Research Topics
| Robert C KnowltonSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Magnetoencephalography in epilepsyRobert C Knowlton
University of Alabama at Birmingham School of Medicine, UAB Epilepsy Center, Birmingham, Alabama 35294, USA
Epilepsia 45:61-71. 2004..Combined with mapping of normal or eloquent brain function, MEG should ultimately play a major role in the totally noninvasive epilepsy surgery evaluation...- In vivo hippocampal glucose metabolism in mesial temporal lobe epilepsyR C Knowlton
Department of Neurology, University of Alabama at Birmingham, 35294, USA
Neurology 57:1184-90. 2001..Increased partial volume effects due to atrophic hippocampi may further increase appearance of hypometabolism... - The role of FDG-PET, ictal SPECT, and MEG in the epilepsy surgery evaluationRobert C Knowlton
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
Epilepsy Behav 8:91-101. 2006..Ultimately, appropriate use of these tests, combined with more comprehensive functional brain mapping (e.g., with MEG or functional MRI), may lead to completely noninvasive epilepsy surgery evaluation... 
Functional imaging: I. Relative predictive value of intracranial electroencephalographyRobert C Knowlton
Department of Neurology, University of Alabama at Birmingham Epilepsy Center, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0001, USA
Ann Neurol 64:25-34. 2008....- Ictal single-photon emission computed tomography imaging in extra temporal lobe epilepsy using statistical parametric mappingRobert C Knowlton
University of Alabama at Birmingham Epilepsy Center, Department of Neurology, School of Medicine, Birmingham, AL 35294, USA
J Neuroimaging 14:324-30. 2004..To examine the application of statistical parametric mapping (SPM) to analyze ictal single-photon emission computed tomography (SPECT) scans in surgical candidates with extratemporal lobe epilepsy... - Ictal SPECT analysis in epilepsy: subtraction and statistical parametric mapping techniquesRobert C Knowlton
Department of Neurology, University of Alabama at Birmingham Epilepsy Center, 1719 6th Avenue South, Birmingham, AL 35294, USA
Neurology 63:10-5. 2004..The limitations of both methodologies are discussed, and suggestions for further study of validation, improvement, and routine clinical implementation of advanced analysis methods are provided... - Multimodality imaging in partial epilepsiesRobert C Knowlton
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
Curr Opin Neurol 17:165-72. 2004.... - Magnetoencephalography: clinical application in epilepsyRobert C Knowlton
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham School of Medicine, 1719 6th Avenue South, Suite 312, Birmingham, AL 35294, USA
Curr Neurol Neurosci Rep 3:341-8. 2003..Ultimately, MEG should play a major role in totally noninvasive epilepsy surgery evaluation... - Magnetic source imaging versus intracranial electroencephalogram in epilepsy surgery: a prospective studyRobert C Knowlton
Department of Neurology, UAB Epilepsy Center, University of Alabama at Birmingham School of Medicine, 35294 0001, USA
Ann Neurol 59:835-42. 2006..This study prospectively examined the agreement between magnetic source imaging (MSI) and ICEEG localization in epilepsy surgery candidates... - In vivo hippocampal metabolic dysfunction in human temporal lobe epilepsyRobert C Knowlton
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham School of Medicine, 35294 0021, USA
Arch Neurol 59:1882-6. 2002..The nature of functional metabolic disturbances in mesial temporal lobe epilepsy remains unclear... - Preference-based quality-of-life measures for neocortical epilepsy surgeryRobert C Knowlton
Department of Neurology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294 0001, USA
Epilepsia 52:1018-20. 2011..Seizure freedom achieved with polytherapy medical management may be less desirable than that achieved with surgery and monotherapy... 
Effect of epilepsy magnetic source imaging on intracranial electrode placementRobert C Knowlton
Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294 0001, USA
Ann Neurol 65:716-23. 2009....- Functional imaging: II. Prediction of epilepsy surgery outcomeRobert C Knowlton
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294 0001, USA
Ann Neurol 64:35-41. 2008.... - Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imagingNathan L Hutcheson
Department of Psychiatry and Behavioral Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA
Schizophr Res 140:136-42. 2012..In this study, we combined proton magnetic resonance spectroscopy (¹H-MRS) and functional magnetic resonance imaging (fMRI) to clarify the neurobiology of memory deficits in schizophrenia... - Temporal lobectomy in congenital porencephaly associated with hippocampal sclerosisJorge G Burneo
Department of Neurology, Epilepsy Center, University of Alabama at Birmingham, 35294, USA
Arch Neurol 60:830-4. 2003..Clinical and neuroimaging features of patients with epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis have been previously described... - Musicogenic seizures can arise from multiple temporal lobe foci: intracranial EEG analyses of three patientsTania F Tayah
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232-8552, USA
Epilepsia 47:1402-6. 2006..Patients with medically intractable musicogenic epilepsy and with unilateral ictal onset zones may be considered candidates for resective epilepsy surgery... - Significance of fornix atrophy in temporal lobe epilepsy surgery outcomeJorge G Burneo
University of Alabama at Birmingham Epilepsy Center, and the Department of Neurology and Neurosurgery, University of Alabama at Birmingham, 35294, USA
Arch Neurol 60:1238-42. 2003..However, in the presence of a normal hippocampus, fornix atrophy may be valuable in predicting seizure-free outcome... - Reliability of language mapping with magnetic source imaging in epilepsy surgery candidatesDongwook Lee
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
Epilepsy Behav 8:742-9. 2006..The results further support the adequacy of this MEG-based brain mapping protocol as a noninvasive tool for receptive language localization in epilepsy surgery candidates... - Left mesial temporal sclerosis and verbal memory: a magnetoencephalography studyLawrence W Ver Hoef
University of Alabama Epilepsy Center, Department of Neurology, Birmingham, Alabama, USA
J Clin Neurophysiol 25:1-6. 2008..A trend toward less left mesial temporal activity in LMTS patients is seen as well. Further study is needed to determine the predictive value of this technique regarding postresection memory outcome... - Cortical reorganization in malformations of cortical development: a magnetoencephalographic studyJorge G Burneo
University of Alabama at Birmingham Epilepsy Center, USA
Neurology 63:1818-24. 2004..e., cortical dysplasia) but may not be in MCDs caused by abnormal cortical organization (i.e., polymicrogyria)... - Dynamic brain activation patterns for face recognition: a magnetoencephalography studyDongwook Lee
Department of Neurology, University of Alabama, Birmingham, AL 35233, USA
Brain Topogr 18:19-26. 2005..The results indicate right hemisphere predominance in the degree of engagement of neurophysiological processes involved in both the pre- and post-recognition phases of face processing... - Short latency activation of cortex by clinically effective thalamic brain stimulation for tremorHarrison C Walker
Department of Neurology, University of Alabama Birmingham, Birmingham, Alabama, USA
Mov Disord 27:1404-12. 2012.... - Advances in intracranial monitoringJeffrey P Blount
Comprehensive Epilepsy Center, University of Alabama at Birmingham, Alabama 35233, USA
Neurosurg Focus 25:E18. 2008..Each form has its own advantages and shortcomings but extensive subdural implantation of electrodes is most common and is most comprehensively discussed. The indications for intracranial electrodes are reviewed... - Confirmation of nonconvulsive limbic status epilepticus with the sodium amytal testJorge G Burneo
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Epilepsia 44:1122-6. 2003..We present the case of a patient who had dominant limbic hippocampal SE, but in whom the diagnosis could not be confirmed until a modified novel use of the sodium amytal test was performed... - Effect of detection parameters on automated electroencephalography spike detection sensitivity and false-positive rateLawrence Ver Hoef
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Clin Neurophysiol 27:12-6. 2010..The authors report sensitivities and false-positive rates for several different sets of detection parameters... - Assessments of function and biochemistry of the anterior cingulate cortex in schizophreniaMeredith A Reid
Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama 35294 0017, USA
Biol Psychiatry 68:625-33. 2010..In this study, we sought to clarify the nature of this abnormality by combining proton magnetic resonance spectroscopy (1H-MRS) with functional magnetic resonance imaging (fMRI) at 3T... - Short latency activation of cortex during clinically effective subthalamic deep brain stimulation for Parkinson's diseaseHarrison C Walker
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
Mov Disord 27:864-73. 2012.... - Evolving antiepileptic drug treatment in juvenile myoclonic epilepsyAvinash Prasad
Epilepsy Division, Department of Neurology, University of Alabama School of Medicine, 312 Civitan International Research Center, 1719 Sixth Avenue, Birmingham, AL 35492, USA
Arch Neurol 60:1100-5. 2003..In the face of availability of newer antiepileptic drugs (AEDs) such as lamotrigine and topiramate, there is need to reassess the role of older AEDs in the treatment of juvenile myoclonic epilepsy (JME)... - Neuroimaging of epilepsyRuben I Kuzniecky
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Semin Neurol 22:279-88. 2002..New developments such as MR spectroscopy, receptor PET, and magnetic source imaging are becoming clinical tools and have the promise of improving diagnosis... - Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary reportRosalyn E Weller
Department of Psychology, University of Alabama at Birmingham UAB, Birmingham, AL, London
Open Neuroimag J 5:57-64. 2011..Reduced gray matter in executive function/inhibitory control regions of the brain in cocaine-dependent individuals may be a preexisting risk factor for the development of addiction and/or a consequence of drug abuse... - Dexmedetomidine as rescue drug during awake craniotomy for cortical motor mapping and tumor resectionThomas A Moore
Department of Anesthesiology, University of Alabama School of Medicine, Birmingham, Alabama 35249 6810, USA
Anesth Analg 102:1556-8. 2006..Herein, we describe the use of dexmedetomidine as a rescue drug during awake craniotomy avoiding conversion to general anesthesia, thus allowing completion of cortical mapping... - Hyperammonemia following intravenous valproate loadingJennifer L DeWolfe
University of Alabama at Birmingham Epilepsy Center, Department of Neurology, 1719 6th Avenue South, CIRC 312, Birmingham, AL 35294 0021, United States
Epilepsy Res 85:65-71. 2009..Valproic acid (VPA) has been associated with hyperammonemia with and without encephalopathy. We report the frequent but transient nature of hyperammonemia following intravenous (IV) administration of loading doses of VPA... - Widespread reward-system activation in obese women in response to pictures of high-calorie foodsLuke E Stoeckel
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294 1170, USA
Neuroimage 41:636-47. 2008..In summary, compared to normal-weight controls, obese women exhibited greater activation in response to pictures of high-calorie foods in a large number of regions hypothesized to mediate motivational effects of food cues... - Electroclinical and magnetoencephalographic studies in epilepsy patients with polymicrogyriaJorge G Burneo
Epilepsy Programme, London Health Sciences Center, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada N6A 5A5
Epilepsy Res 62:125-33. 2004..The present descriptive study analysis the electroclinical and magnetoencephalographic findings of patients with epilepsy and polymicrogyria without schizencephaly... - Race/ethnicity: a predictor of temporal lobe epilepsy surgery outcome?Jorge G Burneo
Epilepsy Programme, University of Western Ontario, London, Canada
Epilepsy Behav 7:486-90. 2005..Nonetheless, whether race influences the outcome of temporal lobe surgery is unknown. The purpose of this study was to evaluate if race plays a role in outcome following surgery... - Kaplan-Meier analysis on seizure outcome after epilepsy surgery: do gender and race influence it?Jorge G Burneo
Epilepsy Programme, University of Western Ontario, London Health Science Center, 339 Windermere Road, London, Ontario, Canada
Seizure 17:314-9. 2008..To evaluate seizure outcome following epilepsy surgery for patients with temporal lobe epilepsy and evaluate is gender and race/ethnicity influence it... - Design and applications of a multimodality image data warehouse frameworkStephen T C Wong
Department of Radiology, University of California San Francisco, 94143, USA
J Am Med Inform Assoc 9:239-54. 2002..The image data warehouse framework can be modified and generalized for new application domains... - Race/ethnicity, sex, and socioeconomic status as predictors of outcome after surgery for temporal lobe epilepsyJorge G Burneo
Epilepsy Programme, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
Arch Neurol 63:1106-10. 2006..1 (95% CI, 0.5-2.6) for the adjusted model, relative to white patients. CONCLUSION: Our data suggest that although sex appears to play a role in the outcomes of surgery for temporal lobe epilepsy, race and socioeconomic status do not...
Research Grants
- ROLE OF FDG-PET, 1H-MRSI, AND MSI IN EPILEPSY SURGERYRobert Knowlton; Fiscal Year: 2005....