Research Topics
| Robert KnoppSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Long-term cholesterol-lowering effects of 4 fat-restricted diets in hypercholesterolemic and combined hyperlipidemic men. The Dietary Alternatives StudyR H Knopp
Northwest Lipid Research Clinic, Department of Medicine, University of Washington, Seattle 98104, USA
JAMA 278:1509-15. 1997..The long-term effect of aggressively vs moderately fat-restricted diets has not been studied extensively in free-living subjects with different types of hyperlipidemia...- Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemiaR H Knopp
Division of Metabolism, Endocrinology and Nutrition, Northwest Lipid Research Clinic, 325 Ninth Avenue, Room 465, Box 359720, Seattle, WA 98104, USA
Eur Heart J 24:729-41. 2003..This randomized, double-blind, placebo-controlled, parallel-group study evaluated the safety and efficacy of ezetimibe 10 mg/day in patients with primary hypercholesterolemia... - Estrogen therapies, lipids, and the heart disease prevention controversyRobert H Knopp
University of Washington, Northwest Lipid Research Clinic, 325 9th Avenue, Box 359720, Seattle, WA 98104, USA
Curr Cardiol Rep 5:477-82. 2003..quot; Until these and other points are formally addressed, the hypothesis that estrogen prevents heart disease remains open... 
Comprehensive lipid management versus aggressive low-density lipoprotein lowering to reduce cardiovascular riskRobert H Knopp
Division of Metabolism, Endocrinology and Nutrition, Northwest Lipid Research Clinic, Seattle, Washington, USA
Am J Cardiol 101:48B-57B. 2008..In conclusion, 5 lines of evidence justify comprehensive diet and drug treatment for combined hyperlipidemia and, at lesser LDL elevations, the atherogenic dyslipidemias of obesity, diabetes mellitus, and the metabolic syndrome...- Lipoprotein effects of combined ezetimibe and colesevelam hydrochloride versus ezetimibe alone in hypercholesterolemic subjects: a pilot studyRobert H Knopp
Northwest Lipid Research Clinic, Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
Metabolism 55:1697-703. 2006..54). In conclusion, in the short term, colesevelam HCl may not consistently add cholesterol-lowering benefit to ezetimibe. This observation requires confirmation... - A moderate-fat diet for combined hyperlipidemia and metabolic syndromeRobert H Knopp
Northwest Lipid Research Clinic, Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, 325 9th Avenue, Box 359720, Seattle, WA 98104, USA
Curr Atheroscler Rep 8:492-500. 2006..A test of this dietary strategy on lipoproteins and downstream benefits on inflammatory mediators, oxidative stress, and vascular reactivity is now underway... - Treatment of hypercholesterolemia in patients with metabolic syndrome: how do different statins compare?Robert H Knopp
University of Washington School of Medicine, and Division of Metabolism, Endocrinology and Nutrition, Harborview Medical Center, Seattle, WA, USA
Nat Clin Pract Endocrinol Metab 2:136-7. 2006 - Efficacy and safety of atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: the Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in non-insulin-dependent diabetes mellitus (ASPEN)Robert H Knopp
Harborview Medical Center, 325 Ninth Ave, 359720, Seattle, WA 98104 2499, USA
Diabetes Care 29:1478-85. 2006..The purpose of this study was to assess the effect of 10 mg of atorvastatin versus placebo on CVD prevention in subjects with type 2 diabetes and LDL cholesterol levels below contemporary guideline targets... - Gender differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular diseaseRobert H Knopp
Northwest Lipid Research Clinic, University of Washington, Box 359720, Seattle, WA 98104, USA
Curr Atheroscler Rep 7:472-9. 2005..Dietary fat restriction in women appears to have a less beneficial lipoprotein effect than in men. Dietary fat restriction for heart disease prevention may be less ideal in women than in men... - Management of patients with diabetic hyperlipidemiaRobert H Knopp
Northwest Lipid Research Clinic and Department of Medicine, University of Washington School of Medicine, Seattle 98104, USA
Am J Cardiol 91:24E-28E. 2003..We also present a case study of a diabetic woman with hyperlipidemia and coronary artery disease... - One-year effects of increasingly fat-restricted, carbohydrate-enriched diets on lipoprotein levels in free-living subjectsR H Knopp
Northwest Lipid Research Clinic and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98104, USA
Proc Soc Exp Biol Med 225:191-9. 2000..The HDL-C decrease in HC women may have a similar cause and points to an underlying male-female difference. Alternative dietary approaches to limit saturated fat intake deserve intensive study... - Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feedingRobert H Knopp
University of Washington, Northwest Lipid Research Clinic, Seattle, Wash 98104, USA
Arterioscler Thromb Vasc Biol 23:1437-43. 2003..This study was undertaken to determine if insulin resistance without and with obesity influences LDL response to dietary cholesterol and saturated fat... - Comparison of the lipoprotein, carbohydrate, and hemostatic effects of phasic oral contraceptives containing desogestrel or levonorgestrelR H Knopp
Northwest Lipid Research Clinic in the Department of Medicine, University of Washington, Seattle, USA
Contraception 63:1-11. 2001..The lipoprotein, SHBG, and protein S and factor V differences are likely due to the lesser androgenicity of DSG allowing for a greater expression of the dose of estrogen... - The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartmentsMiriam Cnop
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98108, USA
Diabetes 51:1005-15. 2002.... 
Combined hyperlipidemia in relation to race/ethnicity, obesity, and insulin resistance in the Multi-Ethnic Study of AtherosclerosisPathmaja Paramsothy
Department of Internal Medicine Division of Cardiology, University of Washington, Seattle, WA 98105, USA
Metabolism 58:212-9. 2009..Further research is needed to determine the most efficacious diet, exercise, and drug management to decrease the risk of CHL and coronary heart disease among racial/ethnic groups in the United States...- HDL in humans with cardiovascular disease exhibits a proteomic signatureTomas Vaisar
Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
Clin Chim Acta 411:972-9. 2010..We tested whether relative levels of proteins in HDL(2) could be used as biomarkers for coronary artery disease (CAD)... - Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responsesKristina M Utzschneider
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
Diabetes Care 29:356-62. 2006..To determine whether the hyperbolic relationship between insulin sensitivity and the acute insulin response to glucose (AIRg) exists in subjects with impaired fasting glucose (IFG) or decreased glucose tolerance... - Association of combinations of lipid parameters with carotid intima-media thickness and coronary artery calcium in the MESA (Multi-Ethnic Study of Atherosclerosis)Pathmaja Paramsothy
Division of Cardiology, Department of Internal Medicine, University of Washington, Seattle, Washington 98104, USA
J Am Coll Cardiol 56:1034-41. 2010..The purpose of this study was to determine the association of combinations of lipid parameters with subclinical atherosclerosis... - Combined statin and niacin therapy remodels the high-density lipoprotein proteomePattie S Green
Department of Medicine, University of Washington, Seattle, WA, USA
Circulation 118:1259-67. 2008..We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes... - Relationship of liver enzymes to insulin sensitivity and intra-abdominal fatTara M Wallace
Department of Medicine, VA Puget Sound Health Care System, and University of Washington, Seattle, WA 98108, USA
Diabetes Care 30:2673-8. 2007..The purpose of this study was to determine the relationship between plasma liver enzyme concentrations, insulin sensitivity, and intra-abdominal fat (IAF) distribution... - Endogenous red blood cell membrane fatty acids and sudden cardiac arrestRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
Metabolism 59:1029-34. 2010..Further work is needed to investigate if conditions that favor de novo fatty acid synthesis, such as high-carbohydrate/low-fat diets, might also increase the risk of SCA... - Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrestRozenn N Lemaitre
Department of Medicine, University of Washington, Seattle, WA 98101, USA
Metabolism 58:534-40. 2009..The association was independent of red blood cell levels of long-chain n-3 fatty acids, trans-fatty acids, and linoleic acid. Higher membrane levels of alpha-linolenic acid are associated with higher risk of sudden cardiac arrest... - Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemiaAndrew N Hoofnagle
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
Arterioscler Thromb Vasc Biol 30:2528-34. 2010..To determine whether obesity and insulin resistance associate with changes in the protein content of high-density lipoprotein (HDL) in 2 different groups of men by using targeted proteomics... - Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndromeDarcy B Carr
Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
Diabetes 53:2087-94. 2004..Of the NCEP criteria, waist circumference and triglycerides may best identify insulin resistance and visceral adiposity in individuals with a fasting plasma glucose <6.4 mmol/l... - Cell membrane trans-fatty acids and the risk of primary cardiac arrestRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
Circulation 105:697-701. 2002..The relation of trans-fatty acid intake to life-threatening arrhythmias and primary cardiac arrest is unknown... - Norgestimate and medroxyprogesterone acetate do not attenuate the atheroprotective effects of 17beta-estradiol in ovariectomized, apolipoprotein E-deficient miceJennifer M Shultz
Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, Seattle 98195, USA
Fertil Steril 82:1133-9. 2004..CONCLUSION(S): There were no significant differences in lesion area in response to estrogen alone or to estrogen plus the different types and doses of progestins... - The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fatDelma J Nieves
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
Diabetes 52:172-9. 2003..Thus an atherogenic lipoprotein profile appears to be the result primarily of an increase in IAF, perhaps via insulin resistance... - Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell functionKristina M Utzschneider
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
Diabetes 53:2867-72. 2004.... - Low-density lipoprotein inhibits secretion of phospholipid transfer protein in human trophoblastic BeWo cellsAn Yue Tu
Department of Medicine, Northwest Lipid Research Laboratories, Northwest Lipid Research Clinic, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, 2121 N 35th Street, Seattle, WA 98103, USA
Exp Biol Med (Maywood) 229:1046-52. 2004..These results support the conclusion that LDL-mediated suppression of PLTP secretion in BeWo cells is through a LDL receptor-independent MAPK signaling pathway... - Management of dyslipidaemiasPathmaja Paramsothy
Division of Cardiology, University of Washington/Harborview Medical Center, Seattle, Washngton 98104, USA
Heart 92:1529-34. 2006 - Improving insulin ordering safely: the development of an inpatient glycemic control programRachel Thompson
Division of General Internal Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
J Hosp Med 4:E30-5. 2009..003). Distinguishing characteristics of this Glycemic Control Program include the use of real-time data to identify patients with out-of-range glucoses and the employment of a single clinician to cover all non-critical care floors... - Enhancing recruitment of healthy African American volunteers in a city with a small African American community: results from a dietary supplement crossover trialCheryl A M Anderson
Department of Epidemiology, University of Washington, USA
Ethn Dis 17:555-9. 2007..To describe strategies for enhancing recruitment of African Americans to a longterm intervention study requiring frequent blood draws and follow-up visits, in a city with relatively few African Americans... - Physician informational needs in providing nutritional guidance to patientsTanis V Mihalynuk
Interdisciplinary Nutritional Sciences Program, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
Fam Med 36:722-6. 2004..Medical nutrition educators should consider the educational needs of the practicing physician... - Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjectsLisa R Tannock
Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195-6426, USA
Circulation 111:3058-62. 2005..CONCLUSIONS: A high-cholesterol diet leads to significant increases in both inflammatory markers and non-HDL cholesterol levels in insulin-sensitive individuals but not in lean or obese insulin-resistant subjects... - Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDLTomas Vaisar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Clin Invest 117:746-56. 2007.... - Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: evidence for a protective adaptation in diabetesLois Jovanovic
University of Washington, 325 Ninth Ave, Box 359720, Seattle, WA 98104, USA
Diabetes Care 28:1113-7. 2005..CONCLUSIONS: Pregnancy losses are increased at the extremes of glycemia in both normal and diabetic pregnancy but at higher levels in diabetic pregnancy. The data suggest defensive adaptations against hyperglycemia in diabetic pregnancy... - Association of lung function with atherosclerotic risk factors among Japanese Americans: Seattle Nikkei Health StudyKenichiro Taneda
Department of Medicine, University of Washington, Washington, USA
Clin Exp Pharmacol Physiol 31:S31-4. 2004..However, our findings imply that light and moderate drinking may be a protective factor of lung function and that hypertension and smoking may impair lung function... - Risk factors for coronary artery disease in womenRobert H Knopp
Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington 98104, USA
Am J Cardiol 89:28E-34E; discussion 34E-35E. 2002..Because of the complex origin of CVD, it is important to target the full array of risk factors for modification, rather than focusing on a single factor or treatment to the exclusion of other important markers... - Survey correlations: proficiency and adequacy of nutrition training of medical studentsTanis V Mihalynuk
Interdisciplinary Nutritional Sciences Program, University of Washington, Seattle, Washington, USA
J Am Coll Nutr 27:59-64. 2008.... - Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention programAllan F Moore
Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Diabetes 57:2503-10. 2008.... - Comparative effects on lipid levels of combination therapy with a statin and extended-release niacin or ezetimibe versus a statin alone (the COMPELL study)James M McKenney
National Clinical Research, Richmond, VA 23227, United States
Atherosclerosis 192:432-7. 2007..No drug-related myopathy or hepatotoxicity was observed. In this study, low to moderate dose combination therapy with a statin and niacin ER provided broad control of lipids and lipoproteins independently associated with CHD... - Effect of raloxifene on serum triglycerides in women with a history of hypertriglyceridemia while on oral estrogen therapyMolly C Carr
Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
Diabetes Care 28:1555-61. 2005..This study was designed to assess the effect of raloxifene on serum triglycerides in postmenopausal women who have a history of increased hypertriglyceridemia with oral estrogen therapy... - Oxidized LDL and abdominal obesity: a key to understanding the metabolic syndromeRobert H Knopp
Am J Clin Nutr 83:1-2. 2006 - Undesirable effects of extreme dietary carbohydrate and saturated fat intakes: the search for the middle groundRobert H Knopp
Curr Atheroscler Rep 7:409-11. 2005 - Comparative effects of rosuvastatin and atorvastatin across their dose ranges in patients with hypercholesterolemia and without active arterial diseaseDennis W Schneck
AstraZeneca LP, Wilmington, Delaware 19850 5437, USA
Am J Cardiol 91:33-41. 2003..Significantly greater triglyceride decreases were seen at 80 mg with atorvastatin over rosuvastatin. Both rosuvastatin and atorvastatin were well tolerated over 6 weeks... - Strategies for reducing cardiovascular risk in patients with hypertriglyceridemiaJanet U Gorkin
Albert Einstein College of Medicine, Bronx, NY USA
J Fam Pract 56:S1-7; quiz S8. 2007 - Estrogens, lipoproteins, and cardiovascular risk factors: an update following the randomized placebo-controlled trials of hormone-replacement therapyMary Seed
Department of Cardiology, Charing Cross Hospital, London, W6 8RF, UK
Curr Opin Lipidol 15:459-67. 2004..Metabolic differences of route of administration of estrogen, particularly on haemostatic variables, may explain this clinical paradox, which continues to be an important research area... - Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS studyRichard H Karas
Division of Cardiology, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
Am J Cardiovasc Drugs 8:69-81. 2008..This fact has focused increased attention on treating abnormalities of non-high-density lipoprotein-cholesterol (non-HDL-C), HDL-C, and triglycerides in national guidelines and has intensified interest in combination therapy... - Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for careJohn L Kitzmiller
Division of Maternal-Fetal Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA
Diabetes Care 31:1060-79. 2008 - Lipid changes on hormone therapy and coronary heart disease events in the Heart and Estrogen/progestin Replacement Study (HERS)Michael G Shlipak
General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, Calif 94121, USA
Am Heart J 146:870-5. 2003..To explore possible mechanisms, we examined the association between lipid changes and CHD outcomes among women assigned to hormone therapy... - Saturated fat prevents coronary artery disease? An American paradoxRobert H Knopp
Am J Clin Nutr 80:1102-3. 2004 - Gestational diabetes and the incidence of type 2 diabetes: a systematic reviewCatherine Kim
Division of General Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Diabetes Care 25:1862-8. 2002..To examine factors associated with variation in the risk for type 2 diabetes in women with prior gestational diabetes mellitus (GDM)... - John B. O'Sullivan: a pioneer in the study of gestational diabetesRobert H Knopp
Diabetes Care 25:943-4. 2002
Research Grants
- NUTRITION ACADEMIC AWARDRobert Knopp; Fiscal Year: 2002..It is time to begin aggressive, substantive nutrition educational programs in cardiovascular disease prevention. ..
- DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROMERobert Knopp; Fiscal Year: 2007..This study will be the first to demonstrate dietary benefit for dyslipidemia, inflammation and vascular stress in MetS at stable weight. ..
- DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROMERobert Knopp; Fiscal Year: 2009..This study will be the first to demonstrate dietary benefit for dyslipidemia, inflammation and vascular stress in MetS at stable weight. ..