Michael R Knowles

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms
    Michael R Knowles
    Department of Medicine, UNC School of Medicine, Chapel Hill, NC 27599, USA Electronic address
    Am J Hum Genet 93:711-20. 2013
  2. pmc Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia
    Michael R Knowles
    Department of Medicine, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Am J Hum Genet 92:99-106. 2013
  3. pmc Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure
    Michael R Knowles
    University of North Carolina, Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, CB 7248, 7123 Thurston Bowles Bldg, Chapel Hill, NC 27599 7248, USA
    Thorax 67:433-41. 2012
  4. pmc Lack of correlation between pulmonary disease and cystic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis: a case report
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital Boston, 300 Longwood Avenue, Boston, USA
    J Med Case Reports 4:117. 2010
  5. ncbi request reprint Gene modifiers of lung disease
    Michael R Knowles
    Cystic Fibrosis Pulmonary Research and Treatment Center, 7011 Thurston Bowles Bldg, CB 7248, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Curr Opin Pulm Med 12:416-21. 2006
  6. ncbi request reprint Nontuberculous mycobacteria. II: nested-cohort study of impact on cystic fibrosis lung disease
    Kenneth N Olivier
    The Cystic Fibrosis Pulmonary Research and Treatment Center, The Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 167:835-40. 2003
  7. pmc Founder mutation in RSPH4A identified in patients of Hispanic descent with primary ciliary dyskinesia
    M Leigh Anne Daniels
    Department of Medicine, UNC School of Medicine, Chapel Hill, North Carolina
    Hum Mutat 34:1352-6. 2013
  8. pmc ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6
    Maimoona A Zariwala
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Hum Genet 93:336-45. 2013
  9. ncbi request reprint Calcium stone lithoptysis in primary ciliary dyskinesia
    Marcus P Kennedy
    UNC Chapel Hill, Division of Pulmonary and Critical Care Medicine, Chapel Hill, NC 277599 7020, USA
    Respir Med 101:76-83. 2007
  10. pmc Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome
    Margaret W Leigh
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Genet Med 11:473-87. 2009

Research Grants

  1. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2001
  2. Genetic Modifiers of CF Liver Disease
    Michael Knowles; Fiscal Year: 2007
  3. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2007
  4. Genetic Disorders of Mucociliary Clearance
    Michael Knowles; Fiscal Year: 2007
  5. Pathogenesis of PCD Lung Disease
    Michael Knowles; Fiscal Year: 2009
  6. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2009
  7. Molecular Phenotypes for Cystic Fibrosis Lung Disease
    Michael Knowles; Fiscal Year: 2009
  8. Pathogenesis of PCD Lung Disease
    Michael R Knowles; Fiscal Year: 2010
  9. Molecular Phenotypes for Cystic Fibrosis Lung Disease
    Fred A Wright; Fiscal Year: 2010
  10. Pathogenesis of PCD Lung Disease
    Michael Knowles; Fiscal Year: 2007

Detail Information

Publications50

  1. pmc Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms
    Michael R Knowles
    Department of Medicine, UNC School of Medicine, Chapel Hill, NC 27599, USA Electronic address
    Am J Hum Genet 93:711-20. 2013
    ..Together, these results demonstrate that mutations in SPAG1 cause PCD with ciliary ODA+IDA defects and that exome sequencing is useful to identify genetic causes of heterogeneous recessive disorders. ..
  2. pmc Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia
    Michael R Knowles
    Department of Medicine, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Am J Hum Genet 92:99-106. 2013
    ..These results revealed that mutations in CCDC114 are a cause of ciliary dysmotility and PCD and further demonstrate the utility of exome sequencing to identify genetic causes in heterogeneous recessive disorders...
  3. pmc Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure
    Michael R Knowles
    University of North Carolina, Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, CB 7248, 7123 Thurston Bowles Bldg, Chapel Hill, NC 27599 7248, USA
    Thorax 67:433-41. 2012
    ....
  4. pmc Lack of correlation between pulmonary disease and cystic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis: a case report
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital Boston, 300 Longwood Avenue, Boston, USA
    J Med Case Reports 4:117. 2010
    ....
  5. ncbi request reprint Gene modifiers of lung disease
    Michael R Knowles
    Cystic Fibrosis Pulmonary Research and Treatment Center, 7011 Thurston Bowles Bldg, CB 7248, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Curr Opin Pulm Med 12:416-21. 2006
    ..Early studies were small and/or phenotyping methodologies were limited; consequently, most findings have not been replicated...
  6. ncbi request reprint Nontuberculous mycobacteria. II: nested-cohort study of impact on cystic fibrosis lung disease
    Kenneth N Olivier
    The Cystic Fibrosis Pulmonary Research and Treatment Center, The Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 167:835-40. 2003
    ..Patients with CF and multiple positive NTM cultures, characteristic HRCT findings, and progression of HRCT changes should be monitored closely and considered for antimycobacterial therapy...
  7. pmc Founder mutation in RSPH4A identified in patients of Hispanic descent with primary ciliary dyskinesia
    M Leigh Anne Daniels
    Department of Medicine, UNC School of Medicine, Chapel Hill, North Carolina
    Hum Mutat 34:1352-6. 2013
    ..921+3_6delAAGT splice-site mutation in RSPH4A were Hispanic with ancestry tracing to Puerto Rico. This mutation is a founder mutation and a common cause of PCD without situs abnormalities in patients of Puerto Rican descent. ..
  8. pmc ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6
    Maimoona A Zariwala
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Hum Genet 93:336-45. 2013
    ..Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function. ..
  9. ncbi request reprint Calcium stone lithoptysis in primary ciliary dyskinesia
    Marcus P Kennedy
    UNC Chapel Hill, Division of Pulmonary and Critical Care Medicine, Chapel Hill, NC 277599 7020, USA
    Respir Med 101:76-83. 2007
    ..An association between lithoptysis and primary ciliary dyskinesia (PCD) has not been previously reported. However, reports of lithoptysis from 2 older patients (>60 yr) prompted a study of this association...
  10. pmc Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome
    Margaret W Leigh
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Genet Med 11:473-87. 2009
    ....
  11. ncbi request reprint High-resolution CT of patients with primary ciliary dyskinesia
    Marcus P Kennedy
    Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC, USA
    AJR Am J Roentgenol 188:1232-8. 2007
    ..We analyzed all high-resolution CT studies of the chest available for a cohort of PCD patients to identify an associated pattern of high-resolution CT changes...
  12. pmc Primary ciliary dyskinesia: improving the diagnostic approach
    Margaret W Leigh
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7220, USA
    Curr Opin Pediatr 21:320-5. 2009
    ..This review outlines the potential utility of new diagnostic tests, including measurement of nasal nitric oxide production and systematic analysis for mutations in genes encoding ciliary proteins...
  13. ncbi request reprint Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia
    Maimoona Zariwala
    University of North Carolina at Chapel Hill School of Medicine, Cystic Fibrosis Pulmonary Research and Treatment Center, Chapel Hill, NC 27599 7248, USA
    Am J Respir Cell Mol Biol 30:428-34. 2004
    ..No disease-causing mutations were confirmed; however, one variant could not be excluded. Therefore, DPCD remains a novel candidate gene for PCD...
  14. ncbi request reprint Genetic causes of bronchiectasis: primary ciliary dyskinesia
    Hilda N Morillas
    CF Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Respiration 74:252-63. 2007
    ....
  15. ncbi request reprint Congenital heart disease and other heterotaxic defects in a large cohort of patients with primary ciliary dyskinesia
    Marcus P Kennedy
    University of North Carolina, Chapel Hill, NC, USA
    Circulation 115:2814-21. 2007
    ..Advances in diagnosis of PCD, such as genetic testing, allow the systematic investigation of this association...
  16. pmc Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC
    Xueliang Guo
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e25452. 2011
    ..4 kb VNTR allele and severity of CF lung disease. The LD pattern with surrounding SNPs suggests that the 6.4 kb allele contains, or is linked to, important functional genetic variation...
  17. pmc Human airway ciliary dynamics
    Patrick R Sears
    Cystic Fibrosis Center, University of North Carolina, 6026 Thurston Bowles Bldg, CB7248, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 304:L170-83. 2013
    ..31(0.04), 0.25(0.06), 0.50(0.12), 0.50(0.10), μm, respectively. In contrast, the same measures for three different PCD waveforms had values far outside this range...
  18. ncbi request reprint A middle-aged woman with recurrent respiratory infections
    Kathryn Chmura
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Respiration 72:427-30. 2005
  19. ncbi request reprint Primary ciliary dyskinesia: diagnostic and phenotypic features
    Peadar G Noone
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 169:459-67. 2004
    ..An increased awareness of the clinical presentation and diagnostic criteria for PCD will help lead to better diagnosis and care for this orphan disease...
  20. pmc The influence of genetics on cystic fibrosis phenotypes
    Michael R Knowles
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Cold Spring Harb Perspect Med 2:a009548. 2012
    ..These unforeseen associations thus provide novel insight into disease pathophysiology, as well as suggesting new therapeutic strategies for CF...
  21. pmc Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis
    Mary J Emond
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Nat Genet 44:886-9. 2012
    ..aeruginosa airway infection, chronic P. aeruginosa infection and mucoid P. aeruginosa in individuals with cystic fibrosis...
  22. pmc The challenges of diagnosing primary ciliary dyskinesia
    Margaret W Leigh
    Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27516, USA
    Proc Am Thorac Soc 8:434-7. 2011
    ..Another chapter in this issue (see Zariwala and colleagues, pp. 430) addresses the progress toward improved capabilities for definitive genetic testing...
  23. ncbi request reprint Genetic defects in ciliary structure and function
    Maimoona A Zariwala
    Department of Medicine, Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Annu Rev Physiol 69:423-50. 2007
    ..Recent mutational analysis demonstrated that 38% of PCD patients carry mutations of the dynein genes DNAI1 and DNAH5. Increased understanding of the pathogenesis will aid in better diagnosis and treatment of PCD...
  24. pmc Next generation massively parallel sequencing of targeted exomes to identify genetic mutations in primary ciliary dyskinesia: implications for application to clinical testing
    Jonathan S Berg
    Departments of Genetics, The University of North Carolina Chapel Hill, North Carolina 27599 7264, USA
    Genet Med 13:218-29. 2011
    ..The objective of this study was to investigate the performance characteristics of exon-capture technology coupled with massively parallel sequencing for clinical diagnostic evaluation...
  25. pmc Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation
    Maimoona A Zariwala
    University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
    Am J Respir Crit Care Med 174:858-66. 2006
    ..Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia...
  26. ncbi request reprint Mucus clearance and lung function in cystic fibrosis with hypertonic saline
    Scott H Donaldson
    University of North Carolina at Chapel Hill Cystic Fibrosis Research and Treatment Center, Chapel Hill 27599, USA
    N Engl J Med 354:241-50. 2006
    ..Through osmotic forces, hypertonic saline may increase the volume of airway surface liquid, restore mucus clearance, and improve lung function...
  27. pmc In vivo airway surface liquid Cl- analysis with solid-state electrodes
    Ray A Caldwell
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Gen Physiol 119:3-14. 2002
    ..3 +/- 7.1 mM, n = 5) and monkey (128.5 +/- 6.8 mM, n = 3). The measured [Cl-], in excess of 100 mM throughout all airway regions tested in multiple species, is consistent with the isotonic volume hypothesis to describe ASL physiology...
  28. pmc Genetic modifiers of liver disease in cystic fibrosis
    Jaclyn R Bartlett
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    JAMA 302:1076-83. 2009
    ..A subset (approximately 3%-5%) of patients with cystic fibrosis (CF) develops severe liver disease with portal hypertension...
  29. pmc SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis
    Barbara R Grubb
    Cystic Fibrosis Pulmonary Research and Treatment Center, 7011 Thurston Bowles Bldg, CB 7248, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    Am J Respir Cell Mol Biol 34:355-63. 2006
    ....
  30. pmc Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2
    Fred A Wright
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Genet 43:539-46. 2011
    ..2 (log(10) odds = 5.03). Our findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder...
  31. pmc Quantification of population structure using correlated SNPs by shrinkage principal components
    Fei Zou
    Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA fzou bios unc edu
    Hum Hered 70:9-22. 2010
    ..It implicitly assumes that the markers are in linkage equilibrium, a condition that is rarely satisfied and that we plan to relax...
  32. ncbi request reprint Mutations in DNAI1 (IC78) cause primary ciliary dyskinesia
    Peadar G Noone
    Division of Pulmonary and Critical Care Medicine, Pulmonary Cystic Fibrosis Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    Chest 121:97S. 2002
  33. pmc Mucus clearance as a primary innate defense mechanism for mammalian airways
    Michael R Knowles
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 109:571-7. 2002
  34. ncbi request reprint Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis
    Kenneth N Olivier
    The Cystic Fibrosis Pulmonary Research and Treatment Center, The Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 167:828-34. 2003
    ..Older age was the most significant predictor for isolation of NTM. The clinical significance of NTM in CF is incompletely defined, but patients with these organisms should be monitored with repeat cultures...
  35. ncbi request reprint What is cystic fibrosis?
    Michael R Knowles
    N Engl J Med 347:439-42. 2002
  36. ncbi request reprint Increasing concentration of inhaled saline with or without amiloride: effect on mucociliary clearance in normal subjects
    Namita Sood
    Division of Pulmonary and Critical Care Medicine, Ohio State University, Columbus 43210, USA
    Am J Respir Crit Care Med 167:158-63. 2003
    ..We conclude that maneuvers that increase the volume of airway surface liquid are associated with increased rates of mucociliary clearance in normal subjects...
  37. pmc Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia
    Manfred Fliegauf
    Department of Pediatrics and Adolescent Medicine, Mathildenstrasse 1, 79106 Freiburg, Germany
    Am J Respir Crit Care Med 171:1343-9. 2005
    ..Diagnosis of PCD usually relies on electron microscopy, which is technically demanding and sometimes difficult to interpret...
  38. ncbi request reprint Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients
    Judit Horvath
    Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Freiburg, Germany
    Am J Respir Cell Mol Biol 33:41-7. 2005
    ..Based on these findings, we considered DNAL1 a candidate for PCD and sequenced all exons of DNAL1 in 86 patients. Mutational analysis was negative, excluding a major role of DNAL1 in the pathogenesis of PCD...
  39. ncbi request reprint Genetic modifiers of lung disease in cystic fibrosis
    Mitchell L Drumm
    Department of Pediatrics, Case Western Reserve University, Cleveland, USA
    N Engl J Med 353:1443-53. 2005
    ..Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis...
  40. pmc DNAH5 mutations are a common cause of primary ciliary dyskinesia with outer dynein arm defects
    Nada Hornef
    Department of Pediatrics and Adolescent Medicine, Mathildenstrasse 1, 79106 Freiburg, Germany
    Am J Respir Crit Care Med 174:120-6. 2006
    ..To date, autosomal recessive mutations have only been identified in a small number of patients involving DNAI1 and DNAH5, which encode outer dynein arm components...
  41. ncbi request reprint Standardized procedure for measurement of nasal potential difference: an outcome measure in multicenter cystic fibrosis clinical trials
    Thomas A Standaert
    University of Washington, Seattle, Washington, USA
    Pediatr Pulmonol 37:385-92. 2004
    ..Valid and consistent results can be attained with trained operators and attention to technical details. These data demonstrate the procedure to be sufficient for multicenter studies in the CF Foundation network...
  42. pmc Classifying severity of cystic fibrosis lung disease using longitudinal pulmonary function data
    Mark D Schluchter
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106 4945, USA
    Am J Respir Crit Care Med 174:780-6. 2006
    ..One type of genetic association study design compares polymorphisms in patients at extremes of phenotype, requiring accurate classification of pulmonary disease at varying ages...
  43. ncbi request reprint Basic protocol for transepithelial nasal potential difference measurements
    Daniel Schüler
    CF Center, Children Hospital of Justus Liebig University, 35385 Giessen, Germany
    J Cyst Fibros 3:151-5. 2004
    ..The article summarizes the objectives and the principle of NPD measurements, describes a hands-on protocol of the procedure and provides quality control measures, practical hints and troubleshooting...
  44. ncbi request reprint Mechanisms of action of the antidepressants fluoxetine and the substance P antagonist L-000760735 are associated with altered neurofilaments and synaptic remodeling
    Paul C Guest
    Neuroscience Research Centre, Merck, Sharp and Dohme, Eastwick Road, Harlow, Essex CM20 2QR, UK
    Brain Res 1002:1-10. 2004
    ....
  45. ncbi request reprint Burkholderia gladioli: five year experience in a cystic fibrosis and lung transplantation center
    Marcus P Kennedy
    Department of Pulmonary Medicine, Unit 403, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Cyst Fibros 6:267-73. 2007
    ..The impact of infection with Burkholderia gladioli in cystic fibrosis, other chronic airway diseases and immunosuppressed patients is unknown...
  46. pmc No detectable improvements in cystic fibrosis transmembrane conductance regulator by nasal aminoglycosides in patients with cystic fibrosis with stop mutations
    John P Clancy
    Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, Birmingham, AL 35233, USA
    Am J Respir Cell Mol Biol 37:57-66. 2007
    ..The study provides valuable information on parameters of the nasal potential difference measurements for use in future multicenter clinical trials...
  47. ncbi request reprint Ionic interaction of amiloride and uridine 5'-triphosphate in nebulizer solutions
    Ronald J Pettis
    Becton Dickinson Technologies, 21 Davis Drive, PO Box 12016, RTP, North Carolina 27709, USA
    J Pharm Sci 93:2399-406. 2004
    ..The solubility suppressing effects of UTP and saline were largely additive. A number of ionic interactions increase complex solubility profile of amiloride hydrochloride in the presence of UTP and NaCl...
  48. ncbi request reprint The I148T CFTR allele occurs on multiple haplotypes: a complex allele is associated with cystic fibrosis
    Elizabeth M Rohlfs
    Genzyme Genetics, Molecular Diagnostic Laboratory, Framingham, Massachusetts 01701, USA
    Genet Med 4:319-23. 2002
    ..To determine whether intragenic changes modulate the cystic fibrosis (CF) phenotype in individuals who are positive for the I148T allele...
  49. ncbi request reprint Multiplex proteomic analysis by two-dimensional differential in-gel electrophoresis
    Michael R Knowles
    Neuroscience Research Centre, Merck, Sharp and Dohme Research Laboratories, Harlow, Essex CM20 2QR, UK
    Proteomics 3:1162-71. 2003
    ..The results illustrate the power of this multiplex proteomics technology and illustrate how proteomics can be used to understand gene function...
  50. ncbi request reprint [Airway calcium deposition and broncholithiasis in disorders of mucociliary clearance]
    Marcus Peter Kennedy
    Arch Bronconeumol 43:474. 2007

Research Grants29

  1. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2001
    ..Identification of genes that modulate the severity of the pulmonary phenotype will improve our understanding of the pathophysiology of CF lung disease, and identify new targets for therapeutic intervention. ..
  2. Genetic Modifiers of CF Liver Disease
    Michael Knowles; Fiscal Year: 2007
    ..Better understanding of the pathobiology of hepatic fibrosis in CF will identify novel targets to prevent (or reduce) the development of CFLD. ..
  3. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2007
    ..Natural variation in the disease proves that there must be ways to alter its course, and this project has the power to identify genetic sources of that variation. ..
  4. Genetic Disorders of Mucociliary Clearance
    Michael Knowles; Fiscal Year: 2007
    ..Finally, we will work with the DTCC to coordinate and expand current websites to provide information to the lay public, patients, and medical professionals for education, referral, and recruitment of study subjects. ..
  5. Pathogenesis of PCD Lung Disease
    Michael Knowles; Fiscal Year: 2009
    ....
  6. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2009
    ..Natural variation in the disease proves that there must be ways to alter its course, and this project has the power to identify genetic sources of that variation. ..
  7. Molecular Phenotypes for Cystic Fibrosis Lung Disease
    Michael Knowles; Fiscal Year: 2009
    ....
  8. Pathogenesis of PCD Lung Disease
    Michael R Knowles; Fiscal Year: 2010
    ....
  9. Molecular Phenotypes for Cystic Fibrosis Lung Disease
    Fred A Wright; Fiscal Year: 2010
    ....
  10. Pathogenesis of PCD Lung Disease
    Michael Knowles; Fiscal Year: 2007
    ..abstract_text> ..
  11. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2006
    ..Natural variation in the disease proves that there must be ways to alter its course, and this project has the power to identify genetic sources of that variation. ..
  12. Genetic Disorders of Mucociliary Clearance
    Michael Knowles; Fiscal Year: 2006
    ..Finally, we will work with the DTCC to coordinate and expand current websites to provide information to the lay public, patients, and medical professionals for education, referral, and recruitment of study subjects. ..
  13. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2002
    ..Identification of genes that modulate the severity of the pulmonary phenotype will improve our understanding of the pathophysiology of CF lung disease, and identify new targets for therapeutic intervention. ..
  14. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2003
    ..Identification of genes that modulate the severity of the pulmonary phenotype will improve our understanding of the pathophysiology of CF lung disease, and identify new targets for therapeutic intervention. ..
  15. Genetic Modifiers of CF Liver Disease
    Michael Knowles; Fiscal Year: 2004
    ..Better understanding of the pathobiology of hepatic fibrosis in CF will identify novel targets to prevent (or reduce) the development of CFLD. ..
  16. Pathogenesis of PCD Lung Disease
    Michael Knowles; Fiscal Year: 2004
    ..abstract_text> ..
  17. Genetic Disorders of Mucociliary Clearance
    Michael Knowles; Fiscal Year: 2004
    ..Finally, we will work with the DTCC to coordinate and expand current websites to provide information to the lay public, patients, and medical professionals for education, referral, and recruitment of study subjects. ..
  18. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2004
    ..Identification of genes that modulate the severity of the pulmonary phenotype will improve our understanding of the pathophysiology of CF lung disease, and identify new targets for therapeutic intervention. ..
  19. Genetic Modifiers of CF Liver Disease
    Michael Knowles; Fiscal Year: 2005
    ..Better understanding of the pathobiology of hepatic fibrosis in CF will identify novel targets to prevent (or reduce) the development of CFLD. ..
  20. Pathogenesis of PCD Lung Disease
    Michael Knowles; Fiscal Year: 2005
    ..abstract_text> ..
  21. Gene Modifiers in CF Lung Disease
    Michael Knowles; Fiscal Year: 2005
    ..Identification of genes that modulate the severity of the pulmonary phenotype will improve our understanding of the pathophysiology of CF lung disease, and identify new targets for therapeutic intervention. ..
  22. Genetic Disorders of Mucociliary Clearance
    Michael Knowles; Fiscal Year: 2005
    ..Finally, we will work with the DTCC to coordinate and expand current websites to provide information to the lay public, patients, and medical professionals for education, referral, and recruitment of study subjects. ..
  23. Pathogenesis of PCD Lung Disease
    Michael Knowles; Fiscal Year: 2006
    ..abstract_text> ..
  24. Genetic Modifiers of CF Liver Disease
    Michael Knowles; Fiscal Year: 2006
    ..Better understanding of the pathobiology of hepatic fibrosis in CF will identify novel targets to prevent (or reduce) the development of CFLD. ..
  25. Gene Modifiers in CF Lung Disease
    Michael R Knowles; Fiscal Year: 2010
    ..Natural variation in the disease proves that there must be ways to alter its course, and this project has the power to identify genetic sources of that variation. ..