S Knight

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study
    Stephen R Piccolo
    Department of Biomedical Informatics, School of Medicine, University of Utah, 26 South 2000 East, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S46. 2009
  2. pmc Pairwise shared genomic segment analysis in high-risk pedigrees: application to Genetic Analysis Workshop 17 exome-sequencing SNP data
    Zheng Cai
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84108, USA
    BMC Proc 5:S9. 2011
  3. doi request reprint Shared genomic segment analysis: the power to find rare disease variants
    Stacey Knight
    Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Ann Hum Genet 76:500-9. 2012
  4. pmc Health insurance, neighborhood income, and emergency department usage by Utah children 1996-1998
    Anthony Suruda
    Intermountain Injury Control Research Center, University of Utah, 615 Arapeen Drive 202, Salt Lake City, Utah 84108, USA
    BMC Health Serv Res 5:29. 2005
  5. pmc Validity and power of association testing in family-based sampling designs: evidence for and against the common wisdom
    Stacey Knight
    Division of Genetic Epidemiology, Salt Lake City, Utah, USA
    Genet Epidemiol 35:174-81. 2011
  6. pmc Pedigree association: assigning individual weights to pedigree members for genetic association analysis
    Stacey Knight
    Biomedical Informatics Department, University of Utah, 26 South 2000 East Room 5775 HSEB, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S121. 2009
  7. pmc Summary of contributions to GAW Group 15: family-based samples are useful in identifying common polymorphisms associated with complex traits
    Stacey Knight
    Biomedical Informatics Department, University of Utah, Salt Lake City, Utah 84108, USA
    Genet Epidemiol 33:S99-104. 2009
  8. pmc Linkage analysis of Tourette syndrome in a large Utah pedigree
    Stacey Knight
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:656-62. 2010
  9. ncbi request reprint Prehospital emergency care for children at school and nonschool locations
    S Knight
    Intermountain Injury Control Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Pediatrics 103:e81. 1999
  10. ncbi request reprint Injuries sustained by students in shop class
    S Knight
    Intermountain Injury Control Research Center, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Pediatrics 106:10-3. 2000

Detail Information

Publications36

  1. pmc Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study
    Stephen R Piccolo
    Department of Biomedical Informatics, School of Medicine, University of Utah, 26 South 2000 East, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S46. 2009
    ..In this paper, we evaluate a weighted and an unweighted approach for estimating the combined effect of multiple markers (using genotypes and haplotypes) on lipid levels for a given individual...
  2. pmc Pairwise shared genomic segment analysis in high-risk pedigrees: application to Genetic Analysis Workshop 17 exome-sequencing SNP data
    Zheng Cai
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84108, USA
    BMC Proc 5:S9. 2011
    ..7 false positives were identified per pedigree. In conclusion, we have demonstrated the potential of our new pSGS method for localizing rare disease causal variants in common disease using high-risk pedigrees and exome sequence data...
  3. doi request reprint Shared genomic segment analysis: the power to find rare disease variants
    Stacey Knight
    Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Ann Hum Genet 76:500-9. 2012
    ..96 Mb region containing the known causal APC gene with genome-wide significance. SGS is a powerful method for detecting rare variants and a valuable complement to genome-wide association studies and linkage analysis...
  4. pmc Health insurance, neighborhood income, and emergency department usage by Utah children 1996-1998
    Anthony Suruda
    Intermountain Injury Control Research Center, University of Utah, 615 Arapeen Drive 202, Salt Lake City, Utah 84108, USA
    BMC Health Serv Res 5:29. 2005
    ..We examined pediatric ED usage in a U.S. state with respect to income, health insurance status, types of medical conditions, and whether introduction of managed care affected utilization by Medicaid children...
  5. pmc Validity and power of association testing in family-based sampling designs: evidence for and against the common wisdom
    Stacey Knight
    Division of Genetic Epidemiology, Salt Lake City, Utah, USA
    Genet Epidemiol 35:174-81. 2011
    ..These results suggest a more complex situation than previously assumed, which has important implications for study design and analysis...
  6. pmc Pedigree association: assigning individual weights to pedigree members for genetic association analysis
    Stacey Knight
    Biomedical Informatics Department, University of Utah, 26 South 2000 East Room 5775 HSEB, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S121. 2009
    ..We compare this new method with an existing weighting algorithm, a naïve analysis (relatedness is ignored), and an empirical method that appropriately accounts for all relationships (the gold standard)...
  7. pmc Summary of contributions to GAW Group 15: family-based samples are useful in identifying common polymorphisms associated with complex traits
    Stacey Knight
    Biomedical Informatics Department, University of Utah, Salt Lake City, Utah 84108, USA
    Genet Epidemiol 33:S99-104. 2009
    ..Our findings highlight the contribution of family-based samples to the genetic dissection of complex traits...
  8. pmc Linkage analysis of Tourette syndrome in a large Utah pedigree
    Stacey Knight
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:656-62. 2010
    ..03). The significant linkage peaks on chromosomes 1p and 3p are in new areas of the genome for TS, and replication of these findings is necessary...
  9. ncbi request reprint Prehospital emergency care for children at school and nonschool locations
    S Knight
    Intermountain Injury Control Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Pediatrics 103:e81. 1999
    ..The purpose of this study was to ascertain whether school-based emergency medical services (EMS) incidents are different from nonschool-based EMS incidents for school-aged children...
  10. ncbi request reprint Injuries sustained by students in shop class
    S Knight
    Intermountain Injury Control Research Center, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Pediatrics 106:10-3. 2000
    ..The purpose of our study was to describe the epidemiology of shop class injuries in Utah public schools for the years 1992-1996...
  11. pmc The fast and the fatal: street racing fatal crashes in the United States
    S Knight
    Intermountain Injury Control Research Center, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, 84108, USA
    Inj Prev 10:53-5. 2004
    ..Compared with other drivers involved in fatal crashes, street racers were more likely to be teenagers, male, and have previous crashes and driving violations. Street racing involves risky driving behaviors and warrants further attention...
  12. ncbi request reprint Against all advice: an analysis of out-of-hospital refusals of care
    Stacey Knight
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA
    Ann Emerg Med 42:689-96. 2003
    ....
  13. ncbi request reprint Shoulder belts in motor vehicle crashes: a statewide analysis of restraint efficacy
    S Knight
    Intermountain Injury Control Research Center, University of Utah, Salt Lake City 84108, USA
    Accid Anal Prev 33:65-71. 2001
    ..1; 95% Cl = 0.9, 1.4). Average hospital inpatient length of stay, charges and injury severity scores were similar for all restraint types. These results stress the need for the use of a lap belt in conjunction with the shoulder belt...
  14. ncbi request reprint Motor vehicle crash characteristics and medical outcomes among older drivers in Utah, 1992-1995
    L J Cook
    University of Utah School of Medicine, Department of Pediatrics, The Intermountain Injury Control Research Center, Salt Lake City, UT, USA
    Ann Emerg Med 35:585-91. 2000
    ..We sought to compare the characteristics and medical outcomes of motor vehicle crashes for drivers 70 years and older with those of drivers between the ages of 30 and 39 years...
  15. ncbi request reprint Analysis of school injuries resulting in emergency department or hospital admission
    E P Junkins
    Division of Pediatric Emergency Medicine, Division of Critical Care Medicine, Primary Children s Medical Center, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84113, USA
    Acad Emerg Med 8:343-8. 2001
    ..To describe the epidemiology of school injuries resulting in emergency department (ED) visits, hospital admission, or death...
  16. pmc The sumLINK statistic for genetic linkage analysis in the presence of heterogeneity
    G B Christensen
    Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84108 1266, USA
    Genet Epidemiol 33:628-36. 2009
    ..Further, loci identified with the sumLINK have good potential for gene localization via statistical recombinant mapping, as, by definition, several linked pedigrees contribute to each peak...
  17. doi request reprint Epidemiology of psychiatric-related visits to emergency departments in a multicenter collaborative research pediatric network
    Prashant Mahajan
    Division of Emergency Medicine, Department of Pediatrics, Children s Hospital of Michigan and Wayne State University, 3901 Beaubien, Detroit, MI 48201, USA
    Pediatr Emerg Care 25:715-20. 2009
    ..Describe the epidemiology of pediatric psychiatric-related visits to emergency departments participating in the Pediatric Emergency Care Applied Research Network...
  18. pmc Multicenter cohort study of out-of-hospital pediatric cardiac arrest
    Frank W Moler
    Pediatric Emergency Care Applied Research Network, Salt Lake City, UT, USA
    Crit Care Med 39:141-9. 2011
    ..These objectives were for planning an interventional trial of therapeutic hypothermia after pediatric cardiac arrest...
  19. doi request reprint Factors associated with cervical spine injury in children after blunt trauma
    Julie C Leonard
    Department of Pediatrics, Division of Emergency Medicine, School of Medicine, Washington University in St Louis, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Ann Emerg Med 58:145-55. 2011
    ..The purpose of our study is to identify risk factors associated with cervical spine injury in children after blunt trauma...
  20. doi request reprint Intracranial hemorrhage after blunt head trauma in children with bleeding disorders
    Lois K Lee
    Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    J Pediatr 158:1003-1008.e1-2. 2011
    ..To determine computerized tomography (CT) use and prevalence of traumatic intracranial hemorrhage (ICH) in children with and without congenital and acquired bleeding disorders...
  21. pmc Automated construction and testing of multi-locus gene-gene associations
    Ryan Abo
    Department of Biomedical Informatics, University of Utah School of Medicine, UT, USA
    Bioinformatics 27:134-6. 2011
    ..This tool provides a flexible data-mining approach to identifying gene-gene effects that otherwise is currently unavailable...
  22. ncbi request reprint The use of generalized estimating equations in the analysis of motor vehicle crash data
    Caroline B Hutchings
    Intermountain Injury Control Research Center, School of Medicine, University of Utah, 615 Arapeen Drive, Suite 202, 84108, Salt Lake City, UT 84108, USA
    Accid Anal Prev 35:3-8. 2003
    ..The odds ratio of seat belt effectiveness in preventing injuries was 12% lower when a one-level nested model was used. Based on these results, we stress the need to use a nested model and GEEs when analyzing motor vehicle crash data...
  23. ncbi request reprint Repeat patients to the emergency department in a statewide database
    Lawrence J Cook
    Intermountain Injury Control Research Center, University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, UT, USA
    Acad Emerg Med 11:256-63. 2004
    ..To describe the epidemiology of repeat users of the emergency department (ED) using a statewide database...
  24. ncbi request reprint Classroom injuries in Utah public schools
    Michael D Kramer
    Department of Pediatrics, and Intermountain Injury Control Research Center, University of Utah School of Medicine, Salt Lake City 84108, USA
    Acad Emerg Med 10:978-84. 2003
    ..School injuries are a serious public health problem, yet classroom injuries have received little attention. The purpose of this study was to describe the epidemiology of classroom injuries in Utah public schools...
  25. pmc hapConstructor: automatic construction and testing of haplotypes in a Monte Carlo framework
    Ryan Abo
    Department of Biomedical Informatics, University of Utah, UT, USA
    Bioinformatics 24:2105-7. 2008
    ..HapConstructor is a useful tool for exploring multi-locus associations in candidate genes and regions...
  26. ncbi request reprint Underestimating injury mortality using statewide databases
    N Clay Mann
    Intermountain Injury Control Research Center, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    J Trauma 58:162-7. 2005
    ....
  27. pmc Prediction of child abuse risk from emergency department use
    Elisabeth Guenther
    Division of Pediatric Emergency Medicine, University of Utah Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158, USA
    J Pediatr 154:272-7. 2009
    ..To examine whether pre-abuse rates and patterns of emergency department (ED) visits between children with supported child abuse and age-matched control subjects are useful markers for abuse risk...
  28. ncbi request reprint A comparison of aggressive and DUI crashes
    Lawrence J Cook
    University of Utah School of Medicine, Department of Pediatrics, Utah CODES, The Intermountain Injury Control Research Center, University of Utah, 295 Chipeta Way, P O Box 581289, Salt Lake City, UT 84158 1289, USA
    J Safety Res 36:491-3. 2005
  29. doi request reprint Modeling motor vehicle crashes for street racers using zero-inflated models
    Zhuo Li
    Department of Family and Preventive Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Accid Anal Prev 40:835-9. 2008
    ..However, drivers with increased numbers of non-street-racing citations experience crash risks approaching those of the cited street racers...
  30. ncbi request reprint Graduated driver licensing in Utah: is it effective?
    Lisa K Hyde
    Intermountain Injury Control Research Center, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Ann Emerg Med 45:147-54. 2005
    ..We seek to examine the effectiveness of the graduated driver licensing system in Utah by determining whether crash rates of 16-year-old drivers decreased after graduated driver licensing implementation...
  31. doi request reprint Emergency department quality: an analysis of existing pediatric measures
    Evaline Alessandrini
    Department of Pediatrics, University of Cincinnati College of Medicine, James M Anderson Center for Health Systems Excellence, Cincinnati Children s Hospital Medical Center EA, KV, OH, USA
    Acad Emerg Med 18:519-26. 2011
    ..The authors undertook this study with the goals of enumerating and categorizing existing performance measures relevant to pediatric emergency care...
  32. ncbi request reprint Lack of agreement in pediatric emergency department discharge diagnoses from clinical and administrative data sources
    Marc H Gorelick
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Acad Emerg Med 14:646-52. 2007
    ..Diagnosis information from existing data sources is used commonly for epidemiologic, administrative, and research purposes. The quality of such data for emergency department (ED) visits is unknown...
  33. doi request reprint Revisiting the emergency medicine services for children research agenda: priorities for multicenter research in pediatric emergency care
    Steven Zane Miller
    Department of Pediatrics, Division of Pediatric Emergency Medicine, Morgan Stanley Children s Hospital of New York Presbyterian, Columbia University Medical Center, New York, NY, USA
    Acad Emerg Med 15:377-83. 2008
    ..They sought to prioritize PECARN research efforts, to guide investigators planning to conduct research in PECARN, and to describe the creation of a prioritized EMSC research agenda specific for multicenter research...
  34. ncbi request reprint Interobserver agreement in assessment of clinical variables in children with blunt head trauma
    Marc H Gorelick
    Department of Pediatrics, Section of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Acad Emerg Med 15:812-8. 2008
    ..The objective was to determine the interobserver agreement in the assessment of historical and physical examination findings of children undergoing emergency department (ED) evaluation for blunt head trauma...
  35. ncbi request reprint Epidemiology of a pediatric emergency medicine research network: the PECARN Core Data Project
    Elizabeth R Alpern
    Department of Pediatrics, Division of Emergency Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Emerg Care 22:689-99. 2006
    ..To examine the epidemiology of pediatric patient visits to emergency departments (ED)...
  36. doi request reprint Perceived challenges to obtaining informed consent for a time-sensitive emergency department study of pediatric status epilepticus: results of two focus groups
    James M Chamberlain
    Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Children s National Medical Center, Washington, DC, USA
    Acad Emerg Med 16:763-70. 2009
    ..The objective was to describe the perspective of research personnel on issues of informed consent in a time-sensitive clinical study under emergency circumstances...