Research Topics
| ROBERT KNIGHTONSummaryAffiliation: University of Miami Country: USA Publications
Research Grants
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Detail Information
Publications
The shape of the ganglion cell plus inner plexiform layers of the normal human maculaRobert W Knighton
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, USA
Invest Ophthalmol Vis Sci 53:7412-20. 2012..To use surfaces generated by two-dimensional penalized splines (2D P-splines) to characterize the shape of the macular ganglion cell plus inner plexiform layers (GCL+IPL) in a group of normal humans...- Variance reduction in a dataset of normal macular ganglion cell plus inner plexiform layer thickness maps with application to glaucoma diagnosisRobert W Knighton
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
Invest Ophthalmol Vis Sci 53:3653-61. 2012..To examine the similarities and differences in the shape of the macular ganglion cell plus inner plexiform layers (GCL+IPL) in a healthy human population, and seek methods to reduce population variance and improve discriminating power... 
Corneal birefringence mapped by scanning laser polarimetryRobert W Knighton
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW Tenth Avenue, Miami, FL 33136, USA
Opt Express 16:13738-51. 2008..Some locations in a few corneas can be uniaxial with the optical axis perpendicular to the surface. Importantly, corneal birefringence varies greatly among people and, within a single cornea, significantly with position...- Linear birefringence of the central human corneaRobert W Knighton
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA
Invest Ophthalmol Vis Sci 43:82-6. 2002..To determine the polarization properties of the central cornea at perpendicular incidence in a normal human population on the assumption that the cornea behaves as a linear retarder... - Analytical model of scanning laser polarimetry for retinal nerve fiber layer assessmentRobert W Knighton
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
Invest Ophthalmol Vis Sci 43:383-92. 2002..To develop a quantitative understanding of scanning laser polarimetry (SLP) for retinal nerve fiber layer (RNFL) assessment in glaucoma diagnosis and management... - Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomographyDavid S Greenfield
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, 7108 Fairway Dr, Suite 340, Palm Beach Gardens, FL 33418, USA
Arch Ophthalmol 121:41-6. 2003..To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography... - Microtubules contribute to the birefringence of the retinal nerve fiber layerXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 46:4588-93. 2005..MTs are generally assumed to be a major contributor, but this has not been demonstrated. In this study, the MT depolymerizing agent colchicine was used to evaluate the contribution of MTs to RNFL birefringence... - Quantifying retinal nerve fiber layer thickness in whole-mounted retinaXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 N W 10th Ave, Miami, FL 33136, USA
Exp Eye Res 83:1096-101. 2006..The cross-sectional images provided thickness measurements of the RNFL over the entire field-of-view, not just at the points represented by the conventional histologic section, resulting in a large increase in available data... - Microtubule contribution to the reflectance of the retinal nerve fiber layerXiang Run Huang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 47:5363-7. 2006..To increase understanding of the anatomic basis for clinical RNFL measurements, this study was conducted to evaluate the MT contribution to RNFL reflectance in rodent retinas by using the MT depolymerizing agent colchicine... - Documentation of optic nerve pit with macular schisis-like cavity by spectral domain OCTGeeta A Lalwani
Department of Ophthalmology Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
Ophthalmic Surg Lasers Imaging 38:262-4. 2007..Spectral domain OCT provides greater detail of the changes in morphology and structure of macular schisis and edema associated with an optic nerve pit... 
Three-dimensional spectral-domain optical coherence tomography images of the retina in the presence of epiretinal membranesJohn E Legarreta
Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, 1638 NW 10th Avenue, Miami, FL 33136, USA
Am J Ophthalmol 145:1023-1030. 2008..To study the inner surface of the retina in the presence of epiretinal membranes (ERMs) using a prototype spectral-domain optical coherence tomography (SD-OCT) device...- Linear birefringence of the retinal nerve fiber layer measured in vitro with a multispectral imaging micropolarimeterXiang-Run Huang
University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida 33136, USA
J Biomed Opt 7:199-204. 2002..These results allow extrapolation of previous visible wavelength measurements to the near-infrared wavelengths used by SLP and validate the use of fixed tissue for RNFL research... - Macular thickness measurements in normal eyes using spectral domain optical coherence tomographyJohn E Legarreta
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmic Surg Lasers Imaging 39:S43-9. 2008..The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT)... - Macular symmetry testing for glaucoma detectionHarmohina Bagga
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, FL, USA
J Glaucoma 14:358-63. 2005..CONCLUSION: Localized macular thickness changes exist in glaucomatous eyes with regional visual field loss. The MST may represent a novel strategy for glaucoma diagnosis... - Correction for corneal polarization axis improves the discriminating power of scanning laser polarimetryDavid S Greenfield
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Florida 33418, USA
Am J Ophthalmol 134:27-33. 2002..The purpose of this investigation was to prospectively determine whether correction for CPA improves the discriminating power of SLP for detection of mild-to-moderate glaucoma... - Scanning laser polarimetry with variable corneal compensation and optical coherence tomography in normal and glaucomatous eyesHarmohina Bagga
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA
Am J Ophthalmol 135:521-9. 2003..92, VCC, P <.001). CONCLUSIONS: Compared with fixed compensation, mean-based SLP parameters generated with SLP-VCC have greater correlation with visual function and RNFL thickness assessments obtained with OCT... - Normative retardation data corrected for the corneal polarization axis with scanning laser polarimetryDavid S Greenfield
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Florida 33418, USA
Ophthalmic Surg Lasers Imaging 34:165-71. 2003..Normal eyes with a CPA of 0 degrees to 20 degrees nasally downward and 60 degrees to 80 degrees nasally downward were characterized by "abnormal" summary retardation parameters as interby scanning laser polarimetry... - Effect of individualized compensation for anterior segment birefringence on retinal nerve fiber layer assessments as determined by scanning laser polarimetryNeil T Choplin
Laser Diagnostic Technologies, Inc, San Diego, California 92127-2402, USA
Ophthalmology 110:719-25. 2003..However, modulation is less affected, and the modulation parameters may thus prove more useful for distinguishing between normal and glaucoma... - Scanning laser polarimetry with variable corneal compensation: identification and correction for corneal birefringence in eyes with macular diseaseHarmohina Bagga
Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA
Invest Ophthalmol Vis Sci 44:1969-76. 2003..The screen method provides a more robust measure of the anterior segment birefringence in some eyes with macular disease... - Optical coherence tomographic findings in acute exudative polymorphous vitelliform maculopathyVanessa Cruz-Villegas
Department of Ophthalmology, University of Miami, School of Medicine, Bascom Palmer Eye Institute, Miami, Florida 33136, USA
Am J Ophthalmol 136:760-3. 2003..Optical coherence tomography reveals characteristic anterior displacement of the photoreceptor layer by a subretinal hypereflective deposit similar to that seen in adult-onset foveomacular vitelliform dystrophy... - Theoretical model of the polarization properties of the retinal nerve fiber layer in reflectionXiang-Run Huang
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Appl Opt 42:5726-36. 2003.... - Diattenuation and polarization preservation of retinal nerve fiber layer reflectanceXiang-Run Huang
Bascom Palmer Eye Institute, University of Miami School of Medicine, PO Box 016880, Miami, Florida 33101-6880, USA
Appl Opt 42:5737-43. 2003..03. Degree of polarization (DOP) for reflection from the RNFL was also measured. DOP was close to unity at all wavelengths, which indicates that the RNFL is a polarization-preserving reflector... - Variation of peripapillary retinal nerve fiber layer birefringence in normal human subjectsXiang Run Huang
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 45:3073-80. 2004..The birefringence (Deltan) depends on the density and composition of axonal organelles. The purpose of this study was to evaluate the distribution of birefringence around the optic nerve head (ONH) in normal subjects... - Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyesDonald L Budenz
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 46:2440-3. 2005..To determine the reproducibility of Stratus Optical Coherence Tomography (OCT) retinal nerve fiber layer (RNFL) measurements around the optic nerve in normal and glaucomatous eyes... - Documentation by spectral domain OCT of spontaneous closure of idiopathic macular holesOmar S Punjabi
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
Ophthalmic Surg Lasers Imaging 38:330-2. 2007..Spontaneous closure and visual acuity improvement occurred in both patients. Useful information about morphology and vitreoretinal relationship of the holes was provided by spectral domain OCT... - Calibration of fundus images using spectral domain optical coherence tomographyBrandon J Lujan
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmic Surg Lasers Imaging 39:S15-20. 2008..However, calibrated spectral domain OCT (SD-OCT) could offer a convenient alternative method for the calibration of any fundus image...
Research Grants
- RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMSROBERT KNIGHTON; Fiscal Year: 1992....
- RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMSXiangrun Huang; Fiscal Year: 2007..Birefringence is an intrinsic property of the tissue, depends directly on RNFL ultrastructure, and may provide a means of early detection of structural damage to ganglion cells in glaucoma. ..