a measure of visual function when assessing frailty may improve upon the usefulness of an index of frailty in predicting incidence of chronic systemic diseases and survival...
Age-related macular degeneration and optic disk cupping: the Beaver Dam Eye StudyEllen R Hall
Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin Madison, 610 North Walnut Street, Madison, WI 53726, USA
Am J Ophthalmol 141:494-7. 2006..To examine the association between presence, severity, and extent of lesions of age-related macular degeneration (AMD) and optic disk and cup diameters in a general population...
Supplements and age-related eye conditions the beaver dam eye studyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Ophthalmology 115:1203-8. 2008..To investigate the association of use of vitamin, mineral, and nonvitamin nonmineral supplements with common age-related eye diseases...
The epidemiology of retinal reticular drusenRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 North Walnut Street, Madison, WI 53726, USA
Am J Ophthalmol 145:317-326. 2008..To describe the prevalence and 15-year cumulative incidence of and risk factors for reticular drusen...
Further observations on the association between smoking and the long-term incidence and progression of age-related macular degeneration: the Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, 417 WARF, Madison, WI 53726 2336, USA
Arch Ophthalmol 126:115-21. 2008..To examine the association between smoking and the 15-year cumulative incidence of age-related macular degeneration (AMD)...
Emphysema, airflow limitation, and early age-related macular degenerationRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, 610 N Walnut St, 450 WARF, Madison, WI 53726 2397, USA
Arch Ophthalmol 128:472-7. 2010..To describe the associations of lung function and emphysema, measured with spirometry and computed tomography (CT), with early age-related macular degeneration (AMD) in a sample of white, black, Hispanic, and Chinese subjects...
The relation of markers of inflammation and endothelial dysfunction to the prevalence and progression of diabetic retinopathy: Wisconsin epidemiologic study of diabetic retinopathyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
Arch Ophthalmol 127:1175-82. 2009....
Changes in visual impairment prevalence by period of diagnosis of diabetes: the Wisconsin Epidemiologic Study of Diabetic RetinopathyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
Ophthalmology 116:1937-42. 2009..To examine relationships of period of diagnosis of type 1 diabetes mellitus (T1DM) to the prevalence of visual impairment (VI)...
Serum cystatin C level, kidney disease markers, and incidence of age-related macular degeneration: the Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, Room 417 WARF, Madison, WI 53726 2336, USA
Arch Ophthalmol 127:193-9. 2009..To examine the associations of the serum cystatin C level and chronic kidney disease with the incidence of age-related macular degeneration (AMD) over 15 years...
The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetesRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
Ophthalmology 116:497-503. 2009..To examine the 25-year cumulative incidence of macular edema (ME) and its relation to various risk factors...
Parents' attained age and biomarkers of aging in their childrenBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
Arch Gerontol Geriatr 49:284-8. 2009....
Cystatin C, other markers of kidney disease, and incidence of age-related cataractBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
Arch Ophthalmol 126:1724-30. 2008..To investigate the 15-year incidence of 3 specific types of age-related cataract as related to cystatin C and other measures of kidney function...
Age-period-cohort effect on the incidence of age-related macular degeneration: the Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
Ophthalmology 115:1460-7. 2008..To examine relationships of age, period, and birth cohort with the 5-year incidence of age-related macular degeneration (AMD)...
The epidemiology of progression of pure geographic atrophy: the Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Am J Ophthalmol 146:692-9. 2008..To examine the change in size and location of pure geographic atrophy (GA)...
Pulmonary disease and age-related macular degeneration: the Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
Arch Ophthalmol 126:840-6. 2008..To examine the association of pulmonary symptoms, disease, and function with the incidence of age-related macular degeneration (AMD)...
Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of AtherosclerosisRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2397, USA
Ophthalmology 115:1742-9. 2008....
Statin use and the five-year incidence and progression of age-related macular degenerationRonald Klein
Department of Ophthalmology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Am J Ophthalmol 144:1-6. 2007..To examine the association of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) with the five-year incidence of age-related macular degeneration (AMD)...
Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of AtherosclerosisRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53726 2397, USA
Arch Ophthalmol 125:534-43. 2007..To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis...
Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
Ophthalmology 114:253-62. 2007..To describe the 15-year cumulative incidence of signs of early and late age-related macular degeneration (AMD)...
Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye StudySandra C Tomany
Department of Ophthalmology and Visual Sciences, Medical School, University of Wisconsin-Madison, 610 N. Walnut Street, Madison, WI 53726, USA
Arch Ophthalmol 122:750-7. 2004....
Life-style correlates of tooth loss in an adult Midwestern populationBarbara E K Klein
Department of Ophthalmology and Visual Sciences, Medical School, University of Wisconsin, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
J Public Health Dent 64:145-50. 2004..To describe life-style correlates of tooth loss in a representative rural American population...
Familial aggregation of retinal vessel caliber in the beaver dam eye studyKristine E Lee
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2336, USA
Invest Ophthalmol Vis Sci 45:3929-33. 2004..To describe familial correlations of retinal vessel measurements...
Systemic markers of inflammation, endothelial dysfunction, and age-related maculopathyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, 53726, USA
Am J Ophthalmol 140:35-44. 2005..To examine the association of systemic markers of inflammatory disease and endothelial dysfunction with age-related maculopathy (ARM)...
Frailty and age-related macular degeneration: the Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, 53726, USA
Am J Ophthalmol 140:129-31. 2005..To investigate the associations of measures of frailty to prevalent age-related maculopathy (ARM)...
Frailty, morbidity and survivalBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 405 WARF, Madison, WI 53726 2336, USA
Arch Gerontol Geriatr 41:141-9. 2005..Greater frailty was associated with greater likelihood of concurrent medical conditions and with decreased survival...
Markers of inflammation, vascular endothelial dysfunction, and age-related cataractBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 N Walnut Street, 460 WARF, Madison, WI 53726, USA
Am J Ophthalmol 141:116-22. 2006..To examine the associations of systemic markers of inflammatory disease and vascular endothelial dysfunction with three types of age-related cataract...
Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye StudyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 N Walnut Street, 450 WARF, Madison, WI 53726, USA
Arch Ophthalmol 124:87-94. 2006..To examine the relationship of systemic markers of inflammation, endothelial dysfunction, and serum folate level to retinal vessel diameter...
Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosisRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726 2336, USA
Ophthalmology 113:373-80. 2006..To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA)...
The relationship of optic disk cupping to retinal vein occlusion: the Beaver Dam Eye StudyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, Madison, WI 53726, USA
Am J Ophthalmol 141:859-62. 2006..To examine the association between optic disk cupping and retinal vein occlusion (RVO)...
Comparison of retinal vessel measurements in digital vs film imagesAnne Mosher
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School Madison, Madison, Wisconsin 53726, USA
Am J Ophthalmol 142:875-8. 2006..To compare central retinal artery equivalents (CRAE) and central retinal vein equivalents (CRVE) from vessels measured from images captured with a digital camera and digitized images taken with a film camera...
Medical records as sources of data on cardiovascular disease events in persons with diabetesBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726, USA
J Diabetes Complications 20:224-7. 2006..The aim of this study is to evaluate medical records as a source of data on cardiovascular disease over a 20-year interval...
Lens opacities associated with performance-based and self-assessed visual functionsBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
Ophthalmology 113:1257-63. 2006..To investigate the relationship of lens opacities to performance-based and self-assessed visual function in persons free of other ocular comorbidities...
Frailty and age-related cataractBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Ophthalmology 113:2209-12. 2006..To determine whether there is an association between age-related cataract and frailty that persists after controlling for visual acuity (VA) and comorbid conditions...
The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetesR Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, 610 North Walnut Street, Fourth Floor WARF, Madison, WI 53726 2397, USA
Diabetologia 53:1638-46. 2010..We examined whether retinal vessel diameter in persons with type 1 diabetes mellitus is associated with changes in subclinical anatomical and functional indicators of diabetic nephropathy...
Age-related eye disease, quality of life, and functional activityMichael D Knudtson
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA
Arch Ophthalmol 123:807-14. 2005..Our data are compatible with the notion that decreased visual function, irrespective of the pathologic reason for the decrease, is associated with diminished quality of life and functional activities of living...
Stability of 35-mm scanners as used in ophthalmologic researchKarl Jensen
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
Ophthalmic Surg Lasers Imaging 41:60-6. 2010..To assess the consistency of digitization of 35-mm slides as practiced in ophthalmologic research and estimate the impact of variation on semi-automated retinal vessel width measurements...
Estrogen replacement therapy and retinal vascular caliberTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Ophthalmology 112:553-8. 2005..It is unclear if estrogen replacement therapy (ERT) has an effect on the retinal circulation. In the current study, we examine the association of ERT, female reproductive factors, and retinal vascular caliber...
Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populationsJie Jin Wang
Centre for Vision Research, Department of Ophthalmology, Westmead Hospital, and the Westmead Millennium Institute, University of Sydney, Australia
Eur Heart J 28:1984-92. 2007..The retinal microvasculature may reflect pre-clinical changes in the cerebral and coronary microcirculations. We assessed whether smaller retinal arterioles and larger venules predicted coronary heart disease (CHD)- and stroke-mortality...
Retinal arteriolar emboli and long-term mortality: pooled data analysis from two older populationsJie Jin Wang
University of Sydney Department of Ophthalmology, Centre for Vision Research, Westmead Hospital, The Westmead Millennium Institute, NSW, Australia
Stroke 37:1833-6. 2006..To assess the relationship between retinal arteriolar emboli and mortality in older people...
Retinal vein occlusion and vascular mortality: pooled data analysis of 2 population-based cohortsSudha Cugati
Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia
Ophthalmology 114:520-4. 2007..To assess the association of retinal vein occlusion (RVO) with cardiovascular and cerebrovascular mortality...
A prospective cohort study of retinal arteriolar narrowing and mortalityTien Yin Wong
Department of Ophthalmology, University of Melbourne, Victoria, Australia
Am J Epidemiol 159:819-25. 2004....
Medication use and retinal vessel diametersTien Yin Wong
Centre for Eye Research Australia, University of Melbourne, East Melbourne 3002, Victoria, Australia
Am J Ophthalmol 139:373-5. 2005..To study the influence of different medications on retinal vessel diameters...
