Research Topics
Genomes and Genes | Paul S KnoepflerSummaryAffiliation: University of California Country: USA Publications
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Publications
Endogenous mammalian histone H3.3 exhibits chromatin-related functions during developmentKelly M Bush
Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, 4303 Tupper Hall, Davis, CA, 95616, USA
Epigenetics Chromatin 6:7. 2013..3 in mammalian cells and during development has been less thoroughly investigated. To address this gap, we report the production and phenotypic analysis of mice and cells with targeted disruption of the H3.3-encoding gene, H3f3b...- Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physiciansPaul S Knoepfler
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Tupper Hall 4303, Davis, CA 95616, USA
Regen Med 8:223-5. 2013..The USA is used here as an example of a medical sphere in which it can be argued that such training would be helpful, however such programs would be quite helpful globally... - Key anticipated regulatory issues for clinical use of human induced pluripotent stem cellsPaul S Knoepfler
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Tupper Hall 4303, Davis, CA 95616, USA
Regen Med 7:713-20. 2012..In this article, I discuss the potential regulatory issues facing hiPSCs and propose some potential changes in the direction of the field in response... 
Myc goes global: new tricks for an old oncogenePaul S Knoepfler
Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, Davis, California 95616, USA
Cancer Res 67:5061-3. 2007..These findings suggest actions for Myc that extend beyond the traditional concept of a targeted gene regulator...- Why myc? An unexpected ingredient in the stem cell cocktailPaul S Knoepfler
Institute of Pediatric Regenerative Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Cell Stem Cell 2:18-21. 2008..Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed... 
Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicinePaul S Knoepfler
Department of Cell Biology and Human Anatomy and Stem Cell Program, University of California Davis School of Medicine, Sacramento, CA, USA
Stem Cells 27:1050-6. 2009..Finally, the most promising emerging approaches for overcoming the challenges of stem cell tumorigenicity are highlighted...- Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cellsNatalia Varlakhanova
Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, CA, USA
Epigenetics Chromatin 4:20. 2011..abstract:.. - Stem cells on the brainPaul S Knoepfler
Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Arch Neurol 65:311-5. 2008 - myc maintains embryonic stem cell pluripotency and self-renewalNatalia V Varlakhanova
Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Differentiation 80:9-19. 2010.... - N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factorRebecca Cotterman
Department of Cell Biology, University of California Davis School of Medicine, Davis, California 95616, USA
Cancer Res 68:9654-62. 2008..These findings support a new dual model for Myc chromatin function with important implications for the role of Myc in cancer and stem cell biology, including that of induced pluripotent stem cells... - c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brainAlice Wey
Institute of Pediatric Regenerative Medicine, Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA
Oncotarget 1:120-30. 2010.... - N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cellsVeronica Martinez-Cerdeno
Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, California, United States of America
PLoS ONE 7:e39456. 2012..Thus, we have defined an important role for GCN5 in NSC and provided evidence that GCN5 is an important Myc transcriptional cofactor in vivo... - Induced pluripotency and oncogenic transformation are related processesJohn W Riggs
Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, California 95616, USA
Stem Cells Dev 22:37-50. 2013..Taken together, these findings support a model in which OF and iPSCs are related, yet distinct cell types, and in which induced pluripotency and induced tumorigenesis are similar processes... - Acting locally and globally: Myc's ever-expanding roles on chromatinNatalia V Varlakhanova
Institute of Pediatric Regenerative Medicine, University of California Davis School of Medicine, Davis, CA 95616, USA
Cancer Res 69:7487-90. 2009..The ability of Myc to act both locally and globally on chromatin may be responsible for its wide-ranging effects on the biology of stem and tumor cells... - N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28bRebecca Cotterman
Department of Cell Biology and Human Anatomy, and Stem Cell Program, University of California Davis School of Medicine, Shriners Hospital for Children Northern California, Sacramento, California, USA
PLoS ONE 4:e5799. 2009..They also suggest mechanisms by which Myc proteins more generally contribute to maintenance of pluripotency and self-renewal of ESC as well as to iPSC formation... - Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolismJohn K Meissen
University of California Davis Genome Center, University of California Davis, Davis, California, USA
PLoS ONE 7:e46770. 2012..The identified metabolomics signatures of iPSCs and ESCs may have important implications for functional regulation of maintenance and induction of pluripotency... - c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar developmentAlice Wey
Institute of Pediatric Regenerative Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Cerebellum 9:537-47. 2010..Together these findings indicate that c- and N-Myc direct cerebellar development by maintaining CGNP and NSC populations through inhibiting differentiation as well as directing rapid cell cycling and active cellular metabolism... - Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiationTadashi Okubo
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 132:1363-74. 2005..We propose a model in which Nmyc is essential in the developing lung for maintaining a distal population of undifferentiated, proliferating progenitor cells... - N-myc coordinates retinal growth with eye size during mouse developmentRodrigo A P Martins
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Genes Dev 22:179-93. 2008..We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and thus coordinates the growth of both the retina and eye through extrinsic cues... - Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakesPaul S Knoepfler
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cell Cycle 5:47-52. 2006..These findings indicate that therapeutic strategies targeting N-myc and the IGF pathway might be effective against medulloblastoma... - Myc influences global chromatin structurePaul S Knoepfler
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
EMBO J 25:2723-34. 2006..This study provides the first evidence for regulation of global chromatin structure by an oncoprotein and may explain the broad effects of Myc on cell behavior and tumorigenesis... - Myc stimulates B lymphocyte differentiation and amplifies calcium signalingTania Habib
Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
J Cell Biol 179:717-31. 2007.... - N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiationPaul S Knoepfler
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 16:2699-712. 2002..Its effects on proliferation and differentiation appear due, at least in part, to down-regulation of a specific subset of cyclin-dependent kinase inhibitors... - N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar developmentFrederique Zindy
Department of Genetics and Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Proc Natl Acad Sci U S A 103:11579-83. 2006..These results provide definitive genetic evidence that expression of N-Myc and concomitant down-regulation of Ink4c and Kip1 contribute to the proper development of the cerebellum... - HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientationsKurt A Swanson
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
Nat Struct Mol Biol 11:738-46. 2004..These results not only provide insights into how multiple, unrelated transcription factors recruit the same coregulator, but also have implications for how sequence similarity searches are conducted... - N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growthBeryl A Hatton
Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
Cancer Res 66:8655-61. 2006.... - Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potentialCharlotte A Berkes
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Mol Cell 14:465-77. 2004..This demonstrates a specific mechanism of targeting MyoD to loci in inactive chromatin and reveals a critical role of homeodomain proteins in marking specific genes for activation in the muscle lineage...
Research Grants
- Analyzing Myc function in neural cancers and developmentPaul Knoepfler; Fiscal Year: 2007..Together these aims will cooperatively address the research goals of defining how myc genes function in neurogenesis and induce neural cancers. ..