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Genomes and Genes | Darin J KnappSummaryAffiliation: University of North Carolina Country: USA Publications
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Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxietyDarin J Knapp
Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Brain Behav Immun 25:S146-54. 2011..Interrupting this potential glial-neuronal interaction could provide a novel means by which to alter the development of emotional states induced by stress that predict relapse in the alcoholic...
Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P ratsDarin J Knapp
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514 7178, USA
Psychopharmacology (Berl) 218:179-89. 2011..Stress may elevate ethanol drinking and anxiety associated with ethanol drinking. Studies to identify relevant neurobiological substrates are needed...- Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P ratsDavid H Overstreet
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 31:1473-81. 2007..Because anxiety is often regarded as a precipitating factor in relapsing alcoholics, we decided to examine the consequences of stressing alcohol-preferring P rats on both voluntary alcohol drinking and withdrawal-induced anxiety... - Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behaviorGeorge R Breese
Department of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA
Neuropsychopharmacology 33:867-76. 2008..Together, these findings indicate that increased cytokine activity induces adaptive change that supports sensitization of ethanol withdrawal-induced anxiety that may be linked to GABA(A)-receptor function... - The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stressDarin J Knapp
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7158, USA
Alcohol Clin Exp Res 31:1872-82. 2007..This investigation explored the potential role of several brain regions (amygdala, raphe, inferior colliculus, nucleus accumbens, and paraventricular hypothalamus) for these actions of flumazenil... - Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitizationMae M Huang
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
J Pharmacol Exp Ther 332:298-307. 2010..These results indicate that CRF released by stress acts on CRF-1 receptors within specific brain regions to produce a cumulative adaptation that sensitizes anxiety-like behavior during withdrawal from chronic ethanol exposure... - Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonistGeorge R Breese
Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
Neuropsychopharmacology 30:1662-9. 2005.... - Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligandsDavid H Overstreet
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 187:1-12. 2006..Anxiety-like behavior resulting from repeated withdrawals from chronic ethanol diets is counteracted by systemic administration of a 5-HT2C receptor antagonist or a 5-HT1A receptor partial agonist... - Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawalDarin J Knapp
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 31:582-95. 2007..The present investigation assessed whether pretreatment of rats with agents targeting receptor systems thought to be important in treating relapse in alcoholic patients would prevent sensitization of anxiety-like behavior... - Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in miceDayna M Hayes
Department of Psychology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, NC, USA
Addict Biol 17:338-50. 2012..Taken together, the current data provide the first evidence that NPY signaling in the NAc core and the Y(2) receptor modulate ethanol-induced behavioral sensitization... - Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligandsDarin J Knapp
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 29:553-63. 2005..The studies reported herein examined the effects of gamma-aminobutyric acid-modulating drugs on social interaction behavior-an established model of anxiety-in rats exposed to repeated cycles of ethanol treatment and withdrawal... - Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult ratsTiffany A Wills
Neurobiology Curriculum, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 33:455-63. 2009..Current experiments determined if adolescent rats exhibit sensitized anxiety-like behavior, the duration of this effect, if drug pretreatments blocked these effects, and if these effects differed from those seen in adults... - Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark proceduresDennis R Sparta
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
Alcohol Clin Exp Res 32:259-65. 2008..The present experiments determined whether the increased ethanol drinking caused by DID procedures can be attenuated by pretreatment with CP-154,526; a corticotropin releasing factor type-1 (CRF1) receptor antagonist... - The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ miceEmily G Lowery
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
Alcohol Clin Exp Res 32:240-8. 2008..The current experiment was conducted to further characterize the role of CRF1 receptor (CRF1R) signaling in stress-induced increases in ethanol consumption in BALB/cJ and C57BL/6N mice... - Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholdsTiffany A Wills
Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 32:1350-60. 2008..While adolescent rats have differential responses to both acute and chronic ethanol treatments, the potential differences in the effects of repeated withdrawals in this population have yet to be determined... - Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptorMontserrat Navarro
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 29:949-57. 2005..These findings strengthen the argument that MCR signaling controls ethanol consumption and that compounds directed at MCR may represent promising targets for treating alcohol abuse disorders in addition to obesity... - The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signalingDennis R Sparta
Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
Alcohol Clin Exp Res 33:31-42. 2009..Therefore, we determined whether the ADE can be observed in C57BL/6J mice using operant self-administration procedures and if expression of the ADE is modulated by the corticotropin releasing factor-1 (CRF-1) receptor... - Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strainsDayna M Hayes
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599-3270, USA
Alcohol Clin Exp Res 29:721-9. 2005.... - Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley ratsDavid H Overstreet
Bowles Center for Alcohol Studies, Department of Psychiatry, 3009 Thurston Bowles Bldg, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Pharmacol Biochem Behav 81:122-30. 2005.... 
The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principlesGeorge R Breese
Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
Brain Res Brain Res Rev 48:57-73. 2005..Despite an extraordinary legacy from studies of the neurobiology of this treatment, a host of unknowns remain that will inspire future investigations...- Decreased immunoreactivity of the melanocortin neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) after chronic ethanol exposure in Sprague-Dawley ratsMontserrat Navarro
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
Alcohol Clin Exp Res 32:266-76. 2008..We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist... - Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedationJon R Fee
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599-3270, USA
Alcohol Clin Exp Res 28:1459-68. 2004.... - Interactions of stress and CRF in ethanol-withdrawal induced anxiety in adolescent and adult ratsTiffany A Wills
Neurobiology Curriculum, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 34:1603-12. 2010..Current experiments determined whether adolescent rats were more sensitive to these challenges in sensitizing ethanol withdrawal-induced anxiety and altering CRF levels in brain during withdrawal... - SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in ratsDarin J Knapp
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Alcohol 32:101-11. 2004..Because anxiety may be a complicating factor in alcohol withdrawal and relapse, future studies of this type are needed to provide focus for the effort to define selective and novel antianxiety agents for these disorders... - Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptorsDavid H Overstreet
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
Pharmacol Biochem Behav 77:405-13. 2004..These findings indicate that the CRF system and CRF(1) receptors play key roles in the adaptive change responsible for the anxiety-like behavior induced by repeated withdrawals from chronic ethanol... - A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in ratsDavid H Overstreet
Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 167:344-52. 2003..The deficits in social interaction behavior following withdrawal from continuous ethanol exposure can be reduced following acute treatments with 5-HT(2C) antagonists or 5-HT(1A) agonists... - Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY)Dennis R Sparta
Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
Drug Alcohol Depend 90:297-300. 2007..5% ethanol... - Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonistGeorge R Breese
Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Neuropsychopharmacology 29:470-82. 2004.... - Peripheral and central administration of a selective neuropeptide Y Y1 receptor antagonist suppresses ethanol intake by C57BL/6J miceDennis R Sparta
Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599-3270, USA
Alcohol Clin Exp Res 28:1324-30. 2004..These results are consistent with observations that hypothalamic infusion of NPY increases ethanol drinking by rats... - Models of chronic alcohol exposure and dependenceDarin J Knapp
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
Methods Mol Biol 829:205-30. 2012..These include but are not limited to intensity and pattern of alcohol exposure, seizure sensitivity during withdrawal, and emotional responding... - Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Glia 55:453-62. 2007..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease... - Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanolDavid H Overstreet
Department of Psychiatry, Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Thurston-Bowles Building 3009, CB #7178, Chapel Hill, NC 27599-7178, USA
Pharmacol Biochem Behav 78:459-64. 2004..Thus, there are no sex differences in the three-cycle multiple-withdrawal paradigm, but there may be differences after briefer exposures... - A selective ALDH-2 inhibitor reduces anxiety in ratsDavid H Overstreet
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, United States
Pharmacol Biochem Behav 94:255-61. 2009..Thus, a non-addictive selective inhibitor of ALDH-2 has both anxiolytic and antidipsotropic properties, which may be dependent, in part on the involvement of the GABA-benzodiazepine system... - Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawalsDavid H Overstreet
Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
Alcohol Clin Exp Res 26:1259-68. 2002..In this article, the effects of a three-cycle model of ethanol exposure and withdrawal on the social interaction test of anxiety are summarized... - Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesisGeorge R Breese
Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, 3007 Thurston Bowles Building CB 7178, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 178:367-80. 2005..The rationale for proposing the "kindling"/stress hypothesis is to provide a conceptual basis for the insidious development and maintenance of alcohol abuse... - Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase AFrank M Ferraro
Department of Psychology, University of North Carolina, Chapel Hill 27599 3270, USA
Alcohol Clin Exp Res 30:825-35. 2006..Therefore, we determined whether the high ethanol consumption characteristic of RIIbeta(-/-) mice would be complemented by increased appetitive ethanol-seeking behavior in an operant paradigm... - Stress enhancement of craving during sobriety: a risk for relapseGeorge R Breese
Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 29:185-95. 2005..Collectively, the presentations provided convincing support for an involvement of stress in the cause of relapse and continuing alcohol abuse and suggested novel pharmacological approaches for treating relapse induced by stress... - Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic modelsDavid H Overstreet
Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
Stress 6:101-10. 2003..Further study with additional tests of anxiety are needed to confirm this intriguing relationship... - Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvementSophia T Papadeas
Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
J Neurosci 24:5863-76. 2004..Ultimately, long-lasting phosphorylation of ERK and CREB in MPC may play a pivotal role in any permanent adaptive change(s) in these animals... - Alcoholism and obesity: overlapping neuropeptide pathways?Todd E Thiele
Department of Psychology, University of North Carolina at Chapel Hill, Davie Hall, CB 3270, Chapel Hill, NC 27599 3270, USA
Neuropeptides 37:321-37. 2003.... - Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsivenessGeorge R Breese
Department of Psychiatry, UNC School of Medicine, University of North Carolina, 3007 Thurston Bowles Bldg, Chapel Hill, NC 27599 7178, USA
Neurosci Biobehav Rev 26:441-55. 2002....