B K Kleinschmidt-Demasters

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Central and extrapontine myelinolysis: then...and now
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neuropathol Exp Neurol 65:1-11. 2006
  2. ncbi request reprint Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous system
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center and The Denver Veterans Administration Hospital, 80262, USA
    Brain Pathol 11:452-64. 2001
  3. ncbi request reprint The expanding spectrum of herpesvirus infections of the nervous system
    B K Kleinschmidt-Demasters
    Department of Neurology, The University of Colorado Health Sciences Center, Denver 80262, USA
    Brain Pathol 11:440-51. 2001
  4. ncbi request reprint Dural metastases. A retrospective surgical and autopsy series
    B K Kleinschmidt-Demasters
    Departments of Pathology and Neurology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Pathol Lab Med 125:880-7. 2001
  5. doi request reprint Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medications
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Neuropathol Exp Neurol 67:1103-11. 2008
  6. ncbi request reprint Varicella-Zoster virus infections of the nervous system: clinical and pathologic correlates
    B K Kleinschmidt-Demasters
    Department of Pathology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Pathol Lab Med 125:770-80. 2001
  7. ncbi request reprint Molecular array analyses of 51 pediatric tumors shows overlap between malignant intracranial ectomesenchymoma and MPNST but not medulloblastoma or atypical teratoid rhabdoid tumor
    B K Kleinschmidt-Demasters
    University of Colorado at Denver and Health Science Center, 4200 East Ninth Avenue, B 216, Denver, CO 80262, USA
    Acta Neuropathol 113:695-703. 2007
  8. ncbi request reprint Characterization of glioblastomas in young adults
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Brain Pathol 16:273-86. 2006
  9. ncbi request reprint An algorithmic approach to the brain biopsy--part I
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B216, Denver, CO 80262, USA
    Arch Pathol Lab Med 130:1630-8. 2006
  10. ncbi request reprint Overlapping features of extrapontine myelinolysis and acquired chronic (non-Wilsonian) hepatocerebral degeneration
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Acta Neuropathol 112:605-16. 2006

Detail Information

Publications81

  1. ncbi request reprint Central and extrapontine myelinolysis: then...and now
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neuropathol Exp Neurol 65:1-11. 2006
    ..Yet, in many respects, this expansion of information over the past nearly 50 years simply represents a continuum, as well as recognition, of the vast gaps that still persist in our understanding of this disorder...
  2. ncbi request reprint Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous system
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center and The Denver Veterans Administration Hospital, 80262, USA
    Brain Pathol 11:452-64. 2001
    ..This review focuses on the use of PCR tests to diagnose HSV and VZV infections of the nervous system...
  3. ncbi request reprint The expanding spectrum of herpesvirus infections of the nervous system
    B K Kleinschmidt-Demasters
    Department of Neurology, The University of Colorado Health Sciences Center, Denver 80262, USA
    Brain Pathol 11:440-51. 2001
    ....
  4. ncbi request reprint Dural metastases. A retrospective surgical and autopsy series
    B K Kleinschmidt-Demasters
    Departments of Pathology and Neurology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Pathol Lab Med 125:880-7. 2001
    ..Some surgical patients have experienced prolonged postoperative survival...
  5. doi request reprint Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medications
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Neuropathol Exp Neurol 67:1103-11. 2008
    ....
  6. ncbi request reprint Varicella-Zoster virus infections of the nervous system: clinical and pathologic correlates
    B K Kleinschmidt-Demasters
    Department of Pathology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Pathol Lab Med 125:770-80. 2001
    ..Among the most diverse disorders caused by a single known toxic, metabolic, neoplastic, or infectious agent are the central and peripheral nervous system complications of varicella-zoster virus (VZV)...
  7. ncbi request reprint Molecular array analyses of 51 pediatric tumors shows overlap between malignant intracranial ectomesenchymoma and MPNST but not medulloblastoma or atypical teratoid rhabdoid tumor
    B K Kleinschmidt-Demasters
    University of Colorado at Denver and Health Science Center, 4200 East Ninth Avenue, B 216, Denver, CO 80262, USA
    Acta Neuropathol 113:695-703. 2007
    ..This suggests a common stem cell origin or embryonic gene recapitulation for these tumors and provides novel insights into their underlying biology...
  8. ncbi request reprint Characterization of glioblastomas in young adults
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Brain Pathol 16:273-86. 2006
    ..GBMs in young adults are a more inhomogeneous tumor group than GBMs occurring in older adult patients and show features that overlap with both pediatric and adult GBMs...
  9. ncbi request reprint An algorithmic approach to the brain biopsy--part I
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B216, Denver, CO 80262, USA
    Arch Pathol Lab Med 130:1630-8. 2006
    ..They can assist pathologists-in-training in developing orderly, sequential, and logical thinking skills when confronting difficult cases...
  10. ncbi request reprint Overlapping features of extrapontine myelinolysis and acquired chronic (non-Wilsonian) hepatocerebral degeneration
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Acta Neuropathol 112:605-16. 2006
    ..We concluded that there was a synergism between the two disorders and raise the possibility that there may be factors common to both disorders that lead to similar anatomic sites for involvement...
  11. ncbi request reprint Glioblastomas in the older old
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Pathol Lab Med 129:624-31. 2005
    ..However, testing has not been conducted on significant numbers of patients of very advanced age, in whom these features might be expected to emerge as even more significant factors...
  12. ncbi request reprint Gamna-Gandy bodies in surgical neuropathology specimens: observations and a historical note
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    J Neuropathol Exp Neurol 63:106-12. 2004
    ..Since 1999 I have accrued all the examples of G-G bodies that I have observed in my practice of surgical neuropathology. These cases are presented here and the historical aspects of the entity are reviewed...
  13. doi request reprint Radiation-induced glioblastoma multiforme in children treated for medulloblastoma with characteristics of both medulloblastoma and glioblastoma multiforme
    Jennifer R Madden
    Department of Neuro Oncology, The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Hematol Oncol 32:e272-8. 2010
    ..We recommend biopsy for tissue confirmation and genetic expression profile to shed light on the etiology of radiation-induced neoplasms...
  14. pmc Impact of rituximab-associated B-cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients
    Marilyn E Levi
    Division of Infectious Diseases, Department of Internal Medicine, University of Colorado Denver, Anschutz Medical Campus, Denver, CO 80045, USA
    Clin Transplant 24:223-8. 2010
    ..She experienced a rapidly progressive and devastating neurological course despite treatment and died three wk after onset of her symptoms. Autopsy revealed extensive meningoencephalomyelitis...
  15. pmc Clinical and molecular characteristics of congenital glioblastoma
    Margaret E Macy
    Department of Pediatrics, University of Colorado, Denver, CO, USA
    Neuro Oncol 14:931-41. 2012
    ..Further study may determine whether identified gene expression differences contribute to the improved survival seen in these tumors...
  16. doi request reprint Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
    Diane K Birks
    Department of Neurosurgery, Anschutz Medical Campus, University of Colorado at Denver, Aurora, Colorado 80010, USA
    Pediatr Blood Cancer 60:1095-102. 2013
    ..The aim of this study was to determine genes and biological process dysregulated in common to both AT/RTs and KRTs...
  17. doi request reprint Phase I trial of hypofractionated intensity-modulated radiotherapy with temozolomide chemotherapy for patients with newly diagnosed glioblastoma multiforme
    Changhu Chen
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Int J Radiat Oncol Biol Phys 81:1066-74. 2011
    ..To determine the maximal tolerated biologic dose intensification of radiotherapy using fractional dose escalation with temozolomide (TMZ) chemotherapy in patients with newly diagnosed glioblastoma multiforme...
  18. ncbi request reprint Radiation-induced meningiomas: clinical, cytogenetic, and microarray features
    Kevin O Lillehei
    Department of Neurosurgery, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
    Acta Neuropathol 116:289-301. 2008
    ..Of note, NF2 was under-expressed in four of five RIMs (P = 0.0065), at a similar level as measured in MEN...
  19. ncbi request reprint Unique molecular characteristics of radiation-induced glioblastoma
    Andrew M Donson
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Neuropathol Exp Neurol 66:740-9. 2007
    ..Western blot analyses confirmed that ErbB3, Sox10, and platelet-derived growth factor receptor-alpha proteins were consistently expressed in RIGs but rarely in pediatric GBMs...
  20. ncbi request reprint Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosis
    D H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Mail Stop B182, Denver, CO 80262, USA
    Arch Neurol 58:43-8. 2001
    ..New sophisticated molecular immunologic techniques described herein should enhance our ability to identify putative antigen(s) targets in MS...
  21. doi request reprint Anaplastic PXA in adults: case series with clinicopathologic and molecular features
    Yao Schmidt
    Department of Pathology, The University of Colorado Health Sciences Center, 12605 E 16th Avenue, Room 3026, MS F768, Aurora, CO 80045, USA
    J Neurooncol 111:59-69. 2013
    ..9 years after diagnosis. All tumors were IDH1 immunonegative. This case series details clinicopathologic features of a subset of rare PXA-As in adults. BRAF V600E mutation was identified in 50 % of these cases...
  22. ncbi request reprint An adult case of leukoencephalopathy with intracranial calcifications and cysts
    John R Corboy
    Department of Neurology, Box B 183, University of Colorado at Denver and Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Neurology 67:1890-2. 2006
    ..Pathologic features on biopsy included angiomatous-like blood vessels, intense gliosis, and Rosenthal fiber formation in the white matter. Genetic analyses did not identify any significant mutations in two candidate genes...
  23. pmc High expression of BMP pathway genes distinguishes a subset of atypical teratoid/rhabdoid tumors associated with shorter survival
    Diane K Birks
    University of Colorado, Denver Anschutz Medical Campus, Department of Neurosurgery, Aurora, CO 80045, USA
    Neuro Oncol 13:1296-307. 2011
    ..Our study indicates that molecular subgroups exist in AT/RTs and that molecular profiling of these comparatively rare tumors may be of diagnostic, prognostic, and therapeutic value...
  24. ncbi request reprint Spinal and cranial hypertrophic neuropathy in multiple sclerosis
    Dianna Quan
    Department of Neurology, University of Colorado Health Sciences Center, Box F727, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Muscle Nerve 31:772-9. 2005
    ..These cases suggest that the mechanism of disease in symptomatic central and peripheral demyelination may differ from that of disease in only one region, and that optimal therapy in this situation must be explored further...
  25. ncbi request reprint Neoplasms involving the central nervous system in the older old
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Hum Pathol 34:1137-47. 2003
    ..1%), and either amplification of epidermal growth factor receptor or gain of chromosome 7 by fluorescence in situ hybridization (93% of assessable cases)...
  26. ncbi request reprint Lymphomatosis cerebri as a cause of white matter dementia
    Karen E Rollins
    Department of Neurology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Hum Pathol 36:282-90. 2005
    ..The neurobehavioral deficits manifested by these patients demonstrate that lymphomatosis cerebri is an additional neoplastic cause of white matter dementia and can be added to the growing list of disorders responsible for this syndrome...
  27. ncbi request reprint Favorable prognosis in patients with high-grade glioma with radiation necrosis: the University of Colorado reoperation series
    Kyle E Rusthoven
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045 0508, USA
    Int J Radiat Oncol Biol Phys 81:211-7. 2011
    ..To analyze the pathology, outcomes, and prognostic factors in patients with high-grade glioma undergoing reoperation after radiotherapy (RT)...
  28. doi request reprint Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize
    Meredith A Lann
    Department of Pathology, University of Colorado Denver, Aurora, Colo, USA
    Am J Forensic Med Pathol 31:7-11. 2010
    ..Treatment for AHLE is not well-established; some authors describe in recent literature that a combination of immunosuppressant medications and/or therapeutic plasma exchange may be of benefit in treating AHLE...
  29. ncbi request reprint PARP1 expression in pediatric central nervous system tumors
    Valerie N Barton
    Department of Pediatrics, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA
    Pediatr Blood Cancer 53:1227-30. 2009
    ..Poly(ADP-ribose) polymerase-1 (PARP1) is a DNA repair protein that has been studied in a variety of malignancies and may interfere with therapy-induced DNA damage, however expression in pediatric CNS tumors is unknown...
  30. pmc Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma
    Jonathon J Parker
    Medical Scientist Training Program, University of Colorado, School of Medicine, Anschutz Medical Campus, Aurora, CO, USA
    Neuro Oncol 15:1048-57. 2013
    ..To explore these questions, we optimized an ex vivo organotypic slice culture system allowing for labeling and tracking of tumor cells in human GBM slice cultures...
  31. ncbi request reprint Genetic characterization of gliomas arising in patients with multiple sclerosis
    Adam Khalil
    University of Colorado at Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    J Neurooncol 109:261-72. 2012
    ..We conclude that gliomas in MS patients have genetic features paralleling counterparts in non-MS patients. There is no strong genetic evidence for GBMs to be secondary GBMs...
  32. doi request reprint Pediatric brainstem gangliogliomas show overexpression of neuropeptide prepronociceptin (PNOC) by microarray and immunohistochemistry
    Michael H Chan
    Department of Neuro Oncology, Children s Hospital Colorado, Aurora, CO 80045, USA
    Pediatr Blood Cancer 59:1173-9. 2012
    ..A less favorable prognosis exists for brainstem GGs, despite their usually identical WHO grade I status. Few large clinical series, and limited biological information, exists on these tumors, especially gene expression...
  33. doi request reprint Clinical implications of growth hormone-secreting tumor subtypes
    Katja Kiseljak-Vassiliades
    Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Endocrine 42:18-28. 2012
    ..Whether these less common variants possess unique clinical features is unknown. Research is needed to identify clinically relevant biomarkers of GH pituitary tumors that predict risk of recurrence and response to medical therapy...
  34. ncbi request reprint Intralesionally implanted cisplatin plus systemic carmustine for the treatment of brain tumor in rats
    Q Kong
    Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
    J Surg Oncol 69:76-82. 1998
    ..To test this hypothesis, either intraperitoneal (i.p.) carmustine or cisplatin was combined with the intracranial (i.c.) administration of polymer-delivered cisplatin in rats with intracranial tumors...
  35. ncbi request reprint The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virus
    D H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurol Sci 159:140-4. 1998
    ....
  36. ncbi request reprint Use of PCR for the diagnosis of herpesvirus infections of the central nervous system
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, CO 80262, USA
    J Clin Virol 25:S5-11. 2002
    ..This review summarizes the role of CSF PCR in the diagnosis and therapeutic management of herpesvirus infections of the nervous system, particularly those caused by HSV and VZV...
  37. doi request reprint Neutrophil degranulation and immunosuppression in patients with GBM: restoration of cellular immune function by targeting arginase I
    Trisha R Sippel
    Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Clin Cancer Res 17:6992-7002. 2011
    ..The source of glioblastoma (GBM)-associated immunosuppression remains multifactorial. We sought to clarify and therapeutically target myeloid cell-derived peripheral immunosuppression in patients with GBM...
  38. ncbi request reprint CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis
    K L Tyler
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 66:361-5. 2006
    ..To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome...
  39. ncbi request reprint Pediatric adrenal cortical carcinoma: brain metastases and relationship to NF-1, case reports and review of the literature
    Aaron Scott Wagner
    Department of Pathology, University of Colorado Health Sciences Center, B 216, Denver, Colorado, 80262, USA
    J Neurooncol 75:127-33. 2005
    ..We review the literature on ACCs in pediatric patients regarding brain metastases and previous associations with NF-1...
  40. ncbi request reprint Secondary central nervous system involvement by follicular lymphoma: case report and review of the literature
    N L Grupka
    Department of Pathology, University of Colorado, Denver, CO 80262, USA
    Surg Neurol 65:590-4. 2006
    ..The differing patterns of lymphomatous involvement of the central nervous system (CNS) are briefly reviewed, with a focus on the patterns seen in secondary CNS spread by low-grade lymphomas...
  41. doi request reprint Atypical teratoid/rhabdoid tumor arising in a ganglioglioma: genetic characterization
    B K Kleinschmidt-Demasters
    Department of Pathology, Anschutz Medical Campus, University of Colorado, Denver, CO 80045, USA
    Am J Surg Pathol 35:1894-901. 2011
    ..Results suggest a postclonal modification in a subset of GG cells, with acquisition of INI-1 loss, confirming by biological methods what was previously suspected in rare reports of AT/RT evolving from other tumor types...
  42. ncbi request reprint Simian varicella virus infects ganglia before rash in experimentally infected monkeys
    R Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
    Virology 279:339-42. 2001
    ..Like other organs, monkey ganglia become infected with SVV before the appearance of rash...
  43. ncbi request reprint Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma
    Hilary L Somerset
    Department of Pathology, The University of Colorado Health Sciences Center, Aurora, CO, USA
    J Neurooncol 98:421-6. 2010
    ..Rare convexity osteochondromas may be mistaken for high-grade meningiomas on neuroimaging studies; their avascular nature, coupled with their complex signal pattern can serve as clues to the correct pre-operative diagnosis...
  44. ncbi request reprint Colorado surveillance program for chronic wasting disease transmission to humans: lessons from 2 highly suspicious but negative cases
    C Alan Anderson
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Neurol 64:439-41. 2007
    ..To describe 2 patients with rapidly progressive dementia and risk factors for exposure to chronic wasting disease (CWD) in whom extensive testing negated the possible transmission of CWD. Design/..
  45. ncbi request reprint Aspergillus terreus brain abscess mimicking tumor progression in a patient with treated glioblastoma multiforme
    D M Damek
    Departments of Neurology, University of Colorado, Health Sciences Center, Aurora, CO 80045, USA
    Clin Neuropathol 27:400-7. 2008
    ..Most systemic invasive mold infections are attributable to Aspergillus fumigatus or Aspergillus flavus...
  46. ncbi request reprint Disseminated Fusarium infection with brain abscesses in a lung transplant recipient
    B K Kleinschmidt-Demasters
    Departments of Pathology, Neurology, and Neurosurgery, University of Colorado Health Sciences Center, Aurora, CO, USA
    Clin Neuropathol 28:417-21. 2009
    ..While reports of disseminated infection in immunosuppressed patients have appeared over the last 30 years, few have emphasized the neuropathological aspects of this emerging pathogen...
  47. ncbi request reprint TGF-beta2 inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumors
    Yang Liu
    Department of Neurosurgery, C 307, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO, 80262, USA
    J Neurooncol 81:149-62. 2007
    ....
  48. doi request reprint Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors
    Katherine A Michaelis
    Department of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Endocrinology 152:3603-13. 2011
    ..Together these studies identify new targets and mechanisms to explore in pituitary tumor initiation and progression...
  49. ncbi request reprint Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 353:369-74. 2005
    ..There was extensive tissue destruction and cavitation in the left frontoparietal area, large numbers of bizarre astrocytes, and inclusion-bearing oligodendrocytes, which were positive for JC virus DNA on in situ hybridization...
  50. ncbi request reprint Gliomatosis cerebri: neurobehavioral and neuropathological observations
    Christopher M Filley
    Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Cogn Behav Neurol 16:149-59. 2003
    ..Whereas this pattern of localization can be predicted to cause significant disturbances of higher function, the neurobehavioral profile of gliomatosis cerebri patients has not been well described...
  51. ncbi request reprint The burden of radiation-induced central nervous system tumors: a single institution s experience
    B K Kleinschmidt-Demasters
    Department of Neurosurgery, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Neuropathol Exp Neurol 65:204-16. 2006
    ..Although radiation-induced neoplasm remain relatively infrequent numerically, each case reminds us of the need for new, less toxic, and more targeted therapies for brain neoplasms...
  52. ncbi request reprint Brain metastases from hepatocellular carcinoma in US patients
    Joshua Seinfeld
    Department of Neurosurgery, University of Colorado Health Sciences Center, Denver, CO, USA
    J Neurooncol 76:93-8. 2006
    ..We expect clinicians and pathologists will encounter more patients with HCC and extrahepatic metastases, particularly those to brain, in the near future...
  53. ncbi request reprint McCune-Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas
    Helen Madsen
    Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA
    J Neurooncol 104:215-24. 2011
    ..Medical therapy was initiated with somatostatin analogues, although responses in both patients have been suboptimal to date. We review the literature on GH excess in MAS to highlight its surgical and medical challenges...
  54. ncbi request reprint N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease
    C Sze
    Department of Pathology, University of Colorado Health Sciences Center, B216, 4200 East 9th Ave, 80262, Denver, CO, USA
    J Neurol Sci 182:151-9. 2001
    ..Our results demonstrate that NMDA receptor subunits are selectively and differentially reduced in areas of AD brain, and these abnormalities correlate with presynaptic alterations and cognitive deficits in AD...
  55. ncbi request reprint Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains
    C I Sze
    Department of Pathology, University of Colorado Health Sciences Center, B 216, 4200 East Ninth Ave, Denver, CO 80262, USA
    J Neurol Sci 175:81-90. 2000
    ..These results suggest that there are selective and early defects in presynaptic vesicle proteins, but not synaptic plasma membrane proteins in AD and that defects correlate with cognitive dysfunction in this disease...
  56. ncbi request reprint Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors
    M T McDermott
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
    Pituitary 2:217-24. 1999
    ..Combined analysis of hormone and transcription factor mRNA in pituitary tumor tissue may therefore be a more meaningful approach to pituitary tumor characterization...
  57. doi request reprint Tumor-to-tumor metastasis from hematopoietic neoplasms to meningiomas: report of two patients with significant cerebral edema
    Lars Widdel
    Department of Neurosurgery, University of Colorado Denver, Aurora, Colorado, USA
    World Neurosurg 74:165-71. 2010
    ..Often there are limited clinical consequences and the condition is an incidental finding identified only on microscopic examination of a resected specimen...
  58. ncbi request reprint Chromosome 1p and 14q FISH analysis in clinicopathologic subsets of meningioma: diagnostic and prognostic implications
    D X Cai
    Department of Pathology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Neuropathol Exp Neurol 60:628-36. 2001
    ..Furthermore, 14q FISH analysis may aid in assessing recurrence risk in histologically benign meningiomas...
  59. ncbi request reprint The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes
    G P Owens
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
    Clin Immunol 98:258-63. 2001
    ..None of the VH sequences expressed in plaque regions were detected in peripheral blood lymphocytes from this patient. These data indicate the presence of a CNS-targeted antigen-driven response in MS plaques...
  60. ncbi request reprint May 2001: 32 year old female with dural mass encircling cervical spinal cord
    P J McCarthy
    Department of Pathology, University of Colorado Health Sciences Center, Denver, USA
    Brain Pathol 11:483-4, 487. 2001
    ..Symptomatic improvement followed surgical decompression and high-dose corticosteroid therapy, with resultant resolution of an elevated c-ANCA titer...
  61. ncbi request reprint The imaging and neuropathological effects of Bevacizumab (Avastin) in patients with leptomeningeal carcinomatosis
    B K Kleinschmidt-Demasters
    Department of Surgical Pathology, University of Colorado Denver, Mail Stop B216, 12631 E 17th Ave, PO Box 6511, Aurora, CO 80045, USA
    J Neurooncol 96:375-84. 2010
    ..More cases will need to be studied to confirm this latter finding...
  62. ncbi request reprint The effects of toluene on the central nervous system
    Christopher M Filley
    Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Neuropathol Exp Neurol 63:1-12. 2004
    ....
  63. ncbi request reprint Giant cell glioblastoma and pleomorphic xanthoastrocytoma show different immunohistochemical profiles for neuronal antigens and p53 but share reactivity for class III beta-tubulin
    Hilda Martinez-Diaz
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Arch Pathol Lab Med 127:1187-91. 2003
    ..While TP53 is mutated in most GCGBMs, a feature usually paralleled by strong immunostaining of the protein, the expression pattern of PXAs has not been extensively studied...
  64. ncbi request reprint Naturally acquired West Nile virus encephalomyelitis in transplant recipients: clinical, laboratory, diagnostic, and neuropathological features
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arch Neurol 61:1210-20. 2004
    ..In the 2003 West Nile virus (WNV) epidemic, Colorado reported more WNV cases than any other state, including an unprecedented number in organ transplant recipients...
  65. ncbi request reprint Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab
    Maria del Pilar Martin
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Neurology Section, Veterans Affairs North Texas Health Care System, Medical Service, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    Arch Neurol 65:1596-603. 2008
    ..We hypothesized that natalizumab reduces the number of antigen presenting cells in CPVS...
  66. ncbi request reprint Rhabdoid glioblastoma
    J Wyatt-Ashmead
    Department of Pathology, The Children's Hospital, Denver, CO, USA
    Clin Neuropathol 20:248-55. 2001
    ..This case documents progressive rhabdoid transformation of a glioma, expands the spectrum of CNS tumor types that can display a rhabdoid phenotype and highlights the diagnostic and therapeutic challenges with this type of tumor...
  67. doi request reprint Spindle cell oncocytoma with late recurrence and unique neuroimaging characteristics due to recurrent subclinical intratumoral bleeding
    Manuel Thomas Borges
    Department of Neuroradiology, The University of Colorado Health Sciences Center, Aurora, CO, USA
    J Neurooncol 101:145-54. 2011
    ..The presence of thyroid disease also links SCO with pituicytoma. The 13-year interval to recurrence is the longest reported to date in SCO; WHO grade I designation may be premature for this neoplasm...
  68. ncbi request reprint Proximal nerve root spinal hemangioblastomas: presentation of three cases, MR appearance, and literature review
    Edward J Escott
    Department of Radiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Surg Neurol 61:262-73; discussion 273. 2004
    ..Few studies have detailed the neuroimaging characteristics of the rare extramedullary variants...
  69. ncbi request reprint Acute multifocal CNS demyelination as first presentation of systemic malignancy
    Nicole Gonzales
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, USA
    Neurology 65:166. 2005
  70. ncbi request reprint A 71-year-old male with 4 decades of symptoms referable to both central and peripheral nervous system
    Dianna Quan
    Department of Neurology, University of Colorado Health Sciences Center, Denver, USA
    Brain Pathol 15:369-70, 373. 2005
    ..Microscopic examination showed some onion bulb formation in the CNS as well as in peripheral nerves. The nosology of these disorders is discussed and relevant animal models briefly reviewed...
  71. ncbi request reprint Survivin in glioblastomas. Protein and messenger RNA expression and comparison with telomerase levels
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver, USA
    Arch Pathol Lab Med 127:826-33. 2003
    ..Little is known about its distribution in brain tumors or how it correlates with other biomarkers of malignancy, such as telomerase, an enzyme that plays a critical role in cellular immortalization and cancer biology...
  72. ncbi request reprint Necrotizing brainstem leukoencephalopathy six weeks following radiotherapy
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
    Clin Neuropathol 14:63-8. 1995
    ..This unusual case of fatal "early delayed" radiation injury is compared to previous literature cases...
  73. pmc Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 77:8934-47. 2003
    ..This provides the first comparative analysis of altered gene expression after infection with viruses of differing apoptotic phenotypes and provides insight into pathogenic mechanisms of virus-induced disease...
  74. ncbi request reprint An algorithmic approach to the brain biopsy--part II
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Arch Pathol Lab Med 130:1639-48. 2006
    ..They can assist pathologists-in-training in developing orderly, sequential, and logical thinking skills when confronting difficult cases...
  75. ncbi request reprint Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literature
    Arie Perry
    Division of Neuropathology, Washington University, St Louis, MO 63110 1093, USA
    Brain Pathol 15:55-65. 2005
    ..In contrast, most perivascular spindled cells of pure MA are genetically and immunohistochemically similar to non-neoplastic meningothelial cells, consistent with current histogenetic theories...
  76. ncbi request reprint Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma
    Steven O Addo-Yobo
    Department of Pediatrics and Pathology, University of Colorado at Denver and Health Sciences Center UCDHSC, 80045, USA
    J Neuropathol Exp Neurol 65:769-75. 2006
    ....
  77. ncbi request reprint Central nervous system aspergillosis: a 20-year retrospective series
    B K Kleinschmidt-Demasters
    Department of Pathology, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hum Pathol 33:116-24. 2002
    ....
  78. ncbi request reprint Subtyping does matter in pituitary adenomas
    B K Kleinschmidt-Demasters
    Acta Neuropathol 111:84-5. 2006
  79. ncbi request reprint Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    J Infect Dis 186:1547-57. 2002
    ..These results suggest that neuronal apoptosis is an important contributing factor to acute CNS injury and may serve as a novel therapeutic target in these patients...
  80. ncbi request reprint Fulminant ascending paralysis as a delayed sequela of diethylene glycol (Sterno) ingestion
    Y D Rollins
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 59:1460-3. 2002
    ..The diethylene glycol in the Sterno was considered responsible for this intoxication...
  81. ncbi request reprint Current perspectives in the management of hyponatremia: prevention of CPM
    Richard H Sterns
    Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine, Rochester, NY, USA
    Expert Rev Neurother 7:1791-7. 2007
    ....