Steven Kliewer

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Regulation of bile acid synthesis by fat-soluble vitamins A and D
    Daniel R Schmidt
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    J Biol Chem 285:14486-94. 2010
  2. pmc The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    Yuan Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States
    elife 1:e00065. 2012
  3. pmc Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo
    Serkan Kir
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41334-41. 2012
  4. pmc FGF21 contributes to neuroendocrine control of female reproduction
    Bryn M Owen
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 19:1153-6. 2013
  5. pmc Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus
    Stan D Atkin
    Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND9 124, Dallas, Texas 75390 9041, USA
    Mol Endocrinol 27:598-605. 2013
  6. ncbi request reprint Pregnane X receptor: predicting and preventing drug interactions
    Steven A Kliewer
    Departments of Molecular Biology and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Thromb Res 117:133-6; discussion 145-51. 2005
  7. ncbi request reprint Anthrax mounts a nuclear attack on glucocorticoid signaling
    Steven A Kliewer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Trends Pharmacol Sci 24:558-9. 2003
  8. ncbi request reprint The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
    Steven A Kliewer
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 23:687-702. 2002
  9. ncbi request reprint The nuclear pregnane X receptor regulates xenobiotic detoxification
    Steven A Kliewer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8594, USA
    J Nutr 133:2444S-2447S. 2003
  10. pmc Fibroblast growth factor 21: from pharmacology to physiology
    Steven A Kliewer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 73590 9041, USA
    Am J Clin Nutr 91:254S-257S. 2010

Research Grants

Collaborators

Detail Information

Publications54

  1. pmc Regulation of bile acid synthesis by fat-soluble vitamins A and D
    Daniel R Schmidt
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    J Biol Chem 285:14486-94. 2010
    ..These results reveal an unexpected link between the intake of fat-soluble vitamins A and D and bile acid metabolism, which may have evolved as a means for these dietary vitamins to regulate their own absorption...
  2. pmc The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    Yuan Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States
    elife 1:e00065. 2012
    ..These findings raise the possibility that FGF21 can be used to extend lifespan in other species.DOI:http://dx.doi.org/10.7554/eLife.00065.001...
  3. pmc Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo
    Serkan Kir
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41334-41. 2012
    ..These findings demonstrate that both HNF4α and LRH-1 are important regulators of Cyp7a1 transcription in vivo...
  4. pmc FGF21 contributes to neuroendocrine control of female reproduction
    Bryn M Owen
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 19:1153-6. 2013
    ..Thus, FGF21 defines an important liver-neuroendocrine axis that modulates female reproduction in response to nutritional challenge. ..
  5. pmc Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus
    Stan D Atkin
    Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND9 124, Dallas, Texas 75390 9041, USA
    Mol Endocrinol 27:598-605. 2013
    ..These studies provide a molecular basis for the differential regulation of basal kisspeptin expression in Arc and AVPV neurons and reveal a prominent role for LRH-1 in hypothalamus in regulating the female reproductive axis...
  6. ncbi request reprint Pregnane X receptor: predicting and preventing drug interactions
    Steven A Kliewer
    Departments of Molecular Biology and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Thromb Res 117:133-6; discussion 145-51. 2005
  7. ncbi request reprint Anthrax mounts a nuclear attack on glucocorticoid signaling
    Steven A Kliewer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Trends Pharmacol Sci 24:558-9. 2003
    ..Thus, these findings suggest that glucocorticoid receptor inactivation contributes to anthrax toxicity and raise the possibility of developing new strategies to combat this deadly disease...
  8. ncbi request reprint The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
    Steven A Kliewer
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 23:687-702. 2002
    ..Thus, assays that detect PXR activity will be useful in developing safer prescription drugs...
  9. ncbi request reprint The nuclear pregnane X receptor regulates xenobiotic detoxification
    Steven A Kliewer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8594, USA
    J Nutr 133:2444S-2447S. 2003
    ..John's wort represents the molecular basis for an important class of drug-drug interactions. Assays that detect PXR activation can now be used to predict and prevent these drug-drug interactions...
  10. pmc Fibroblast growth factor 21: from pharmacology to physiology
    Steven A Kliewer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 73590 9041, USA
    Am J Clin Nutr 91:254S-257S. 2010
    ..This article highlights recent advances in our understanding of FGF21's pharmacologic and physiologic actions...
  11. pmc Cholesterol detoxification by the nuclear pregnane X receptor
    Steven A Kliewer
    Departmens of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Proc Natl Acad Sci U S A 102:2675-6. 2005
  12. ncbi request reprint Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors
    Linda B Moore
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 16:977-86. 2002
    ..Modeling studies suggest that the H1-3 insert contributes to the promiscuity of the PXRs by facilitating the unwinding of helices-6 and -7, thereby expanding the ligand binding pocket...
  13. ncbi request reprint Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
    Jodi M Maglich
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 62:638-46. 2002
    ..These findings underscore the importance of these two nuclear receptors in defending the body against a broad array of potentially harmful xenobiotics...
  14. pmc Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
    Bryan Goodwin
    Nuclear Receptor Discovery Research, GlaxoSmithKline Inc, Five Moore Drive, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 100:223-8. 2003
    ..In addition, this study demonstrates that animal models with alterations in gene expression can be used to identify endogenous ligands for orphan nuclear receptors...
  15. ncbi request reprint Regulation of cyp3a gene transcription by the pregnane x receptor
    Bryan Goodwin
    Nuclear Receptor Systems Research, GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA
    Annu Rev Pharmacol Toxicol 42:1-23. 2002
    ..On the other hand, PXR agonists may prove useful in the treatment of diseases in which toxic metabolites accumulate, such as cholestatic liver disease...
  16. pmc Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
    Jason A Holt
    Nuclear Receptor Discovery Research, High Throughput Biology, Gene Interference, Transgenics, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Genes Dev 17:1581-91. 2003
    ..This signaling cascade defines a novel mechanism for feedback repression of bile acid biosynthesis and underscores the vital role of FXR in the regulation of multiple pathways of cholesterol catabolism in the liver...
  17. ncbi request reprint CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans
    Timothy K Tippin
    Drug Metabolism and Pharmacokinetics Department, Metabolic and Viral Diseases Center of Excellence in Drug Discovery, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Drug Metab Dispos 31:870-7. 2003
    ..In conclusion, GW3333 is a potential inducer of CYP3A expression in vivo in humans, but other N-hydroxyformamides are less likely to induce CYP3A...
  18. pmc FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    Matthew J Potthoff
    Department of Pharmacology, Howard Hughes Medical Institute, Advanced Imaging Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:10853-8. 2009
    ..These results reveal an unexpected relationship between FGF21 and PGC-1alpha and demonstrate an important role for FGF21 in coordinately regulating carbohydrate and fatty acid metabolism during the progression from fasting to starvation...
  19. ncbi request reprint Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 2:217-25. 2005
    ..These studies define FGF15 and FGFR4 as components of a gut-liver signaling pathway that synergizes with SHP to regulate bile acid synthesis...
  20. ncbi request reprint Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
    Steven A Kliewer
    Nuclear Receptor Discovery Research, GlaxoSmithKline, 5 Moore Drive, Room V118 1B, Research Triangle Park, NC 27709, USA
    J Lipid Res 43:359-64. 2002
    ....
  21. ncbi request reprint PXR, CAR and drug metabolism
    Timothy M Willson
    GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709, USA
    Nat Rev Drug Discov 1:259-66. 2002
    ..In this review, we provide an examination of the roles of PXR and CAR as xenobiotic sensors, and discuss the application of this knowledge to toxicological screening in drug discovery...
  22. ncbi request reprint FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption
    Diana Jung
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    J Lipid Res 48:2693-700. 2007
    ..These findings suggest that FXR agonists or FGF15 could be used therapeutically to interrupt the cycle of excessive bile acid production in patients with bile acid malabsorption...
  23. ncbi request reprint Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates
    Stacey A Jones
    Department of Nuclear Receptor Functional Analysis, High Throughput Biology, GlaxoSmithKline, Inc, Research Triangle Park, North Carolina 27709, USA
    Methods Enzymol 357:161-70. 2002
  24. pmc Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:3920-5. 2006
    ....
  25. pmc Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis
    Youn Kyoung Lee
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Mol Endocrinol 22:1345-56. 2008
    ..Taken together, these data reveal a broad role for LRH-1 in regulating bile acid homeostasis but demonstrate that LRH-1 is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors...
  26. ncbi request reprint Nuclear receptor regulation of genes involved in bile acid metabolism
    John T Moore
    GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Crit Rev Eukaryot Gene Expr 12:119-35. 2002
    ..These studies highlight the dynamic interplay between nuclear receptors in the regulation of specific metabolic pathways...
  27. pmc Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism
    Santhosh Satapati
    The Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diabetes 57:2012-21. 2008
    ..The purpose of this study is to determine whether abnormal mitochondrial metabolism plays a role in the dysregulation of both hepatic fat and glucose metabolism during diabetes...
  28. pmc Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 8:77-83. 2008
    ..Chronic exposure to FGF21 markedly inhibits growth in mice. These data suggest a central role for FGF21 in inhibiting growth as part of its broader role in inducing the adaptive response to starvation...
  29. ncbi request reprint Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
    ..These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation...
  30. ncbi request reprint Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
    Jodi M Maglich
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:17277-83. 2003
    ..Notably, CAR and PXR activators differentially regulated the expression of several genes, demonstrating that these two nuclear receptors subserve overlapping but distinct biological functions in human hepatocytes...
  31. ncbi request reprint Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha
    H Eric Xu
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Nature 415:813-7. 2002
    ..Biochemical analyses and structure-based mutagenesis indicate that this mode of co-repressor binding is highly conserved across nuclear receptors...
  32. ncbi request reprint Nuclear receptors. I. Nuclear receptors and bile acid homeostasis
    Bryan Goodwin
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Gastrointest Liver Physiol 282:G926-31. 2002
    ..A greater understanding of these receptors should afford novel opportunities for therapeutic intervention in chronic diseases such as cholestasis and dyslipidemia...
  33. ncbi request reprint Cell-free ligand binding assays for nuclear receptors
    Stacey A Jones
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709 3398, USA
    Methods Enzymol 364:53-71. 2003
    ....
  34. pmc Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
    Yaping Liu
    Nuclear Receptor Functional Analysis, High Thruput Biology, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 112:1678-87. 2003
    ..The hepatoprotection seen in these animal models by the synthetic FXR agonist suggests FXR agonists may be useful in the treatment of cholestatic liver disease...
  35. ncbi request reprint Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha
    Bryan Goodwin
    Nuclear Receptor Discovery Research, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:386-94. 2003
    ..Our data reveal a fundamental difference in the regulation of CYP7A1 in rodent and human hepatocytes and provide evidence that different species employ distinct molecular strategies to regulate cholesterol homeostasis...
  36. ncbi request reprint Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system
    Karl D Whitney
    GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 16:1378-85. 2002
    ....
  37. ncbi request reprint Identification of a hormonal basis for gallbladder filling
    Mihwa Choi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Med 12:1253-5. 2006
    ..These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility...
  38. pmc Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    Hiroshi Kurosu
    Departments of Pathology and Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Biol Chem 282:26687-95. 2007
    ..We conclude that the expression of betaKlotho, in combination with particular FGFR isoforms, determines the tissue-specific metabolic activities of FGF19 and FGF21...
  39. pmc Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes
    Zhu Wang
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:9138-43. 2009
    ..stercoralis DAF-12 ligand-binding domain cocrystallized with dafachronic acids. These results reveal the molecular basis for DAF-12 ligand binding and identify nuclear receptors as unique therapeutic targets in parasitic nematodes...
  40. pmc MicroRNA let-7 regulates 3T3-L1 adipogenesis
    Tingwan Sun
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390 9050, USA
    Mol Endocrinol 23:925-31. 2009
    ..These results suggest that let-7 plays an important role in adipocyte differentiation and that it does so in part by targeting HMGA2, thereby regulating the transition from clonal expansion to terminal differentiation...
  41. pmc Weaving betaKlotho into bile acid metabolism
    Antonio Moschetta
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Clin Invest 115:2075-7. 2005
    ..These findings highlight the central role of betaKlotho in bile acid homeostasis and raise the possibility that this protein could be a pharmacologic target for the treatment of gallstones...
  42. ncbi request reprint Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines
    Jon L Collins
    J Med Chem 45:1963-6. 2002
    ..12 will be a valuable chemical tool to investigate the role of LXR in the regulation of reverse cholesterol transport and lipid metabolism...
  43. ncbi request reprint 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin
    Ryan E Watkins
    Department of Chemistry, The University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Biochemistry 42:1430-8. 2003
    ....
  44. ncbi request reprint Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    Grace L Guo
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45062-71. 2003
    ..Furthermore, FXR, PXR, and CAR protect against hepatic bile acid toxicity in a complementary manner, suggesting that they serve as redundant but distinct layers of defense to prevent overt hepatic damage by bile acids during cholestasis...
  45. ncbi request reprint Enhanced acetaminophen toxicity by activation of the pregnane X receptor
    Grace L Guo
    Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA
    Toxicol Sci 82:374-80. 2004
    ..Thus, these results suggest that PXR plays a critical role in APAP-induced hepatic toxicity, probably by inducing CYP3A11 expression and hence increasing bioactivation...
  46. pmc Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner
    Yong Li
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 102:9505-10. 2005
    ..These results establish a structural model for understanding how SHP interacts with LRH-1 to regulate cholesterol homeostasis and provide new insights into how nuclear receptor/coregulator selectivity is achieved...
  47. pmc Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development
    Peili Gu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:3492-505. 2005
    ....
  48. ncbi request reprint Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1
    Yong Li
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA
    Mol Cell 17:491-502. 2005
    ..These findings provide evidence that SF-1 is regulated by endogenous ligands and suggest an unexpected relationship between phospholipids and endocrine development and function...
  49. ncbi request reprint Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    Insook Kim
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 48:2664-72. 2007
    ..These data provide evidence that FXR-mediated repression of bile acid synthesis requires the complementary actions of FXR in both liver and intestine and reveal mechanistic differences in feedback repression of CYP7A1 and CYP8B1...
  50. ncbi request reprint The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization
    Kelly Suino
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA
    Mol Cell 16:893-905. 2004
    ..These structural observations provide a molecular framework for understanding the atypical transcriptional activation properties of CAR...
  51. ncbi request reprint International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor
    David D Moore
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Pharmacol Rev 58:742-59. 2006
    ..This review summarizes results of structural, pharmacologic, and genetic studies of these receptors...
  52. ncbi request reprint Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition
    Yu Xue
    Department of Chemistry, CB 3290, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    Mol Endocrinol 21:1028-38. 2007
    ..The results provide detailed insights into the manner in which human PXR responds to a wide range of endobiotic compounds...
  53. ncbi request reprint Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells
    Deborah M Muoio
    Department of Medicine and Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diabetes 51:901-9. 2002
    ..These results demonstrate a role for hPPAR-alpha in regulating muscle lipid homeostasis...
  54. ncbi request reprint Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin
    Jill E Chrencik
    Department of Chemistry, Campus Box 3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Mol Endocrinol 19:1125-34. 2005
    ..These observations highlight the key role that structural flexibility plays in PXR's promiscuous response to xenobiotics...

Research Grants11

  1. Protection of Intestine by the Bile Acid Receptor FXR
    Steven Kliewer; Fiscal Year: 2007
    ..abstract_text> ..
  2. Bile Acid and Estrogen Receptors in Colon Cancer
    Steven Kliewer; Fiscal Year: 2009
    ..Moreover, since both FXR and ERbeta can be regulated by small molecule ligands, these studies may reveal novel opportunities for treating and preventing colon cancer. ..
  3. Regulation of Metabolism by the Hormone FGF15/19
    Steven A Kliewer; Fiscal Year: 2010
    ..Insights from these studies may provide new clinical strategies for treating obesity, diabetes, and other forms of metabolic disease. ..
  4. Protection of Intestine by the Bile Acid Receptor FXR
    Steven Kliewer; Fiscal Year: 2004
    ..abstract_text> ..
  5. Regulation of Metabolism by the Hormone FGF15/19
    Steven Kliewer; Fiscal Year: 2009
    ..Insights from these studies may provide new clinical strategies for treating obesity, diabetes, and other forms of metabolic disease. ..
  6. Bile Acid and Estrogen Receptors in Colon Cancer
    Steven Kliewer; Fiscal Year: 2007
    ..Moreover, since both FXR and ERbeta can be regulated by small molecule ligands, these studies may reveal novel opportunities for treating and preventing colon cancer. ..
  7. Bile Acid and Estrogen Receptors in Colon Cancer
    Steven Kliewer; Fiscal Year: 2006
    ..Moreover, since both FXR and ERbeta can be regulated by small molecule ligands, these studies may reveal novel opportunities for treating and preventing colon cancer. ..
  8. Protection of Intestine by the Bile Acid Receptor FXR
    Steven Kliewer; Fiscal Year: 2006
    ..abstract_text> ..
  9. Protection of Intestine by the Bile Acid Receptor FXR
    Steven Kliewer; Fiscal Year: 2005
    ..abstract_text> ..