Helmut U Klein

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Cardiac resynchronization therapy in asymptomatic or mildly symptomatic heart failure patients
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, 601 Elmwood Avenue, Box 653, Rochester, NY, 14642, USA
    Curr Treat Options Cardiovasc Med 12:431-42. 2010
  2. doi request reprint Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter defibrillator (WCD)
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 33:353-67. 2010
  3. doi request reprint Michel Mirowski and the beginning of a new era of fighting sudden arrhythmic death
    Helmut U Klein
    Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    Herzschrittmacherther Elektrophysiol 26:61-9. 2015
  4. doi request reprint Risk stratification for implantable cardioverter defibrillator therapy: the role of the wearable cardioverter-defibrillator
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Box 653, 265 Crittenden Blvd Rochester, NY 14620, USA
    Eur Heart J 34:2230-42. 2013
  5. ncbi request reprint Vagus nerve stimulation: A new approach to reduce heart failure
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, NY 14642, USA
    Cardiol J 17:638-44. 2010
  6. ncbi request reprint Implantable defibrillators: 30 years of history
    Helmut U Klein
    Heart Research Follow Up Program, University of Rochester Medical Center, 601 Elmwood Avenue, Box 653, Rochester, NY 14642, USA
    G Ital Cardiol (Rome) 11:48S-52S. 2010
  7. ncbi request reprint Pilot study: Noninvasive monitoring of oral flecainide's effects on atrial electrophysiology during persistent human atrial fibrillation using the surface electrocardiogram
    Daniela Husser
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    Ann Noninvasive Electrocardiol 10:206-10. 2005
  8. ncbi request reprint Echocardiographic and electrocardiographic predictors for atrial fibrillation recurrence following cardioversion
    Andreas Bollmann
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    J Cardiovasc Electrophysiol 14:S162-5. 2003
  9. doi request reprint Effect of elapsed time from coronary revascularization to implantation of a cardioverter defibrillator on long-term survival in the MADIT-II trial
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 22:1237-42. 2011
  10. doi request reprint Impact of the right ventricular lead position on clinical outcome and on the incidence of ventricular tachyarrhythmias in patients with CRT-D
    Valentina Kutyifa
    University of Rochester Medical Center, Rochester, New York Semmelweis University, Heart Center, Budapest, Hungary, and Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    Heart Rhythm 10:1770-7. 2013

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Cardiac resynchronization therapy in asymptomatic or mildly symptomatic heart failure patients
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, 601 Elmwood Avenue, Box 653, Rochester, NY, 14642, USA
    Curr Treat Options Cardiovasc Med 12:431-42. 2010
    ..It is time to change the guidelines for heart failure treatment...
  2. doi request reprint Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter defibrillator (WCD)
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 33:353-67. 2010
    ..Additionally, data are reported on the clinical experience with the WCD based on 354 patients from Germany hospitalized between 2000 and 2008 who wore the WCD for a mean of 3 months...
  3. doi request reprint Michel Mirowski and the beginning of a new era of fighting sudden arrhythmic death
    Helmut U Klein
    Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    Herzschrittmacherther Elektrophysiol 26:61-9. 2015
    ..Today it is hard to imagine modern medicine without ICD therapy. This article provides the reader a history of the development of the ICD...
  4. doi request reprint Risk stratification for implantable cardioverter defibrillator therapy: the role of the wearable cardioverter-defibrillator
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Box 653, 265 Crittenden Blvd Rochester, NY 14620, USA
    Eur Heart J 34:2230-42. 2013
    ..This review describes the technical details and characteristics of the WCD, discusses its various potential applications, and reports the currently available experience with the wearable defibrillator. ..
  5. ncbi request reprint Vagus nerve stimulation: A new approach to reduce heart failure
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, NY 14642, USA
    Cardiol J 17:638-44. 2010
    ..A prospective randomized trial with a larger patient cohort is needed to confirm these beneficial results of VNS...
  6. ncbi request reprint Implantable defibrillators: 30 years of history
    Helmut U Klein
    Heart Research Follow Up Program, University of Rochester Medical Center, 601 Elmwood Avenue, Box 653, Rochester, NY 14642, USA
    G Ital Cardiol (Rome) 11:48S-52S. 2010
    ..Device technology has impressively improved, but the principal concept remained the same: automatic shock delivery to a fibrillating heart by an implanted defibrillator will restore normal heart rhythm and save the life of the patient...
  7. ncbi request reprint Pilot study: Noninvasive monitoring of oral flecainide's effects on atrial electrophysiology during persistent human atrial fibrillation using the surface electrocardiogram
    Daniela Husser
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    Ann Noninvasive Electrocardiol 10:206-10. 2005
    ....
  8. ncbi request reprint Echocardiographic and electrocardiographic predictors for atrial fibrillation recurrence following cardioversion
    Andreas Bollmann
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    J Cardiovasc Electrophysiol 14:S162-5. 2003
    ....
  9. doi request reprint Effect of elapsed time from coronary revascularization to implantation of a cardioverter defibrillator on long-term survival in the MADIT-II trial
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 22:1237-42. 2011
    ..This study was designed to evaluate the effect of elapsed time from CR on long-term mortality and arrhythmic risk among patients who receive an implantable cardioverter defibrillator (ICD)...
  10. doi request reprint Impact of the right ventricular lead position on clinical outcome and on the incidence of ventricular tachyarrhythmias in patients with CRT-D
    Valentina Kutyifa
    University of Rochester Medical Center, Rochester, New York Semmelweis University, Heart Center, Budapest, Hungary, and Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    Heart Rhythm 10:1770-7. 2013
    ..Data on the impact of right ventricular (RV) lead location on clinical outcome and ventricular tachyarrhythmias in cardiac resynchronization therapy with defibrillator (CRT-D) patients are limited...
  11. doi request reprint Angiotensin II-antagonist in paroxysmal atrial fibrillation (ANTIPAF) trial
    Andreas Goette
    University Hospital Magdeburg, Magdeburg, Germany
    Circ Arrhythm Electrophysiol 5:43-51. 2012
    ....
  12. doi request reprint Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:2416-23. 2011
    ..We aimed to evaluate the relationship between echocardiographic response to cardiac resynchronization therapy (CRT) and the risk of subsequent ventricular tachyarrhythmias (VTAs)...
  13. doi request reprint Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1622-30. 2011
    ..We evaluated the outcome of patients enrolled in MADIT-CRT by ischaemic and non-ischaemic aetiology of cardiomyopathy (ICM and non-ICM, respectively)...
  14. doi request reprint Time-dependent benefit of preventive cardiac resynchronization therapy after myocardial infarction
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1614-21. 2011
    ..The present study was designed to evaluate the relationship between elapsed time from MI and the benefit of preventive CRT-D therapy in patients with ischaemic cardiomyopathy (ICM)...
  15. pmc Cigarette smoking induces atrial fibrosis in humans via nicotine
    Andreas Goette
    Institute of Experimental Internal Medicine, Division of Cardiology, Department of Cardiovascular Surgery, University Hospital Magdeburg, Magdeburg, Germany
    Heart 93:1056-63. 2007
    ..Cigarette smoking (CS) promotes endothelial dysfunction and atherosclerosis in the vascular bed. The impact of smoking on atrial myocardium is not defined in humans...
  16. doi request reprint Effect on cardiac function of cardiac resynchronization therapy in patients with right bundle branch block (from the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy [MADIT-CRT] trial)
    Christine Tompkins
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Am J Cardiol 112:525-9. 2013
    ..This echocardiographic benefit did not translate into a reduction in heart failure or death during a 3-year follow-up period...
  17. ncbi request reprint Time-frequency analysis of the surface electrocardiogram for monitoring antiarrhythmic drug effects in atrial fibrillation
    Daniela Husser
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    Am J Cardiol 95:526-8. 2005
    ..Effects were more pronounced with flecainide than with amiodarone...
  18. doi request reprint Improved outcome with preventive cardiac resynchronization therapy in the elderly: a MADIT-CRT substudy
    Justin Penn
    Department of Internal Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 22:892-7. 2011
    ..Elderly patients comprise a large portion of patients with heart failure (HF). Limited data exist on the effectiveness of cardiac resynchronization therapy with defibrillator (CRT-D) in patients with mild HF symptoms in this population...
  19. doi request reprint Clinical significance of ventricular tachyarrhythmias in patients treated with CRT-D
    Valentina Kutyifa
    University of Rochester Medical Center, Rochester, New York 14642, USA roehester edu
    Heart Rhythm 10:943-50. 2013
    ..Data on the outcome of cardiac resynchronization therapy with defibrillator (CRT-D) in patients developing ventricular arrhythmias are limited...
  20. doi request reprint Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 8:212-8. 2011
    ..Limited data regarding the effect of right ventricular pacing (RVP) on long-term survival following implantable cardioverter-defibrillator (ICD) implantation are available...
  21. doi request reprint Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression
    Andreas Goette
    Division of Cardiology, Otto von Guericke University Hospital Magdeburg, Magdeburg, Germany
    Circulation 117:732-42. 2008
    ....
  22. doi request reprint Long-term outcome with cardiac resynchronization therapy in mild heart failure patients with left bundle branch block from US and Europe MADIT-CRT
    Yitschak Biton
    Heart Research Follow Up Program, Division of Cardiology, Department of Medicine, University of Rochester Medical Center, 265 Crittenden Blvd, PO Box 653, Rochester, NY, 14642, USA
    Heart Fail Rev 20:535-43. 2015
    ..Despite differences in baseline disease severity, European and US patients with LBBB experienced a similar clinical and echocardiographic response to cardiac resynchronization therapy during long-term follow-up...
  23. doi request reprint Asymmetric dimethylarginine predicts appropriate implantable cardioverter-defibrillator intervention in patients with left ventricular dysfunction
    H Immo Lehmann
    Division of Cardiology, Department of Internal Medicine, Otto von Guericke University, Magdeburg, Germany
    Europace 13:1428-35. 2011
    ..We sought to investigate whether biomarkers of nitric oxide metabolism can predict the occurrence of ventricular tachyarrhythmias and might be used as risk markers in these pts...
  24. doi request reprint Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy
    Cecilia Fantoni
    Division of Cardiology, University Hospital, Magdeburg, Germany
    Eur J Heart Fail 10:298-307. 2008
    ..Diabetes mellitus is an independent risk factor for increased morbidity and mortality in heart failure (HF) patients...
  25. ncbi request reprint Frequency measures obtained from the surface electrocardiogram in atrial fibrillation research and clinical decision-making
    Andreas Bollmann
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    J Cardiovasc Electrophysiol 14:S154-61. 2003
    ..This article describes the experience with these two different frequency analysis techniques in consecutive AF patients and discusses possible applications in AF research and clinical decision-making...
  26. ncbi request reprint Cardiac resynchronization therapy improves heart rate profile and heart rate variability of patients with moderate to severe heart failure
    Cecilia Fantoni
    Division of Cardiology, University Hospital, Magdeburg, Germany
    J Am Coll Cardiol 46:1875-82. 2005
    ....
  27. ncbi request reprint Catheter ablation of ventricular tachycardia by intramyocardial injection of ethanol in an animal model of chronic myocardial infarction
    Sven Reek
    Division of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    J Cardiovasc Electrophysiol 15:332-41. 2004
    ..The aim of this study was to investigate the effects of direct ethanol injection on the inducibility of ventricular tachycardia (VT) in an animal model of chronic myocardial infarction...
  28. ncbi request reprint Time dependence of defibrillator benefit after coronary revascularization in the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 47:1811-7. 2006
    ....
  29. ncbi request reprint Expression of opioid receptor subtypes and their ligands in fibrillating human atria
    Uwe Lendeckel
    Institute of Experimental Internal Medicine, Otto von Magdeburg, Magdeburg, Germany
    Pacing Clin Electrophysiol 28:S275-9. 2005
    ..Persistent AF is associated with the down-regulation of the opioid receptor/ligand expression. This suggests a loss of protective capacity in the fibrillating atrial tissue, resulting in an ultrastructural remodeling of atrial myocytes...
  30. ncbi request reprint Right and left ventricular activation sequence in patients with heart failure and right bundle branch block: a detailed analysis using three-dimensional non-fluoroscopic electroanatomic mapping system
    Cecilia Fantoni
    Division of Cardiology, University Hospital, Magdeburg, Germany
    J Cardiovasc Electrophysiol 16:112-9; discussion 120-1. 2005
    ..Three-dimensional mapping in RBBB and heart failure...
  31. ncbi request reprint Angiotensin II antagonist in paroxysmal atrial fibrillation (ANTIPAF) trial: rationale and study design
    Andreas Goette
    Division of Cardiology, Otto von Guericke University Hospital Magdeburg, Magdeburg, Germany
    Clin Drug Investig 27:697-705. 2007
    ..The ANTIPAF trial is the first placebo-controlled trial analysing the occurrence of AF as the primary study endpoint...
  32. ncbi request reprint Effect of physical exercise on platelet activity and the von-Willebrand-factor in patients with persistent lone atrial fibrillation
    Andreas Goette
    Department of Internal Medicine, University Hospital Magdeburg, Magdeburg, Germany
    J Interv Card Electrophysiol 10:139-46. 2004
    ..The purpose of this study was to assess the effect of physical exercise on platelet activity, thrombin generation, and levels of von-Willebrand-factor in patients with persistent AF...
  33. ncbi request reprint Treatment of atrial fibrillation with an implantable atrial defibrillator--long term results
    J Christoph Geller
    University Hospitals of Magdeburg, Magdeburg, Germany
    Eur Heart J 24:2083-9. 2003
    ..To evaluate the long-term outcome with an implantable atrial defibrillator (IAD) in patients with recurrent atrial fibrillation (AF)...
  34. ncbi request reprint Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers
    Caroline Schmidt-Lucke
    Department of Internal Medicine, Division of Cardiology, Angiology and Pneumology, Otto von Guericke University, Magdeburg, Germany
    Int J Cardiol 100:207-12. 2005
    ..To relate levels of vascular endothelial growth factor (VEGF) and its soluble receptor, sFlt-1, with endothelial function in healthy smokers...
  35. ncbi request reprint Balanced steady-state free precession vs. segmented fast low-angle shot for the evaluation of ventricular volumes, mass, and function at 3 Tesla
    Frank Grothues
    Department of Cardiology, Otto von Guericke University, Magdeburg, Germany
    J Magn Reson Imaging 26:392-400. 2007
    ..To compare balanced steady-state free precession (SSFP) and segmented fast low angle shot (FLASH) for quantification of left and right ventricular volumes and function and for left ventricular mass at high field (3 Tesla)...
  36. ncbi request reprint Importance of left atrial diameter and atrial fibrillatory frequency for conversion of persistent atrial fibrillation with oral flecainide
    Andreas Bollmann
    Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    Am J Cardiol 90:1011-4. 2002
  37. ncbi request reprint G-CSF-induced mobilization of CD34(+) progenitor cells and proarrhythmic effects in patients with severe coronary artery disease
    Oliver Wolfram
    Division of Cardiology, University Hospital Magdeburg, Magdeburg, Germany
    Pacing Clin Electrophysiol 30:S166-9. 2007
    ..The in vivo mobilization of endothelial progenitor cells (EPCs) and the possible proarrhythmic effects in patients with severe coronary artery disease (CAD) and inducible ischemia have not been described...