Research Topics
| Barbara Eden Kobrin KleinSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Long-term use of aspirin and age-related macular degenerationBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53726 2336, USA
JAMA 308:2469-78. 2012..Aspirin is widely used for relief of pain and for cardioprotective effects. Its use is of concern to ophthalmologists when ocular surgery is being considered and also in the presence of age-related macular degeneration (AMD)...
The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye StudyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Ophthalmology 119:1628-33. 2012..To examine the associations of cataract and cataract surgery with early and late age-related macular degeneration (AMD) over a 20-year interval...- Cross-sectional associations of blood elements, clotting factors, nephropathy, and retinal outcomes in long duration type 1 diabetesBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
Ophthalmic Epidemiol 19:120-6. 2012..To determine the association of blood elements, selected clotting factors, and nephropathy with proliferative diabetic retinopathy (PDR) and macular edema (ME) in those with long duration type 1 diabetes... 
Familial aggregation of components of the multiple metabolic syndrome in the Framingham Heart and Offspring Cohorts: Genetic Analysis Workshop Problem 1Kristine E Lee
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
BMC Genet 4:S94. 2003..Measures of plasma cholesterol (total and HDL), body mass index (BMI), and systolic blood pressure were used from selected calendar years of exams. Familial correlations were calculated using FCOR in S.A.G.E...- The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC StudyYu Yan
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
BMC Endocr Disord 10:9. 2010..We therefore aimed to investigate the association between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and retinal microvascular phenotypes in the Atherosclerosis Risk in Communities (ARIC) Study (1993-1995)... - Self- and registry-reported cancer in a population-based longitudinal studyBarbara E K Klein
University of Wisconsin Madison, School of Medicine and Public Health, Department of Ophthalmology and Visual Sciences, 610 N Walnut St, 4th Fl WARF, Madison, WI 53726 2336, USA
WMJ 109:261-6. 2010..To evaluate the concordance of cancer diagnosis from self- and registry reports... 
Attained parental age and children's survival at mid-life ages in a large populationBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisc, USA
Gerontology 53:399-403. 2007..Long-lived persons tend to share a survival advantage with their parents and siblings; however, there is limited information on benefit beyond the extremes of longevity. We evaluated a survival benefit associated with age of parents...- Overview of epidemiologic studies of diabetic retinopathyBarbara Eden Kobrin Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Ophthalmic Epidemiol 14:179-83. 2007..This is important because the increasing burden of diabetes will place a greater burden on the population and the medical care systems that will be caring for them... - Lifestyle exposures and eye diseases in adultsBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
Am J Ophthalmol 144:961-969. 2007..To provide a perspective of observed associations between lifestyle exposures and eye diseases in adults... - Supplements and age-related eye conditions the beaver dam eye studyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Ophthalmology 115:1203-8. 2008..To investigate the association of use of vitamin, mineral, and nonvitamin nonmineral supplements with common age-related eye diseases... - Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye StudyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Ophthalmology 115:477-82. 2008..To describe the long-term incidence of nuclear cataract, cortical cataract, and posterior subcapsular cataract (PSC) and to evaluate age and cohort effects on these rates... - Cystatin C, other markers of kidney disease, and incidence of age-related cataractBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
Arch Ophthalmol 126:1724-30. 2008..To investigate the 15-year incidence of 3 specific types of age-related cataract as related to cystatin C and other measures of kidney function... - Parents' attained age and biomarkers of aging in their childrenBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
Arch Gerontol Geriatr 49:284-8. 2009.... - The relation of markers of inflammation and endothelial dysfunction to the prevalence and progression of diabetic retinopathy: Wisconsin epidemiologic study of diabetic retinopathyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
Arch Ophthalmol 127:1175-82. 2009.... - Complete blood cell count and retinal vessel diametersBarbara E K Klein
Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin Madison, 610 N Walnut Street, Madison, WI 53726 2336, USA
Arch Ophthalmol 129:490-7. 2011..To examine the cross-sectional associations of components of the complete blood cell count with retinal vessel diameters... - Refraction in adults with diabetesBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, Fourth Floor, Wisconsin Alumni Research Foundation, Madison, WI 53726 2336, USA
Arch Ophthalmol 129:56-62. 2011..To examine refraction, change in refraction, and risk factors for change in refraction in adults with type 1 and type 2 diabetes mellitus... - Selected sun-sensitizing medications and incident cataractBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726 2336, USA
Arch Ophthalmol 128:959-63. 2010..To examine the relationship between the use of sun-sensitizing medications and cumulative incidence of age-related cataract... - Retrodots in the lens in the Beaver Dam Eye Study cohortBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
Ophthalmology 117:1889-93. 2010..To determine the prevalence of retrodots in the lens and the association of these lesions to age-related cataract, and to assess their association with visual impairment and contrast sensitivity... - Progression of retinopathy in persons with type 2 diabetes: new data, same conclusions?Barbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, United States
Pol Arch Med Wewn 120:413-6. 2010..However, the apparent paradoxical effects of intensive glycemic control on macrovascular and microvascular disease suggests caution in the care of persons with type 2 diabetes who are judged to be at high risk for cardiovascular events... - Frailty and age-related cataractBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
Ophthalmology 113:2209-12. 2006..To determine whether there is an association between age-related cataract and frailty that persists after controlling for visual acuity (VA) and comorbid conditions... - Lens opacities associated with performance-based and self-assessed visual functionsBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
Ophthalmology 113:1257-63. 2006..To investigate the relationship of lens opacities to performance-based and self-assessed visual function in persons free of other ocular comorbidities... - Heritability of risk factors for primary open-angle glaucoma: the Beaver Dam Eye StudyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2336, USA
Invest Ophthalmol Vis Sci 45:59-62. 2004..To investigate the family aggregation and heritability of risk indicators of primary open-angle glaucoma... - Socioeconomic and lifestyle factors and the 10-year incidence of age-related cataractsBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2397, USA
Am J Ophthalmol 136:506-12. 2003..To investigate the association of socioeconomic and lifestyle factors with incidence of age-related cataracts... - Associations of selected medications and visual function: the Beaver Dam Eye StudyB E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53726 2397, USA
Br J Ophthalmol 87:403-8. 2003..To investigate association of drug use and visual function... - Cataract and hearing loss in a population-based study: the Beaver Dam studiesB E Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, Madison, WI 53705 2397, USA
Am J Ophthalmol 132:537-43. 2001..For these reasons, we sought to estimate the risk factors for comorbidity of age-related cataract and hearing loss... - Risk of incident age-related eye diseases in people with an affected sibling : The Beaver Dam Eye StudyB E Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison Medical School, Madison, WI 53705 2397, USA
Am J Epidemiol 154:207-11. 2001..These findings suggest that strong family determinants of lesions of age-related maculopathy are likely, less so for age-related cataract, which confer risk of the same lesion in a younger sibling... - Lens thickness and five-year cumulative incidence of cataracts: The Beaver Dam Eye StudyB E Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705 2397, USA
Ophthalmic Epidemiol 7:243-8. 2000..To evaluate whether lens thickness is related to incidence of cataracts... - Reproductive exposures, incident age-related cataracts, and age-related maculopathy in women: the beaver dam eye studyB E Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705 2397, USA
Am J Ophthalmol 130:322-6. 2000..To evaluate the relationship of reproductive exposures and incident age-related cataract and maculopathy in women... - Exogenous estrogen exposures and changes in diabetic retinopathy. The Wisconsin Epidemiologic Study of Diabetic RetinopathyB E Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705 2397, USA
Diabetes Care 22:1984-7. 1999..To investigate whether the use of exogenous estrogen is associated with changes in the severity of diabetic retinopathy and the incidence of macular edema... - Life-style correlates of tooth loss in an adult Midwestern populationBarbara E K Klein
Department of Ophthalmology and Visual Sciences, Medical School, University of Wisconsin, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
J Public Health Dent 64:145-50. 2004..To describe life-style correlates of tooth loss in a representative rural American population... - The comparability of estimates of retroilluminated lens opacities as judged from film-based and digital imagingBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
Am J Ophthalmol 138:668-70. 2004..A digital imaging system is now available for imaging these opacities. We sought to compare gradings of images from both systems... - Medical records as sources of data on cardiovascular disease events in persons with diabetesBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726, USA
J Diabetes Complications 20:224-7. 2006..The aim of this study is to evaluate medical records as a source of data on cardiovascular disease over a 20-year interval... - Statin use and incident nuclear cataractBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
JAMA 295:2752-8. 2006..Oxidative stress is believed to play a role in the development of nuclear cataract, but little is known regarding the relationship of statin use and cataract incidence... - Is serum cholesterol associated with progression of diabetic retinopathy or macular edema in persons with younger-onset diabetes of long duration?B E Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705 2397, USA
Am J Ophthalmol 128:652-4. 1999..To quantitate the relationships of total cholesterol and high-density lipoprotein cholesterol to the incidence and progression of diabetic retinopathy and macular edema 5 years later in those with younger-onset diabetes of long duration... - The relationship of optic disk cupping to retinal vein occlusion: the Beaver Dam Eye StudyBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, Madison, WI 53726, USA
Am J Ophthalmol 141:859-62. 2006..To examine the association between optic disk cupping and retinal vein occlusion (RVO)... - Frailty, morbidity and survivalBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 405 WARF, Madison, WI 53726 2336, USA
Arch Gerontol Geriatr 41:141-9. 2005..Greater frailty was associated with greater likelihood of concurrent medical conditions and with decreased survival... - Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye StudyB E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53726 2336, USA
Br J Ophthalmol 89:284-7. 2005..To investigate the relation between change in systemic blood pressures and change in intraocular pressure... - Electrocardiographic abnormalities in individuals with long-duration type 1 diabetesBarbara E K Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, School of Medicine, Madison, Wisconsin 53726, USA
Diabetes Care 28:145-7. 2005 - Association of retinal vessel caliber to optic disc and cup diametersKristine E Lee
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
Invest Ophthalmol Vis Sci 48:63-7. 2007..To investigate whether optic disc size is related to retinal venule and arteriole diameters... - The epidemiology of eye disease: from glycemia to genetics: the Friedenwald LectureRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
Invest Ophthalmol Vis Sci 47:1746-53. 2006
Research Grants
- PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVALBarbara Klein; Fiscal Year: 2002....
- Family Clustering of Incidence & Progression of CataractBarbara Klein; Fiscal Year: 2003..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
- Linkage Studies of Quantitative Ocular TraitsBarbara Klein; Fiscal Year: 2006..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..