Paul S Knoepfler
Affiliation: University of California
Knoepfler P. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells. 2009;27:1050-6 pubmed publisher
..Finally, the most promising emerging approaches for overcoming the challenges of stem cell tumorigenicity are highlighted. ..
Varlakhanova N, Cotterman R, Bradnam K, Korf I, Knoepfler P. Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics Chromatin. 2011;4:20 pubmed publisher
..These data also support a new model of how Myc and Miz-1 function on chromatin. ..
Knoepfler P. From bench to FDA to bedside: US regulatory trends for new stem cell therapies. Adv Drug Deliv Rev. 2015;82-83:192-6 pubmed publisher
..Together these rapidly changing stem cell product development and regulatory pathways raise many scientific, ethical, and medical questions. These emerging trends and their potential consequences are reviewed here. ..
Knoepfler P. Reviewing post-publication peer review. Trends Genet. 2015;31:221-3 pubmed publisher
..I discuss the rapid evolution of PPPR, its impact, and the challenges associated with it. ..
Knoepfler P. Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends. Cell Stem Cell. 2018;: pubmed publisher
..Here, I discuss why there may be too much carrot and not enough stick by regulators for effective enforcement. ..
Klein R, Tung P, Somanath P, Fehling H, Knoepfler P. Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer. Stem Cell Res. 2018;31:83-94 pubmed publisher
..Together these data provide novel insights into Dppa4 function in both pluripotent and oncogenic contexts. ..
Turner L, Knoepfler P. Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry. Cell Stem Cell. 2016;19:154-157 pubmed publisher
..Such commercial activity suggests that regulatory agencies must better oversee this marketplace. ..
Bush K, Yuen B, Barrilleaux B, Riggs J, O Geen H, Cotterman R, et al
. Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics Chromatin. 2013;6:7 pubmed publisher
..Taken together, our studies suggest that endogenous mammalian histone H3.3 has important roles in regulating chromatin and chromosome functions that in turn are important for cell division, genome integrity, and development. ..
Yuen B, Bush K, Barrilleaux B, Cotterman R, Knoepfler P. Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Development. 2014;141:3483-94 pubmed publisher
..Taken together, our studies indicate a major role for H3.3 in spermatogenesis through regulation of chromatin dynamics. ..