ANNE KNOWLTON

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Estrogen and the female heart
    A A Knowlton
    The Department of Veteran s Affairs, Northern California VA, Sacramento, CA, USA Molecular and Cellular Cardiology, Departments of Medicine and Pharmacology, University of California, Davis, USA Electronic address
    Mol Cell Endocrinol 389:31-9. 2014
  2. pmc Aging, estrogen loss and epoxyeicosatrienoic acids (EETs)
    Alison R Lee
    Molecular and Cellular Cardiology, Cardiovascular Division, Department of Medicine, University of California Davis, Davis, California, USA
    PLoS ONE 8:e70719. 2013
  3. pmc OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability
    Le Chen
    Department of Medicine, University of California, Davis, CA 95616, USA
    J Am Heart Assoc 1:e003012. 2012
  4. doi request reprint Estrogen and the cardiovascular system
    A A Knowlton
    Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
    Pharmacol Ther 135:54-70. 2012
  5. pmc Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function
    Se Chan Kim
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    BMC Physiol 7:5. 2007
  6. ncbi request reprint HSP60, Bax, and cardiac apoptosis
    A A Knowlton
    Cardiovascular Division, Department of Medicine, University of California, Davis 95616, USA
    Cardiovasc Toxicol 3:263-8. 2003
  7. ncbi request reprint HSP60, Bax, apoptosis and the heart
    S Gupta
    Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
    J Cell Mol Med 9:51-8. 2005
  8. ncbi request reprint HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis
    Li Lin
    Molecular and Cellular Cardiology, Cardiovascular Division, University of California, Davis, California 95616, USA
    Am J Physiol Heart Circ Physiol 293:H2238-47. 2007
  9. pmc 17β-Estradiol, aging, inflammation, and the stress response in the female heart
    James P Stice
    Molecular and Cellular Cardiology, Genomics and Biomedical Sciences Facility, Room 6317, University of California, Davis, 451 Health Sciences Way, Davis, California 95616, USA
    Endocrinology 152:1589-98. 2011
  10. ncbi request reprint HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway
    Sanjiv Gupta
    Molecular and Cellular Cardiology, Cardiovascular Division, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 292:H3052-6. 2007

Research Grants

  1. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2005
  2. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2006
  3. HSPs, Inflammatory Response and Cardiovascular Disease
    ANNE KNOWLTON; Fiscal Year: 2006
  4. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2007
  5. HSPs, Inflammatory Response and Cardiovascular Disease
    ANNE KNOWLTON; Fiscal Year: 2007
  6. HSPs, Inflammatory Response and Cardiovascular Disease
    ANNE KNOWLTON; Fiscal Year: 2009
  7. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2009
  8. AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    ANNE KNOWLTON; Fiscal Year: 2005
  9. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2004
  10. PHOSPHORYLATION OF HSP 72 AND CARDIAC PROTECTION
    ANNE KNOWLTON; Fiscal Year: 1999

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Estrogen and the female heart
    A A Knowlton
    The Department of Veteran s Affairs, Northern California VA, Sacramento, CA, USA Molecular and Cellular Cardiology, Departments of Medicine and Pharmacology, University of California, Davis, USA Electronic address
    Mol Cell Endocrinol 389:31-9. 2014
    ..Thus more work is needed focusing on the effects of aging vs. estrogen loss on the cardiovascular system. ..
  2. pmc Aging, estrogen loss and epoxyeicosatrienoic acids (EETs)
    Alison R Lee
    Molecular and Cellular Cardiology, Cardiovascular Division, Department of Medicine, University of California Davis, Davis, California, USA
    PLoS ONE 8:e70719. 2013
    ..However, plasma 14,15 DHET was increased in aged Ovx, and 5,6 DHET in adult OP. In conclusion neither aging nor estrogen loss decreased the anti-inflammatory EETs in the cardiovascular system. ..
  3. pmc OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability
    Le Chen
    Department of Medicine, University of California, Davis, CA 95616, USA
    J Am Heart Assoc 1:e003012. 2012
    ..Previously we reported that the fusion protein optic atrophy 1 (OPA1) is decreased in heart failure...
  4. doi request reprint Estrogen and the cardiovascular system
    A A Knowlton
    Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
    Pharmacol Ther 135:54-70. 2012
    ..Further basic research into the underlying molecular mechanisms of estrogen's actions is essential to provide a better comprehension of the many properties of this powerful hormone...
  5. pmc Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function
    Se Chan Kim
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    BMC Physiol 7:5. 2007
    ..In a chronic closed-chest model we assessed whether cardiac function is preserved in TLR4-deficient mice (C3H/HeJ) following MI/R, and whether myocardial and systemic cytokine expression differed compared to wild type (WT)...
  6. ncbi request reprint HSP60, Bax, and cardiac apoptosis
    A A Knowlton
    Cardiovascular Division, Department of Medicine, University of California, Davis 95616, USA
    Cardiovasc Toxicol 3:263-8. 2003
    ..Redistribution of cytosolic HSP60 to the plasma membrane during hypoxia appears to contribute to the initiation of the apoptotic cascade with hypoxia and reoxygenation...
  7. ncbi request reprint HSP60, Bax, apoptosis and the heart
    S Gupta
    Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
    J Cell Mol Med 9:51-8. 2005
    ..HSP60 has also been shown to accelerate the cleavage of pro-caspase3. Thus, HSP60 has a complex role in apoptosis in the cell. Its binding to Bax under normal conditions suggests a key regulatory role in apoptosis...
  8. ncbi request reprint HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis
    Li Lin
    Molecular and Cellular Cardiology, Cardiovascular Division, University of California, Davis, California 95616, USA
    Am J Physiol Heart Circ Physiol 293:H2238-47. 2007
    ..Thus abnormal trafficking of HSP60 to the cell surface may be an early trigger for myocyte loss and the progression of heart failure...
  9. pmc 17β-Estradiol, aging, inflammation, and the stress response in the female heart
    James P Stice
    Molecular and Cellular Cardiology, Genomics and Biomedical Sciences Facility, Room 6317, University of California, Davis, 451 Health Sciences Way, Davis, California 95616, USA
    Endocrinology 152:1589-98. 2011
    ..This study demonstrates that while aging in female rats led to a loss of the cardioprotective HSP response, E(2) retains its protective cellular properties...
  10. ncbi request reprint HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway
    Sanjiv Gupta
    Molecular and Cellular Cardiology, Cardiovascular Division, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 292:H3052-6. 2007
    ..We found that HSP60 is released via exosomes, and that within the exosome, HSP60 is tightly attached to the exosome membrane...
  11. pmc Regulation of heat shock protein 60 and 72 expression in the failing heart
    Y Wang
    Cardiovascular Division, University of California, Davis, CA 95616, USA
    J Mol Cell Cardiol 48:360-6. 2010
    ..In conclusion, HSP72 is not increased in heart failure because HSF activity is not changed; increased expression of HSP60 may be driven by NFkappaB activation...
  12. pmc Mitochondria and heart failure: new insights into an energetic problem
    L Chen
    Molecular and Cellular Cardiology, University of California, Davis, Davis, CA, USA
    Minerva Cardioangiol 58:213-29. 2010
    ..Aging alone contributes to the development of HF through multiple mechanisms. These new insights into HF have implications for our understanding of this important disease, and will be reviewed here...
  13. ncbi request reprint Life, death, the unfolded protein response and apoptosis
    Anne A Knowlton
    Cardiovasc Res 73:1-2. 2007
  14. ncbi request reprint Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2
    Ling Lu
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, One Shields Avenue, GBSF 6315, Davis, CA 95616, USA
    Circ Res 100:112-20. 2007
    ....
  15. ncbi request reprint Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression
    Karyn L Hamilton
    College of Applied Human Sciences, Colorado State University, Fort Collins, Colorado 80523 1582, USA
    Physiol Genomics 32:254-63. 2008
    ..In light of these findings, investigation into the net effect of OVX on inflammation is warranted. These experiments add to existing evidence that estrogen can protect against negative changes associated with estrogen removal...

Research Grants22

  1. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2005
    ..The long-term goal of this research initiative is to further understand the mechanisms underlying heart failure's progression. ..
  2. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2006
    ..The long-term goal of this research initiative is to further understand the mechanisms underlying heart failure's progression. ..
  3. HSPs, Inflammatory Response and Cardiovascular Disease
    ANNE KNOWLTON; Fiscal Year: 2006
    ..The long term goal of the Pi's research is to understand the role of heat shock proteins in cardiac injury, and thus, to achieve further insights into how to prevent as well as treat cardiac injury. ..
  4. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2007
    ..The long-term goal of this research initiative is to further understand the mechanisms underlying heart failure's progression. ..
  5. HSPs, Inflammatory Response and Cardiovascular Disease
    ANNE KNOWLTON; Fiscal Year: 2007
    ..The long term goal of the Pi's research is to understand the role of heat shock proteins in cardiac injury, and thus, to achieve further insights into how to prevent as well as treat cardiac injury. ..
  6. HSPs, Inflammatory Response and Cardiovascular Disease
    ANNE KNOWLTON; Fiscal Year: 2009
    ..The long term goal of the Pi's research is to understand the role of heat shock proteins in cardiac injury, and thus, to achieve further insights into how to prevent as well as treat cardiac injury. ..
  7. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2009
    ....
  8. AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    ANNE KNOWLTON; Fiscal Year: 2005
    ..The long-term goal of this research initiative is to understand gender differences in the HSPs and changes in the HSPs with aging in the heart. ..
  9. Human Cardiomyopathy and HSP60
    ANNE KNOWLTON; Fiscal Year: 2004
    ..The long-term goal of this research initiative is to further understand the mechanisms underlying heart failure's progression. ..
  10. PHOSPHORYLATION OF HSP 72 AND CARDIAC PROTECTION
    ANNE KNOWLTON; Fiscal Year: 1999
    ..These studies will further the ultimate goal of understanding the regulation and function of this endogenous protective protein so that expression can be manipulated for the benefit of cardiac patients. ..
  11. PHOSPHORYLATION OF HSP 72 AND CARDIAC PROTECTION
    ANNE KNOWLTON; Fiscal Year: 2000
    ..These studies will further the ultimate goal of understanding the regulation and function of this endogenous protective protein so that expression can be manipulated for the benefit of cardiac patients. ..
  12. AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    ANNE KNOWLTON; Fiscal Year: 2001
    ..The long-term goal of this research initiative is to understand gender differences in the HSPs and changes in the HSPs with aging in the heart. ..
  13. PHOSPHORYLATION OF HSP 72 AND CARDIAC PROTECTION
    ANNE KNOWLTON; Fiscal Year: 2001
    ..These studies will further the ultimate goal of understanding the regulation and function of this endogenous protective protein so that expression can be manipulated for the benefit of cardiac patients. ..
  14. AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    ANNE KNOWLTON; Fiscal Year: 2003
    ..The long-term goal of this research initiative is to understand gender differences in the HSPs and changes in the HSPs with aging in the heart. ..
  15. AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    ANNE KNOWLTON; Fiscal Year: 2002
    ..The long-term goal of this research initiative is to understand gender differences in the HSPs and changes in the HSPs with aging in the heart. ..
  16. PHOSPHORYLATION OF HSP 72 AND CARDIAC PROTECTION
    ANNE KNOWLTON; Fiscal Year: 2001
    ..These studies will further the ultimate goal of understanding the regulation and function of this endogenous protective protein so that expression can be manipulated for the benefit of cardiac patients. ..
  17. AGING, ESTROGEN, HSPS AND MYOCARDIAL ISCHEMIA
    ANNE KNOWLTON; Fiscal Year: 2004
    ..The long-term goal of this research initiative is to understand gender differences in the HSPs and changes in the HSPs with aging in the heart. ..
  18. Human Cardiomyopathy and HSP60
    Anne A Knowlton; Fiscal Year: 2010
    ....