D Kleinfeld

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Chronic optical access through a polished and reinforced thinned skull
    Patrick J Drew
    Department of Physics, University of California at San Diego, San Diego, California, USA
    Nat Methods 7:981-4. 2010
  2. pmc A guide to delineate the logic of neurovascular signaling in the brain
    David Kleinfeld
    Department of Physics, University of California San Diego La Jolla, CA, USA
    Front Neuroenergetics 3:1. 2011
  3. ncbi request reprint Coding of efferent signals in monkey neostriatum
    B F Tolkunov
    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr Morisa Toreza 44, St Petersburg, 194223 Russia
    Dokl Biol Sci 387:513-6. 2002
  4. pmc Neuronal basis for object location in the vibrissa scanning sensorimotor system
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:455-68. 2011
  5. pmc Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion
    Chris B Schaffer
    Department of Physics, University of California San Diego, La Jolla, California, USA
    PLoS Biol 4:e22. 2006
  6. ncbi request reprint Distributed representation of vibrissa movement in the upper layers of somatosensory cortex revealed with voltage-sensitive dyes
    D Kleinfeld
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
    J Comp Neurol 375:89-108. 1996
  7. ncbi request reprint Active sensation: insights from the rodent vibrissa sensorimotor system
    David Kleinfeld
    Department of Physics, University of California at San Diego, 9500 Gilman Drive 0374, La Jolla, 92093, USA
    Curr Opin Neurobiol 16:435-44. 2006
  8. pmc From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging
    David Kleinfeld
    Department of Physics, University of California, San Diego, La Jolla, California, USA
    PLoS Biol 3:e355. 2005
  9. pmc Large-scale automated histology in the pursuit of connectomes
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 31:16125-38. 2011
  10. ncbi request reprint Adaptive filtering of vibrissa input in motor cortex of rat
    David Kleinfeld
    Department of Physics, Graduate Program in Neurosciences, University of Californai, San Diego, La Jolla, CA 92093, USA
    Neuron 34:1021-34. 2002

Collaborators

Detail Information

Publications50

  1. pmc Chronic optical access through a polished and reinforced thinned skull
    Patrick J Drew
    Department of Physics, University of California at San Diego, San Diego, California, USA
    Nat Methods 7:981-4. 2010
    ..We also repeatedly imaged dendritic spines, microglia and angioarchitecture, as well as used illumination to drive motor output via optogenetics and induce microstrokes via photosensitizers...
  2. pmc A guide to delineate the logic of neurovascular signaling in the brain
    David Kleinfeld
    Department of Physics, University of California San Diego La Jolla, CA, USA
    Front Neuroenergetics 3:1. 2011
    ..This confounds naïve interpretations of functional brain images. We discuss experimental approaches to detect signaling molecules in vivo with the goal of formulating an empirical basis for the observed logic of neurovascular control...
  3. ncbi request reprint Coding of efferent signals in monkey neostriatum
    B F Tolkunov
    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr Morisa Toreza 44, St Petersburg, 194223 Russia
    Dokl Biol Sci 387:513-6. 2002
  4. pmc Neuronal basis for object location in the vibrissa scanning sensorimotor system
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:455-68. 2011
    ..Efferent signals in motor cortex report the range of the scan. Collectively, these signals allow the rodent to form a percept of object location...
  5. pmc Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion
    Chris B Schaffer
    Department of Physics, University of California San Diego, La Jolla, California, USA
    PLoS Biol 4:e22. 2006
    ..Thus the cortical arteriolar network supports collateral flow that may mitigate the effects of vessel obstruction, as may occur secondary to neurovascular pathology...
  6. ncbi request reprint Distributed representation of vibrissa movement in the upper layers of somatosensory cortex revealed with voltage-sensitive dyes
    D Kleinfeld
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
    J Comp Neurol 375:89-108. 1996
    ..We suggest that these patterns of activity are a manifestation of the dynamic interaction among neighboring cortical columns...
  7. ncbi request reprint Active sensation: insights from the rodent vibrissa sensorimotor system
    David Kleinfeld
    Department of Physics, University of California at San Diego, 9500 Gilman Drive 0374, La Jolla, 92093, USA
    Curr Opin Neurobiol 16:435-44. 2006
    ..Recent in vivo and in vitro electrophysiological measurements provide insight into the algorithms and mechanisms that underlie these behavioral-based computations...
  8. pmc From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging
    David Kleinfeld
    Department of Physics, University of California, San Diego, La Jolla, California, USA
    PLoS Biol 3:e355. 2005
  9. pmc Large-scale automated histology in the pursuit of connectomes
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 31:16125-38. 2011
    ..Analysis at the scale of tens of nanometers yields connections between identified neurons, while analysis at the micrometer scale yields probabilistic rules of connection between neurons and exact vascular connectivity...
  10. ncbi request reprint Adaptive filtering of vibrissa input in motor cortex of rat
    David Kleinfeld
    Department of Physics, Graduate Program in Neurosciences, University of Californai, San Diego, La Jolla, CA 92093, USA
    Neuron 34:1021-34. 2002
    ..Thus, the S1 to M1 transformation extracts the fundamental frequency from a spectrally rich stimulus. We discuss our results in terms of a band-pass filter with a center frequency that adapts to the change in stimulation rate...
  11. ncbi request reprint Anatomical loops and their electrical dynamics in relation to whisking by rat
    D Kleinfeld
    Department of Physics, University of California, La Jolla 92093, USA
    Somatosens Mot Res 16:69-88. 1999
    ..In contrast, for correlation-based schemes the output is maximal when the angle of contact equals the preferred phase...
  12. pmc Phase-to-rate transformations encode touch in cortical neurons of a scanning sensorimotor system
    John C Curtis
    Division of Biological Sciences, University of California, San Diego, California, USA
    Nat Neurosci 12:492-501. 2009
    ..The underlying computation is consistent with gating by an inhibitory shunt...
  13. ncbi request reprint Coherent electrical activity between vibrissa sensory areas of cerebellum and neocortex is enhanced during free whisking
    Sean M O'Connor
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    J Neurophysiol 87:2137-48. 2002
    ....
  14. ncbi request reprint Positive feedback in a brainstem tactile sensorimotor loop
    Quoc Thang Nguyen
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    Neuron 45:447-57. 2005
    ..On the basis of these findings, we propose that the trigeminal loop provides an enhancement of vibrissa muscle tone upon contact during active touch...
  15. pmc Spectral mixing of rhythmic neuronal signals in sensory cortex
    Kurt F Ahrens
    Department of Physics, University of California at San Diego, La Jolla 92093, USA
    Proc Natl Acad Sci U S A 99:15176-81. 2002
    ..In general, our results provide a neurological substrate for the modulation and demodulation of rhythmic neuronal signals for sensory coding and feedback stabilization of motor output...
  16. ncbi request reprint Wilder Penfield in the age of YouTube: visualizing the sequential activation of sensorimotor areas across neocortex
    David Kleinfeld
    Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA
    Neuron 56:760-2. 2007
    ..imaging activity across the cortical mantle in awake mice, show in this issue of Neuron that touch by a single vibrissa leads to a rapid depolarization of primary sensory and motor areas that subsequently spreads across most of cortex...
  17. pmc Texture coding in the rat whisker system: slip-stick versus differential resonance
    Jason Wolfe
    Department of Physics, University of California San Diego, La Jolla, California, United States of America
    PLoS Biol 6:e215. 2008
    ..These results suggest that texture is encoded not by differential resonant motion across whiskers, but by the magnitude and temporal pattern of slip-stick motion. These findings predict a temporal code for texture in neural spike trains...
  18. pmc Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal
    Anna Devor
    Department of Neurosciences, University of California, San Diego, California 92093, USA
    J Neurosci 27:4452-9. 2007
    ....
  19. ncbi request reprint MPScope: a versatile software suite for multiphoton microscopy
    Quoc Thang Nguyen
    Physics Department, University of California, San Diego, CA 92093 7697, USA
    J Neurosci Methods 156:351-9. 2006
    ..The combination of optimized code, multithreading and COM (Common Object Model) technologies enables MPScope to fully take advantage of custom-built two-photon microscopes and to simplify their realization...
  20. pmc Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke
    Andy Y Shih
    Department of Physics, University of California at San Diego, La Jolla, California 92093 0374, USA
    J Cereb Blood Flow Metab 29:738-51. 2009
    ..These findings indicate that selective reactivity of small pial arterioles is preserved in the stroke penumbra and acts to conserve RBC flux during reperfusion...
  21. ncbi request reprint Cortical imaging through the intact mouse skull using two-photon excitation laser scanning microscopy
    Elizabeth J Yoder
    Department of Physics, University of California, San Diego, La Jolla, California 92093 0319, USA
    Microsc Res Tech 56:304-5. 2002
  22. pmc Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat
    Karunesh Ganguly
    Department of Physics, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:12348-53. 2004
    ..We conclude that the behavioral context of a whisking task can increase the modulation of S1 cortical activity by motor output without a concomitant increase in the magnitude of activity...
  23. ncbi request reprint Current flow in vibrissa motor cortex can phase-lock with exploratory rhythmic whisking in rat
    Kurt F Ahrens
    Dept of Physics 0374, University of California, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Neurophysiol 92:1700-7. 2004
    ....
  24. ncbi request reprint Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke
    Nozomi Nishimura
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    Nat Methods 3:99-108. 2006
    ..This demonstrates that a single blockage to a microvessel can lead to local cortical ischemia. Lastly, we show that hemodilution leads to a restoration of flow in secondary downstream vessels...
  25. pmc Seeing what the mouse sees with its vibrissae: a matter of behavioral state
    John C Curtis
    Graduate Program in Computational Neuroscience, University of California at San Diego, La Jolla, California 92037, USA
    Neuron 50:524-6. 2006
    ..In this issue of Neuron, Ferezou, Bolea, and Petersen show that the level and spatial extent of activation of vibrissa sensory cortex critically depend on behavioral context and mode of stimulation, i.e., passive versus active contact...
  26. ncbi request reprint Frisking the whiskers: patterned sensory input in the rat vibrissa system
    Samar B Mehta
    Graduate Program in Neurosciences, University of California, San Diego, La Jolla, 92093, USA
    Neuron 41:181-4. 2004
    ..The combination of contact and reference signals may be used to decode spatial variations in the environment, particularly the location of objects in head-centered coordinates...
  27. ncbi request reprint All-optical histology using ultrashort laser pulses
    Philbert S Tsai
    Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 39:27-41. 2003
    ..In a second example, the microvasculature within a block of neocortex was measured and reconstructed with micron resolution...
  28. pmc Topological basis for the robust distribution of blood to rodent neocortex
    Pablo Blinder
    Department of Physics, Division of Biology, Graduate Program in Neurosciences, and Center for Neural Circuits and Behavior, University of California, La Jolla, CA, 92093, USA
    Proc Natl Acad Sci U S A 107:12670-5. 2010
    ..The combined results of the present and prior studies imply that the pial network reallocates blood in response to changing metabolic needs...
  29. ncbi request reprint Vibrissa movement elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory whisking
    Rune W Berg
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    J Neurophysiol 90:2950-63. 2003
    ..Beyond issues of natural motor control, our result may bear on the design of algorithms for neuroprosthetic control of motor output...
  30. ncbi request reprint Activation of nucleus basalis facilitates cortical control of a brain stem motor program
    Rune W Berg
    Department of Physics 0374, University of California at San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA
    J Neurophysiol 94:699-711. 2005
    ..We conclude that NBM significantly facilitates the ability of M1 cortex to control movements. Our results bear on the importance of cholinergic activation in schemes for neuroprosthetic control of movement...
  31. doi request reprint Biomechanics of the vibrissa motor plant in rat: rhythmic whisking consists of triphasic neuromuscular activity
    Dan N Hill
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 28:3438-55. 2008
    ..The results of simulations of the model quantify how the combination of extrinsic and intrinsic muscle activity leads to an enhanced range of vibrissa motion than would be available from the intrinsic muscles alone...
  32. pmc Developmental regulation of active and passive membrane properties in rat vibrissa motoneurones
    Quoc Thang Nguyen
    Department of Physics and Graduate Program in Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    J Physiol 556:203-19. 2004
    ..We conjecture that resonance properties in vibrissa, hypoglossal, and potentially other motoneurones, may serve to transiently and purposely synchronize different orofacial behaviours...
  33. pmc Active spatial perception in the vibrissa scanning sensorimotor system
    Samar B Mehta
    Neurosciences Graduate Program, University of California at San Diego, La Jolla, California, United States of America
    PLoS Biol 5:e15. 2007
    ..The ability to judge angular position with a single vibrissa thus connects previously described, motion-sensitive neurophysiological signals to perception in the behaving animal...
  34. ncbi request reprint Exploratory whisking by rat is not phase locked to the hippocampal theta rhythm
    Rune W Berg
    Department of Physics, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 26:6518-22. 2006
    ..We observe that the correlation is weak and insignificant (six of eight animals and as a population average). We conclude that there is no relationship between the whisking and theta rhythms, at least when animals whisk in air...
  35. pmc Penetrating arterioles are a bottleneck in the perfusion of neocortex
    Nozomi Nishimura
    Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:365-70. 2007
    ..We conclude that penetrating arterioles are a bottleneck in the supply of blood to neocortex, at least to superficial layers...
  36. ncbi request reprint Imaging reveals synaptic targets of a swim-terminating neuron in the leech CNS
    Adam L Taylor
    Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 23:11402-10. 2003
    ..Two of the novel targets, cell 256 and cell 54, terminate swimming when stimulated. These neurons are likely to mediate swim cessation caused by cell Tr2 activity, and thus play the role of intermediate control cells in the leech CNS...
  37. pmc Temporally focused femtosecond laser pulses for low numerical aperture micromachining through optically transparent materials
    Dawn N Vitek
    Center for Micro integrated Optics for Advanced Bio imaging and Control, Department of Physics, Colorado School of Mines, Golden, Colorado 80401, USA
    Opt Express 18:18086-94. 2010
    ..04-0.05 NA. This technique is applied to the fabrication of microfluidic devices by ablation through the back surface of thick (6 mm) fused silica substrates. It is also used to ablate bone under aqueous immersion to produce craniotomies...
  38. ncbi request reprint Rhythmic whisking by rat: retraction as well as protraction of the vibrissae is under active muscular control
    Rune W Berg
    Department of Physics, University of California at San Diego, La Jolla 92093, USA
    J Neurophysiol 89:104-17. 2003
    ..These data point to the existence of a dual-phase central pattern generator that drives the vibrissae...
  39. doi request reprint Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels
    Philbert S Tsai
    Department of Physics, Center for Neural Circuits and Behavior, and Graduate Program in Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 29:14553-70. 2009
    ..The absence of a disproportionate density of blood vessels in granular lamina is argued to be consistent with the initial locus of functional brain imaging signals...
  40. pmc Photon counting, censor corrections, and lifetime imaging for improved detection in two-photon microscopy
    Jonathan D Driscoll
    Department of Physics, University of California at San Diego, La Jolla, CA 92093 0374, USA
    J Neurophysiol 105:3106-13. 2011
    ..The same system can be rapidly reconfigured in software for fluorescence lifetime imaging, which we illustrate by distinguishing between two spectrally similar fluorophores in an in vivo model of microstroke...
  41. pmc An in vivo biosensor for neurotransmitter release and in situ receptor activity
    Quoc Thang Nguyen
    Physics Department, University of California San Diego, La Jolla, California, USA
    Nat Neurosci 13:127-32. 2010
    ..We found that these drugs potently inhibited in situ muscarinic receptor activity...
  42. pmc Severe blood-brain barrier disruption and surrounding tissue injury
    Bo Chen
    Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, USA
    Stroke 40:e666-74. 2009
    ..We sought to use simple fluorescent tracers to allow wide-scale visualization of severely damaged vessels and determine whether such vascular disruption colocalized with regions of severe parenchymal injury...
  43. pmc Acute vascular disruption and aquaporin 4 loss after stroke
    Beth Friedman
    Department of Neurosciences, UCSD School of Medicine, San Diego, CA, USA
    Stroke 40:2182-90. 2009
    ..However, it is not known whether AQP4 is rapidly reduced during acute stroke in animals with normal AQP4 phenotype, which may provide a potential self-protective mechanism...
  44. doi request reprint Finding coherence in spontaneous oscillations
    Patrick J Drew
    Department of Physics, University of California at San Diego, La Jolla, Califorina 92093 0374, USA
    Nat Neurosci 11:991-3. 2008
    ..A new study now reports that this activity is correlated between functionally related areas across hemispheres in humans...
  45. ncbi request reprint Large two-photon absorptivity of hemoglobin in the infrared range of 780-880 nm
    G Omar Clay
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    J Chem Phys 126:025102. 2007
    ..g., sigmaTPA=61 GM versus sigmaTPA=18 GM, respectively, at lambda0=850 nm, which shows that the ligand affects the electronic states involved in TPA...
  46. ncbi request reprint Unilateral vibrissa contact: changes in amplitude but not timing of rhythmic whisking
    Robert N S Sachdev
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Somatosens Mot Res 20:163-9. 2003
    ..These data show that the amplitude of the vibrissae on the two sides of the face can be controlled independently, while the timing of vibrissa movement is largely synchronous...
  47. ncbi request reprint Closed-loop neuronal computations: focus on vibrissa somatosensation in rat
    Ehud Ahissar
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Cereb Cortex 13:53-62. 2003
    ..These loops are likely to be components within a greater closed-loop vibrissa sensorimotor system, which optimizes sensory processing...
  48. ncbi request reprint Coding of stimulus frequency by latency in thalamic networks through the interplay of GABAB-mediated feedback and stimulus shape
    David Golomb
    Center for Theoretical Biological Physics, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel
    J Neurophysiol 95:1735-50. 2006
    ..We suggest that GABAB-mediated inhibition is a substrate of temporal coding in normal brain function...
  49. doi request reprint 'Where' and 'what' in the whisker sensorimotor system
    Mathew E Diamond
    Cognitive Neuroscience Sector, International School for Advanced Studies SISSA, 34014 Trieste, Italy
    Nat Rev Neurosci 9:601-12. 2008
    ..Future research may elucidate this and show how the transformation of one representation to another is achieved...
  50. ncbi request reprint Is there a common origin to surround-inhibition as seen through electrical activity versus hemodynamic changes? Focus on "Duration-dependent response in SI to vibrotactile stimulation in squirrel monkey"
    Anna Devor
    J Neurophysiol 97:1880-2. 2007

Research Grants31

  1. DEEP MULTI-PHOTON IMAGING OF BRAIN STRUCTURE & FUNCTION
    David Kleinfeld; Fiscal Year: 2000
    ....
  2. Multi-scale mapping of 3D spatial-temporal cortical hemodynamics at the level of
    David Kleinfeld; Fiscal Year: 2007
    ..Our work will define the normal state of flow and bears on disruption to the normal state. It will help define optical- and MRI-based diagnostics for the detection of dysfunction and clinically appropriate interventionist therapies. ..
  3. Manipulating Neural Tissue With Ultra-Short Laser Pulses
    David Kleinfeld; Fiscal Year: 2007
    ..For type specifications, see instructions on page6.) RESEARCH GRANT TABLE OFCONTENTS Page Numbers Face Page 1 Description, ..
  4. Sensorimotor loops in vibrissa somatosensation
    David Kleinfeld; Fiscal Year: 2010
    ..Thus the vibrissa system provides an experimentally accessible computational test- bed for fundamental concepts in neuromuscular control. ..
  5. Manipulating Neural Tissue With Ultra-Short Laser Pulses
    David Kleinfeld; Fiscal Year: 2009
    ..We will make these tools reliable and readily available to the biomedical community. The proposed model systems may lead to improvements in preclinical models to assay therapeutics for stroke. ..
  6. CNiFERs Cell-based Neurotransmitter Fluorescent Engineered Reporters
    David Kleinfeld; Fiscal Year: 2010
    ....
  7. Femtosecond Light to Manipulate Neurons and Vasculature
    David Kleinfeld; Fiscal Year: 2007
    ..Fortype specifications, see instructions on page6.) ; RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  8. OPTICAL IMAGER FOR ELECTRICAL DYNAMICS IN CORTEX
    David Kleinfeld; Fiscal Year: 2001
    ..These proposed studies of stimulus representation in the rat vibrissa sensorimotor pathway will serve as a scientific test-bed for the proposed technology. ..
  9. OPTICAL IMAGER FOR ELECTRICAL DYNAMICS IN CORTEX
    David Kleinfeld; Fiscal Year: 2000
    ..These proposed studies of stimulus representation in the rat vibrissa sensorimotor pathway will serve as a scientific test-bed for the proposed technology. ..
  10. Manipulating Neural Tissue With Ultra-Short Laser Pulses
    David Kleinfeld; Fiscal Year: 2005
    ..We will make these tools reliable and readily available to the biomedical community. The proposed model systems may lead to improvements in preclinical models to assay therapeutics for stroke. ..
  11. DEEP MULTI-PHOTON IMAGING OF BRAIN STRUCTURE & FUNCTION
    David Kleinfeld; Fiscal Year: 2001
    ....
  12. Sensorimotor loops in vibrissa somatosensation
    David Kleinfeld; Fiscal Year: 2009
    ..Thus the vibrissa system provides an experimentally accessible computational test- bed for fundamental concepts in neuromuscular control. ..
  13. Manipulating Neural Tissue With Ultra-Short Laser Pulses
    David Kleinfeld; Fiscal Year: 2009
    ..We will make these tools reliable and readily available to the biomedical community. The proposed model systems may lead to improvements in preclinical models to assay therapeutics for stroke. ..
  14. Neuronal Signaling, Network Topology, and Blood Flow Dynamics in Cortex
    David Kleinfeld; Fiscal Year: 2009
    ..Further, our work may suggest pathways for the potential treatment of microstroke and microvascular diseases. ..
  15. MOTOR MODULATION OF SENSORY INPUT IN RAT VIBRISSA CORTEX
    David Kleinfeld; Fiscal Year: 2001
    ..How does a fast spike train signal in sensory cortex get transformed into a slow motor control signal in motor cortex? ..
  16. Neuronal Signaling, Network Topology, and Blood Flow Dynamics in Cortex
    David Kleinfeld; Fiscal Year: 2010
    ..Further, our work may suggest pathways for the potential treatment of microstroke and microvascular diseases. ..
  17. MOTOR MODULATION OF SENSORY INPUT IN RAT VIBRISSA CORTEX
    David Kleinfeld; Fiscal Year: 2000
    ..How does a fast spike train signal in sensory cortex get transformed into a slow motor control signal in motor cortex? ..
  18. All-Optical Histology for 3-D Cortical Reconstructions
    David Kleinfeld; Fiscal Year: 2006
    ..We will make this tool readily available to the biomedical community. The proposed model system may substantially improve upon our understanding of the large-scale structure of brain architectonics. ..
  19. DEEP MULTI-PHOTON IMAGING OF BRAIN STRUCTURE & FUNCTION
    David Kleinfeld; Fiscal Year: 2002
    ....
  20. Manipulating Neural Tissue With Ultra-Short Laser Pulses
    David Kleinfeld; Fiscal Year: 2006
    ..We will make these tools reliable and readily available to the biomedical community. The proposed model systems may lead to improvements in preclinical models to assay therapeutics for stroke. ..
  21. Sensorimotor loops in vibrissa somatosensation
    David Kleinfeld; Fiscal Year: 2007
    ..Thus the vibrissa system provides an experimentally accessible computational test- bed for fundamental concepts in neuromuscular control. ..
  22. Manipulating Neural Tissue With Ultra-Short Laser Pulses
    David Kleinfeld; Fiscal Year: 2007
    ..We will make these tools reliable and readily available to the biomedical community. The proposed model systems may lead to improvements in preclinical models to assay therapeutics for stroke. ..
  23. MOTOR MODULATION OF SENSORY INPUT IN RAT VIBRISSA CORTEX
    David Kleinfeld; Fiscal Year: 2003
    ..How does a fast spike train signal in sensory cortex get transformed into a slow motor control signal in motor cortex? ..
  24. MOTOR MODULATION OF SENSORY INPUT IN RAT VIBRISSA CORTEX
    David Kleinfeld; Fiscal Year: 2002
    ..How does a fast spike train signal in sensory cortex get transformed into a slow motor control signal in motor cortex? ..
  25. Sentinel cells that report neural and neurovascular signaling
    David Kleinfeld; Fiscal Year: 2007
    ..The assay has wide ranging applications, including, but not limited to research on abused substances. ..
  26. Manipulating Neural Tissue With Ultra-Short Laser Pulses
    Jeff A Squier; Fiscal Year: 2010
    ..The second is an understanding of the normal patterns of blood flow throughout the brain, which provide the basis for interpreting medical images of brain function. ..