Michele Klingbeil

Summary

Affiliation: University of Massachusetts
Country: USA

Publications

  1. doi request reprint Unraveling the secrets of regulating mitochondrial DNA replication
    Michele M Klingbeil
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    Mol Cell 35:398-400. 2009
  2. pmc Closing the gaps in kinetoplast DNA network replication
    Michele M Klingbeil
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    Proc Natl Acad Sci U S A 101:4333-4. 2004
  3. pmc Stem-loop silencing reveals that a third mitochondrial DNA polymerase, POLID, is required for kinetoplast DNA replication in trypanosomes
    Julian Chandler
    Department of Microbiology, University of Massachusetts, 639 North Pleasant Street, Amherst, MA 01003, USA
    Eukaryot Cell 7:2141-6. 2008
  4. doi request reprint Mitochondrial DNA polymerase POLIB is essential for minicircle DNA replication in African trypanosomes
    David F Bruhn
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    Mol Microbiol 75:1414-25. 2010
  5. pmc Three mitochondrial DNA polymerases are essential for kinetoplast DNA replication and survival of bloodstream form Trypanosoma brucei
    David F Bruhn
    Department of Microbiology, University of Massachusetts, 639 North Pleasant Street, Amherst, MA 01003, USA
    Eukaryot Cell 10:734-43. 2011

Research Grants

  1. Trypanosomatid Mitochondrial DNA Polymerases
    Michele Klingbeil; Fiscal Year: 2007

Collaborators

  • PAUL ENGLUND
  • David F Bruhn
  • Brian Mozeleski
  • Julian Chandler
  • Mark P Sammartino
  • Laurie Falkin
  • Anthula V Vandoros

Detail Information

Publications5

  1. doi request reprint Unraveling the secrets of regulating mitochondrial DNA replication
    Michele M Klingbeil
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    Mol Cell 35:398-400. 2009
    ..In this issue, Liu et al. (2009) report that maxicircle DNA copy number in trypanosomes is regulated by proteolysis of a helicase; the complex kinetoplast DNA system yields a clear view of how mitochondrial DNA replication can be regulated...
  2. pmc Closing the gaps in kinetoplast DNA network replication
    Michele M Klingbeil
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    Proc Natl Acad Sci U S A 101:4333-4. 2004
  3. pmc Stem-loop silencing reveals that a third mitochondrial DNA polymerase, POLID, is required for kinetoplast DNA replication in trypanosomes
    Julian Chandler
    Department of Microbiology, University of Massachusetts, 639 North Pleasant Street, Amherst, MA 01003, USA
    Eukaryot Cell 7:2141-6. 2008
    ..While other eukaryotes utilize a single DNA Pol (Pol gamma) for replication of mitochondrial DNA, T. brucei requires at least three to maintain the complex kDNA network...
  4. doi request reprint Mitochondrial DNA polymerase POLIB is essential for minicircle DNA replication in African trypanosomes
    David F Bruhn
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    Mol Microbiol 75:1414-25. 2010
    ..Based on these data, we propose that POLIB performs an essential role at the core of the minicircle replication machinery...
  5. pmc Three mitochondrial DNA polymerases are essential for kinetoplast DNA replication and survival of bloodstream form Trypanosoma brucei
    David F Bruhn
    Department of Microbiology, University of Massachusetts, 639 North Pleasant Street, Amherst, MA 01003, USA
    Eukaryot Cell 10:734-43. 2011
    ....

Research Grants4

  1. Trypanosomatid Mitochondrial DNA Polymerases
    Michele Klingbeil; Fiscal Year: 2007
    ..The T. brucei pol I-like protein family also offers the unique opportunity to uncover insights into the evolutionary strategies used to produce a replicative polymerase. ..