Research Topics
| M M KnudsonSummaryAffiliation: University of California Country: USA Publications
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Publications
Nonoperative management of solid organ injuries. Past, present, and futureM M Knudson
Department of Surgery, University of California, San Francisco, USA
Surg Clin North Am 79:1357-71. 1999..Currently, the morbidity and mortality rates of nonoperative management are acceptably low, but surgeons still must monitor their results carefully as they apply these methods more liberally among injured patients...
Acquired A amyloidosis from injection drug use presenting with atraumatic splenic rupture in a hospitalized patient: a case reportGarrett R Roll
Department of Surgery, University of California San Francisco, San Francisco, USA
J Med Case Reports 5:29. 2011..abstract:..- Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysisMitchell J Cohen
Department of Surgery, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Crit Care 14:R10. 2010..We hypothesized that processing of multivariate data using hierarchical clustering techniques would allow identification of otherwise hidden patient physiologic patterns that would be predictive of outcome... - Venous thromboembolism after traumaM Margaret Knudson
Department of Surgery, University of California, San Francisco, California 94110, USA
Curr Opin Crit Care 10:539-48. 2004..Special attention is paid to patients with spinal cord injury, patients with head injury, and pediatric trauma patients... - Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data BankM Margaret Knudson
Department of Surgery, San Francisco General Hospital, CA 94110, USA
Ann Surg 240:490-6; discussion 496-8. 2004..Venous thromboembolic events (VTE) are potentially preventable causes of morbidity and mortality after injury. We hypothesized that the current clinical incidence of VTE is relatively low and that VTE risk factors could be identified... - Improving outcomes in pediatric trauma care: essential characteristics of the trauma centerM Margaret Knudson
Department of Surgery, University of California San Francisco, USA
J Trauma 63:S140-2. 2007..Each of these areas encompasses important unanswered questions... 
Trauma training in simulation: translating skills from SIM time to real timeM Margaret Knudson
Department of Surgery, University of California, San Francisco, California, USA
J Trauma 64:255-63; discussion 263-4. 2008..Simulation may have a role in this educational process, but only if it can be demonstrated that skills learned in a simulated environment translate into enhanced performance in real-life trauma situations...- Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201M Margaret Knudson
San Francisco Injury Center, University of California, USA
J Trauma 54:242-52. 2003..We further hypothesized that changes in tissue oxygen tension measurements in the deltoid muscle would reflect the changes seen in the liver and could thus be used as a monitor of splanchnic resuscitation... - Three thousand seven hundred thirty-eight posttraumatic pulmonary emboli: a new look at an old diseaseM Margaret Knudson
Department of Surgery, University of California, San Francisco, CA 94110, USA
Ann Surg 254:625-32. 2011..This study was undertaken to determine the current incidence of pulmonary embolism (PE) and its attributable mortality after injury... - Trauma/critical care surgeryM Margaret Knudson
University of California, San Francisco, Campus Box 0807, San Francisco, CA 94143 0807, USA
Am J Surg 199:266-8. 2010..However, careers in trauma/critical care and emergency surgery can offer a controlled lifestyle, challenging cases that cross over many disciplines, and a rich field for scientific investigation... - Timing of urgent thoracotomy for hemorrhage after trauma: a multicenter studyR Karmy-Jones
Department of Surgery, Campus Box 359796, 325 Ninth Ave, Harborview Medical Center, Seattle, WA 98104, USA
Arch Surg 136:513-8. 2001..It is possible to quantify an amount of thoracic hemorrhage, after blunt and penetrating injury, at which delay of thoracotomy is associated with increased mortality... - Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigationGuy Rosenthal
Department of Neurosurgery, University of California, San Francisco, CA 94117, USA
J Neurosurg 108:575-87. 2008..We studied the effects of hemoglobin-based oxygen-carrying (HBOC)-201 solution compared with lactated Ringer (LR) solution in a large animal model of brain injury and hemorrhage, in a blinded prospective randomized study... - Trauma assessment training with a patient simulator: a prospective, randomized studySeong K Lee
Department of Surgery, University of California, San Francisco, California 94110, USA
J Trauma 55:651-7. 2003..05). CONCLUSION: Use of a patient simulator to introduce trauma assessment training is feasible and compares favorably to training in a moulage setting. Continued research in this area of physician education is warranted... - Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygenJ C Hemphill
Department of Neurology, University of California San Francisco, 94143-0112, USA
Neurosurgery 48:377-83; discussion 383-4. 2001..The relationship of PbrO2 with ET-CO2 and MAP appears to be similar to those historically established for CBF with ET-CO2 and MAP. This suggests that, under normal conditions, PbrO2 is strongly influenced by factors that regulate CBF... - Delayed internal fixation of femoral shaft fracture reduces mortality among patients with multisystem traumaSaam Morshed
University of California at San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Room 3A 36, San Francisco, CA 94110, USA
J Bone Joint Surg Am 91:3-13. 2009..The appropriate timing of fracture repair is controversial. The purpose of the present study was to assess the effect of timing of internal fixation on mortality in patients with multisystem trauma... - Continuous muscle tissue oxygenation in critically injured patients: a prospective observational studyDanagra G Ikossi
Department of Surgery, University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California, USA
J Trauma 61:780-8; discussion 788-90. 2006..PmO2 monitoring may be useful in identifying patients in the state of occult underresuscitation who remain at risk for developing infection and MOF... - Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter studyJohn H Chi
Department of Surgery, The University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California 94143, USA
J Trauma 61:1134-41. 2006.... - Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ bedsJennifer J Wan
Department of Surgery, University of California, San Francisco and the San Francisco Injury Center for Research and Prevention, San Francisco, California, USA
J Trauma 66:353-7. 2009..We further hypothesized that PmO2 would decrease even as PbrO2 increased when vasopressor therapy was used... - Controlled cortical impact in swine: pathophysiology and biomechanicsGeoffrey T Manley
Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
J Neurotrauma 23:128-39. 2006..Physiological parameters after injury are readily monitored in a setting mimicking conditions of an intensive care unit, establishing a more clinically relevant experimental model for future investigations... - Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swineSeong K Lee
San Francisco Injury Center, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
Acad Emerg Med 9:969-76. 2002..The results of this preliminary study demonstrate that HBOC-201 could potentially improve current resuscitation measures and that further investigations with HBOC-201 are warranted... - Trauma, transfusions, and use of recombinant factor VIIa: A multicenter case registry report of 380 patients from the Western Trauma AssociationM Margaret Knudson
Department of Surgery, University of California, San Francisco, USA
J Am Coll Surg 212:87-95. 2011..We hypothesized that we could describe the setting in which rFVIIa would be most successful in arresting hemorrhage after injury... - Urgent and emergent thoracotomy for penetrating chest traumaRiyad Karmy-Jones
Department of Surgery, Box 359796, 325 Ninth Avenue, Harborview Medical Center, Seattle, WA 98104, USA
J Trauma 56:664-8; discussion 668-9. 2004..Although the major factor in outcome is presenting physiology, the site of the TCY may influence survival, with the operating room offering a superior environment to the emergency room... - Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenationGeoffrey T Manley
School of Medicine, University of California San Francisco, San Francisco Injury Center, Department of Neurological Surgery, USA
Adv Exp Med Biol 530:311-7. 2003..These results suggest that a small-volume bolus of HBOC-201 may provide adequate oxygen and pressure support during the initial management of hemorrhage... - Down's syndrome, precocious puberty, and transverse vaginal septum: an unusual cause of abdominal painT Quinn
Department of Surgery, University of California, San Francisco, CA 94110, USA
J Pediatr Surg 36:641-3. 2001..The diagnosis was facilitated using a combination of computed tomography and ultrasound scanning. J Pediatr Surg 36:641-643... - Management of traumatic lung injury: a Western Trauma Association Multicenter reviewR Karmy-Jones
Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
J Trauma 51:1049-53. 2001..Improved outcomes following lung injury have been reported using "lung sparing" techniques... - Hypotension, hypoxia, and head injury: frequency, duration, and consequencesG Manley
Department of Surgery, San Francisco General Hospital, Ward 3A, 1001 Potrero Ave, San Francisco, CA 94110, USA
Arch Surg 136:1118-23. 2001..These prospective data reinforce the need for early continuous monitoring and improved treatment of hypotension in brain-injured patients... - The effect of a change in the surgeon response time mandate on outcomes within Ohio level III trauma centers: it is all about commitmentAngela Ingraham
Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267 0558, USA
J Trauma 68:1038-43. 2010.... - Fondaparinux for prevention of venous thromboembolism in high-risk trauma patients: a pilot studyJong Ping Lu
Department of Surgery, University of California San Francisco, San Francisco, CA
J Am Coll Surg 209:589-94. 2009..We hypothesized that the occult deep vein thrombosis (DVT) rate in high-risk patients receiving fondaparinux would be <5%... - First Trauma Verification Review Committee site visit outside the U.S.: Landstuhl Regional Medical Center, GermanyM Margaret Knudson
University of California, San Francisco, USA
Bull Am Coll Surg 92:16-9. 2007 - The abdominal compartment syndrome complicating nonoperative management of major blunt liver injuries: recognition and treatment using multimodality therapyEdmund Y Yang
Department of Surgery, University of California, San Francisco 94110, USA
J Trauma 52:982-6. 2002 - Surgeons and injury prevention: what you don't know can hurt you!M M Knudson
San Francisco Injury Center, University of California, USA
J Am Coll Surg 193:119-24. 2001..Advancements in the field of injury control will require efforts to educate medical professionals and the public... - Management of patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trialWalter L Biffl
Department of Surgery, Denver Health Medical Center University of Colorado Denver, Denver, Colorado 80204 4507, USA
J Trauma 66:1294-301. 2009.... - Posttraumatic stress symptoms in children after mild to moderate pediatric trauma: a longitudinal examination of symptom prevalence, correlates, and parent-child symptom reportingHerbert Schreier
Department of Psychiatry, Children's Hospital and Research Center at Oakland, Oakland, CA 94110, USA
J Trauma 58:353-63. 2005..The high presence of symptoms in this population underscores the need for treatment efficacy studies and parent/medical staff education in identification of PTSD... - Surgeon-performed bedside organ assessment with sonography after trauma (BOAST): a pilot study from the WTA Multicenter GroupGrace S Rozycki
Department of Surgery, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, GA 30303, USA
J Trauma 59:1356-64. 2005.... - Lion heart: Saleh KhalefM Margaret Knudson
University of California, San Francisco, USA
Bull Am Coll Surg 91:27-33. 2006 - Mental illness as an independent risk factor for unintentional injury and injury recidivismJennifer J Wan
Department of Surgery at the University of California, San Francisco, California, USA
J Trauma 61:1299-304. 2006.... - Fractures in access to and assessment of trauma systemsMary J Vassar
San Francisco Injury Center, University of California, San Francisco, San Francisco, CA, USA
J Am Coll Surg 197:717-25. 2003..Efforts to understand why undertriage is occurring so frequently are hampered by fragmentation of the systems of care, inadequate data management systems, and lack of trauma care performance reporting by non-trauma center hospitals... - Blood doping in the surgical intensive care unitJennifer J Wan
Department of Surgery, University of California, San Francisco-East Bay Alameda County Medical Center, Oakland, USA
Surgery 140:6-8. 2006 - Profile of mothers at risk: an analysis of injury and pregnancy loss in 1,195 trauma patientsDanagra G Ikossi
Department of Surgery, University of California-San Francisco, and San Francisco Injury Center, San Francisco, CA 94110, USA
J Am Coll Surg 200:49-56. 2005..Reduction of secondary insults and early recognition of fetal distress may improve outcomes for both the mother and fetus in this high-risk group... - Military-civilian collaboration in trauma care and the senior visiting surgeon programErnest E Moore
Department of Surgery at the Denver Health Medical Center, University of Colorado at Denver, Denver, USA
N Engl J Med 357:2723-7. 2007 - Splenic embolization revisited: a multicenter reviewJames M Haan
Department of Surgical Critical Care, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, 22 South Green Street, Baltimore, MD 21201 1595, USA
J Trauma 56:542-7. 2004..Splenic embolization can increase nonoperative salvage. However, complications are not clearly defined. A retrospective multicenter review was performed to delineate the risks and benefits of splenic embolization... - An evaluation of the American College of Surgeons' ultrasound education programEdgar D Staren
Cancer Treatment Centers of America, 2520 Elisha Ave, Zion, IL 60099, USA
Am J Surg 191:489-96. 2006..The purpose of this study was to evaluate the impact and effectiveness of the ACoS ultrasound education program... - Motorcycle helmet laws: every surgeon's responsibilityM Margaret Knudson
J Am Coll Surg 199:261-4. 2004
Research Grants
- San Franisco Injury Center for Research and PreventionM Knudson; Fiscal Year: 2007....