Marina Kniazeva

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans
    Marina Kniazeva
    Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genetics 163:159-69. 2003
  2. pmc A new locus for autosomal dominant stargardt-like disease maps to chromosome 4
    M Kniazeva
    Department of Molecular, Cellular, and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA
    Am J Hum Genet 64:1394-9. 1999
  3. pmc Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development
    Marina Kniazeva
    Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, USA
    PLoS Biol 2:E257. 2004
  4. pmc A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans
    Marina Kniazeva
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 22:2102-10. 2008
  5. pmc Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans
    Rencheng Wang
    Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
    PLoS ONE 8:e76270. 2013
  6. pmc Fat chance for longevity
    Marina Kniazeva
    Department of Molecular, Cell, and Developmental Biology, Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Genes Dev 27:351-4. 2013
  7. pmc A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans
    Huanhu Zhu
    Howard Hughes Medical Institute, University of Colorado, Boulder, Boulder, United States Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Boulder, United States
    elife 2:e00429. 2013
  8. pmc Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans
    Marina Kniazeva
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 26:554-66. 2012

Collaborators

Detail Information

Publications8

  1. pmc Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans
    Marina Kniazeva
    Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genetics 163:159-69. 2003
    ..elegans. The presented data indicate that suppression of a single enzyme of the FA elongation machinery is enough to affect various organs and systems in worms. This effect resembles syndromic disorders in humans...
  2. pmc A new locus for autosomal dominant stargardt-like disease maps to chromosome 4
    M Kniazeva
    Department of Molecular, Cellular, and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA
    Am J Hum Genet 64:1394-9. 1999
    ..00, for marker D4S403. Analysis of extended haplotypes localized the disease gene to an approximately 12-cM interval between loci D4S1582 and D4S2397. Therefore, this kindred establishes a new dominant Stargardt-like locus, STGD4...
  3. pmc Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development
    Marina Kniazeva
    Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, USA
    PLoS Biol 2:E257. 2004
    ..This study exposes unexpected and crucial physiological functions of C15ISO and C17ISO in C. elegans and suggests a potentially important role for mmBCFAs in other eukaryotes...
  4. pmc A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans
    Marina Kniazeva
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 22:2102-10. 2008
    ..Our data suggest that C17ISO may act as a chemical/nutritional factor in a mechanism that regulates post-embryonic development in response to the metabolic state of the organism...
  5. pmc Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans
    Rencheng Wang
    Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
    PLoS ONE 8:e76270. 2013
    ..This work reveals a novel connection between peroxisomal functions and mmBCFA metabolism. ..
  6. pmc Fat chance for longevity
    Marina Kniazeva
    Department of Molecular, Cell, and Developmental Biology, Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Genes Dev 27:351-4. 2013
    ..The impact of this finding is discussed with regard to the nutritional value of ω-6 fatty acids and regulatory functions of fat metabolism beyond its well-known role in energy storage...
  7. pmc A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans
    Huanhu Zhu
    Howard Hughes Medical Institute, University of Colorado, Boulder, Boulder, United States Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Boulder, United States
    elife 2:e00429. 2013
    ..DOI:http://dx.doi.org/10.7554/eLife.00429.001...
  8. pmc Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans
    Marina Kniazeva
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 26:554-66. 2012
    ..This study shows a novel role of branched chain FAs whose functions in humans and animals are unknown and uncovers a novel intercellular regulatory pathway linking a specific FA-ACS interaction to specific developmental events...