Barbara Eden Kobrin Klein

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Attained parental age and children's survival at mid-life ages in a large population
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisc, USA
    Gerontology 53:399-403. 2007
  2. pmc Changing incidence of lens extraction over 20 years: the Beaver Dam eye study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Electronic address
    Ophthalmology 121:5-9. 2014
  3. doi request reprint Nitrate-nitrogen levels in rural drinking water: Is there an association with age-related macular degeneration?
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 48:1757-63. 2013
  4. pmc Long-term use of aspirin and age-related macular degeneration
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53726 2336, USA
    JAMA 308:2469-78. 2012
  5. pmc The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ophthalmology 119:1628-33. 2012
  6. pmc Cross-sectional associations of blood elements, clotting factors, nephropathy, and retinal outcomes in long duration type 1 diabetes
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Ophthalmic Epidemiol 19:120-6. 2012
  7. pmc Familial aggregation of components of the multiple metabolic syndrome in the Framingham Heart and Offspring Cohorts: Genetic Analysis Workshop Problem 1
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    BMC Genet 4:S94. 2003
  8. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
  9. pmc Cystatin C, other markers of kidney disease, and incidence of age-related cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
    Arch Ophthalmol 126:1724-30. 2008
  10. ncbi request reprint Supplements and age-related eye conditions the beaver dam eye study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 115:1203-8. 2008

Research Grants

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Attained parental age and children's survival at mid-life ages in a large population
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisc, USA
    Gerontology 53:399-403. 2007
    ..Long-lived persons tend to share a survival advantage with their parents and siblings; however, there is limited information on benefit beyond the extremes of longevity. We evaluated a survival benefit associated with age of parents...
  2. pmc Changing incidence of lens extraction over 20 years: the Beaver Dam eye study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Electronic address
    Ophthalmology 121:5-9. 2014
    ..To investigate trends in the incidence of lens extraction over the past 20 years...
  3. doi request reprint Nitrate-nitrogen levels in rural drinking water: Is there an association with age-related macular degeneration?
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 48:1757-63. 2013
    ..3% for low and 5.1% for the medium or high nitrate-nitrogen level, for the right eye). The OR for medium or high nitrate-nitrogen groups was 2.80 (95% CI: 1.07-7.31) compared to the low nitrate-nitrogen group. ..
  4. pmc Long-term use of aspirin and age-related macular degeneration
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53726 2336, USA
    JAMA 308:2469-78. 2012
    ..Aspirin is widely used for relief of pain and for cardioprotective effects. Its use is of concern to ophthalmologists when ocular surgery is being considered and also in the presence of age-related macular degeneration (AMD)...
  5. pmc The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ophthalmology 119:1628-33. 2012
    ..To examine the associations of cataract and cataract surgery with early and late age-related macular degeneration (AMD) over a 20-year interval...
  6. pmc Cross-sectional associations of blood elements, clotting factors, nephropathy, and retinal outcomes in long duration type 1 diabetes
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Ophthalmic Epidemiol 19:120-6. 2012
    ..To determine the association of blood elements, selected clotting factors, and nephropathy with proliferative diabetic retinopathy (PDR) and macular edema (ME) in those with long duration type 1 diabetes...
  7. pmc Familial aggregation of components of the multiple metabolic syndrome in the Framingham Heart and Offspring Cohorts: Genetic Analysis Workshop Problem 1
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    BMC Genet 4:S94. 2003
    ..Measures of plasma cholesterol (total and HDL), body mass index (BMI), and systolic blood pressure were used from selected calendar years of exams. Familial correlations were calculated using FCOR in S.A.G.E...
  8. pmc The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Endocr Disord 10:9. 2010
    ..We therefore aimed to investigate the association between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and retinal microvascular phenotypes in the Atherosclerosis Risk in Communities (ARIC) Study (1993-1995)...
  9. pmc Cystatin C, other markers of kidney disease, and incidence of age-related cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
    Arch Ophthalmol 126:1724-30. 2008
    ..To investigate the 15-year incidence of 3 specific types of age-related cataract as related to cystatin C and other measures of kidney function...
  10. ncbi request reprint Supplements and age-related eye conditions the beaver dam eye study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 115:1203-8. 2008
    ..To investigate the association of use of vitamin, mineral, and nonvitamin nonmineral supplements with common age-related eye diseases...
  11. pmc Lifestyle exposures and eye diseases in adults
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    Am J Ophthalmol 144:961-969. 2007
    ..To provide a perspective of observed associations between lifestyle exposures and eye diseases in adults...
  12. ncbi request reprint Overview of epidemiologic studies of diabetic retinopathy
    Barbara Eden Kobrin Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmic Epidemiol 14:179-83. 2007
    ..This is important because the increasing burden of diabetes will place a greater burden on the population and the medical care systems that will be caring for them...
  13. pmc Parents' attained age and biomarkers of aging in their children
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
    Arch Gerontol Geriatr 49:284-8. 2009
    ....
  14. pmc The relation of markers of inflammation and endothelial dysfunction to the prevalence and progression of diabetic retinopathy: Wisconsin epidemiologic study of diabetic retinopathy
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
    Arch Ophthalmol 127:1175-82. 2009
    ....
  15. pmc Selected sun-sensitizing medications and incident cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726 2336, USA
    Arch Ophthalmol 128:959-63. 2010
    ..To examine the relationship between the use of sun-sensitizing medications and cumulative incidence of age-related cataract...
  16. pmc Retrodots in the lens in the Beaver Dam Eye Study cohort
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 117:1889-93. 2010
    ..To determine the prevalence of retrodots in the lens and the association of these lesions to age-related cataract, and to assess their association with visual impairment and contrast sensitivity...
  17. ncbi request reprint Progression of retinopathy in persons with type 2 diabetes: new data, same conclusions?
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, United States
    Pol Arch Med Wewn 120:413-6. 2010
    ..However, the apparent paradoxical effects of intensive glycemic control on macrovascular and microvascular disease suggests caution in the care of persons with type 2 diabetes who are judged to be at high risk for cardiovascular events...
  18. pmc Self- and registry-reported cancer in a population-based longitudinal study
    Barbara E K Klein
    University of Wisconsin Madison, School of Medicine and Public Health, Department of Ophthalmology and Visual Sciences, 610 N Walnut St, 4th Fl WARF, Madison, WI 53726 2336, USA
    WMJ 109:261-6. 2010
    ..To evaluate the concordance of cancer diagnosis from self- and registry reports...
  19. pmc Refraction in adults with diabetes
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, Fourth Floor, Wisconsin Alumni Research Foundation, Madison, WI 53726 2336, USA
    Arch Ophthalmol 129:56-62. 2011
    ..To examine refraction, change in refraction, and risk factors for change in refraction in adults with type 1 and type 2 diabetes mellitus...
  20. pmc Complete blood cell count and retinal vessel diameters
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin Madison, 610 N Walnut Street, Madison, WI 53726 2336, USA
    Arch Ophthalmol 129:490-7. 2011
    ..To examine the cross-sectional associations of components of the complete blood cell count with retinal vessel diameters...
  21. ncbi request reprint Frailty and age-related cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 113:2209-12. 2006
    ..To determine whether there is an association between age-related cataract and frailty that persists after controlling for visual acuity (VA) and comorbid conditions...
  22. ncbi request reprint Lens opacities associated with performance-based and self-assessed visual functions
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Ophthalmology 113:1257-63. 2006
    ..To investigate the relationship of lens opacities to performance-based and self-assessed visual function in persons free of other ocular comorbidities...
  23. ncbi request reprint Heritability of risk factors for primary open-angle glaucoma: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2336, USA
    Invest Ophthalmol Vis Sci 45:59-62. 2004
    ..To investigate the family aggregation and heritability of risk indicators of primary open-angle glaucoma...
  24. ncbi request reprint Socioeconomic and lifestyle factors and the 10-year incidence of age-related cataracts
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2397, USA
    Am J Ophthalmol 136:506-12. 2003
    ..To investigate the association of socioeconomic and lifestyle factors with incidence of age-related cataracts...
  25. pmc Associations of selected medications and visual function: the Beaver Dam Eye Study
    B E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53726 2397, USA
    Br J Ophthalmol 87:403-8. 2003
    ..To investigate association of drug use and visual function...
  26. ncbi request reprint Cataract and hearing loss in a population-based study: the Beaver Dam studies
    B E Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, Madison, WI 53705 2397, USA
    Am J Ophthalmol 132:537-43. 2001
    ..For these reasons, we sought to estimate the risk factors for comorbidity of age-related cataract and hearing loss...
  27. ncbi request reprint Risk of incident age-related eye diseases in people with an affected sibling : The Beaver Dam Eye Study
    B E Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison Medical School, Madison, WI 53705 2397, USA
    Am J Epidemiol 154:207-11. 2001
    ..These findings suggest that strong family determinants of lesions of age-related maculopathy are likely, less so for age-related cataract, which confer risk of the same lesion in a younger sibling...
  28. ncbi request reprint Lens thickness and five-year cumulative incidence of cataracts: The Beaver Dam Eye Study
    B E Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705 2397, USA
    Ophthalmic Epidemiol 7:243-8. 2000
    ..To evaluate whether lens thickness is related to incidence of cataracts...
  29. ncbi request reprint Reproductive exposures, incident age-related cataracts, and age-related maculopathy in women: the beaver dam eye study
    B E Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705 2397, USA
    Am J Ophthalmol 130:322-6. 2000
    ..To evaluate the relationship of reproductive exposures and incident age-related cataract and maculopathy in women...
  30. ncbi request reprint Exogenous estrogen exposures and changes in diabetic retinopathy. The Wisconsin Epidemiologic Study of Diabetic Retinopathy
    B E Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705 2397, USA
    Diabetes Care 22:1984-7. 1999
    ..To investigate whether the use of exogenous estrogen is associated with changes in the severity of diabetic retinopathy and the incidence of macular edema...
  31. ncbi request reprint Life-style correlates of tooth loss in an adult Midwestern population
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, Medical School, University of Wisconsin, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
    J Public Health Dent 64:145-50. 2004
    ..To describe life-style correlates of tooth loss in a representative rural American population...
  32. ncbi request reprint The comparability of estimates of retroilluminated lens opacities as judged from film-based and digital imaging
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Am J Ophthalmol 138:668-70. 2004
    ..A digital imaging system is now available for imaging these opacities. We sought to compare gradings of images from both systems...
  33. ncbi request reprint Medical records as sources of data on cardiovascular disease events in persons with diabetes
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726, USA
    J Diabetes Complications 20:224-7. 2006
    ..The aim of this study is to evaluate medical records as a source of data on cardiovascular disease over a 20-year interval...
  34. ncbi request reprint Statin use and incident nuclear cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    JAMA 295:2752-8. 2006
    ..Oxidative stress is believed to play a role in the development of nuclear cataract, but little is known regarding the relationship of statin use and cataract incidence...
  35. doi request reprint Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 115:477-82. 2008
    ..To describe the long-term incidence of nuclear cataract, cortical cataract, and posterior subcapsular cataract (PSC) and to evaluate age and cohort effects on these rates...
  36. ncbi request reprint The relationship of optic disk cupping to retinal vein occlusion: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, Madison, WI 53726, USA
    Am J Ophthalmol 141:859-62. 2006
    ..To examine the association between optic disk cupping and retinal vein occlusion (RVO)...
  37. ncbi request reprint Is serum cholesterol associated with progression of diabetic retinopathy or macular edema in persons with younger-onset diabetes of long duration?
    B E Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705 2397, USA
    Am J Ophthalmol 128:652-4. 1999
    ..To quantitate the relationships of total cholesterol and high-density lipoprotein cholesterol to the incidence and progression of diabetic retinopathy and macular edema 5 years later in those with younger-onset diabetes of long duration...
  38. ncbi request reprint Frailty, morbidity and survival
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 405 WARF, Madison, WI 53726 2336, USA
    Arch Gerontol Geriatr 41:141-9. 2005
    ..Greater frailty was associated with greater likelihood of concurrent medical conditions and with decreased survival...
  39. pmc Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study
    B E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53726 2336, USA
    Br J Ophthalmol 89:284-7. 2005
    ..To investigate the relation between change in systemic blood pressures and change in intraocular pressure...
  40. ncbi request reprint Electrocardiographic abnormalities in individuals with long-duration type 1 diabetes
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, School of Medicine, Madison, Wisconsin 53726, USA
    Diabetes Care 28:145-7. 2005
  41. ncbi request reprint Association of retinal vessel caliber to optic disc and cup diameters
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Invest Ophthalmol Vis Sci 48:63-7. 2007
    ..To investigate whether optic disc size is related to retinal venule and arteriole diameters...
  42. ncbi request reprint The epidemiology of eye disease: from glycemia to genetics: the Friedenwald Lecture
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Invest Ophthalmol Vis Sci 47:1746-53. 2006

Research Grants7

  1. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  2. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  3. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..