K U Knowlton

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3
    K U Knowlton
    Department of Medicine, University of California, San Diego 92103, USA
    J Virol 70:7811-8. 1996
  2. ncbi CVB infection and mechanisms of viral cardiomyopathy
    K U Knowlton
    Department of Medicine and Institute of Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0613K, USA
    Curr Top Microbiol Immunol 323:315-35. 2008
  3. ncbi Highlights of the year in JACC 2003
    Anthony N Demaria
    Cardiology Division, University of California-San Diego Medical Center, San Diego, California 92103, USA
    J Am Coll Cardiol 42:2156-66. 2003
  4. ncbi Chronic thromboembolic pulmonary hypertension
    William R Auger
    Division of Pulmonary and Critical Care Medicine, University of California, San Diego, 9300 Campus Point Drive, La Jolla, CA 92037, USA
    Cardiol Clin 22:453-66, vii. 2004
  5. ncbi Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension
    Nick H S Kim
    University of California, San Diego, 9300 Campus Point Dr, M/C 7381, La Jolla, CA 92037-1300, USA
    Circulation 109:18-22. 2004
  6. ncbi Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy
    C Badorff
    Department of Medicine, University of California, San Diego 92093, USA
    Nat Med 5:320-6. 1999
  7. ncbi Prion-induced amyloid heart disease with high blood infectivity in transgenic mice
    Matthew J Trifilo
    Viral-Immunobiology Laboratory, Departments of Molecular and Integrative Neurosciences and Infectology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 313:94-7. 2006
  8. ncbi Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside
    Cornel Badorff
    Department of Medicine, University of California, San Diego, USA
    Med Microbiol Immunol 193:121-6. 2004
  9. ncbi The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury
    Hideo Yasukawa
    Institute of Molecular Medicine, Department of Medicine, and. Division of Cardiothoracic Surgery, University of California at San Diego, La Jolla, California 92093-0613, USA
    J Clin Invest 111:469-78. 2003
  10. ncbi Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy
    Dingding Xiong
    University of California, San Diego, Department of Medicine, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Circulation 115:94-102. 2007

Research Grants

  1. MOLECULAR PATHWAYS FOR HYPERTROPHY AND CARDIOMYOPATHY
    Kirk Knowlton; Fiscal Year: 2007
  2. Cardiac SOCS Proteins: A Role in Enterovirus Infection
    Kirk Knowlton; Fiscal Year: 2007
  3. TRAINING IN CARDIOVASCULAR PHYSIOLOGY AND PHARMACOLOGY
    Kirk Knowlton; Fiscal Year: 2007
  4. Dystrophin-glycoprotein complex in viral cardiomyopathy
    Kirk Knowlton; Fiscal Year: 2004
  5. MYOCYTE APOPTOSIS AND A TRANSGENIC HEART FAILURE MODEL
    Kirk Knowlton; Fiscal Year: 2001

Collaborators

Detail Information

Publications21

  1. ncbi A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3
    K U Knowlton
    Department of Medicine, University of California, San Diego 92103, USA
    J Virol 70:7811-8. 1996
    ..In addition, the data demonstrate that a point mutation in the puff region of VP2 can markedly alter the ability of CVB3 to induce myocarditis in mice and tumor necrosis factor alpha secretion from infected BALB/c monocytes...
  2. ncbi CVB infection and mechanisms of viral cardiomyopathy
    K U Knowlton
    Department of Medicine and Institute of Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0613K, USA
    Curr Top Microbiol Immunol 323:315-35. 2008
    ..In summary, the interaction between coxsackievirus and the infected myocyte has a significant role in the pathogenesis of viral myocarditis and the susceptibility to viral infection...
  3. ncbi Highlights of the year in JACC 2003
    Anthony N Demaria
    Cardiology Division, University of California-San Diego Medical Center, San Diego, California 92103, USA
    J Am Coll Cardiol 42:2156-66. 2003
  4. ncbi Chronic thromboembolic pulmonary hypertension
    William R Auger
    Division of Pulmonary and Critical Care Medicine, University of California, San Diego, 9300 Campus Point Drive, La Jolla, CA 92037, USA
    Cardiol Clin 22:453-66, vii. 2004
    ....
  5. ncbi Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension
    Nick H S Kim
    University of California, San Diego, 9300 Campus Point Dr, M/C 7381, La Jolla, CA 92037-1300, USA
    Circulation 109:18-22. 2004
    ..Patients with CTEPH and Rup value <60% appear to be at highest risk...
  6. ncbi Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy
    C Badorff
    Department of Medicine, University of California, San Diego 92093, USA
    Nat Med 5:320-6. 1999
    ..We suggest a molecular mechanism through which enteroviral infection contributes to the pathogenesis of acquired forms of dilated cardiomyopathy...
  7. ncbi Prion-induced amyloid heart disease with high blood infectivity in transgenic mice
    Matthew J Trifilo
    Viral-Immunobiology Laboratory, Departments of Molecular and Integrative Neurosciences and Infectology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 313:94-7. 2006
    ..The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained PrPres-positive amyloid deposits that led to myocardial stiffness and cardiac disease...
  8. ncbi Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside
    Cornel Badorff
    Department of Medicine, University of California, San Diego, USA
    Med Microbiol Immunol 193:121-6. 2004
    ..These findings demonstrate that in human coxsackievirus B myocarditis a focal disruption of the DGC can principally occur and may contribute to the pathogenesis of human enterovirus-induced dilated cardiomyopathy...
  9. ncbi The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury
    Hideo Yasukawa
    Institute of Molecular Medicine, Department of Medicine, and. Division of Cardiothoracic Surgery, University of California at San Diego, La Jolla, California 92093-0613, USA
    J Clin Invest 111:469-78. 2003
    ..These results indicate that strategies directed at inhibition of SOCS in the heart and perhaps other organs can augment the host-cell antiviral system, thus preventing viral-mediated end-organ damage during the early stages of infection...
  10. ncbi Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy
    Dingding Xiong
    University of California, San Diego, Department of Medicine, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Circulation 115:94-102. 2007
    ..However, the direct effect of protease 2A in enteroviral cardiomyopathy is less clear because other viral proteins are also expressed with viral infection...
  11. ncbi Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice
    Yi Xin Wang
    Berlex Biosciences, Richmond, CA, USA
    Am J Physiol Heart Circ Physiol 293:H69-76. 2007
    ..However, the potential mechanisms leading to a differential host response for the two isoforms of mIFN remain to be elucidated...
  12. ncbi Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling
    Toshitaka Yajima
    Department of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0613, USA
    Circulation 114:2364-73. 2006
    ..Therefore, we hypothesized that inhibition of gp130 signaling by SOCS3 would change cardiac myocyte susceptibility to virus infection without affecting IFN signaling...
  13. ncbi alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture
    Farah Sheikh
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0613, USA
    Circulation 114:1046-55. 2006
    ..Although alpha-E-catenin is expressed in the adherens junction of the cardiomyocyte intercalated disc, and perturbations in its expression are observed in models of dilated cardiomyopathy, its role in the myocardium remains unknown...
  14. ncbi Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle
    Marie Louise Bang
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 173:905-16. 2006
    ..The functional importance of nebulin in skeletal muscle function was revealed by isometric contractility assays, which demonstrated a dramatic reduction in force production in nebulin-deficient skeletal muscle...
  15. ncbi Long-term cardiac gene expression using a coxsackieviral vector
    Byung-Kwan Lim
    Department of Medicine, Sungkyunkwan University School of Medicine, Cardiac and Vascular Center, Samsung Medical Center, 50 Il-Won Dong, Kangnam-ku, Seoul 135-710, South Korea
    J Mol Cell Cardiol 38:745-51. 2005
    ..These results demonstrated that the cardiac tropism of CVB3 could be used to design vectors for efficient gene expression in the intact heart...
  16. ncbi Highlights of the year in JACC 2004
    Anthony N Demaria
    Cardiology Division, University of California-San Diego, San Diego, California
    J Am Coll Cardiol 45:137-53. 2005
  17. ncbi Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster
    Tsutomu Ryoke
    Shimonoseki Kosei Hospital, Department of Cardiology, Yamaguchi, Japan
    Basic Res Cardiol 97:65-75. 2002
    ....
  18. ncbi Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis?
    Kirk U Knowlton
    J Am Coll Cardiol 44:1298-300. 2004
  19. ncbi Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease
    Dingding Xiong
    Department of Medicine, Institute of Molecular Medicine and The Cardiovascular Center, University of California, San Diego, California, USA
    Nat Med 8:872-7. 2002
    ..These results indicate that viral infection can influence the severity and penetrance of the cardiomyopathy that occurs in the hearts of dystrophin-deficient individuals...
  20. ncbi Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection
    Andrea Dorner
    Department of Medicine, University of California, San Diego, California 92093, USA
    J Biol Chem 279:18497-503. 2004
    ....
  21. ncbi Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
    Byung Kwan Lim
    Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
    J Clin Invest 118:2758-70. 2008
    ..Furthermore, localization of connexin 45 at the AV-node cell-cell junction and of beta-catenin and ZO-1 at the ventricular intercalated disc are dependent on CAR...

Research Grants15

  1. MOLECULAR PATHWAYS FOR HYPERTROPHY AND CARDIOMYOPATHY
    Kirk Knowlton; Fiscal Year: 2007
    ..In addition, we will interactively address costameric molecules on the cytoplasmic side of the sarcolemma in the integrin complex (vinculin, metavinculin, talin and PINCH). ..
  2. Cardiac SOCS Proteins: A Role in Enterovirus Infection
    Kirk Knowlton; Fiscal Year: 2007
    ..These aims will provide a novel insight into the mechanisms by which JAK-STAT-SOCS activation within the cardiac myocyte regulates the innate anti-viral response. ..
  3. TRAINING IN CARDIOVASCULAR PHYSIOLOGY AND PHARMACOLOGY
    Kirk Knowlton; Fiscal Year: 2007
    ....
  4. Dystrophin-glycoprotein complex in viral cardiomyopathy
    Kirk Knowlton; Fiscal Year: 2004
    ..4. Determine whether conditional expression of Coxsackieviral protease 2A in the cardiac myocyte is sufficient to induce cardiomyopathy and disruption of the sarcolemma via cleavage of dystrophin. ..
  5. MYOCYTE APOPTOSIS AND A TRANSGENIC HEART FAILURE MODEL
    Kirk Knowlton; Fiscal Year: 2001
    ..These experiments will facilitate our understanding of the mechanisms by which ventricular function deteriorates with expression of specific proteins that are associated with cardiomyopathy. ..