C M Klinge

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Biol Chem 272:31465-74. 1997
  2. ncbi hsp70 is not required for high affinity binding of purified calf uterine estrogen receptor to estrogen response element DNA in vitro
    C M Klinge
    Department of Biochemistry, The University of Louisville School of Medicine, KY 40292, USA
    J Steroid Biochem Mol Biol 63:283-301. 1997
  3. ncbi Comparison of tamoxifen ligands on estrogen receptor interaction with estrogen response elements
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    Mol Cell Endocrinol 143:79-90. 1998
  4. ncbi The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    Mol Cell Endocrinol 157:105-19. 1999
  5. ncbi Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor (COUP-TF)
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    J Steroid Biochem Mol Biol 71:1-19. 1999
  6. ncbi Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta
    J L Bowers
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Kentucky 40292, USA
    Endocrinology 141:3657-67. 2000
  7. ncbi Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT)
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Arch Biochem Biophys 390:64-70. 2001
  8. ncbi Estrogen response element sequence impacts the conformation and transcriptional activity of estrogen receptor alpha
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Mol Cell Endocrinol 174:151-66. 2001
  9. ncbi Comparison of transcriptional synergy of estrogen receptors alpha and beta from multiple tandem estrogen response elements
    V V Tyulmenkov
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Mol Cell Endocrinol 165:151-61. 2000
  10. ncbi A mathematical approach to predict the affinity of estrogen receptors alpha and beta binding to DNA
    V V Tyulmenkov
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Mol Cell Endocrinol 182:109-19. 2001

Collaborators

Detail Information

Publications21

  1. ncbi Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Biol Chem 272:31465-74. 1997
    ....
  2. ncbi hsp70 is not required for high affinity binding of purified calf uterine estrogen receptor to estrogen response element DNA in vitro
    C M Klinge
    Department of Biochemistry, The University of Louisville School of Medicine, KY 40292, USA
    J Steroid Biochem Mol Biol 63:283-301. 1997
    ..Additionally, once ER is activated and bound by ligand, the receptor assumes its proper tertiary structure, and hsp70 does not impact ER ligand binding domain conformation...
  3. ncbi Comparison of tamoxifen ligands on estrogen receptor interaction with estrogen response elements
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    Mol Cell Endocrinol 143:79-90. 1998
    ..These findings indicate that the behavior of the ER liganded by TAM is generally similar to that of the antiestrogen 4-OHT...
  4. ncbi The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    Mol Cell Endocrinol 157:105-19. 1999
    ..We propose that at least part of the mechanism by which the AHR/ARNT complex inhibits estrogen action is by competitively inhibiting ER alpha binding to imperfect ERE sites, adjacent to or overlapping XREs...
  5. ncbi Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor (COUP-TF)
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    J Steroid Biochem Mol Biol 71:1-19. 1999
    ..We suggest that COUP-TFI plays a role in mitigating estrogen-responsive gene expression...
  6. ncbi Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta
    J L Bowers
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Kentucky 40292, USA
    Endocrinology 141:3657-67. 2000
    ..In contrast, resveratrol shows no E2 antagonist activity with ERbeta. These data indicate that resveratrol differentially affects the transcriptional activity of ERalpha and ERbeta in an ERE sequence-dependent manner...
  7. ncbi Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT)
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Arch Biochem Biophys 390:64-70. 2001
    ..SHP inhibited AHR/ARNT-DNA binding in vitro. These results identify ARNT as a novel SHP target. We speculate a role for SHP in the suppression of agonist-activated AHR/ARNT activity...
  8. ncbi Estrogen response element sequence impacts the conformation and transcriptional activity of estrogen receptor alpha
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Mol Cell Endocrinol 174:151-66. 2001
    ..Our results support the hypothesis that the ERE sequence acts as an allosteric effector, altering ER conformation. We speculate that ERE-induced alterations in ERalpha conformation modulate interaction with co-regulatory proteins...
  9. ncbi Comparison of transcriptional synergy of estrogen receptors alpha and beta from multiple tandem estrogen response elements
    V V Tyulmenkov
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Mol Cell Endocrinol 165:151-61. 2000
    ..We also postulate that interaction of ERalpha and ERbeta with coactivators may also play a role in transcriptional synergy...
  10. ncbi A mathematical approach to predict the affinity of estrogen receptors alpha and beta binding to DNA
    V V Tyulmenkov
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Mol Cell Endocrinol 182:109-19. 2001
    ..The equations developed here can be used to screen the promoters of estrogen-responsive genes for candidate ERE sequences...
  11. ncbi Estrogen receptors alpha and beta exhibit different estradiol and estrogen response element binding in the presence of nonspecific DNA
    V V Tyulmenkov
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Arch Biochem Biophys 390:253-64. 2001
    ..We speculate that interaction of ER with genomic DNA may contribute to ER activation and play a role in the observed differences in transcriptional activity of ER alpha and ER beta...
  12. pmc Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitro
    C M Klinge
    Department of Biochemistry, The University of Louisville School of Medicine, Louisville, KY 40292, USA
    Nucleic Acids Res 25:1903-12. 1997
    ....
  13. ncbi Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors
    C M Klinge
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Mol Endocrinol 33:387-410. 2004
    ..These data demonstrated that the ERE sequence impacts estradiol-and 4-hydroxytamoxifen-occupied ERalpha and ERbeta interaction with coregulators as measured by transcriptional activity in mammalian cells...
  14. ncbi The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1
    C M Klinge
    Department of Biochemistry, University of Louisville School of Medicine, Louisville, Kentucky, 40292, USA
    Arch Biochem Biophys 373:163-74. 2000
    ....
  15. ncbi Estrogen response element binding induces alterations in estrogen receptor-alpha conformation as revealed by susceptibility to partial proteolysis
    T L Ramsey
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Mol Endocrinol 27:275-92. 2001
    ..We hypothesize that ERE-induced alterations in ERalpha conformation modulate interaction with coregulatory proteins, resulting in synergistic transcriptional activation...
  16. ncbi Estrogen receptor binding to estrogen response elements slows ligand dissociation and synergistically activates reporter gene expression
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    Mol Cell Endocrinol 150:99-111. 1999
    ..Since the number of copies of EREc38 did not alter E2 dissociation kinetics, functional synergy must involve cellular factors in addition to the ER ligand...
  17. ncbi Selectivity of antibodies to estrogen receptors alpha and beta (ERalpha and ERbeta) for detecting DNA-bound ERalpha and ERbeta in vitro
    V V Tyulmenkov
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA
    Steroids 65:505-12. 2000
    ..We conclude that a cognate ER antibody that retards the migration of the ER-ERE complex by at least 40% or inhibits ER-ERE interaction by at least 8% provides a reliable detection of a specific ER isoform in EMSA...
  18. pmc Estrogen receptor interaction with estrogen response elements
    C M Klinge
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Nucleic Acids Res 29:2905-19. 2001
    ....
  19. ncbi Response element sequence modulates estrogen receptor alpha and beta affinity and activity
    P C Kulakosky
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Mol Endocrinol 29:137-52. 2002
    ....
  20. ncbi Regulation of estrogenic and nuclear factor kappa B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells
    N Shah
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, NJ 08903, USA
    Oncogene 20:1715-29. 2001
    ..Our results with BE-3-4-3 and BE-3-3-3 suggest that down-regulation of ER alpha- and NF-kappa B-regulated genes is a possible mechanism for the action of polyamine analogs in inducing apoptosis of breast cancer cells...
  21. ncbi Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells
    J S Lewis
    Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08903, USA
    J Mol Endocrinol 27:293-307. 2001
    ..These results show that 16alpha-OHE(1) is a potent estrogen capable of accelerating cell cycle kinetics and stimulating the expression of cell cycle regulatory proteins...