Research Topics
Species | B K Kleinschmidt-DemastersSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
An algorithmic approach to the brain biopsy--part IB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B216, Denver, CO 80262, USA
Arch Pathol Lab Med 130:1630-8. 2006..They can assist pathologists-in-training in developing orderly, sequential, and logical thinking skills when confronting difficult cases...- Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous systemB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center and The Denver Veterans Administration Hospital, 80262, USA
Brain Pathol 11:452-64. 2001..This review focuses on the use of PCR tests to diagnose HSV and VZV infections of the nervous system... - Glioblastomas in the older oldB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Arch Pathol Lab Med 129:624-31. 2005..However, testing has not been conducted on significant numbers of patients of very advanced age, in whom these features might be expected to emerge as even more significant factors... - Molecular array analyses of 51 pediatric tumors shows overlap between malignant intracranial ectomesenchymoma and MPNST but not medulloblastoma or atypical teratoid rhabdoid tumorB K Kleinschmidt-Demasters
University of Colorado at Denver and Health Science Center, 4200 East Ninth Avenue, B 216, Denver, CO 80262, USA
Acta Neuropathol 113:695-703. 2007..This suggests a common stem cell origin or embryonic gene recapitulation for these tumors and provides novel insights into their underlying biology... - Gamna-Gandy bodies in surgical neuropathology specimens: observations and a historical noteB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
J Neuropathol Exp Neurol 63:106-12. 2004..Since 1999 I have accrued all the examples of G-G bodies that I have observed in my practice of surgical neuropathology. These cases are presented here and the historical aspects of the entity are reviewed... - Characterization of glioblastomas in young adultsB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Brain Pathol 16:273-86. 2006..GBMs in young adults are a more inhomogeneous tumor group than GBMs occurring in older adult patients and show features that overlap with both pediatric and adult GBMs... 
Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medicationsB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
J Neuropathol Exp Neurol 67:1103-11. 2008....- Central and extrapontine myelinolysis: then...and nowB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neuropathol Exp Neurol 65:1-11. 2006..Yet, in many respects, this expansion of information over the past nearly 50 years simply represents a continuum, as well as recognition, of the vast gaps that still persist in our understanding of this disorder... - Overlapping features of extrapontine myelinolysis and acquired chronic (non-Wilsonian) hepatocerebral degenerationB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
Acta Neuropathol 112:605-16. 2006..We concluded that there was a synergism between the two disorders and raise the possibility that there may be factors common to both disorders that lead to similar anatomic sites for involvement... - Dural metastases. A retrospective surgical and autopsy seriesB K Kleinschmidt-Demasters
Departments of Pathology and Neurology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
Arch Pathol Lab Med 125:880-7. 2001..Some surgical patients have experienced prolonged postoperative survival... - Varicella-Zoster virus infections of the nervous system: clinical and pathologic correlatesB K Kleinschmidt-Demasters
Department of Pathology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
Arch Pathol Lab Med 125:770-80. 2001..Among the most diverse disorders caused by a single known toxic, metabolic, neoplastic, or infectious agent are the central and peripheral nervous system complications of varicella-zoster virus (VZV)... - The expanding spectrum of herpesvirus infections of the nervous systemB K Kleinschmidt-Demasters
Department of Neurology, The University of Colorado Health Sciences Center, Denver 80262, USA
Brain Pathol 11:440-51. 2001.... - Radiation-induced glioblastoma multiforme in children treated for medulloblastoma with characteristics of both medulloblastoma and glioblastoma multiformeJennifer R Madden
Department of Neuro Oncology, The Children s Hospital, Aurora, CO 80045, USA
J Pediatr Hematol Oncol 32:e272-8. 2010..We recommend biopsy for tissue confirmation and genetic expression profile to shed light on the etiology of radiation-induced neoplasms... 
Impact of rituximab-associated B-cell defects on West Nile virus meningoencephalitis in solid organ transplant recipientsMarilyn E Levi
Division of Infectious Diseases, Department of Internal Medicine, University of Colorado Denver, Anschutz Medical Campus, Denver, CO 80045, USA
Clin Transplant 24:223-8. 2010..She experienced a rapidly progressive and devastating neurological course despite treatment and died three wk after onset of her symptoms. Autopsy revealed extensive meningoencephalomyelitis...- Clinical and molecular characteristics of congenital glioblastomaMargaret E Macy
Department of Pediatrics, University of Colorado, Denver, CO, USA
Neuro Oncol 14:931-41. 2012..Further study may determine whether identified gene expression differences contribute to the improved survival seen in these tumors... - Phase I trial of hypofractionated intensity-modulated radiotherapy with temozolomide chemotherapy for patients with newly diagnosed glioblastoma multiformeChanghu Chen
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Int J Radiat Oncol Biol Phys 81:1066-74. 2011..To determine the maximal tolerated biologic dose intensification of radiotherapy using fractional dose escalation with temozolomide (TMZ) chemotherapy in patients with newly diagnosed glioblastoma multiforme... - Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosisD H Gilden
Department of Neurology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Mail Stop B182, Denver, CO 80262, USA
Arch Neurol 58:43-8. 2001..New sophisticated molecular immunologic techniques described herein should enhance our ability to identify putative antigen(s) targets in MS... - Unique molecular characteristics of radiation-induced glioblastomaAndrew M Donson
Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
J Neuropathol Exp Neurol 66:740-9. 2007..Western blot analyses confirmed that ErbB3, Sox10, and platelet-derived growth factor receptor-alpha proteins were consistently expressed in RIGs but rarely in pediatric GBMs... - Radiation-induced meningiomas: clinical, cytogenetic, and microarray featuresKevin O Lillehei
Department of Neurosurgery, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
Acta Neuropathol 116:289-301. 2008..Of note, NF2 was under-expressed in four of five RIMs (P = 0.0065), at a similar level as measured in MEN... - An adult case of leukoencephalopathy with intracranial calcifications and cystsJohn R Corboy
Department of Neurology, Box B 183, University of Colorado at Denver and Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
Neurology 67:1890-2. 2006..Pathologic features on biopsy included angiomatous-like blood vessels, intense gliosis, and Rosenthal fiber formation in the white matter. Genetic analyses did not identify any significant mutations in two candidate genes... - High expression of BMP pathway genes distinguishes a subset of atypical teratoid/rhabdoid tumors associated with shorter survivalDiane K Birks
University of Colorado, Denver Anschutz Medical Campus, Department of Neurosurgery, Aurora, CO 80045, USA
Neuro Oncol 13:1296-307. 2011..Our study indicates that molecular subgroups exist in AT/RTs and that molecular profiling of these comparatively rare tumors may be of diagnostic, prognostic, and therapeutic value... - Favorable prognosis in patients with high-grade glioma with radiation necrosis: the University of Colorado reoperation seriesKyle E Rusthoven
Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045 0508, USA
Int J Radiat Oncol Biol Phys 81:211-7. 2011..To analyze the pathology, outcomes, and prognostic factors in patients with high-grade glioma undergoing reoperation after radiotherapy (RT)... - Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognizeMeredith A Lann
Department of Pathology, University of Colorado Denver, Aurora, Colo, USA
Am J Forensic Med Pathol 31:7-11. 2010..Treatment for AHLE is not well-established; some authors describe in recent literature that a combination of immunosuppressant medications and/or therapeutic plasma exchange may be of benefit in treating AHLE... - Neoplasms involving the central nervous system in the older oldB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Hum Pathol 34:1137-47. 2003..1%), and either amplification of epidermal growth factor receptor or gain of chromosome 7 by fluorescence in situ hybridization (93% of assessable cases)... - PARP1 expression in pediatric central nervous system tumorsValerie N Barton
Department of Pediatrics, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA
Pediatr Blood Cancer 53:1227-30. 2009..Poly(ADP-ribose) polymerase-1 (PARP1) is a DNA repair protein that has been studied in a variety of malignancies and may interfere with therapy-induced DNA damage, however expression in pediatric CNS tumors is unknown... - Spinal and cranial hypertrophic neuropathy in multiple sclerosisDianna Quan
Department of Neurology, University of Colorado Health Sciences Center, Box F727, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
Muscle Nerve 31:772-9. 2005..These cases suggest that the mechanism of disease in symptomatic central and peripheral demyelination may differ from that of disease in only one region, and that optimal therapy in this situation must be explored further... - Lymphomatosis cerebri as a cause of white matter dementiaKaren E Rollins
Department of Neurology, University of Colorado School of Medicine, Denver, CO 80262, USA
Hum Pathol 36:282-90. 2005..The neurobehavioral deficits manifested by these patients demonstrate that lymphomatosis cerebri is an additional neoplastic cause of white matter dementia and can be added to the growing list of disorders responsible for this syndrome... - Genetic characterization of gliomas arising in patients with multiple sclerosisAdam Khalil
University of Colorado at Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
J Neurooncol 109:261-72. 2012..We conclude that gliomas in MS patients have genetic features paralleling counterparts in non-MS patients. There is no strong genetic evidence for GBMs to be secondary GBMs... - Pediatric brainstem gangliogliomas show overexpression of neuropeptide prepronociceptin (PNOC) by microarray and immunohistochemistryMichael H Chan
Department of Neuro Oncology, Children s Hospital Colorado, Aurora, CO 80045, USA
Pediatr Blood Cancer 59:1173-9. 2012..A less favorable prognosis exists for brainstem GGs, despite their usually identical WHO grade I status. Few large clinical series, and limited biological information, exists on these tumors, especially gene expression... - Clinical implications of growth hormone-secreting tumor subtypesKatja Kiseljak-Vassiliades
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Endocrine 42:18-28. 2012..Whether these less common variants possess unique clinical features is unknown. Research is needed to identify clinically relevant biomarkers of GH pituitary tumors that predict risk of recurrence and response to medical therapy... - Intralesionally implanted cisplatin plus systemic carmustine for the treatment of brain tumor in ratsQ Kong
Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
J Surg Oncol 69:76-82. 1998..To test this hypothesis, either intraperitoneal (i.p.) carmustine or cisplatin was combined with the intracranial (i.c.) administration of polymer-delivered cisplatin in rats with intracranial tumors... - Use of PCR for the diagnosis of herpesvirus infections of the central nervous systemRoberta L Debiasi
Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, CO 80262, USA
J Clin Virol 25:S5-11. 2002..This review summarizes the role of CSF PCR in the diagnosis and therapeutic management of herpesvirus infections of the nervous system, particularly those caused by HSV and VZV... - The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virusD H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
J Neurol Sci 159:140-4. 1998.... - Neutrophil degranulation and immunosuppression in patients with GBM: restoration of cellular immune function by targeting arginase ITrisha R Sippel
Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA
Clin Cancer Res 17:6992-7002. 2011..The source of glioblastoma (GBM)-associated immunosuppression remains multifactorial. We sought to clarify and therapeutically target myeloid cell-derived peripheral immunosuppression in patients with GBM... - CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitisK L Tyler
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Neurology 66:361-5. 2006..To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome... - Secondary central nervous system involvement by follicular lymphoma: case report and review of the literatureN L Grupka
Department of Pathology, University of Colorado, Denver, CO 80262, USA
Surg Neurol 65:590-4. 2006..Its manifestation as a massive, singular lesion is unique and prompted diagnostic confusion... - Pediatric adrenal cortical carcinoma: brain metastases and relationship to NF-1, case reports and review of the literatureAaron Scott Wagner
Department of Pathology, University of Colorado Health Sciences Center, B-216, Denver, Colorado, 80262, USA
J Neurooncol 75:127-33. 2005..We review the literature on ACCs in pediatric patients regarding brain metastases and previous associations with NF-1... - Atypical teratoid/rhabdoid tumor arising in a ganglioglioma: genetic characterizationB K Kleinschmidt-Demasters
Department of Pathology, Anschutz Medical Campus, University of Colorado, Denver, CO 80045, USA
Am J Surg Pathol 35:1894-901. 2011..Results suggest a postclonal modification in a subset of GG cells, with acquisition of INI-1 loss, confirming by biological methods what was previously suspected in rare reports of AT/RT evolving from other tumor types... - Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningiomaHilary L Somerset
Department of Pathology, The University of Colorado Health Sciences Center, Aurora, CO, USA
J Neurooncol 98:421-6. 2010..Rare convexity osteochondromas may be mistaken for high-grade meningiomas on neuroimaging studies; their avascular nature, coupled with their complex signal pattern can serve as clues to the correct pre-operative diagnosis... - Brain metastases from hepatocellular carcinoma in US patientsJoshua Seinfeld
Department of Neurosurgery, University of Colorado Health Sciences Center, Denver, CO, USA
J Neurooncol 76:93-8. 2006..We expect clinicians and pathologists will encounter more patients with HCC and extrahepatic metastases, particularly those to brain, in the near future... - Simian varicella virus infects ganglia before rash in experimentally infected monkeysR Mahalingam
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
Virology 279:339-42. 2001..Like other organs, monkey ganglia become infected with SVV before the appearance of rash... - Colorado surveillance program for chronic wasting disease transmission to humans: lessons from 2 highly suspicious but negative casesC Alan Anderson
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Arch Neurol 64:439-41. 2007..To describe 2 patients with rapidly progressive dementia and risk factors for exposure to chronic wasting disease (CWD) in whom extensive testing negated the possible transmission of CWD. Design/.. - The burden of radiation-induced central nervous system tumors: a single institution s experienceB K Kleinschmidt-Demasters
Department of Neurosurgery, University of Colorado Health Sciences Center, Denver, 80262, USA
J Neuropathol Exp Neurol 65:204-16. 2006..Although radiation-induced neoplasm remain relatively infrequent numerically, each case reminds us of the need for new, less toxic, and more targeted therapies for brain neoplasms... - Disseminated Fusarium infection with brain abscesses in a lung transplant recipientB K Kleinschmidt-Demasters
Departments of Pathology, Neurology, and Neurosurgery, University of Colorado Health Sciences Center, Aurora, CO, USA
Clin Neuropathol 28:417-21. 2009..While reports of disseminated infection in immunosuppressed patients have appeared over the last 30 years, few have emphasized the neuropathological aspects of this emerging pathogen... - Aspergillus terreus brain abscess mimicking tumor progression in a patient with treated glioblastoma multiformeD M Damek
Departments of Neurology, University of Colorado, Health Sciences Center, Aurora, CO 80045, USA
Clin Neuropathol 27:400-7. 2008..Most systemic invasive mold infections are attributable to Aspergillus fumigatus or Aspergillus flavus... - Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumorsKatherine A Michaelis
Department of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado 80045, USA
Endocrinology 152:3603-13. 2011..Together these studies identify new targets and mechanisms to explore in pituitary tumor initiation and progression... - Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosisB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
N Engl J Med 353:369-74. 2005..There was extensive tissue destruction and cavitation in the left frontoparietal area, large numbers of bizarre astrocytes, and inclusion-bearing oligodendrocytes, which were positive for JC virus DNA on in situ hybridization... - McCune-Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomasHelen Madsen
Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA
J Neurooncol 104:215-24. 2011..Medical therapy was initiated with somatostatin analogues, although responses in both patients have been suboptimal to date. We review the literature on GH excess in MAS to highlight its surgical and medical challenges... - Gliomatosis cerebri: neurobehavioral and neuropathological observationsChristopher M Filley
Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Cogn Behav Neurol 16:149-59. 2003..Whereas this pattern of localization can be predicted to cause significant disturbances of higher function, the neurobehavioral profile of gliomatosis cerebri patients has not been well described... - TGF-beta2 inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumorsYang Liu
Department of Neurosurgery, C 307, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO, 80262, USA
J Neurooncol 81:149-62. 2007.... - Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brainsC I Sze
Department of Pathology, University of Colorado Health Sciences Center, B 216, 4200 East Ninth Ave, Denver, CO 80262, USA
J Neurol Sci 175:81-90. 2000..These results suggest that there are selective and early defects in presynaptic vesicle proteins, but not synaptic plasma membrane proteins in AD and that defects correlate with cognitive dysfunction in this disease... - N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's diseaseC Sze
Department of Pathology, University of Colorado Health Sciences Center, B216, 4200 East 9th Ave, 80262, Denver, CO, USA
J Neurol Sci 182:151-9. 2001..Our results demonstrate that NMDA receptor subunits are selectively and differentially reduced in areas of AD brain, and these abnormalities correlate with presynaptic alterations and cognitive deficits in AD... - Anaplastic PXA in adults: case series with clinicopathologic and molecular featuresYao Schmidt
Department of Pathology, The University of Colorado Health Sciences Center, 12605 E 16th Avenue, Room 3026, MS F768, Aurora, CO 80045, USA
J Neurooncol 111:59-69. 2013..9 years after diagnosis. All tumors were IDH1 immunonegative. This case series details clinicopathologic features of a subset of rare PXA-As in adults. BRAF V600E mutation was identified in 50 % of these cases... - Tumor-to-tumor metastasis from hematopoietic neoplasms to meningiomas: report of two patients with significant cerebral edemaLars Widdel
Department of Neurosurgery, University of Colorado Denver, Aurora, Colorado, USA
World Neurosurg 74:165-71. 2010..Often there are limited clinical consequences and the condition is an incidental finding identified only on microscopic examination of a resected specimen... - The effects of toluene on the central nervous systemChristopher M Filley
Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Neuropathol Exp Neurol 63:1-12. 2004.... - Giant cell glioblastoma and pleomorphic xanthoastrocytoma show different immunohistochemical profiles for neuronal antigens and p53 but share reactivity for class III beta-tubulinHilda Martinez-Diaz
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
Arch Pathol Lab Med 127:1187-91. 2003..These results provide further evidence of neuronal antigen expression by PXA... - Rhabdoid glioblastomaJ Wyatt-Ashmead
Department of Pathology, The Children's Hospital, Denver, CO, USA
Clin Neuropathol 20:248-55. 2001..This case documents progressive rhabdoid transformation of a glioma, expands the spectrum of CNS tumor types that can display a rhabdoid phenotype and highlights the diagnostic and therapeutic challenges with this type of tumor... - May 2001: 32 year old female with dural mass encircling cervical spinal cordP J McCarthy
Department of Pathology, University of Colorado Health Sciences Center, Denver, USA
Brain Pathol 11:483-4, 487. 2001..Symptomatic improvement followed surgical decompression and high-dose corticosteroid therapy, with resultant resolution of an elevated c-ANCA titer... - Chromosome 1p and 14q FISH analysis in clinicopathologic subsets of meningioma: diagnostic and prognostic implicationsD X Cai
Department of Pathology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Neuropathol Exp Neurol 60:628-36. 2001..Furthermore, 14q FISH analysis may aid in assessing recurrence risk in histologically benign meningiomas... - The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytesG P Owens
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
Clin Immunol 98:258-63. 2001..None of the VH sequences expressed in plaque regions were detected in peripheral blood lymphocytes from this patient. These data indicate the presence of a CNS-targeted antigen-driven response in MS plaques... - Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumorsM T McDermott
Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
Pituitary 2:217-24. 1999..Combined analysis of hormone and transcription factor mRNA in pituitary tumor tissue may therefore be a more meaningful approach to pituitary tumor characterization... - Naturally acquired West Nile virus encephalomyelitis in transplant recipients: clinical, laboratory, diagnostic, and neuropathological featuresB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Arch Neurol 61:1210-20. 2004.... - The imaging and neuropathological effects of Bevacizumab (Avastin) in patients with leptomeningeal carcinomatosisB K Kleinschmidt-Demasters
Department of Surgical Pathology, University of Colorado Denver, Mail Stop B216, 12631 E 17th Ave, PO Box 6511, Aurora, CO 80045, USA
J Neurooncol 96:375-84. 2010..More cases will need to be studied to confirm this latter finding... - Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumabMaria del Pilar Martin
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Neurology Section, Veterans Affairs North Texas Health Care System, Medical Service, 4500 S Lancaster Rd, Dallas, TX 75216, USA
Arch Neurol 65:1596-603. 2008..We hypothesized that natalizumab reduces the number of antigen presenting cells in CPVS... - A 71-year-old male with 4 decades of symptoms referable to both central and peripheral nervous systemDianna Quan
Department of Neurology, University of Colorado Health Sciences Center, Denver, USA
Brain Pathol 15:369-70, 373. 2005..Microscopic examination showed some onion bulb formation in the CNS as well as in peripheral nerves. The nosology of these disorders is discussed and relevant animal models briefly reviewed... - Proximal nerve root spinal hemangioblastomas: presentation of three cases, MR appearance, and literature reviewEdward J Escott
Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Surg Neurol 61:262-73; discussion 273. 2004..It is important to consider HBLs in the differential diagnosis, as they are vascular and have the propensity for causing significant blood loss at surgery... - Spindle cell oncocytoma with late recurrence and unique neuroimaging characteristics due to recurrent subclinical intratumoral bleedingManuel Thomas Borges
Department of Neuroradiology, The University of Colorado Health Sciences Center, Aurora, CO, USA
J Neurooncol 101:145-54. 2011..The presence of thyroid disease also links SCO with pituicytoma. The 13-year interval to recurrence is the longest reported to date in SCO; WHO grade I designation may be premature for this neoplasm... - Acute multifocal CNS demyelination as first presentation of systemic malignancyNicole Gonzales
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, USA
Neurology 65:166. 2005 - Survivin in glioblastomas. Protein and messenger RNA expression and comparison with telomerase levelsB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver, USA
Arch Pathol Lab Med 127:826-33. 2003..Mechanisms that promote both cell proliferation (telomerase expression) and cell survival (survivin expression) are often activated in GBMs... - Necrotizing brainstem leukoencephalopathy six weeks following radiotherapyB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
Clin Neuropathol 14:63-8. 1995..This unusual case of fatal "early delayed" radiation injury is compared to previous literature cases... - Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesisRoberta L Debiasi
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 77:8934-47. 2003..This provides the first comparative analysis of altered gene expression after infection with viruses of differing apoptotic phenotypes and provides insight into pathogenic mechanisms of virus-induced disease... - Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytomaSteven O Addo-Yobo
Department of Pediatrics and Pathology, University of Colorado at Denver and Health Sciences Center UCDHSC, 80045, USA
J Neuropathol Exp Neurol 65:769-75. 2006.... - Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literatureArie Perry
Division of Neuropathology, Washington University, St Louis, MO 63110 1093, USA
Brain Pathol 15:55-65. 2005..In contrast, most perivascular spindled cells of pure MA are genetically and immunohistochemically similar to non-neoplastic meningothelial cells, consistent with current histogenetic theories... - An algorithmic approach to the brain biopsy--part IIRichard A Prayson
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Arch Pathol Lab Med 130:1639-48. 2006..CONCLUSIONS: In Part II, we assist the resident in arriving at the correct diagnosis for neuropathologic lesions containing granulomatous inflammation, macrophages, or abnormal blood vessels... - Subtyping does matter in pituitary adenomasB K Kleinschmidt-Demasters
Acta Neuropathol 111:84-5. 2006 - Central nervous system aspergillosis: a 20-year retrospective seriesB K Kleinschmidt-Demasters
Department of Pathology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
Hum Pathol 33:116-24. 2002.... - Fulminant ascending paralysis as a delayed sequela of diethylene glycol (Sterno) ingestionY D Rollins
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Neurology 59:1460-3. 2002..The diethylene glycol in the Sterno was considered responsible for this intoxication... - Current perspectives in the management of hyponatremia: prevention of CPMRichard H Sterns
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine, Rochester, NY, USA
Expert Rev Neurother 7:1791-7. 2007.... - Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitisRoberta L Debiasi
Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
J Infect Dis 186:1547-57. 2002..These results suggest that neuronal apoptosis is an important contributing factor to acute CNS injury and may serve as a novel therapeutic target in these patients...