ROBERT KNIGHTON

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc The shape of the ganglion cell plus inner plexiform layers of the normal human macula
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, USA
    Invest Ophthalmol Vis Sci 53:7412-20. 2012
  2. pmc Variance reduction in a dataset of normal macular ganglion cell plus inner plexiform layer thickness maps with application to glaucoma diagnosis
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 53:3653-61. 2012
  3. ncbi request reprint Corneal birefringence mapped by scanning laser polarimetry
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW Tenth Avenue, Miami, FL 33136, USA
    Opt Express 16:13738-51. 2008
  4. ncbi request reprint Linear birefringence of the central human cornea
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA
    Invest Ophthalmol Vis Sci 43:82-6. 2002
  5. ncbi request reprint Analytical model of scanning laser polarimetry for retinal nerve fiber layer assessment
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:383-92. 2002
  6. ncbi request reprint Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography
    David S Greenfield
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, 7108 Fairway Dr, Suite 340, Palm Beach Gardens, FL 33418, USA
    Arch Ophthalmol 121:41-6. 2003
  7. ncbi request reprint Microtubules contribute to the birefringence of the retinal nerve fiber layer
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:4588-93. 2005
  8. ncbi request reprint Quantifying retinal nerve fiber layer thickness in whole-mounted retina
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 N W 10th Ave, Miami, FL 33136, USA
    Exp Eye Res 83:1096-101. 2006
  9. ncbi request reprint Microtubule contribution to the reflectance of the retinal nerve fiber layer
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 47:5363-7. 2006
  10. ncbi request reprint Documentation of optic nerve pit with macular schisis-like cavity by spectral domain OCT
    Geeta A Lalwani
    Department of Ophthalmology Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Ophthalmic Surg Lasers Imaging 38:262-4. 2007

Research Grants

  1. RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMS
    ROBERT KNIGHTON; Fiscal Year: 1992
  2. RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMS
    Xiangrun Huang; Fiscal Year: 2007

Collaborators

Detail Information

Publications26

  1. pmc The shape of the ganglion cell plus inner plexiform layers of the normal human macula
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, USA
    Invest Ophthalmol Vis Sci 53:7412-20. 2012
    ..To use surfaces generated by two-dimensional penalized splines (2D P-splines) to characterize the shape of the macular ganglion cell plus inner plexiform layers (GCL+IPL) in a group of normal humans...
  2. pmc Variance reduction in a dataset of normal macular ganglion cell plus inner plexiform layer thickness maps with application to glaucoma diagnosis
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 53:3653-61. 2012
    ..To examine the similarities and differences in the shape of the macular ganglion cell plus inner plexiform layers (GCL+IPL) in a healthy human population, and seek methods to reduce population variance and improve discriminating power...
  3. ncbi request reprint Corneal birefringence mapped by scanning laser polarimetry
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW Tenth Avenue, Miami, FL 33136, USA
    Opt Express 16:13738-51. 2008
    ..Some locations in a few corneas can be uniaxial with the optical axis perpendicular to the surface. Importantly, corneal birefringence varies greatly among people and, within a single cornea, significantly with position...
  4. ncbi request reprint Linear birefringence of the central human cornea
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA
    Invest Ophthalmol Vis Sci 43:82-6. 2002
    ..To determine the polarization properties of the central cornea at perpendicular incidence in a normal human population on the assumption that the cornea behaves as a linear retarder...
  5. ncbi request reprint Analytical model of scanning laser polarimetry for retinal nerve fiber layer assessment
    Robert W Knighton
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:383-92. 2002
    ..To develop a quantitative understanding of scanning laser polarimetry (SLP) for retinal nerve fiber layer (RNFL) assessment in glaucoma diagnosis and management...
  6. ncbi request reprint Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography
    David S Greenfield
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, 7108 Fairway Dr, Suite 340, Palm Beach Gardens, FL 33418, USA
    Arch Ophthalmol 121:41-6. 2003
    ..To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography...
  7. ncbi request reprint Microtubules contribute to the birefringence of the retinal nerve fiber layer
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:4588-93. 2005
    ..MTs are generally assumed to be a major contributor, but this has not been demonstrated. In this study, the MT depolymerizing agent colchicine was used to evaluate the contribution of MTs to RNFL birefringence...
  8. ncbi request reprint Quantifying retinal nerve fiber layer thickness in whole-mounted retina
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 N W 10th Ave, Miami, FL 33136, USA
    Exp Eye Res 83:1096-101. 2006
    ..The cross-sectional images provided thickness measurements of the RNFL over the entire field-of-view, not just at the points represented by the conventional histologic section, resulting in a large increase in available data...
  9. ncbi request reprint Microtubule contribution to the reflectance of the retinal nerve fiber layer
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 47:5363-7. 2006
    ..To increase understanding of the anatomic basis for clinical RNFL measurements, this study was conducted to evaluate the MT contribution to RNFL reflectance in rodent retinas by using the MT depolymerizing agent colchicine...
  10. ncbi request reprint Documentation of optic nerve pit with macular schisis-like cavity by spectral domain OCT
    Geeta A Lalwani
    Department of Ophthalmology Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Ophthalmic Surg Lasers Imaging 38:262-4. 2007
    ..Spectral domain OCT provides greater detail of the changes in morphology and structure of macular schisis and edema associated with an optic nerve pit...
  11. doi request reprint Three-dimensional spectral-domain optical coherence tomography images of the retina in the presence of epiretinal membranes
    John E Legarreta
    Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, 1638 NW 10th Avenue, Miami, FL 33136, USA
    Am J Ophthalmol 145:1023-1030. 2008
    ..To study the inner surface of the retina in the presence of epiretinal membranes (ERMs) using a prototype spectral-domain optical coherence tomography (SD-OCT) device...
  12. ncbi request reprint Linear birefringence of the retinal nerve fiber layer measured in vitro with a multispectral imaging micropolarimeter
    Xiang Run Huang
    University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida 33136, USA
    J Biomed Opt 7:199-204. 2002
    ..These results allow extrapolation of previous visible wavelength measurements to the near-infrared wavelengths used by SLP and validate the use of fixed tissue for RNFL research...
  13. ncbi request reprint Macular thickness measurements in normal eyes using spectral domain optical coherence tomography
    John E Legarreta
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmic Surg Lasers Imaging 39:S43-9. 2008
    ..The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT)...
  14. ncbi request reprint Macular symmetry testing for glaucoma detection
    Harmohina Bagga
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, FL, USA
    J Glaucoma 14:358-63. 2005
    ..To evaluate structural asymmetry in the macula using optical coherence tomography (OCT) in glaucomatous eyes with visual field defects localized to one hemifield...
  15. ncbi request reprint Correction for corneal polarization axis improves the discriminating power of scanning laser polarimetry
    David S Greenfield
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Florida 33418, USA
    Am J Ophthalmol 134:27-33. 2002
    ..The purpose of this investigation was to prospectively determine whether correction for CPA improves the discriminating power of SLP for detection of mild-to-moderate glaucoma...
  16. ncbi request reprint Scanning laser polarimetry with variable corneal compensation and optical coherence tomography in normal and glaucomatous eyes
    Harmohina Bagga
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA
    Am J Ophthalmol 135:521-9. 2003
    ..To evaluate the relationship between visual function and retinal nerve fiber layer (RNFL) measurements obtained with scanning laser polarimetry with variable corneal compensation (SLP-VCC) and optical coherence tomography (OCT)...
  17. ncbi request reprint Normative retardation data corrected for the corneal polarization axis with scanning laser polarimetry
    David S Greenfield
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Florida 33418, USA
    Ophthalmic Surg Lasers Imaging 34:165-71. 2003
    ..To evaluate the distribution of retinal nerve fiber layer thickness measurements in normal eyes corrected for corneal polarization axis (CPA)...
  18. ncbi request reprint Effect of individualized compensation for anterior segment birefringence on retinal nerve fiber layer assessments as determined by scanning laser polarimetry
    Neil T Choplin
    Laser Diagnostic Technologies, Inc, San Diego, California 92127 2402, USA
    Ophthalmology 110:719-25. 2003
    ....
  19. ncbi request reprint Scanning laser polarimetry with variable corneal compensation: identification and correction for corneal birefringence in eyes with macular disease
    Harmohina Bagga
    Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 44:1969-76. 2003
    ..The purpose of this investigation was to validate this strategy in eyes with macular structural disease...
  20. ncbi request reprint Optical coherence tomographic findings in acute exudative polymorphous vitelliform maculopathy
    Vanessa Cruz-Villegas
    Department of Ophthalmology, University of Miami, School of Medicine, Bascom Palmer Eye Institute, Miami, Florida 33136, USA
    Am J Ophthalmol 136:760-3. 2003
    ..To report two cases of acute exudative polymorphous vitelliform maculopathy...
  21. ncbi request reprint Theoretical model of the polarization properties of the retinal nerve fiber layer in reflection
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Appl Opt 42:5726-36. 2003
    ....
  22. ncbi request reprint Diattenuation and polarization preservation of retinal nerve fiber layer reflectance
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami School of Medicine, PO Box 016880, Miami, Florida 33101 6880, USA
    Appl Opt 42:5737-43. 2003
    ..03. Degree of polarization (DOP) for reflection from the RNFL was also measured. DOP was close to unity at all wavelengths, which indicates that the RNFL is a polarization-preserving reflector...
  23. ncbi request reprint Variation of peripapillary retinal nerve fiber layer birefringence in normal human subjects
    Xiang Run Huang
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 45:3073-80. 2004
    ..The birefringence (Deltan) depends on the density and composition of axonal organelles. The purpose of this study was to evaluate the distribution of birefringence around the optic nerve head (ONH) in normal subjects...
  24. ncbi request reprint Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyes
    Donald L Budenz
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:2440-3. 2005
    ..To determine the reproducibility of Stratus Optical Coherence Tomography (OCT) retinal nerve fiber layer (RNFL) measurements around the optic nerve in normal and glaucomatous eyes...
  25. ncbi request reprint Documentation by spectral domain OCT of spontaneous closure of idiopathic macular holes
    Omar S Punjabi
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Ophthalmic Surg Lasers Imaging 38:330-2. 2007
    ..Spontaneous closure and visual acuity improvement occurred in both patients. Useful information about morphology and vitreoretinal relationship of the holes was provided by spectral domain OCT...
  26. ncbi request reprint Calibration of fundus images using spectral domain optical coherence tomography
    Brandon J Lujan
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmic Surg Lasers Imaging 39:S15-20. 2008
    ..However, calibrated spectral domain OCT (SD-OCT) could offer a convenient alternative method for the calibration of any fundus image...

Research Grants15

  1. RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMS
    ROBERT KNIGHTON; Fiscal Year: 1992
    ....
  2. RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMS
    Xiangrun Huang; Fiscal Year: 2007
    ..Birefringence is an intrinsic property of the tissue, depends directly on RNFL ultrastructure, and may provide a means of early detection of structural damage to ganglion cells in glaucoma. ..