Research Topics
Genomes and Genes | Dietmar KültzSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The combinatorial nature of osmosensing in fishesDietmar Kültz
Department of Animal Science, Physiological Genomics Group, University of California, Davis, Davis, California, USA
Physiology (Bethesda) 27:259-75. 2012..Input from numerous osmosensors is integrated to encode magnitude, direction, and ionic basis of osmolality change. This combinatorial nature of osmosensing is discussed with emphasis on fishes...
Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous functionDietmar Kültz
University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA
J Exp Biol 206:3119-24. 2003..This mechanism affords time for a separate set of stressor-specific adaptations, designed to re-establish cellular homeostasis, to take action. Supporting evidence, emerging conclusions, and ways to test this hypothesis are presented...- Functional genomics and proteomics of the cellular osmotic stress response in 'non-model' organismsDietmar Kültz
Physiological Genomics Group, Department of Animal Science, One Shields Avenue, University of California, Davis, CA 95616, USA
J Exp Biol 210:1593-601. 2007..To minimize such dependence, focusing on a single biological process (rather than attempting to describe the system as a whole) is key when applying 'omics' approaches to non-model organisms... - Molecular and evolutionary basis of the cellular stress responseDietmar Kültz
Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, California 95616, USA
Annu Rev Physiol 67:225-57. 2005..In addition, cells can quantify stress and activate a death program (apoptosis) when tolerance limits are exceeded... - Hypertonicity and TonEBP promote development of the renal concentrating systemDietmar Kültz
Physiological Genomics Group, Dept of Animal Science, University of California Davis, Meyer Hall, 1 Shields Avenue, Davis, CA 95616, USA
Am J Physiol Renal Physiol 287:F876-7. 2004 
Hyperosmolality triggers oxidative damage in kidney cellsDietmar Kültz
Department of Animal Sciences, Section of Physiological Genomics, University of California, One Shields Avenue, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 101:9177-8. 2004- Mechanisms of seawater acclimation in a primitive, anadromous fish, the green sturgeonPeter J Allen
Department of Wildlife, Fish, and Conservation Biology, University of California, 1 Shields Avenue, Davis, CA, 95616, USA
J Comp Physiol B 179:903-20. 2009..Green sturgeon osmo- and ionoregulate with similar mechanisms to more-derived teleosts, indicating the importance of these mechanisms during the evolution of fishes, although salinity acclimation may be more dependent on body size... - Rapid changes in plasma cortisol, osmolality, and respiration in response to salinity stress in tilapia (Oreochromis mossambicus)Brittany D Kammerer
Physiological Genomics Group, Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Comp Biochem Physiol A Mol Integr Physiol 157:260-5. 2010..No significant changes in blood hematocrit were observed, which suggests that tilapia are capable of rapidly counteracting dehydration during acute hyperosmotic stress... - Determination of cytotoxicity of nephrotoxins on murine and human kidney cell linesEun Kee Park
Department of Entomology and Cancer Research Center, University of California Davis, CA, USA
J Environ Sci Health B 43:71-4. 2008..Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat... - Salinity stress results in rapid cell cycle changes of tilapia (Oreochromis mossambicus) gill epithelial cellsBrittany D Kammerer
Physiological Genomics Group, Department of Animal Science, University of California, Davis, Davis, California 95616, USA
J Exp Zool A Ecol Genet Physiol 311:80-90. 2009..We interpret the G2 arrest that occurs after an initial wave of transient increase in MRC mitosis as a means for conserving energy for dealing with the osmotic stress imposed during the exposure of FW fish to SW... - Osmo- and ionoregulatory responses of green sturgeon (Acipenser medirostris) to salinity acclimationBrian A Sardella
Department of Animal Science, University of California, Davis, CA 95616, USA
J Comp Physiol B 179:383-90. 2009..The presence of the NKCC in FW-acclimated sturgeon may indicate the development of SW-readiness at this age/size... - A novel GRAIL E3 ubiquitin ligase promotes environmental salinity tolerance in euryhaline tilapiaDiego F Fiol
Physiological Genomics Group, Department of Animal Sciences, University of California at Davis, CA 95616, USA
Biochim Biophys Acta 1810:439-45. 2011..Tilapia GRAIL contains a PA (protease associated) domain and a C3H2C3 RING finger domain indicative of E3 ubiquitin ligase activity... - Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck miceNelly Valkova
Physiological Genomics Group, Department of Animal Science, University of California, Davis, California 95616, USA
Mol Cell Proteomics 4:1009-18. 2005..The discovery of these proteins will provide new information on the molecular and cellular processes associated with the mechanism of ARPKD... - Pathway analysis of kidney cancer using proteomics and metabolic profilingBertrand Perroud
Genome Center, University of California, Davis, CA, USA
Mol Cancer 5:64. 2006.... - Compensatory proteome adjustments imply tissue-specific structural and metabolic reorganization following episodic hypoxia or anoxia in the epaulette shark (Hemiscyllium ocellatum)W Wesley Dowd
Department of Animal Science, University of California, Davis, California, USA
Physiol Genomics 42:93-114. 2010..Overall, our data show that episodic hypoxic or anoxic exposure and recovery in the epaulette shark amplifies a constitutive suite of compensatory mechanisms that further prepares them for subsequent insults... - Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stressDiego F Fiol
Physiological Genomics Group, Department of Animal Science, University of California, Davis, CA 95616, USA
FEBS J 274:109-24. 2007..TSC22D2 and TSC22D4 are involved in adaptation of renal cells to hypertonicity suggesting that they represent important elements of osmosensory signal transduction in mouse kidney cells... - Prolonged apoptosis in mitochondria-rich cells of tilapia (Oreochromis mossambicus) exposed to elevated salinityBrittany D Kammerer
Department of Animal Science, University of California, Davis, One Shields Avenue, Meyer Hall, Davis, CA 95616, USA
J Comp Physiol B 179:535-42. 2009.... - A novel tilapia prolactin receptor is functionally distinct from its paralogDiego F Fiol
Physiological Genomics Group, Department of Animal Science, University of California Davis, Davis, CA 95616, USA
J Exp Biol 212:2007-15. 2009..Expression of a short PRLR2 variant may serve to inhibit PRL binding during osmotic stress and in male tissues... - Salinity-dependent changes in Na(+)/K (+)-ATPase content of mitochondria-rich cells contribute to differences in thermal tolerance of Mozambique tilapiaBrian A Sardella
Department of Zoology, University of British Columbia, 6270 University Blvd, Vancouver, BC, Canada, V6T 1Z4
J Comp Physiol B 178:249-56. 2008..We conclude on the basis of the different responses to temperature acclimation that salinity-induced changes in the NKA concentration of MRCs alter thermal tolerance limits of tilapia... - Osmotic stress sensing and signaling in fishesDiego F Fiol
Physiological Genomics Group, Department of Animal Science, University of California, Davis, CA 95616, USA
FEBS J 274:5790-8. 2007..However, euryhaline fish species represent excellent models for answering critical emerging questions in this field and for elucidating the underlying molecular mechanisms of osmosensory signal transduction... - A proteomic analysis of green and white sturgeon larvae exposed to heat stress and seleniumFrederic Silvestre
Department of Animal Science, University of California, Davis, CA 95616, USA
Sci Total Environ 408:3176-88. 2010..Potential use of such proteins as biomarkers of environmental stressors in larval sturgeons could indicate early warning signals preceding population decline... - The acute temperature tolerance of green sturgeon (Acipenser medirostris) and the effect of environmental salinityBrian A Sardella
Department of Animal Science, University of California, Davis, California 95616, USA
J Exp Zool A Ecol Genet Physiol 309:477-83. 2008..To our knowledge, this represents the first evidence for an effect of salinity on the upper thermal tolerance of sturgeon, as well as the first investigation of the osmoregulatory consequences of exposure to near-lethal temperatures... - Osmotic stress sensing and signaling in animalsDietmar Kültz
Physiological Genomics Group, Department of Animal Science, University of California, Davis, CA, USA
FEBS J 274:5781. 2007 - Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cellsEun Kee Park
Department of Entomology and Cancer Research Center, University of California, Davis, California, USA
J Toxicol Environ Health A 70:2092-5. 2007..The present study also establishes mIMCD3 cells as a valuable model for evaluation of cytotoxicity of nephrotoxic compounds... - Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stressSally K Mak
Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, California 95616, USA
J Biol Chem 279:39075-84. 2004.... - Ultrasound detection and characterization of polycystic kidney disease in a mouse modelRachel Pollard
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, USA
Comp Med 56:215-21. 2006..Cortical intensity is greater in jck versus WT mice and appears affected by percentage cyst area and mean cyst size... - In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screensKi Chang Ahn
Department of Entomology and Cancer Research Center, University of California, Davis, Davis, CA 95616, USA
Environ Health Perspect 116:1203-10. 2008..Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects...
Research Grants
- Mechanisms of renal cell adaptation to hypertonicityDIETMAR KUELTZ; Fiscal Year: 2006..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..