C A Klug

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells
    Hyung Gyoon Kim
    Department of Microbiology and Division of Developmental and Clinical Immunology, The University of Alabama at Birmingham, WTI Room 387, 1824 Sixth Ave South, Birmingham AL 35294 3300, USA
    Blood 104:3894-900. 2004
  2. pmc Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
    C A Klug
    Department of Pathology, Stanford University School of Medicine, CA 94305 5428, USA
    Proc Natl Acad Sci U S A 95:657-62. 1998
  3. ncbi Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny
    C A Klug
    Department of Pathology and Developmental Biology, Stanford University Medical Center, CA, USA
    Blood 96:894-901. 2000
  4. pmc Contribution of intrarenal cells to cellular repair after acute kidney injury: subcapsular implantation technique
    Lisa M Curtis
    Nephrology and Research Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 4412, USA
    Am J Physiol Renal Physiol 295:F310-4. 2008
  5. pmc Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
    Cristina G de Guzman
    Department of Human Genetics, University of Alabama at Birmingham, 1824 6th Avenue South, Birmingham, AL 35294, USA
    Mol Cell Biol 22:5506-17. 2002
  6. pmc Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice
    Zheng Zhang
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, AL, USA
    Blood 109:2190-7. 2007
  7. pmc Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage
    Zheng Zhang
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    EMBO J 22:4759-69. 2003
  8. pmc Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor
    Sheetal J Purohit
    Department of Microbiology and Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    EMBO J 22:5511-21. 2003
  9. ncbi Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development
    Claudiu V Cotta
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Blood 101:4342-6. 2003
  10. ncbi The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo
    Cristina G de Guzman
    Department of Human Genetics, University of Alabama at Birmingham, AL 35294, USA
    Blood Cells Mol Dis 30:201-6. 2003

Collaborators

Detail Information

Publications17

  1. ncbi The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells
    Hyung Gyoon Kim
    Department of Microbiology and Division of Developmental and Clinical Immunology, The University of Alabama at Birmingham, WTI Room 387, 1824 Sixth Ave South, Birmingham AL 35294 3300, USA
    Blood 104:3894-900. 2004
    ..5 and e16.5. These data suggest that PU.1 plays an important role in the maintenance or expansion of HSC number in murine fetal liver...
  2. pmc Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
    C A Klug
    Department of Pathology, Stanford University School of Medicine, CA 94305 5428, USA
    Proc Natl Acad Sci U S A 95:657-62. 1998
    ..Unexpectedly, we found Ikaros localized to heterochromatin in Abelson-transformed pre-B lymphocytes by using immunogold electron microscopy. These observations suggest a complex role for Ikaros in lymphoid development...
  3. ncbi Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny
    C A Klug
    Department of Pathology and Developmental Biology, Stanford University Medical Center, CA, USA
    Blood 96:894-901. 2000
    ..These observations suggest at least 2 distinct mechanisms of silencing retrovirally expressed genes in hematopoietic cells...
  4. pmc Contribution of intrarenal cells to cellular repair after acute kidney injury: subcapsular implantation technique
    Lisa M Curtis
    Nephrology and Research Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 4412, USA
    Am J Physiol Renal Physiol 295:F310-4. 2008
    ....
  5. pmc Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
    Cristina G de Guzman
    Department of Human Genetics, University of Alabama at Birmingham, 1824 6th Avenue South, Birmingham, AL 35294, USA
    Mol Cell Biol 22:5506-17. 2002
    ..This suggests that the principal contribution of AML1-ETO to acute myeloid leukemia is the inhibition of multiple developmental pathways...
  6. pmc Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice
    Zheng Zhang
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, AL, USA
    Blood 109:2190-7. 2007
    ..These results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non-DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage...
  7. pmc Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage
    Zheng Zhang
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    EMBO J 22:4759-69. 2003
    ..These data suggest that EBF can restrict lymphopoiesis to the B cell lineage by blocking development of other lymphoid-derived cell pathways...
  8. pmc Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor
    Sheetal J Purohit
    Department of Microbiology and Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    EMBO J 22:5511-21. 2003
    ..1(-)Ly-6C(-) cells failed to express EBF and Pax5. These results suggest that transient downregulation of IL-7R signaling is a necessary event for induction of EBF and Pax5 expression and B-lymphocyte commitment...
  9. ncbi Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development
    Claudiu V Cotta
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Blood 101:4342-6. 2003
    ..These results implicate Pax5 as a critical regulator of B- versus T-cell developmental fate and suggest that Pax5 may promote commitment to the B-cell lineage by mechanisms that are independent of myeloid gene repression...
  10. ncbi The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo
    Cristina G de Guzman
    Department of Human Genetics, University of Alabama at Birmingham, AL 35294, USA
    Blood Cells Mol Dis 30:201-6. 2003
    ....
  11. pmc Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells
    Colleen M Witt
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Mol Cell Biol 23:8637-50. 2003
    ..This study implicates a role for Notch2 in the maturation of the CD8 lineage and suggests a novel function for Notch2 in the development of the B1 B-cell subset...
  12. pmc TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability
    Ning Wang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    EMBO J 25:1469-80. 2006
    ....
  13. ncbi Differential gene expression profiling of adult murine hematopoietic stem cells
    In Kyung Park
    University of Michigan, Department of Internal Medicine, Ann Arbor, USA
    Blood 99:488-98. 2002
    ..A large number of genes that were differentially expressed by enriched populations of HSCs and MPP cells were identified. These included transcription factors, signaling molecules, and previously unknown genes...
  14. ncbi Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia
    Kyoko Kojima
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Res 67:8121-30. 2007
    ..This indicates that Smad4 is dispensable for normal pancreatic development but is critical for at least partial suppression of multiple Kras(G12D)-dependent disease-associated phenotypes...
  15. pmc FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia
    Hyung Gyoon Kim
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Blood 111:1567-74. 2008
    ..These results indicate that FLT3-activating mutations can cooperate with CBFbeta-SMMHC in an animal model of inv(16)-associated AML...
  16. pmc Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia
    Rose M Ko
    Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Leuk Res 32:1101-11. 2008
    ..These results strongly suggest that p15(Ink4b) loss must be accompanied by additional oncogenic changes for RUNX1-ETO-associated AML to develop...
  17. ncbi Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells
    Colleen M Witt
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 171:2783-8. 2003
    ..These results provide evidence that Notch2 plays a determining role in the development and/or the maintenance of B1 B and MZ B cells...