Research Topics
Genomes and Genes | C G KleerSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
On how CCN6 suppresses breast cancer growth and invasionWei Huang
Department of Pathology and 4217 Comprehensive Cancer Center, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA
J Cell Commun Signal 6:5-10. 2012..Thus, our work provides new insights into the functions and mechanisms of tumor suppression exerted by CCN6 in the breast...
Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cellsYanhong Zhang
Department of Pathology, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Breast Cancer Res 7:R1080-9. 2005..We hypothesized that inhibition of CCN6 might result in the loss of a growth regulatory function that protects mammary epithelial cells from the tumorigenic effects of growth factors, particularly IGF-1...- E-cadherin expression in primary carcinomas of the breast and its distant metastasesPaul J Kowalski
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
Breast Cancer Res 5:R217-22. 2003..Invasive lobular carcinomas have a different pattern of E-cadherin expression, suggesting a different role for E-cadherin in this form of breast carcinoma... 
Fine-needle aspiration of breast carcinomas with prominent lymphocytic infiltrateC G Kleer
Department of Pathology, University of Michigan Medical Center, Ann Arbor 48109 0054, USA
Diagn Cytopathol 23:39-42. 2000..Lymphocytosis may be part of the carcinoma or may originate from a lymph node involved by metastases. In rare cases, a prominent neutrophilic infiltrate may also be present...- EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsCelina G Kleer
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:11606-11. 2003..This study provides compelling evidence for a functional link between dysregulated cellular memory, transcriptional repression, and neoplastic transformation... 
Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functionsCelina G Kleer
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
Arch Pathol Lab Med 133:1822-5. 2009..These concepts illustrate the important relationships among histopathologic features; genomic profile; single gene abnormalities, such as BRCA1 and EZH2; and growth regulation in this subset of breast carcinomas...- CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancerCelina G Kleer
Department of Pathology, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, Mich 48109, USA
Cells Tissues Organs 185:95-9. 2007..This review will focus on the current knowledge regarding the function of CCN6 in breast cancer with special emphasis on the emerging role of CCN6 as a regulator of the epithelial phenotype and E-cadherin expression in the breast... - RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breastCelina G Kleer
Department of Pathology and Internal Medicine, University of Michigan, Ann Arbour, MI 48109 0054, USA
Breast Cancer Res Treat 93:101-10. 2005..We hypothesized that RhoC expression would identify aggressive, non-IBC tumors breast cancer patients at any stage with worse outcomes defined as recurrence and/or metastasis... - Persistent E-cadherin expression in inflammatory breast cancerC G Kleer
Department of Pathology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA
Mod Pathol 14:458-64. 2001..In our study, we demonstrate that circulating IBC tumor cells strongly express E-cadherin, thereby providing an important exception to the positive association between E-cadherin loss and poor prognosis in breast cancer... - Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic abilityCelina G Kleer
Department of Pathology, Division of Hematology and Oncology, 2G332 University Hospital, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
Am J Pathol 160:579-84. 2002..RhoC is specifically expressed in invasive breast carcinomas capable of metastasizing, and it may be clinically useful in patients with tumors smaller than 1 cm to guide treatment... - Pathologic, immunohistochemical, and molecular features of benign and malignant phyllodes tumors of the breastC G Kleer
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
Mod Pathol 14:185-90. 2001..Neither Ki-67 nor p53 can reliably predict recurrence. Histologically high-grade malignant PT have a favorable prognosis if widely excised. We emphasize the importance of adequate margins in the treatment of benign and malignant PT... - WISP3 is a novel tumor suppressor gene of inflammatory breast cancerCelina G Kleer
Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
Oncogene 21:3172-80. 2002..Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis... - Squamous cell carcinoma of the thyroid: an aggressive tumor associated with tall cell variant of papillary thyroid carcinomaC G Kleer
Department of Pathology, University of Michigan Medical Center, Ann Arbor, USA
Mod Pathol 13:742-6. 2000..Primary SCT is an aggressive neoplasm that may be found in association with TCV. p53 expression and high MIB1 labeling index occur in these tumors and may be useful prognosticators... - Detection of Epstein-Barr virus in rapidly growing fibroadenomas of the breast in immunosuppressed hostsCelina G Kleer
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
Mod Pathol 15:759-64. 2002..This is the first study suggesting a role for EBV in the pathogenesis of fibroadenomas... - Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1Wei Huang
Department of Pathology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0605, USA
Am J Pathol 172:893-904. 2008..Together, our results lead to a new hypothesis that Snail and ZEB1 are downstream of CCN6 and play a critical role in CCN6-mediated regulation of E-cadherin in breast cancer... - Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1M E Gonzalez
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Oncogene 28:843-53. 2009..Blockade of EZH2 may provide a prime target to prevent and/or halt ER-negative breast cancer progression... - Axillary staging prior to neoadjuvant chemotherapy for breast cancer: predictors of recurrenceKandice E Kilbride
Department of Surgical Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Ann Surg Oncol 15:3252-8. 2008..The value of axillary staging prior to delivery of neoadjuvant chemotherapy (NEO) for breast cancer is controversial. Our goal was to analyze the prognostic and therapeutic impact of axillary staging on recurrence... - Enhancer of Zeste 2 as a marker of preneoplastic progression in the breastLei Ding
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Res 66:9352-5. 2006.... - Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppressionLisa M Privette
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0638, USA
Cancer Res 67:6064-74. 2007.... - Repression of E-cadherin by the polycomb group protein EZH2 in cancerQ Cao
Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
Oncogene 27:7274-84. 2008..Taken together, these observations provide a novel mechanism of E-cadherin regulation and establish a functional link between dysregulation of EZH2 and repression of E-cadherin during cancer progression... - Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysisRohit Mehra
Department of Pathology, University of Michigan Medical School, Ann Arbor, 48109, USA
Cancer Res 65:11259-64. 2005..Our data suggest that immunohistochemical analysis of GATA3 may be the basis for a new clinically applicable test to predict tumor recurrence early in the progression of breast cancer... - RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neckCelina G Kleer
Department of Pathology, University of Michigan, Ann Arbor, 48109, USA
Clin Cancer Res 12:4485-90. 2006..This study evaluated the expression of RhoC in head and neck carcinoma and investigated the prognostic use of this marker on a large cohort of previously untreated patients with SCCHN... - WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancerCelina G Kleer
Department of Pathology, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
Neoplasia 6:179-85. 2004.... - Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesionsLakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
Pathol Int 58:620-5. 2008..Despite matching for tumor size, grade 1 IDC have a higher incidence of lymph node metastasis and may have Her-2-neu overexpression compared to TC... - The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cellsMichael Zeidler
Department of Pathology, University of Michigan, Arbor, MI, USA
Neoplasia 7:1011-9. 2005..Our study paves the way for exploring the blockade of EZH2 overexpression as a novel approach for the prevention and treatment of breast cancer... - WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancerCelina G Kleer
Department of Pathology, University of Michigan, Ann Arbor, MI, USA
Breast Cancer Res 6:R110-5. 2004..We propose a model of this interaction as a starting point for further investigations... - Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinomaAdam D Toll
Department of Pathology, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
Hum Pathol 41:1205-9. 2010..Our study suggests that E-cadherin down-regulation may lead to enhancer of zeste homologue 2-mediated invasion and metastasis... - p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinomaMeryem M Koker
Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109 0054, USA
Am J Surg Pathol 28:1506-12. 2004..7% and 99.4%, respectively. We propose the inclusion of p63 as part of the diagnostic workup of challenging spindle cell tumors of the breast as a highly specific marker for metaplastic carcinomas... - The reversible epigenetic silencing of BRM: implications for clinical targeted therapyS Glaros
Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
Oncogene 26:7058-66. 2007..Thus, BRG1 and BRM are silenced by different mechanisms, and it may be possible to clinically target and reexpress BRM in a number of tumor types, potentially impacting tumor development... - Small (< 2.0-cm) breast cancers: mammographic and US findings at US-guided cryoablation--initial experienceMarilyn A Roubidoux
Department of Radiology, University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Drive, Room 2910H, Ann Arbor, MI 48109-0326, USA
Radiology 233:857-67. 2004..Tumor size, mammographic density, and US characteristics may be indicators of likelihood of complete cryoablation... - Comprehensive axillary evaluation in neoadjuvant chemotherapy patients with ultrasonography and sentinel lymph node biopsyAmina Khan
Department of Surgery, Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan, 48109, USA
Ann Surg Oncol 12:697-704. 2005.... - Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysisAgnieszka K Witkiewicz
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 14:1418-23. 2005..Quantitative image analysis is a novel way to accurately and reproducibly evaluate immunohistochemistry in breast tissue samples using high-density tissue microarrays... - Significance of flat epithelial atypia on mammotome core needle biopsy: Should it be excised?Lakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48331, USA
Hum Pathol 38:35-41. 2007..Chronic inflammation and stromal changes are present in a subset of cases. Flat epithelial atypia shows a risk of upgrade to carcinoma similar to that of ADH and, hence, should be recognized and warrants a follow-up excision... - WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancerCelina G Kleer
Department of Pathology, Univeristy of Michigan, Ann Arbor, MI, USA
Breast Cancer Res 6:R110-5. 2004..This provides further evidence that these two genes act in concert to give rise to the highly aggressive IBC phenotype. We propose a model of this interaction as a starting point for further investigations... - The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancerMichael Zeidler
Department of Pathology and Comprehensive Cancer Center, University of Michigan, 3510C MSRB1, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
J Mol Histol 37:219-23. 2006..In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis... - ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeChristophe Ginestier
Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
Cell Stem Cell 1:555-67. 2007..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts... - Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networksSuling Liu
Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
Cancer Res 71:614-24. 2011..Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population... - Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cellsWei Huang
Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 70:3340-50. 2010..These results enable us to pinpoint one mechanism by which CCN6 controls survival of breast cells mediated by the PI3K/Akt-1 pathway... - Residual disease after re-excision lumpectomy for close marginsMichael S Sabel
Division of Surgical Oncology, Department of Surgery, Biostatistics Core of the University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
J Surg Oncol 99:99-103. 2009..We sought to examine the incidence of residual disease after re-excision for close margins and to identify predictive factors that may better select patients for re-excision... - Expression of polycomb group protein EZH2 in nevi and melanomaJonathan B McHugh
Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, MI 48109, USA
J Cutan Pathol 34:597-600. 2007..We sought to determine the pattern of EZH2 expression in benign and malignant melanocytic tumors to see if EZH2 might play a role in melanoma pathogenesis and progression... - Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patientsAn Chi Lo
Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA
Breast Cancer Res Treat 112:141-7. 2008..A higher frequency of IBC and a more aggressive IBC phenotype was reported in Egypt than in the United States. This difference in disease frequency and presentation might be related to molecular epidemiologic factors... - Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapyQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
Cancer Res 65:8366-71. 2005..Taken together, these results revealed that PKC epsilon plays a critical and causative role in promoting an aggressive metastatic breast cancer phenotype and as a target for anticancer therapy... - Pathologic features of breast cancer associated with complete response to neoadjuvant chemotherapy: importance of tumor necrosisRobert T Pu
Department of Pathology, University of Michigan, Ann Arbor, MI, USA
Am J Surg Pathol 29:354-8. 2005..0062, P = 0.0249, and P = 0.0021, respectively). Although preliminary, our study suggests that the presence of tumor necrosis and ALI in the core biopsy may be important features to be included in the standard report... - Clinical and radiologic assessments to predict breast cancer pathologic complete response to neoadjuvant chemotherapyAnne F Schott
Hematology Oncology Division, Department of Internal Medicine, University of Michigan, MI 48109 0848, USA
Breast Cancer Res Treat 92:231-8. 2005.... - Sentinel node biopsy prior to neoadjuvant chemotherapyMichael S Sabel
Breast Oncology Program and Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
Am J Surg 186:102-5. 2003..Sentinel lymph node biopsy prior to induction chemotherapy may address both... - Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cellsDinesh S Rao
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor 48109, USA
Cancer Cell 3:471-82. 2003..Thus, HIP1 overexpression promotes tumor formation and is associated with a general alteration in receptor trafficking. HIP1 is the first endocytic protein to be directly implicated in tumor formation... - Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 casesRiccardo Valdez
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Mod Pathol 16:223-8. 2003..These findings suggest that despite the presence of B-cell-predominant lymphoid infiltrates and lymphoepithelial lesions, lymphocytic mastitis and diabetic mastopathy do not appear to be associated with an increased risk for lymphoma... - Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissuesLei Ding
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
Cancer Res 66:4095-9. 2006..We identify EZH2 as a potential marker for detecting preneoplastic lesions of the breast in vivo and as a possible target for preventative intervention... - Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patientsAn Chi Lo
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Breast 18:55-9. 2009..Future studies should focus on relating epidemiologic factors to molecular features of IBC in this population... - Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell linesMichael E Ray
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0948, USA
Cancer Res 64:40-7. 2004..This study has identified new candidate oncogenes within the 8p11-p12 region, supporting the hypothesis that genes other than FGFR1 may contribute to oncogenesis in breast cancers with proximal 8p amplification... - BRCA1 regulates human mammary stem/progenitor cell fateSuling Liu
Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 105:1680-5. 2008..Because BRCA1 also plays a role in DNA repair, our work suggests that loss of BRCA1 may result in the accumulation of genetically unstable breast stem cells, providing prime targets for further carcinogenic events... - ADAM15 disintegrin is associated with aggressive prostate and breast cancer diseaseRainer Kuefer
Department of Urology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 0944, USA
Neoplasia 8:319-29. 2006..These results suggest that ADAM15 is generally overexpressed in adenocarcinoma and is highly associated with metastatic progression of prostate and breast cancers... - Is lobular carcinoma in situ as a component of breast carcinoma a risk factor for local failure after breast-conserving therapy? Results of a matched pair analysisMerav A Ben-David
Department of Radiation Oncology, Cancer and Geriatrics Center, University of Michigan Medical School, Ann Arbor, Michigan 48109 0010, USA
Cancer 106:28-34. 2006.... - Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesisQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 62:4854-9. 2002..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors... - AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonistDaniel R Rhodes
Michigan Center for Translational Pathology, Howard Hughes Medical Institute, and Departments of Urology, and Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 5602
Proc Natl Acad Sci U S A 106:10284-9. 2009..Taken together, these observations indicate that marked AGTR1 overexpression defines a subpopulation of ER-positive, ERBB2-negative breast cancer that may benefit from targeted therapy with AGTR1 antagonists, such as losartan... - Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progressionCelina G Kleer
Department of Pathology, University of Michigan Cancer Center, Ann Arbor, Michigan, USA
Clin Cancer Res 14:5357-67. 2008..To evaluate the expression of cathepsin K (CTSK) and CXCL14 in stromal and epithelial cells in human breast tumor progression... - Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breastMichael J Hayes
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Clin Cancer Res 14:4038-44. 2008..By immunohistochemistry, normal beta-catenin was seen as membrane staining, and it was aberrant when >5% of tumor cells had nuclear or cytoplasmic accumulation or reduced membrane staining... - Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinomaQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Mol Cancer Ther 2:617-22. 2003..4 +/- 14.3% greater than that in doxorubicin-treated mice. These results suggest that TM may enhance the rate of pathological complete response when used in combination with an anthracycline in neoadjuvant therapy of breast carcinoma... - Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasiaXin Li
Department of Pathology, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Am J Pathol 175:1246-54. 2009.... - Alpha-Methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesionsMing Zhou
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, USA
Am J Surg Pathol 26:926-31. 2002..In conclusion, our study suggests that AMACR is potentially an important tumor marker for several cancers and their precursor lesions, especially those linked to high-fat diets... - Changes in surgical management resulting from case review at a breast cancer multidisciplinary tumor boardErika A Newman
Department of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
Cancer 107:2346-51. 2006..Multidisciplinary review can provide patients with useful additional information when making difficult treatment decisions... - African ancestry and higher prevalence of triple-negative breast cancer: findings from an international studyAzadeh Stark
Department of Pathology, Ford Health System, Detroit, Michigan, USA
Cancer 116:4926-32. 2010..The study of breast cancer in women with African ancestry offers the promise of identifying markers for risk assessment and treatment of triple-negative disease... - A pilot study to establish a clinical model to perform phase II studies of breast cancer chemopreventive agents in women at high risk with biomarkers as surrogate endpoints for activityVered Stearns
Breast Cancer Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
Clin Cancer Res 10:8332-40. 2004..We chose tamoxifen to establish proof of principal with a known effective agent... - A putative role for psoriasin in breast tumor progressionIan Krop
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer Res 65:11326-34. 2005.... - Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breastFrances P O'Malley
Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
Mod Pathol 19:172-9. 2006..1-97.4%), than for determining its presence (90.4%: 95% CI, 79.9-96.7%). We conclude that the diagnosis of FEA and its distinction from CCLs without atypia is highly reproducible with the use of available diagnostic criteria... - CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculatureZhenhua Miao
ChemoCentryx, Inc, Mountain View, CA 94043, USA
Proc Natl Acad Sci U S A 104:15735-40. 2007..Taken together, these data suggest that CXCR7 has key functions in promoting tumor development and progression... - Sentinel lymph node biopsy for breast cancer: how many nodes are enough?Shaheen Zakaria
Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
J Surg Oncol 96:554-9. 2007..Sentinel lymph node (SLN) biopsy using blue dye and radioisotope often results in the removal of multiple SLNs. We sought to determine whether there is a point where the surgeon can terminate the procedure without sacrificing accuracy... - Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cellsJulie Hanson Ostrander
Department of Medicine, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Cancer Res 67:4199-209. 2007..These results place Brk in a novel signaling pathway downstream of ErbB receptors and upstream of Rac, p38 MAPK, and ERK5 and establish the ErbB-Brk-Rac-p38 MAPK pathway as a critical mediator of breast cancer cell migration...
Research Grants
- Role of LIBC in Inflammatory Breast Cancer PhenotypeCelina Kleer; Fiscal Year: 2007..Also, understanding the role of WISP3 will shed light on the mechanisms of cancer development in general and serve as a model for other related CCN genes involved in carcinogenesis. ..
- Role of EZH2 in Breast CancerCelina Kleer; Fiscal Year: 2007..In summary, this proposal addresses the clinical utility and functional role of EZH2 in the regulation of breast cancer progression. ..
- Role of EZH2 in Breast CancerCelina Kleer; Fiscal Year: 2009..In summary, this proposal addresses the clinical utility and functional role of EZH2 in the regulation of breast cancer progression. ..
- Role of CCN6 (WISP3) in the progression and metastasis of breast cancerCelina Kleer; Fiscal Year: 2009..These studies may form the basis of intervention and therapy in breast cancer, potentially preventing premalignant lesions from becoming malignant and metastasizing. ..
- Role of CCN6 (WISP3) in the progression and metastasis of breast cancerCelina G Kleer; Fiscal Year: 2010..These studies may form the basis of intervention and therapy in breast cancer, potentially preventing premalignant lesions from becoming malignant and metastasizing. ..
- Role of EZH2 in Breast Cancer ProgressionCelina G Kleer; Fiscal Year: 2010..These studies may form the basis of intervention and therapy in breast cancer, potentially preventing premalignant lesions from becoming malignant and metastasizing. ..