Research Topics
Species | Dawn O KleindorferSummaryAffiliation: University of Cincinnati Country: USA Publications
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Publications
Patients living in impoverished areas have more severe ischemic strokesDawn Kleindorfer
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Stroke 43:2055-9. 2012..However, predictors of initial stroke severity have not been well-described within a population. We hypothesized that poorer patients would have a higher initial stroke severity on presentation to medical attention...- Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genesRitesh Kaushal
Department of Environmental Health, Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA
BMC Med Genet 8:49. 2007..Associations were tested at genotype, allele, and haplotype levels. A genomic control analysis was performed to check for spurious associations resulting from population substructure... - The use of standardized patients for mock oral board exams in neurology: a pilot studyBrett Kissela
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
BMC Med Educ 6:22. 2006..We sought to create a standardized patient mock oral board exam that would allow comparison of residents' clinical performance... - Stroke incidence is decreasing in whites but not in blacks: a population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati/Northern Kentucky Stroke StudyDawn O Kleindorfer
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45242, USA
Stroke 41:1326-31. 2010..The objective of this study was to examine temporal trends in stroke incidence and case-fatality within a large biracial population over time by comparing stroke incidence rates from 1993 to 1994, 1999, and 2005... 
Temporal trends in the incidence and case fatality of stroke in children and adolescentsDawn Kleindorfer
Department of Neurology, University of Cincinnati College of Medicine, OH 45267 0525, USA
J Child Neurol 21:415-8. 2006..Based on our data, we conservatively estimated that approximately 3000 children less than 20 years old would have a stroke in the United States in 2004...- The unchanging incidence and case-fatality of stroke in the 1990s: a population-based studyDawn Kleindorfer
University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
Stroke 37:2473-8. 2006..The objective of this study was to examine temporal trends in stroke incidence and case-fatality within a large, biracial population during the 1990s... - Impact of socioeconomic status on stroke incidence: a population-based studyDawn O Kleindorfer
Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
Ann Neurol 60:480-4. 2006 - Emergency department arrival times after acute ischemic stroke during the 1990sDawn O Kleindorfer
University of Cincinnati Medical Center, 231 Albert Sabin Way, MSB Room 5059A, Cincinnati, OH 45267 0525, USA
Neurocrit Care 7:31-5. 2007..We sought to investigate whether patients are arriving to the ED more quickly in 1999 than in 1993/94 within our large biracial population of 1.3 million... 
Ischemic stroke survivors' opinion regarding research utilizing exception from informed consentDawn Kleindorfer
University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
Cerebrovasc Dis 32:321-6. 2011..We obtained ischemic stroke survivors' opinions regarding hypothetical enrollment into a clinical trial at the time of their stroke without personal or proxy consent...- Self-reported stroke symptoms without a prior diagnosis of stroke or transient ischemic attack: a powerful new risk factor for strokeDawn Kleindorfer
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0525, USA
Stroke 42:3122-6. 2011..We sought to evaluate the additional impact of these stroke symptoms on risk for subsequent stroke... - The challenges of community-based research: the beauty shop stroke education projectDawn Kleindorfer
Department of Neurology, University of Cincinnati, MSB 0525, Cincinnati, OH 45219, USA
Stroke 39:2331-5. 2008..We sought to design a creative new way to educate black women by working through local beauty salons and measuring the results of the intervention... - Temporal trends in public awareness of stroke: warning signs, risk factors, and treatmentDawn Kleindorfer
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA
Stroke 40:2502-6. 2009..We describe public knowledge of t-PA as a treatment for IS, as well as changes over time in knowledge of stroke warning signs (WS) and risk factors (RF)... - US geographic distribution of rt-PA utilization by hospital for acute ischemic strokeDawn Kleindorfer
Department of Neurology, University of Cincinnati, Ohio 45267 0525, USA
Stroke 40:3580-4. 2009..We describe the US geographic distribution of hospitals using rt-PA for acute ischemic stroke... - National US estimates of recombinant tissue plasminogen activator use: ICD-9 codes substantially underestimateDawn Kleindorfer
University of Cincinnati College of Medicine, Department of Neurology, 231 Albert Sabin Way ML 0525, Cincinnati, Ohio 45267 0525, USA
Stroke 39:924-8. 2008..We sought to compare the utilization of rt-PA in acute ischemic stroke in the MEDPAR database to another national hospital database with drug utilization information... - Community socioeconomic status and prehospital times in acute stroke and transient ischemic attack: do poorer patients have longer delays from 911 call to the emergency department?Dawn O Kleindorfer
Department of Neurology, The Institute for the Study of Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0525, USA
Stroke 37:1508-13. 2006..We examined the effect of socioeconomic status on prehospital delays in stroke and transient ischemic attack (TIA) patients within a large, biracial population... - Incidence and short-term prognosis of transient ischemic attack in a population-based studyDawn Kleindorfer
Department of Emergency Medicine, University of Cincinnati, Ohio, USA
Stroke 36:720-3. 2005..We present the incidence and short-term prognosis of TIA within a large population with a significant proportion of minorities with out-of-hospital TIA... - A description of Canadian and United States physician reimbursement for thrombolytic therapy administration in acute ischemic strokeDawn Kleindorfer
Department of Neurology, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0525, Cincinnati, Ohio 45267 0525, USA
Stroke 36:682-7. 2005..We describe the physician reimbursement for thrombolytic therapy for the stroke team physicians serving the Greater Cincinnati/Northern Kentucky region (GCNK), and the Alberta region... - Eligibility for recombinant tissue plasminogen activator in acute ischemic stroke: a population-based studyDawn Kleindorfer
Department of Neurology, University of Cincinnati College of Medicine, The Neuroscience Institute, OH 45267, USA
Stroke 35:e27-9. 2004..Acute ischemic stroke patients are infrequently treated with recombinant tissue plasminogen activator (rtPA). We present unique population-based data regarding the eligibility of ischemic stroke patients for rtPA treatment... - Age at stroke: temporal trends in stroke incidence in a large, biracial populationBrett M Kissela
University of Cincinnati College of Medicine, Cincinnati, OH, USA
Neurology 79:1781-7. 2012..We hypothesized that stroke incidence in younger adults (age 20-54) increased over time, most notably between 1999 and 2005... - Trends in substance abuse preceding stroke among young adults: a population-based studyFelipe de Los Ríos
University of Cincinnati College of Medicine, Department of Neurology, and Cincinnati Children s Hospital, 260 Stetson St, Suite 2300, Cincinnati, OH 45267, USA
Stroke 43:3179-83. 2012..Approximately 5% of strokes occur in adults aged 18 to 44 years. Substance abuse is a prevalent risk factor for stroke in young adults. We sought to identify trends in substance abuse detection among stroke patients... - Eligibility for Intravenous Recombinant Tissue-Type Plasminogen Activator Within a Population: The Effect of the European Cooperative Acute Stroke Study (ECASS) III TrialFelipe de Los Ríos la Rosa
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA
Stroke 43:1591-5. 2012..5 hours from symptom onset. The impact of the expanded time window on treatment rates has not been comprehensively evaluated in a population-based study... - Potential eligibility for recombinant tissue plasminogen activator therapy in children: a population-based studyLaura L Lehman
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Child Neurol 26:1121-5. 2011..Thus, recruitment for clinical studies is likely to be challenging and requires a concerted multicenter effort... - Incidence of seizures in the acute phase of stroke: a population-based studyJerzy P Szaflarski
Department of Neurology and the Neuroscience Institute, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45267 0525, USA
Epilepsia 49:974-81. 2008..We aimed to establish the incidence of acute poststroke seizures in a biracial cohort and to determine whether acute seizure occurrence differs by race/ethnicity, stroke subtype, and/or stroke localization... - Withdrawal of antithrombotic agents and its impact on ischemic stroke occurrenceJoseph P Broderick
University of Cincinnati, Department of Neurology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center MSB 0525, Cincinnati, OH 45242, USA
Stroke 42:2509-14. 2011..These medications are also stopped by patients for various reasons such as cost, side effects, or unwillingness to take medication... - Comparison of two depression measures for predicting stroke outcomesLawson Wulsin
University of Cincinnati, Department of Psychiatry, Cincinnati, OH 45267 0559, United States
J Psychosom Res 72:175-9. 2012..This study compared a measure of current symptoms of depression at the time of the stroke and a measure of lifetime history of depression for their ability to predict quality of life and functioning at 3 and 12 months after stroke... - Seizures are common in the acute setting of childhood stroke: a population-based studyMadeline A Chadehumbe
Division of Child Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Child Neurol 24:9-12. 2009..As compared with adults, seizures within the acute setting of childhood stroke are common with an occurrence rate in our population of 58%... - Association of ALOX5AP with ischemic stroke: a population-based case-control studyRitesh Kaushal
Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0525, USA
Hum Genet 121:601-7. 2007..In conclusion, we report significant association of variants of ALOX5AP with ischemic stroke and ischemic stroke subtypes among whites. No significant association was identified among blacks... - Age accounts for racial differences in ischemic stroke volume in a population-based studyTarek Zakaria
Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267 0525, USA
Cerebrovasc Dis 26:376-80. 2008..5 cm. However, it is not known if stroke volume was similar between black and white patients within the same study population... - Risk factors for intracerebral hemorrhage differ according to hemorrhage locationSharyl R Martini
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Neurology 79:2275-82. 2012..Risk factors have been described for spontaneous intracerebral hemorrhage (ICH); their relative contribution to lobar vs nonlobar hemorrhage location is less clear. Our purpose here was to investigate risk factors by hemorrhage location... - Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trialsPooja Khatri
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
Stroke 41:2581-6. 2010..We sought to further characterize the patients with minor stroke who were included in the National Institute of Neurological Disorders and Stroke trials... - Which stroke symptoms prompt a 911 call? A population-based studyDawn Kleindorfer
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
Am J Emerg Med 28:607-12. 2010..Most studies have found that less than half of stroke/transient ischemic attack (TIA) events result in a 911 call. We sought to determine which symptoms prompt the public to call 911... - Racial disparities in awareness and treatment of atrial fibrillation: the REasons for Geographic and Racial Differences in Stroke (REGARDS) studyJames F Meschia
Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
Stroke 41:581-7. 2010..Differences in awareness and treatment of AF may contribute to racial and geographic disparities in stroke mortality. The objective was to examine predictors of awareness of the diagnosis of AF and treatment with warfarin... - Burden of risk alleles for hypertension increases risk of intracerebral hemorrhageGuido J Falcone
Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, and Department of Epidemiology, Harvard School of Public Health, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
Stroke 43:2877-83. 2012..We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN... - Stroke in a biracial population: the excess burden of stroke among blacksBrett Kissela
Department of Neurology, Neuroscience Institute, University of Cincinnati, OH 45267 0525, USA
Stroke 35:426-31. 2004..31 million people, which is representative of the US white and black populations with regard to many demographic and socioeconomic characteristics... - Association of apolipoprotein E4 and haplotypes of the apolipoprotein E gene with lobar intracerebral hemorrhageDaniel Woo
University of Cincinnati, Cincinnati, OH, USA
Stroke 36:1874-9. 2005..We genotyped 12 single-nucleotide polymorphisms in the 5' upstream regulatory, exonic, and intronic regions of the apo E gene and performed genotype and haplotype association analyses... - How much would performing diffusion-weighted imaging for all transient ischemic attacks increase MRI utilization?Opeolu Adeoye
Departments of Emergency Medicine and Neurosurgery, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
Stroke 41:2218-22. 2010..We determined how frequently MRI/DWI was performed for TIA and ascertained the proportion of clinically defined TIA patients who had ischemic lesions on DWI in our community in 2005... - Effect of untreated hypertension on hemorrhagic strokeDaniel Woo
University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0525, Cincinnati, OH 45267 0525, USA
Stroke 35:1703-8. 2004..Hypertension is an important risk factor for these subtypes of stroke. We sought to determine whether untreated hypertension carries a different risk from treated hypertension for hemorrhagic stroke... - Trends in surgical management and mortality of intracerebral hemorrhage in the United States before and after the STICH trialOpeolu Adeoye
Department of Emergency Medicine, UC Neuroscience Institute, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
Neurocrit Care 13:82-6. 2010..Using a national hospital database, we determined trends in surgery for ICH before and after publication of STICH. We also determined trends in ICH mortality during the study period... - Hypercholesterolemia, HMG-CoA reductase inhibitors, and risk of intracerebral hemorrhage: a case-control studyDaniel Woo
Department of Neurology and the Neuroscience Institute, University of Cincinnati, College of Medicine, 231 Bethesda Avenue ML 0525, Cincinnati, Ohio 45267 0525, USA
Stroke 35:1360-4. 2004..We tested the hypothesis that hypercholesterolemia or use of HMG-CoA reductase inhibitors (statin) agents, or both, are associated with ICH... - Racial variations in location and risk of intracerebral hemorrhageMatthew L Flaherty
Department of Neurology, University of Cincinnati Medical Center, Ohio 45267 0525, USA
Stroke 36:934-7. 2005..Incidence rates of ICH are known to be higher in American blacks than whites, but how rates may differ by hemorrhage location is unknown. We sought to define incidence rates for different ICH locations in a biracial population... - FAST Stroke Prevention Educational Program for Middle School Students: pilot study resultsElaine Tilka Miller
University of Cincinnati, College of Nursing, Cincinnati, OH, USA
J Neurosci Nurs 39:236-42. 2007..Additional research using a variety of educational strategies and a longer time frame of intervention is recommended to further expand use of this program... - Eligibility for the surgical trial in intracerebral hemorrhage II study in a population-based cohortOpeolu Adeoye
Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
Neurocrit Care 9:237-41. 2008..We sought to determine how many patients in a population-based ICH cohort would have been eligible for surgery using the Surgical Trial in Intracerebral Hemorrhage II (STICH II) criteria... - Association of Phosphodiesterase 4D with ischemic stroke: a population-based case-control studyDaniel Woo
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0525, USA
Stroke 37:371-6. 2006..None of the reports included significant proportions of blacks. We tested for genotype and haplotype association of polymorphisms of the PDE4D gene with ischemic stroke in a population-based, biracial, case-control study... - Location and outcome of anticoagulant-associated intracerebral hemorrhageMatthew L Flaherty
Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
Neurocrit Care 5:197-201. 2006..The characteristics of patients with anticoagulant-associated intracerebral hemorrhage (AAICH) have not been well characterized in a population-based setting... - The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trialArthur M Pancioli
Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0769, USA
Stroke 39:3268-76. 2008.... - Potential applicability of recombinant factor VIIa for intracerebral hemorrhageMatthew L Flaherty
Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
Stroke 36:2660-4. 2005..We sought to determine the potential applicability of rFVIIa in a large, population-based cohort of ICH patients... - Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and raceBrett Kissela
Department of Neurology, University of Cincinnati, Ohio, USA
Stroke 40:530-6. 2009.... - Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysmsJoseph P Broderick
Department of Neurology, Center for Stroke and Cerebrovascular Disease, University of Cincinnati Neuroscience Institute, UC College of Medicine, 260 Stetson Street, Cincinnati, OH 45267 0525, USA
Stroke 40:1952-7. 2009..The risk of intracranial aneurysm (IA) rupture in asymptomatic members of families who have multiple affected individuals is not known... - Emergency medical services use by stroke patients: a population-based studyOpeolu Adeoye
Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
Am J Emerg Med 27:141-5. 2009..In an epidemiological study, we determined the proportion of stroke patients who used EMS, hypothesizing that demographics, stroke severity, stroke type, and location at stroke onset would be associated with EMS use... - Epidemiology of ischemic stroke in patients with diabetes: the greater Cincinnati/Northern Kentucky Stroke StudyBrett M Kissela
Department of Neurology, University of Cincinnati, 231 Albert Sabin Way, ML 0525, Cincinnati, OH 45267 0525, USA
Diabetes Care 28:355-9. 2005..Diabetes is a well known risk factor for stroke, but the impact of diabetes on stroke incidence rates is not known. This study uses a population-based study to describe the epidemiology of ischemic stroke in diabetic patients... - Ischemic stroke subtypes: a population-based study of incidence rates among blacks and whitesAlexander T Schneider
Department of Neurology and the Neuroscience Institute, 231 Albert Sabin Way, University of Cincinnati, ML 0525, Cincinnati, Ohio 45267, USA
Stroke 35:1552-6. 2004..The objective of this study is to compare the incidence rates of ischemic stroke subtypes between blacks and whites within a large, representative, biracial population... - Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detectionRobert D Brown
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
J Neurosurg 108:1132-8. 2008..A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies... - The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysmRanjan Deka
Department of Neurology, UC Neuroscience Institute, University of Cincinnati Academic Health Center, 260 Stetson Street, Suite 2300, PO Box 670525, Cincinnati, OH 45267 0525, USA
Stroke 41:1132-7. 2010..The purpose of this study was to replicate the previous association of single nucleotide polymorphisms (SNPs) with risk of intracranial aneurysm (IA) and to examine the relationship of smoking with these variants and the risk of IA... - Genome screen to detect linkage to common susceptibility genes for intracranial and aortic aneurysmsBradford B Worrall
University of Virginia Health System, Department of Neurology, Box 800394, Charlottesville, VA 22908, USA
Stroke 40:71-6. 2009..We performed a genomewide linkage analysis in multiplex families with both IA and AA from the Familial Intracranial Aneurysm study... - Designing a message for public education regarding stroke: does FAST capture enough stroke?Dawn O Kleindorfer
Stroke 38:2864-8. 2007..We sought to assess the percentage of stroke/transient ischemic attack (TIA) patients identified by both public awareness messages by examining presenting symptoms of all stroke/TIA patients from a large, biracial population in 1999... - Reasons for exclusion from thrombolytic therapy following acute ischemic strokeDawn O Kleindorfer
Neurology 65:1844; author reply 1844. 2005
Research Grants
- The Effect of Socioeconomic Status on Outcome After StrokeDawn Kleindorfer; Fiscal Year: 2007..It is my ultimate goal to become an expert in outcomes research andthe socioeconomics of medicine, andto useclinical research to improve the lives of stroke patients from all social classes.. ..