Peter S Klein

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The Frizzled family: receptors for multiple signal transduction pathways
    Hui Chuan Huang
    Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6148, USA
    Genome Biol 5:234. 2004
  2. pmc Arginine methylation of vasa protein is conserved across phyla
    Yohei Kirino
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 285:8148-54. 2010
  3. ncbi request reprint Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus
    Jinling Wu
    Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, 364 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Biol 279:220-32. 2005
  4. ncbi request reprint Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
    Jinling Wu
    Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 133:3651-60. 2006
  5. ncbi request reprint PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development
    Jing Yang
    Department of Medicine Hematology Oncology Institute, University of Pennsylvania School of Medicine, 364 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Development 130:5569-78. 2003
  6. ncbi request reprint Phosphorylation of frizzled-3
    Wang A Yanfeng
    Cell and Molecular Biology Graduate Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Biol Chem 281:11603-9. 2006
  7. ncbi request reprint Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3
    Fang Zhang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 278:33067-77. 2003
  8. ncbi request reprint Histone deacetylase is a target of valproic acid-mediated cellular differentiation
    Nadia Gurvich
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Res 64:1079-86. 2004
  9. pmc Regulation of primitive hematopoiesis by class I histone deacetylases
    Rishita R Shah
    Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Dyn 242:108-21. 2013
  10. ncbi request reprint Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability
    Oxana M Tsygankova
    Department of Pharmacology, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:5501-7. 2004

Research Grants

  1. Phase II trial of valproic acid in myelodysplasia
    Peter Klein; Fiscal Year: 2006
  2. MOLECULAR MECHANISM FOR LITHIUM ACTION
    Peter Klein; Fiscal Year: 2000
  3. Early activation of the zygotic genome
    Peter Klein; Fiscal Year: 2007
  4. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2007
  5. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2009
  6. Early activation of the zygotic genome
    Peter Klein; Fiscal Year: 2009
  7. A Novel Molecular Target of Valproic Acid
    Peter Klein; Fiscal Year: 2006
  8. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2005
  9. A Molecular Mechanism for Lithium Action
    Peter S Klein; Fiscal Year: 2010

Collaborators

Detail Information

Publications33

  1. pmc The Frizzled family: receptors for multiple signal transduction pathways
    Hui Chuan Huang
    Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6148, USA
    Genome Biol 5:234. 2004
    ..It is not yet clear how Frizzleds couple to downstream effectors, and this is a focus of intense study...
  2. pmc Arginine methylation of vasa protein is conserved across phyla
    Yohei Kirino
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 285:8148-54. 2010
    ..Arginine methylation is thus emerging as a conserved and pivotal post-translational modification of proteins that is essential for germline development...
  3. ncbi request reprint Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus
    Jinling Wu
    Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, 364 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Biol 279:220-32. 2005
    ....
  4. ncbi request reprint Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
    Jinling Wu
    Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 133:3651-60. 2006
    ....
  5. ncbi request reprint PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development
    Jing Yang
    Department of Medicine Hematology Oncology Institute, University of Pennsylvania School of Medicine, 364 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Development 130:5569-78. 2003
    ..These data demonstrate a positive role for PP2A:B56epsilon in the Wnt pathway...
  6. ncbi request reprint Phosphorylation of frizzled-3
    Wang A Yanfeng
    Cell and Molecular Biology Graduate Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Biol Chem 281:11603-9. 2006
    ..Mutation of C-terminal serines including serine 576 significantly enhances Frizzled-3-mediated induction of neural crest markers, suggesting that C-terminal phosphorylation plays a role in down-regulating Frizzled signaling...
  7. ncbi request reprint Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3
    Fang Zhang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 278:33067-77. 2003
    ..Finally, evidence is presented that N-terminal phosphorylation of GSK-3 can be regulated by the GSK-3-dependent protein phosphatase-1.inhibitor-2 complex...
  8. ncbi request reprint Histone deacetylase is a target of valproic acid-mediated cellular differentiation
    Nadia Gurvich
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Res 64:1079-86. 2004
    ..These findings provide additional evidence that VPA, a well-tolerated, orally administered drug with extensive clinical experience, may serve as an effective chemotherapeutic agent through targeting of HDACs...
  9. pmc Regulation of primitive hematopoiesis by class I histone deacetylases
    Rishita R Shah
    Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Dyn 242:108-21. 2013
    ..Here, we employed the class I selective HDAC inhibitor, valproic acid (VPA), to show that HDAC activity is required for primitive hematopoiesis...
  10. ncbi request reprint Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability
    Oxana M Tsygankova
    Department of Pharmacology, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:5501-7. 2004
    ..These data are the first to show that Rap1GAP protein levels are tightly regulated and are the first to support a role for Rap1GAP as a tumor suppressor...
  11. pmc Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice
    Jian Huang
    Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:3519-29. 2009
    ....
  12. ncbi request reprint Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium
    W Timothy O'Brien
    Division of Hematology Oncology, Department of Medicine, and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Neurosci 24:6791-8. 2004
    ..These observations support a central role for GSK-3beta in mediating behavioral responses to lithium...
  13. pmc Validating GSK3 as an in vivo target of lithium action
    W Timothy O'Brien
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biochem Soc Trans 37:1133-8. 2009
    ..These observations, from several independent laboratories, support a central role for GSK3 in mediating behavioural responses to lithium...
  14. pmc Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways
    Jian Huang
    Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Med 18:1778-85. 2012
    ..We also show that the combination of two clinically approved medications that together activate Wnt-β-catenin and inhibit mTOR signaling increases the number (but not the proportion) of long-term HSCs in vivo...
  15. pmc Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
    W Timothy O'Brien
    Department of Medicine, Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:3756-62. 2011
    ..We believe these findings reveal a new role for GSK-3 within the β-arrestin complex and demonstrate that GSK-3 is a critical target of lithium in mammalian behaviors...
  16. pmc The poly(rC)-binding protein alphaCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation
    Melanie R Vishnu
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    RNA 17:944-56. 2011
    ....
  17. pmc Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability
    Yohei Kirino
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 11:652-8. 2009
    ..Our findings underscore the significance of sDMA modification of Piwi proteins in the germline and suggest an interacting pathway of genes that are required for piRNA function and PGC specification...
  18. ncbi request reprint Wnt-frizzled signaling in the induction and differentiation of the neural crest
    Wang Yanfeng
    Cell and Molecular Biology Graduate Group, Department of Medicine and Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bioessays 25:317-25. 2003
    ..We also summarize the timing of expression of a number of Wnt ligands and receptors with respect to neural crest induction...
  19. ncbi request reprint GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides
    Christopher J Phiel
    Department of Medicine, Division of Hematology Oncology and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Philadelphia 19104 6148, USA
    Nature 423:435-9. 2003
    ....
  20. ncbi request reprint Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, and University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Science 311:1002-5. 2006
    ..Control of Rev-erbalpha protein stability is thus a critical component of the peripheral clock and a biological target of lithium therapy...
  21. pmc O2 regulates stem cells through Wnt/β-catenin signalling
    Jolly Mazumdar
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nat Cell Biol 12:1007-13. 2010
    ..This decline correlates with reduced Wnt/β-catenin signalling in the subgranular zone. O2 availability, therefore, may have a direct role in stem cell regulation through HIF-1α modulation of Wnt/β-catenin signalling...
  22. pmc An essential role for transcription before the MBT in Xenopus laevis
    Jennifer Skirkanich
    Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA
    Dev Biol 357:478-91. 2011
    ..Finally, xnr5 and xnr6 can also activate their own expression during cleavage stages, indicating that preMBT transcription contributes to a feed-forward system that allows robust activation of Nodal signaling at the MBT...
  23. ncbi request reprint Switching on a signaling pathway with an organoruthenium complex
    Douglas S Williams
    Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA
    Angew Chem Int Ed Engl 44:1984-7. 2005
  24. ncbi request reprint Wnt-frizzled signaling in neural crest formation
    Jinling Wu
    Cell and Molecular Biology Graduate Group, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Neurosci 26:40-5. 2003
  25. ncbi request reprint Interactions between BMP and Wnt signaling pathways in mammalian cancers
    Hui Chuan Huang
    Department of Medicine Hematology Oncology, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    Cancer Biol Ther 3:676-8. 2004
    ..extend these studies and propose interesting potential interactions between BMP and Wnt signaling in transformed mammalian cells that could have important implications for the control of human cancers...
  26. pmc Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity
    Alexander J Valvezan
    Cell and Molecular Biology Graduate Group, The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:3823-32. 2012
    ..APC regulation of GSK-3 also provides a novel mechanism for Wnt regulation of multiple downstream effectors, including β-catenin and mTOR...
  27. ncbi request reprint Beta-catenin/Tcf-regulated transcription prior to the midblastula transition
    Jing Yang
    Department of Medicine Hematology Oncology and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 129:5743-52. 2002
    ....
  28. pmc Regulation of glycogen synthase kinase-3 in patients with affective disorders
    W Timothy O'Brien
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biol Psychiatry 61:139-41. 2007
  29. pmc Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1
    Patrick A Mayes
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Cancer Res 71:5265-75. 2011
    ....
  30. ncbi request reprint Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease
    Hui Chuan Huang
    Department of Medicine Hematology Oncology, 364 Clinical Research Building, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6148, USA
    Curr Drug Targets 7:1389-97. 2006
    ..Here we will briefly review the molecular understanding of AD pathogenesis as it stands at this point, and then discuss the emerging role of GSK-3 in regulating these processes...
  31. ncbi request reprint Lithium and valproic acid: parallels and contrasts in diverse signaling contexts
    Nadia Gurvich
    Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacol Ther 96:45-66. 2002
    ..We then describe some of the physiological effects common to the two drugs, in addition to treatment of BPD, and address signaling pathways that could be regulated by both lithium and VPA...
  32. pmc Chromatin immunoprecipitation in early Xenopus laevis embryos
    Shelby A Blythe
    Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Dev Dyn 238:1422-32. 2009
    ..Developmental Dynamics 238:1422-1432, 2009. (c) 2009 Wiley-Liss, Inc...
  33. ncbi request reprint SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1
    G Praveen Raju
    Cell and Molecular Biology Graduate Group, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:428-37. 2003
    ..These studies define a new mode of regulation for intracellular BMP/Smad1 signaling...

Research Grants22

  1. Phase II trial of valproic acid in myelodysplasia
    Peter Klein; Fiscal Year: 2006
    ..VPA offers the significant advantages that it is a clinically well-characterized, relatively safe medication that can be administered orally and can be accurately monitored by well-established methods. ..
  2. MOLECULAR MECHANISM FOR LITHIUM ACTION
    Peter Klein; Fiscal Year: 2000
    ....
  3. Early activation of the zygotic genome
    Peter Klein; Fiscal Year: 2007
    ..The research proposed here should provide insights into how errors in embryonic gene expression could cause profound developmental defects in humans. ..
  4. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2007
    ....
  5. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2009
    ....
  6. Early activation of the zygotic genome
    Peter Klein; Fiscal Year: 2009
    ..The research proposed here should provide insights into how errors in embryonic gene expression could cause profound developmental defects in humans. ..
  7. A Novel Molecular Target of Valproic Acid
    Peter Klein; Fiscal Year: 2006
    ..Furthermore, identification of HDAC as a likely target for VPA induced teratogenesis should allow a direct in vitro test of teratogenic potential of VPA related compounds. ..
  8. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2005
    ....
  9. A Molecular Mechanism for Lithium Action
    Peter S Klein; Fiscal Year: 2010
    ....