Marlise I Klein

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomics
    Marlise I Klein
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    PLoS ONE 7:e45795. 2012
  2. pmc Molecular approaches for viable bacterial population and transcriptional analyses in a rodent model of dental caries
    M I Klein
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Oral Microbiol 27:350-61. 2012
  3. pmc Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo
    Megan L Falsetta
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Antimicrob Agents Chemother 56:6201-11. 2012
  4. pmc Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo
    Megan L Falsetta
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 82:1968-81. 2014
  5. pmc The specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts Streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms
    Guoping Feng
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Biofouling 29:629-40. 2013
  6. pmc The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm
    Jin Xiao
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Pathog 8:e1002623. 2012
  7. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
  8. pmc Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms
    Jae Gyu Jeon
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    BMC Microbiol 9:228. 2009
  9. pmc Elevated incidence of dental caries in a mouse model of cystic fibrosis
    Marcelo A Catalán
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 6:e16549. 2011
  10. doi request reprint pH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence
    Benjamin Horev
    Department of Biomedical Engineering, Center for Oral Biology, Department of Chemical Engineering, and Center of Musculoskeletal Research, University of Rochester, Rochester, New York 14627, United States
    ACS Nano 9:2390-404. 2015

Collaborators

Detail Information

Publications12

  1. pmc Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomics
    Marlise I Klein
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    PLoS ONE 7:e45795. 2012
    ..This reflects the intricate physiological processes linked to expression of virulence by this bacterium within complex biofilms...
  2. pmc Molecular approaches for viable bacterial population and transcriptional analyses in a rodent model of dental caries
    M I Klein
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Oral Microbiol 27:350-61. 2012
    ..Our approach could enhance the value of the current rodent model in further understanding the pathophysiology of this disease and facilitating the exploration of novel anti-caries therapies...
  3. pmc Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo
    Megan L Falsetta
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Antimicrob Agents Chemother 56:6201-11. 2012
    ..These observations may have relevance for development of enhanced therapies against other biofilm-dependent infections...
  4. pmc Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo
    Megan L Falsetta
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 82:1968-81. 2014
    ..Altogether, we demonstrate a novel mutualistic bacterium-fungus relationship that occurs at a clinically relevant site to amplify the severity of a ubiquitous infectious disease. ..
  5. pmc The specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts Streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms
    Guoping Feng
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Biofouling 29:629-40. 2013
    ..This study identified putative molecular targets of A-type cranberry PACs in S. mutans while demonstrating that PAC oligomers with a specific DP may be effective in disrupting the assembly of cariogenic biofilms. ..
  6. pmc The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm
    Jin Xiao
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Pathog 8:e1002623. 2012
    ..These observations may have relevance beyond the mouth, as matrix is inherent to all biofilms...
  7. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
    ..Our data show complex remodeling of S. mutans-transcriptome in response to changing environmental conditions in situ, which could modulate the dynamics of biofilm development and pathogenicity...
  8. pmc Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms
    Jae Gyu Jeon
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    BMC Microbiol 9:228. 2009
    ..mutans within biofilms and their structural organization using real-time PCR and confocal fluorescence microscopy...
  9. pmc Elevated incidence of dental caries in a mouse model of cystic fibrosis
    Marcelo A Catalán
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 6:e16549. 2011
    ..Given the close relationship between pH and caries development, we hypothesized that caries incidence might be elevated in the mouse CF model...
  10. doi request reprint pH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence
    Benjamin Horev
    Department of Biomedical Engineering, Center for Oral Biology, Department of Chemical Engineering, and Center of Musculoskeletal Research, University of Rochester, Rochester, New York 14627, United States
    ACS Nano 9:2390-404. 2015
    ..Nanoparticle carriers have great potential to enhance the efficacy of antibiofilm agents through multitargeted binding and pH-responsive drug release due to microenvironmental triggers. ..
  11. doi request reprint Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms
    Marlise I Klein
    Center for Oral Biology, University of Rochester Rochester, NY, USA
    Front Cell Infect Microbiol 5:10. 2015
    ..Enhanced understanding about the assembly principles of the matrix may lead to efficacious approaches to control biofilm-related diseases. ..
  12. doi request reprint Analysis of the mechanical stability and surface detachment of mature Streptococcus mutans biofilms by applying a range of external shear forces
    Geelsu Hwang
    a Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Biofouling 30:1079-91. 2014
    ..The data reveal how incremental increases in shear stress cause distinctive patterns of biofilm detachment, while demonstrating that the exopolysaccharide matrix modulates the resistance of biofilms to mechanical clearance...