Darin J Knapp

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P rats
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514 7178, USA
    Psychopharmacology (Berl) 218:179-89. 2011
  2. pmc Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Brain Behav Immun 25:S146-54. 2011
  3. pmc Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:1473-81. 2007
  4. pmc Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior
    George R Breese
    Department of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA
    Neuropsychopharmacology 33:867-76. 2008
  5. pmc The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7158, USA
    Alcohol Clin Exp Res 31:1872-82. 2007
  6. pmc Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization
    Mae M Huang
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 332:298-307. 2010
  7. pmc Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1662-9. 2005
  8. pmc Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 187:1-12. 2006
  9. pmc Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal
    Darin J Knapp
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:582-95. 2007
  10. pmc Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice
    Dayna M Hayes
    Department of Psychology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, NC, USA
    Addict Biol 17:338-50. 2012

Collaborators

Detail Information

Publications43

  1. doi request reprint Effects of a stressor and corticotrophin releasing factor on ethanol deprivation-induced ethanol intake and anxiety-like behavior in alcohol-preferring P rats
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514 7178, USA
    Psychopharmacology (Berl) 218:179-89. 2011
    ..Stress may elevate ethanol drinking and anxiety associated with ethanol drinking. Studies to identify relevant neurobiological substrates are needed...
  2. pmc Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Brain Behav Immun 25:S146-54. 2011
    ..Interrupting this potential glial-neuronal interaction could provide a novel means by which to alter the development of emotional states induced by stress that predict relapse in the alcoholic...
  3. pmc Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:1473-81. 2007
    ..Because anxiety is often regarded as a precipitating factor in relapsing alcoholics, we decided to examine the consequences of stressing alcohol-preferring P rats on both voluntary alcohol drinking and withdrawal-induced anxiety...
  4. pmc Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior
    George R Breese
    Department of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA
    Neuropsychopharmacology 33:867-76. 2008
    ..Together, these findings indicate that increased cytokine activity induces adaptive change that supports sensitization of ethanol withdrawal-induced anxiety that may be linked to GABA(A)-receptor function...
  5. pmc The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7158, USA
    Alcohol Clin Exp Res 31:1872-82. 2007
    ..This investigation explored the potential role of several brain regions (amygdala, raphe, inferior colliculus, nucleus accumbens, and paraventricular hypothalamus) for these actions of flumazenil...
  6. pmc Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization
    Mae M Huang
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 332:298-307. 2010
    ..These results indicate that CRF released by stress acts on CRF-1 receptors within specific brain regions to produce a cumulative adaptation that sensitizes anxiety-like behavior during withdrawal from chronic ethanol exposure...
  7. pmc Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1662-9. 2005
    ....
  8. pmc Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 187:1-12. 2006
    ..Anxiety-like behavior resulting from repeated withdrawals from chronic ethanol diets is counteracted by systemic administration of a 5-HT2C receptor antagonist or a 5-HT1A receptor partial agonist...
  9. pmc Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal
    Darin J Knapp
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:582-95. 2007
    ..The present investigation assessed whether pretreatment of rats with agents targeting receptor systems thought to be important in treating relapse in alcoholic patients would prevent sensitization of anxiety-like behavior...
  10. pmc Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice
    Dayna M Hayes
    Department of Psychology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, NC, USA
    Addict Biol 17:338-50. 2012
    ..Taken together, the current data provide the first evidence that NPY signaling in the NAc core and the Y(2) receptor modulate ethanol-induced behavioral sensitization...
  11. pmc Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligands
    Darin J Knapp
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:553-63. 2005
    ..The studies reported herein examined the effects of gamma-aminobutyric acid-modulating drugs on social interaction behavior-an established model of anxiety-in rats exposed to repeated cycles of ethanol treatment and withdrawal...
  12. pmc Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark procedures
    Dennis R Sparta
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 32:259-65. 2008
    ..The present experiments determined whether the increased ethanol drinking caused by DID procedures can be attenuated by pretreatment with CP-154,526; a corticotropin releasing factor type-1 (CRF1) receptor antagonist...
  13. pmc The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice
    Emily G Lowery
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 32:240-8. 2008
    ..The current experiment was conducted to further characterize the role of CRF1 receptor (CRF1R) signaling in stress-induced increases in ethanol consumption in BALB/cJ and C57BL/6N mice...
  14. pmc Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholds
    Tiffany A Wills
    Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 32:1350-60. 2008
    ..While adolescent rats have differential responses to both acute and chronic ethanol treatments, the potential differences in the effects of repeated withdrawals in this population have yet to be determined...
  15. pmc Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats
    Tiffany A Wills
    Neurobiology Curriculum, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 33:455-63. 2009
    ..Current experiments determined if adolescent rats exhibit sensitized anxiety-like behavior, the duration of this effect, if drug pretreatments blocked these effects, and if these effects differed from those seen in adults...
  16. pmc The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling
    Dennis R Sparta
    Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    Alcohol Clin Exp Res 33:31-42. 2009
    ..Therefore, we determined whether the ADE can be observed in C57BL/6J mice using operant self-administration procedures and if expression of the ADE is modulated by the corticotropin releasing factor-1 (CRF-1) receptor...
  17. pmc Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor
    Montserrat Navarro
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:949-57. 2005
    ..Here we assessed the possibility that MC receptor (MCR) agonists modulate ethanol intake via the MC3 receptor (MC3R) and/or the MC4 receptor (MC4R) and whether the MCR antagonist AgRP-(83-132) controls ethanol consumption...
  18. pmc Comparison of basal neuropeptide Y and corticotropin releasing factor levels between the high ethanol drinking C57BL/6J and low ethanol drinking DBA/2J inbred mouse strains
    Dayna M Hayes
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 29:721-9. 2005
    ..Therefore, we used immunohistochemical techniques to determine if basal NPY and/or CRF levels differed in predicted directions between C57BL/6J and DBA/2J mice...
  19. pmc Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, 3009 Thurston Bowles Bldg, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 81:122-30. 2005
    ....
  20. ncbi request reprint The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 48:57-73. 2005
    ..Despite an extraordinary legacy from studies of the neurobiology of this treatment, a host of unknowns remain that will inspire future investigations...
  21. pmc Interactions of stress and CRF in ethanol-withdrawal induced anxiety in adolescent and adult rats
    Tiffany A Wills
    Neurobiology Curriculum, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 34:1603-12. 2010
    ..Current experiments determined whether adolescent rats were more sensitive to these challenges in sensitizing ethanol withdrawal-induced anxiety and altering CRF levels in brain during withdrawal...
  22. pmc SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 32:101-11. 2004
    ..Because anxiety may be a complicating factor in alcohol withdrawal and relapse, future studies of this type are needed to provide focus for the effort to define selective and novel antianxiety agents for these disorders...
  23. pmc Decreased immunoreactivity of the melanocortin neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) after chronic ethanol exposure in Sprague-Dawley rats
    Montserrat Navarro
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 32:266-76. 2008
    ..We also determined if ethanol exposure would alter the immunoreactivity of agouti-related protein (AgRP), an endogenous MCR antagonist...
  24. pmc Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation
    Jon R Fee
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 28:1459-68. 2004
    ..We determined whether high ethanol intake by the RIIbeta(-/-) mice on alternate genetic backgrounds is reliably predicted by high basal levels of anxiety or resistance to the sedative effects of ethanol...
  25. pmc Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
    David H Overstreet
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 77:405-13. 2004
    ..These findings indicate that the CRF system and CRF(1) receptors play key roles in the adaptive change responsible for the anxiety-like behavior induced by repeated withdrawals from chronic ethanol...
  26. pmc Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY)
    Dennis R Sparta
    Department of Psychology, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    Drug Alcohol Depend 90:297-300. 2007
    ..5% ethanol...
  27. pmc A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 167:344-52. 2003
    ..The deficits in social interaction behavior following withdrawal from continuous ethanol exposure can be reduced following acute treatments with 5-HT(2C) antagonists or 5-HT(1A) agonists...
  28. pmc Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonist
    George R Breese
    Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 29:470-82. 2004
    ....
  29. pmc Peripheral and central administration of a selective neuropeptide Y Y1 receptor antagonist suppresses ethanol intake by C57BL/6J mice
    Dennis R Sparta
    Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 28:1324-30. 2004
    ....
  30. doi request reprint Models of chronic alcohol exposure and dependence
    Darin J Knapp
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 829:205-30. 2012
    ..These include but are not limited to intensity and pattern of alcohol exposure, seizure sensitivity during withdrawal, and emotional responding...
  31. pmc Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol
    David H Overstreet
    Department of Psychiatry, Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Thurston Bowles Building 3009, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 78:459-64. 2004
    ..Thus, there are no sex differences in the three-cycle multiple-withdrawal paradigm, but there may be differences after briefer exposures...
  32. pmc Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Glia 55:453-62. 2007
    ..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease...
  33. pmc Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J mice
    Sheryl S Moy
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 36:36-46. 2013
    ..Overall, these findings demonstrate that moderate alteration of NMDA, dopamine, or serotonin function can attenuate social preference in wild type mice...
  34. pmc A selective ALDH-2 inhibitor reduces anxiety in rats
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, United States
    Pharmacol Biochem Behav 94:255-61. 2009
    ..Thus, a non-addictive selective inhibitor of ALDH-2 has both anxiolytic and antidipsotropic properties, which may be dependent, in part on the involvement of the GABA-benzodiazepine system...
  35. pmc Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawals
    David H Overstreet
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 26:1259-68. 2002
    ..In this article, the effects of a three-cycle model of ethanol exposure and withdrawal on the social interaction test of anxiety are summarized...
  36. pmc Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, 3007 Thurston Bowles Building CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 178:367-80. 2005
    ..The rationale for proposing the "kindling"/stress hypothesis is to provide a conceptual basis for the insidious development and maintenance of alcohol abuse...
  37. pmc Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase A
    Frank M Ferraro
    Department of Psychology, University of North Carolina, Chapel Hill 27599 3270, USA
    Alcohol Clin Exp Res 30:825-35. 2006
    ..Therefore, we determined whether the high ethanol consumption characteristic of RIIbeta(-/-) mice would be complemented by increased appetitive ethanol-seeking behavior in an operant paradigm...
  38. pmc The Cytokine mRNA Increase Induced by Withdrawal from Chronic Ethanol in the Sterile Environment of Brain is Mediated by CRF and HMGB1 Release
    Buddy A Whitman
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Department of Curriculum in Neurobiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Alcohol Clin Exp Res 37:2086-97. 2013
    ....
  39. pmc Stress enhancement of craving during sobriety: a risk for relapse
    George R Breese
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:185-95. 2005
    ..Collectively, the presentations provided convincing support for an involvement of stress in the cause of relapse and continuing alcohol abuse and suggested novel pharmacological approaches for treating relapse induced by stress...
  40. ncbi request reprint Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models
    David H Overstreet
    Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Stress 6:101-10. 2003
    ..Further study with additional tests of anxiety are needed to confirm this intriguing relationship...
  41. pmc Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement
    Sophia T Papadeas
    Neurobiology Curriculum, Department of Psychiatry and University of North Carolina Neuroscience Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    J Neurosci 24:5863-76. 2004
    ..Ultimately, long-lasting phosphorylation of ERK and CREB in MPC may play a pivotal role in any permanent adaptive change(s) in these animals...
  42. ncbi request reprint Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, 3007 Thurston Bowles Bldg, Chapel Hill, NC 27599 7178, USA
    Neurosci Biobehav Rev 26:441-55. 2002
    ....
  43. ncbi request reprint Alcoholism and obesity: overlapping neuropeptide pathways?
    Todd E Thiele
    Department of Psychology, University of North Carolina at Chapel Hill, Davie Hall, CB 3270, Chapel Hill, NC 27599 3270, USA
    Neuropeptides 37:321-37. 2003
    ....