Dietmar Kültz

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint The combinatorial nature of osmosensing in fishes
    Dietmar Kültz
    Department of Animal Science, Physiological Genomics Group, University of California, Davis, Davis, California, USA
    Physiology (Bethesda) 27:259-75. 2012
  2. ncbi request reprint Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function
    Dietmar Kültz
    University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA
    J Exp Biol 206:3119-24. 2003
  3. ncbi request reprint Molecular and evolutionary basis of the cellular stress response
    Dietmar Kültz
    Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, California 95616, USA
    Annu Rev Physiol 67:225-57. 2005
  4. ncbi request reprint Hypertonicity and TonEBP promote development of the renal concentrating system
    Dietmar Kültz
    Physiological Genomics Group, Dept of Animal Science, University of California Davis, Meyer Hall, 1 Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Renal Physiol 287:F876-7. 2004
  5. pmc Hyperosmolality triggers oxidative damage in kidney cells
    Dietmar Kültz
    Department of Animal Sciences, Section of Physiological Genomics, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:9177-8. 2004
  6. ncbi request reprint Functional genomics and proteomics of the cellular osmotic stress response in 'non-model' organisms
    Dietmar Kültz
    Physiological Genomics Group, Department of Animal Science, One Shields Avenue, University of California, Davis, CA 95616, USA
    J Exp Biol 210:1593-601. 2007
  7. ncbi request reprint Regulation of osmotic stress transcription factor 1 (Ostf1) in tilapia (Oreochromis mossambicus) gill epithelium during salinity stress
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, One Shields Avenue, Meyer Hall, Davis, CA 95616, USA
    J Exp Biol 209:3257-65. 2006
  8. pmc Rapid hyperosmotic coinduction of two tilapia (Oreochromis mossambicus) transcription factors in gill cells
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Science, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:927-32. 2005
  9. doi request reprint Rapid changes in plasma cortisol, osmolality, and respiration in response to salinity stress in tilapia (Oreochromis mossambicus)
    Brittany D Kammerer
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Comp Biochem Physiol A Mol Integr Physiol 157:260-5. 2010
  10. pmc Mechanisms of seawater acclimation in a primitive, anadromous fish, the green sturgeon
    Peter J Allen
    Department of Wildlife, Fish, and Conservation Biology, University of California, 1 Shields Avenue, Davis, CA, 95616, USA
    J Comp Physiol B 179:903-20. 2009

Research Grants

Collaborators

Detail Information

Publications37

  1. doi request reprint The combinatorial nature of osmosensing in fishes
    Dietmar Kültz
    Department of Animal Science, Physiological Genomics Group, University of California, Davis, Davis, California, USA
    Physiology (Bethesda) 27:259-75. 2012
    ..Input from numerous osmosensors is integrated to encode magnitude, direction, and ionic basis of osmolality change. This combinatorial nature of osmosensing is discussed with emphasis on fishes...
  2. ncbi request reprint Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function
    Dietmar Kültz
    University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA
    J Exp Biol 206:3119-24. 2003
    ..This mechanism affords time for a separate set of stressor-specific adaptations, designed to re-establish cellular homeostasis, to take action. Supporting evidence, emerging conclusions, and ways to test this hypothesis are presented...
  3. ncbi request reprint Molecular and evolutionary basis of the cellular stress response
    Dietmar Kültz
    Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, California 95616, USA
    Annu Rev Physiol 67:225-57. 2005
    ..In addition, cells can quantify stress and activate a death program (apoptosis) when tolerance limits are exceeded...
  4. ncbi request reprint Hypertonicity and TonEBP promote development of the renal concentrating system
    Dietmar Kültz
    Physiological Genomics Group, Dept of Animal Science, University of California Davis, Meyer Hall, 1 Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Renal Physiol 287:F876-7. 2004
  5. pmc Hyperosmolality triggers oxidative damage in kidney cells
    Dietmar Kültz
    Department of Animal Sciences, Section of Physiological Genomics, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:9177-8. 2004
  6. ncbi request reprint Functional genomics and proteomics of the cellular osmotic stress response in 'non-model' organisms
    Dietmar Kültz
    Physiological Genomics Group, Department of Animal Science, One Shields Avenue, University of California, Davis, CA 95616, USA
    J Exp Biol 210:1593-601. 2007
    ..To minimize such dependence, focusing on a single biological process (rather than attempting to describe the system as a whole) is key when applying 'omics' approaches to non-model organisms...
  7. ncbi request reprint Regulation of osmotic stress transcription factor 1 (Ostf1) in tilapia (Oreochromis mossambicus) gill epithelium during salinity stress
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, One Shields Avenue, Meyer Hall, Davis, CA 95616, USA
    J Exp Biol 209:3257-65. 2006
    ....
  8. pmc Rapid hyperosmotic coinduction of two tilapia (Oreochromis mossambicus) transcription factors in gill cells
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Science, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:927-32. 2005
    ..We conclude that OSTF1 and TFIIB are critical elements of osmosensory signal transduction in euryhaline teleosts that mediate osmotic adaptation by means of transcriptional regulation...
  9. doi request reprint Rapid changes in plasma cortisol, osmolality, and respiration in response to salinity stress in tilapia (Oreochromis mossambicus)
    Brittany D Kammerer
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Comp Biochem Physiol A Mol Integr Physiol 157:260-5. 2010
    ..No significant changes in blood hematocrit were observed, which suggests that tilapia are capable of rapidly counteracting dehydration during acute hyperosmotic stress...
  10. pmc Mechanisms of seawater acclimation in a primitive, anadromous fish, the green sturgeon
    Peter J Allen
    Department of Wildlife, Fish, and Conservation Biology, University of California, 1 Shields Avenue, Davis, CA, 95616, USA
    J Comp Physiol B 179:903-20. 2009
    ..Green sturgeon osmo- and ionoregulate with similar mechanisms to more-derived teleosts, indicating the importance of these mechanisms during the evolution of fishes, although salinity acclimation may be more dependent on body size...
  11. doi request reprint Osmo- and ionoregulatory responses of green sturgeon (Acipenser medirostris) to salinity acclimation
    Brian A Sardella
    Department of Animal Science, University of California, Davis, CA 95616, USA
    J Comp Physiol B 179:383-90. 2009
    ..The presence of the NKCC in FW-acclimated sturgeon may indicate the development of SW-readiness at this age/size...
  12. doi request reprint Salinity stress results in rapid cell cycle changes of tilapia (Oreochromis mossambicus) gill epithelial cells
    Brittany D Kammerer
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, Davis, California 95616, USA
    J Exp Zool A Ecol Genet Physiol 311:80-90. 2009
    ..We interpret the G2 arrest that occurs after an initial wave of transient increase in MRC mitosis as a means for conserving energy for dealing with the osmotic stress imposed during the exposure of FW fish to SW...
  13. ncbi request reprint Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines
    Eun Kee Park
    Department of Entomology and Cancer Research Center, University of California Davis, CA, USA
    J Environ Sci Health B 43:71-4. 2008
    ..Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat...
  14. ncbi request reprint Laser scanning cytometry and tissue microarray analysis of salinity effects on killifish chloride cells
    Raquel N Lima
    University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    J Exp Biol 207:1729-39. 2004
    ..These results also demonstrate the power of LSC and TMA for comparative biology...
  15. ncbi request reprint Constitutive and inducible stress proteins dominate the proteome of the murine inner medullary collecting duct-3 (mIMCD3) cell line
    Nelly Valkova
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Biochim Biophys Acta 1764:1007-20. 2006
    ..8-fold higher phosphorylation level of the most acidic isoform of the heat shock protein Hsp27 compared to its phosphorylation level under iso-osmotic conditions...
  16. doi request reprint A novel GRAIL E3 ubiquitin ligase promotes environmental salinity tolerance in euryhaline tilapia
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Sciences, University of California at Davis, CA 95616, USA
    Biochim Biophys Acta 1810:439-45. 2011
    ..Tilapia GRAIL contains a PA (protease associated) domain and a C3H2C3 RING finger domain indicative of E3 ubiquitin ligase activity...
  17. ncbi request reprint Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice
    Nelly Valkova
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, California 95616, USA
    Mol Cell Proteomics 4:1009-18. 2005
    ..The discovery of these proteins will provide new information on the molecular and cellular processes associated with the mechanism of ARPKD...
  18. pmc Pathway analysis of kidney cancer using proteomics and metabolic profiling
    Bertrand Perroud
    Genome Center, University of California, Davis, CA, USA
    Mol Cancer 5:64. 2006
    ....
  19. ncbi request reprint Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, CA 95616, USA
    FEBS J 274:109-24. 2007
    ..TSC22D2 and TSC22D4 are involved in adaptation of renal cells to hypertonicity suggesting that they represent important elements of osmosensory signal transduction in mouse kidney cells...
  20. pmc Compensatory proteome adjustments imply tissue-specific structural and metabolic reorganization following episodic hypoxia or anoxia in the epaulette shark (Hemiscyllium ocellatum)
    W Wesley Dowd
    Department of Animal Science, University of California, Davis, California, USA
    Physiol Genomics 42:93-114. 2010
    ..Overall, our data show that episodic hypoxic or anoxic exposure and recovery in the epaulette shark amplifies a constitutive suite of compensatory mechanisms that further prepares them for subsequent insults...
  21. doi request reprint A novel tilapia prolactin receptor is functionally distinct from its paralog
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Science, University of California Davis, Davis, CA 95616, USA
    J Exp Biol 212:2007-15. 2009
    ..Expression of a short PRLR2 variant may serve to inhibit PRL binding during osmotic stress and in male tissues...
  22. doi request reprint Prolonged apoptosis in mitochondria-rich cells of tilapia (Oreochromis mossambicus) exposed to elevated salinity
    Brittany D Kammerer
    Department of Animal Science, University of California, Davis, One Shields Avenue, Meyer Hall, Davis, CA 95616, USA
    J Comp Physiol B 179:535-42. 2009
    ....
  23. ncbi request reprint Salinity-dependent changes in Na(+)/K (+)-ATPase content of mitochondria-rich cells contribute to differences in thermal tolerance of Mozambique tilapia
    Brian A Sardella
    Department of Zoology, University of British Columbia, 6270 University Blvd, Vancouver, BC, Canada, V6T 1Z4
    J Comp Physiol B 178:249-56. 2008
    ..We conclude on the basis of the different responses to temperature acclimation that salinity-induced changes in the NKA concentration of MRCs alter thermal tolerance limits of tilapia...
  24. pmc Controlling proteome degradation in Daphnia pulex
    Catherine Jarrett Kemp
    Department of Animal Science, University of California, Davis, California, USA
    J Exp Zool A Ecol Genet Physiol 317:645-51. 2012
    ..We interpret these data as evidence for salinity-induced inhibition of proteolysis in Daphnia...
  25. ncbi request reprint Osmotic stress sensing and signaling in fishes
    Diego F Fiol
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, CA 95616, USA
    FEBS J 274:5790-8. 2007
    ..However, euryhaline fish species represent excellent models for answering critical emerging questions in this field and for elucidating the underlying molecular mechanisms of osmosensory signal transduction...
  26. doi request reprint The acute temperature tolerance of green sturgeon (Acipenser medirostris) and the effect of environmental salinity
    Brian A Sardella
    Department of Animal Science, University of California, Davis, California 95616, USA
    J Exp Zool A Ecol Genet Physiol 309:477-83. 2008
    ..To our knowledge, this represents the first evidence for an effect of salinity on the upper thermal tolerance of sturgeon, as well as the first investigation of the osmoregulatory consequences of exposure to near-lethal temperatures...
  27. pmc A proteomic analysis of green and white sturgeon larvae exposed to heat stress and selenium
    Frederic Silvestre
    Department of Animal Science, University of California, Davis, CA 95616, USA
    Sci Total Environ 408:3176-88. 2010
    ..Potential use of such proteins as biomarkers of environmental stressors in larval sturgeons could indicate early warning signals preceding population decline...
  28. pmc Salinity-induced regulation of the myo-inositol biosynthesis pathway in tilapia gill epithelium
    Romina Sacchi
    Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, One Shields Avenue, Meyer Hall, Davis, CA 95616, USA
    J Exp Biol 216:4626-38. 2013
    ..We conclude that the MIB pathway represents a major salinity stress coping mechanism that is regulated at multiple levels in euryhaline fish but absent in stenohaline zebrafish. ..
  29. pmc Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis
    Alison M Gardell
    Department of Animal Science, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Exp Biol 216:4615-25. 2013
    ....
  30. pmc Quantitative molecular phenotyping of gill remodeling in a cichlid fish responding to salinity stress
    Dietmar Kültz
    Physiological Genomics Group, Department of Animal Sciences, University of California Davis, One Shields Avenue, Davis, California 95616
    Mol Cell Proteomics 12:3962-75. 2013
    ....
  31. ncbi request reprint Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress
    Sally K Mak
    Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 279:39075-84. 2004
    ....
  32. ncbi request reprint Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cells
    Eun Kee Park
    Department of Entomology and Cancer Research Center, University of California, Davis, California, USA
    J Toxicol Environ Health A 70:2092-5. 2007
    ..The present study also establishes mIMCD3 cells as a valuable model for evaluation of cytotoxicity of nephrotoxic compounds...
  33. ncbi request reprint Ultrasound detection and characterization of polycystic kidney disease in a mouse model
    Rachel Pollard
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, USA
    Comp Med 56:215-21. 2006
    ..Cortical intensity is greater in jck versus WT mice and appears affected by percentage cyst area and mean cyst size...
  34. ncbi request reprint The physiological responses of green sturgeon (Acipenser medirostris) to potential global climate change stressors
    Brian A Sardella
    Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, California 95616
    Physiol Biochem Zool 87:456-63. 2014
    ..Sturgeon can acclimate to changes in salinity; however, salinity fluctuations resulted in substantial cellular stress...
  35. pmc Derivation and Osmotolerance Characterization of Three Immortalized Tilapia (Oreochromis mossambicus) Cell Lines
    Alison M Gardell
    Department of Animal Science, University of California Davis, Davis, California, United States of America
    PLoS ONE 9:e95919. 2014
    ..Therefore, the newly established tilapia cells lines represent valuable tools for studying molecular mechanisms involved in the osmotic stress response of euryhaline fish. ..
  36. ncbi request reprint Osmotic stress sensing and signaling in animals
    Dietmar Kültz
    Physiological Genomics Group, Department of Animal Science, University of California, Davis, CA, USA
    FEBS J 274:5781. 2007
  37. pmc In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens
    Ki Chang Ahn
    Department of Entomology and Cancer Research Center, University of California, Davis, Davis, CA 95616, USA
    Environ Health Perspect 116:1203-10. 2008
    ..Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects...

Research Grants6

  1. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2002
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  2. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2002
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  3. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2003
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  4. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2004
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  5. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2005
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  6. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2006
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..