ANTHONY KLINE

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Evaluation of a combined treatment paradigm consisting of environmental enrichment and the 5-HT1A receptor agonist buspirone after experimental traumatic brain injury
    Anthony E Kline
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurotrauma 29:1960-9. 2012
  2. ncbi request reprint Bromocriptine reduces lipid peroxidation and enhances spatial learning and hippocampal neuron survival in a rodent model of focal brain trauma
    Anthony E Kline
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 21:1712-22. 2004
  3. ncbi request reprint The therapeutic efficacy conferred by the 5-HT(1A) receptor agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) after experimental traumatic brain injury is not mediated by concomitant hypothermia
    Anthony E Kline
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 21:175-85. 2004
  4. pmc Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Behav Brain Res 177:186-94. 2007
  5. pmc Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurosci Lett 448:263-7. 2008
  6. pmc Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 27:2021-32. 2010
  7. ncbi request reprint Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats
    Anthony E Kline
    Department of Neurological Surgery and Brain Trauma Research Center, University of Pittsburgh, 3434 Fifth Avenue, Suite 201, Pittsburgh, PA 15260, USA
    Brain Res 937:22-31. 2002
  8. pmc Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience
    Ann N Hoffman
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Neurosci Lett 431:226-30. 2008
  9. pmc A delayed and chronic treatment regimen with the 5-HT1A receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning
    Jeffrey P Cheng
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Behav Brain Res 194:79-85. 2008
  10. pmc Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury
    Christopher N Sozda
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 27:1047-57. 2010

Collaborators

Detail Information

Publications25

  1. pmc Evaluation of a combined treatment paradigm consisting of environmental enrichment and the 5-HT1A receptor agonist buspirone after experimental traumatic brain injury
    Anthony E Kline
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurotrauma 29:1960-9. 2012
    ..The evaluation of buspirone in a delayed-and-abbreviated EE paradigm is ongoing in our laboratory...
  2. ncbi request reprint Bromocriptine reduces lipid peroxidation and enhances spatial learning and hippocampal neuron survival in a rodent model of focal brain trauma
    Anthony E Kline
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 21:1712-22. 2004
    ..44 +/- 0.44 versus 6.96 +/- 0.77). These findings suggest that TBI-induced oxidative stress is attenuated by acute BRO treatment, which may, in part, explain the benefit in cognitive and histological outcome...
  3. ncbi request reprint The therapeutic efficacy conferred by the 5-HT(1A) receptor agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) after experimental traumatic brain injury is not mediated by concomitant hypothermia
    Anthony E Kline
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 21:175-85. 2004
    ..The mechanisms for the protective effects of 8-OH-DPAT after TBI require further inquiry...
  4. pmc Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Behav Brain Res 177:186-94. 2007
    ..One explanation for the lack of an additive effect is that EE is a very effective treatment and thus there is very little room for 8-OH-DPAT to confer additional statistically significant improvement...
  5. pmc Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurosci Lett 448:263-7. 2008
    ..These data indicate that chronic administration of RISP and HAL impede behavioral recovery after TBI and impair performance in uninjured controls...
  6. pmc Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 27:2021-32. 2010
    ..The findings underscore the complexity of combinational therapies and of elucidating potential targets for TBI...
  7. ncbi request reprint Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats
    Anthony E Kline
    Department of Neurological Surgery and Brain Trauma Research Center, University of Pittsburgh, 3434 Fifth Avenue, Suite 201, Pittsburgh, PA 15260, USA
    Brain Res 937:22-31. 2002
    ..Rather, IL-10 administration suppressed the beneficial effects produced by hypothermia alone after TBI. The mechanism(s) for the negative effects of IL-10 combined with hypothermia after TBI remain to be determined...
  8. pmc Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience
    Ann N Hoffman
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Neurosci Lett 431:226-30. 2008
    ..These data suggest that EE-mediated functional improvement after TBI is contingent on task-specific neurobehavioral experience...
  9. pmc A delayed and chronic treatment regimen with the 5-HT1A receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning
    Jeffrey P Cheng
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Behav Brain Res 194:79-85. 2008
    ..A delayed and chronic treatment regimen may be more clinically feasible...
  10. pmc Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury
    Christopher N Sozda
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 27:1047-57. 2010
    ..These data suggest that exposing TBI rats to any of the three components individually may be more advantageous than no enrichment, but only exposure to typical EE yields optimal benefits...
  11. pmc Administration of haloperidol and risperidone after neurobehavioral testing hinders the recovery of traumatic brain injury-induced deficits
    Ann N Hoffman
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Life Sci 83:602-7. 2008
    ..Hence, the current study reevaluated the behavioral effects of haloperidol and risperidone when provided after daily testing, thus circumventing the potential sedative effect...
  12. pmc Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:919-24. 2007
    ..To clarify the issue, the present study evaluated the effect of single and multiple administrations of haloperidol and risperidone on functional outcome after traumatic brain injury...
  13. ncbi request reprint Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact
    Anthony E Kline
    The Brain Trauma Research Center, Department of Neurosurgery, University of Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 19:415-25. 2002
    ..These data reveal that CCI produces working memory deficits in rats that are similar to those observed following FP, and that the delayed and chronic bromocriptine treatment regimen conferred cognitive and neural protection after TBI...
  14. pmc Gel-based hippocampal proteomic analysis 2 weeks following traumatic brain injury to immature rats using controlled cortical impact
    Ashley R Kochanek
    Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Dev Neurosci 28:410-9. 2006
    ....
  15. ncbi request reprint Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats
    Anthony E Kline
    Department of Physical Medicine and Rehabilitation, 201 Lillian Kaufmann Building, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurosci Lett 333:179-82. 2002
    ..vehicle (P < 0.05). These data augment published reports that 5-HT(1A) receptor agonists confer neuroprotective effects after experimental TBI...
  16. ncbi request reprint Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, 3471 5th Avenue, Kaufmann Building, Suite 201, University of Pittsburgh, Pittsburgh, PA, USA
    Neurosci Lett 334:165-8. 2002
    ..EE did not impact motor performance in this setting. These findings have gender specific implications for how to approach and evaluate treatments and interventions after TBI...
  17. ncbi request reprint Acute etomidate treatment reduces cognitive deficits and histopathology in rats with traumatic brain injury
    C Edward Dixon
    Department of Neurological Surgery and Safar Center for Resuscitation Research, University of Pittsburgh, PA 15260, USA
    Crit Care Med 31:2222-7. 2003
    ..To test the hypothesis that etomidate treatment improves functional, cognitive, and histologic outcome after experimental traumatic brain injury...
  18. ncbi request reprint Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 201 Pittsburgh, PA 15213, USA
    Brain Res 998:113-21. 2004
    ..The impact of early neuroprotection on later behavioral outcome and the anatomic structural specificity of hormonal neuroprotection require further study...
  19. pmc Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
    Behav Brain Res 181:200-9. 2007
    ..However there are gender specific drug differences in behavioral performance and sensitivity to treatment with MPH that may have implications for treatment efficacy and dosing clinically after TBI...
  20. pmc The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window
    Jeffrey P Cheng
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neurosci Lett 416:165-8. 2007
    ..The critical window corresponds to the well documented TBI-induced glutamate increase, suggesting that 8-OH-DPAT may be conferring neuroprotection by attenuating this acute deleterious surge...
  21. ncbi request reprint Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 195:475-83. 2005
    ..These findings may have some relevance to treatment paradigms using dopaminergic neurostimulants after TBI...
  22. pmc Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis
    James W Bales
    Brain Trauma Research Center, University of Pittsburgh, PA 15260, USA
    Neurosci Biobehav Rev 33:981-1003. 2009
    ....
  23. ncbi request reprint Traumatic brain injury reduces dopamine transporter protein expression in the rat frontal cortex
    Hong Qu Yan
    Departments of Neurological Surgery, The Safar Center for Resuscitation Research, University of Pittsburgh, 200 Lothrop Street, Suite B 400, Pittsburgh, PA 15213, USA
    Neuroreport 13:1899-901. 2002
    ..The decrease in dopamine transporter protein levels may reflect a traumatic brain-injury-induced down-regulation of dopamine transporter and/or a loss of dopaminergic fibers...
  24. pmc Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats
    Wei Min Gao
    Neurological Surgery, U Pittsburgh, Pittsburgh, PA 15260, USA
    Brain Res 1070:31-4. 2006
    ..Decreased histone H3 acetylation and methylation suggest altered hippocampal CA3 epigenetic signaling during the first hours to days after TBI...
  25. ncbi request reprint Time dependent alterations in dopamine tissue levels and metabolism after experimental traumatic brain injury in rats
    Jaime L Massucci
    Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Neurosci Lett 372:127-31. 2004
    ..DA and DOPAC levels were significantly increased bilaterally at 1h in the striatum versus sham. These data indicate that TBI induces an early increase in DA and DOPAC, which returns to sham levels over time...

Research Grants7

  1. Environmental Enrichment and Cholinergic Mechanisms after TBI
    Anthony E Kline; Fiscal Year: 2010
    ..The outcome has the potential to provide a novel treatment strategy for rehabilitation of TBI patients. ..
  2. Interaction of Serotonin & Cholinergic Systems After TBI
    ANTHONY KLINE; Fiscal Year: 2004
    ..The long-term goal is to develop pharmacotherapies that attenuate posttraumatic neuronal cell death and facilitate cognitive performance after human TBI. ..
  3. Novel Rehabilitative Approaches for Recovery from TBI
    ANTHONY KLINE; Fiscal Year: 2007
    ..Our long-term goal is to develop therapies that facilitate functional recovery after human TBI. ..
  4. Environmental Enrichment and Cholinergic Mechanisms after TBI
    ANTHONY KLINE; Fiscal Year: 2009
    ..The outcome has the potential to provide a novel treatment strategy for rehabilitation of TBI patients. ..
  5. Environmental Enrichment and Cholinergic Mechanisms after TBI
    ANTHONY KLINE; Fiscal Year: 2009
    ..The outcome has the potential to provide a novel treatment strategy for rehabilitation of TBI patients. ..