Research Topics
| D K KlassenSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Pancreas allograft biopsy: safety of percutaneous biopsy-results of a large experienceDavid K Klassen
Department of Medicine, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
Transplantation 73:553-5. 2002..The safety and success rate of the procedure with current surgical techniques is unclear. We report the complications and success rate in 426 consecutive percutaneous pancreas allograft biopsies performed at a single center...
How aggressively should blood pressure be treated in renal transplant recipients?D K Klassen
Division of Nephrology, University of Maryland Medical Systems, 22 S Greene Street N3W143, Baltimore, MD 21201, USA
Curr Hypertens Rep 2:473-7. 2000..Extrapolating from data from nonrenal transplant patients suggests that aggressive treatment of hypertension in renal transplant patients may improve allograft and patient survival...
Histologic grading of acute allograft rejection in pancreas needle biopsy: correlation to serum enzymes, glycemia, and response to immunosuppressive treatmentJ C Papadimitriou
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
Transplantation 66:1741-5. 1998..The correlation between clinical evidence of graft dysfunction (increased serum enzymes and glucose), severity of acute rejection on biopsy (rejection grade), and response to treatment has not been previously studied...
Morphological spectrum of polyoma virus disease in renal allografts: diagnostic accuracy of urine cytologyR C Drachenberg
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
Am J Transplant 1:373-81. 2001..We conclude that urine cytology is useful to evaluate renal transplant patients with PV reactivation because sloughed tubular cells are found in urine and positive urine samples are a consistent manifestation of PV renal involvement...
Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathyC Drachenberg
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Transplant Proc 36:3028-31. 2004..Rationale selection of screening protocols based on the current knowledge of the infection and tailored to the available laboratory capabilities in each transplantation center can optimize the use of resources...
Tubular epithelial cell and podocyte apoptosis with de novo sirolimus based immunosuppression in renal allograft recipients with DGFR Munivenkatappa
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Histol Histopathol 25:189-96. 2010..007). There was no podocyte expression of activated mTOR, activated caspase-3, or Bcl-2 in either group. These data suggest that DGF patients treated with sirolimus have increased renal tubular cell apoptosis and podocyte apoptosis...
Long-term impact of discontinued or reduced calcineurin inhibitor in patients with chronic allograft nephropathyM R Weir
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
Kidney Int 59:1567-73. 2001..Chronic allograft nephropathy is the major cause of progressive renal failure in renal transplant recipients. It has no definitive treatment...
Specificity of intertubular capillary changes: comparative ultrastructural studies in renal allografts and native kidneysC B Drachenberg
Department of Pathology, University of Maryland School of Medicine, Baltimore, USA
Ultrastruct Pathol 21:227-33. 1997..This association is particularly true for cases with severe ITC abnormalities...
Early steroid withdrawal in solitary pancreas transplantation results in equivalent graft and patient survival compared with maintenance steroid therapyGhazal Vessal
School of Pharmacy, University of Maryland, Baltimore, MD, USA
Clin Transplant 21:491-7. 2007..We conclude that early corticosteroid withdrawal in isolated pancreas transplantation results in fewer infections and can be achieved without an increased risk of rejection or graft loss over the first year...
Guidelines for the diagnosis of antibody-mediated rejection in pancreas allografts-updated Banff grading schemaC B Drachenberg
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
Am J Transplant 11:1792-802. 2011..A systematized clinicopathological approach to AMR is essential for the development and assessment of much needed therapeutic interventions...
Association of serum uric acid with graft survival after kidney transplantation: a time-varying analysisA Haririan
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Am J Transplant 11:1943-50. 2011..Its negative impact seems to be worse with lower eGFR...
MIC expression in renal and pancreatic allograftsKim G Hankey
Department of Pathology, University of Maryland Medical System, Baltimore, Maryland 21201, USA
Transplantation 73:304-6. 2002..In addition to previous findings of alloantibodies against MICA, expression of these gene products may play a role in allograft rejection...
Glomerular inflammation in renal allografts biopsies after the first year: cell types and relationship with antibody-mediated rejection and graft outcomeJohn C Papadimitriou
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
Transplantation 90:1478-85. 2010..The role of glomerular inflammation (GI) components in the development of TG and their impact on outcome are incompletely understood...
The independent association between serum uric acid and graft outcomes after kidney transplantationAbdolreza Haririan
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W143, Baltimore, MD 21201, USA
Transplantation 89:573-9. 2010..We sought to evaluate the predictive value of mean uric acid (UA) level during the first 6 months posttransplant for graft survival and function...
Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant functionMatthew R Weir
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Nephrol 24:379-86. 2004....
Polyomavirus reactivation in native kidneys of pancreas alone allograft recipientsAbdolreza Haririan
Division of Nephrology, Department of Medicine, Wayne State University, School of Medicine, Detroit, MI, USA
Transplantation 75:1186-90. 2003..The results also suggest that patients who are exposed to higher blood levels of tacrolimus are at higher risk of viral reactivation...
Clinical course of polyoma virus nephropathy in 67 renal transplant patientsEmilio Ramos
Departments of Medicine, Pathology, Pharmacy Services, and Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Am Soc Nephrol 13:2145-51. 2002..Although multiple factors probably play a role in the development of PVN, judicious use of immunosuppressive agents is indicated to minimize the occurrence of this infection...
Histological grading of chronic pancreas allograft rejection/graft sclerosisJohn C Papadimitriou
Department of Pathology, University of Maryland, School of Medicine, Baltimore MD, USA
Am J Transplant 3:599-605. 2003..87), substantial for Grade CII (0.61) and moderate for Grade CI (0.59). The proposed grading scheme provides a reliable and reproducible tool for the assessment of CR in percutaneous needle biopsies, with definite prognostic significance...
Polyomavirus nephropathy in native kidneys of a solitary pancreas transplant recipientAbdolreza Haririan
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Transplantation 73:1350-3. 2002..This should be considered in the differential diagnosis of renal impairment in these patients. The effects of PV reactivation on long-term native kidney function are not known...
Banff schema for grading pancreas allograft rejection: working proposal by a multi-disciplinary international consensus panelC B Drachenberg
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
Am J Transplant 8:1237-49. 2008....
Improved outcome of polyoma virus allograft nephropathy with early biopsyC B Drachenberg
Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Transplant Proc 36:758-9. 2004..Irreversible renal fibrosis due to late diagnosis is likely to be one of the important causes of treatment failure. Early biopsy in 14 patients resulted in stable graft function after a mean follow-up of 22 months...
Assessment of blood pressure during naproxen therapy in hypertensive patients treated with nicardipineD K Klassen
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
Am J Hypertens 8:146-53. 1995..60 and P = .071, respectively). These results indicate that despite a significant increase in body weight, the antihypertensive action of the calcium channel blocker nicardipine is not significantly affected by cotreatment with naproxen...
Histologic features of mycophenolate mofetil-related colitis: a graft-versus-host disease-like patternJohn C Papadimitriou
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Int J Surg Pathol 11:295-302. 2003..This form of injury could be related to either direct toxicity or an "innocent by-stander" phenomenon secondary to the alteration of the immunologic microenvironment of the colon caused by the MMF...
Relationship between patients' perceptions of disadvantage and discrimination and listing for kidney transplantationAnn C Klassen
Department of Health Policy and Management, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
Am J Public Health 92:811-7. 2002..This study explored wait-listing decisions among African American and White men and women eligible for kidney transplants, focusing on lifetime experiences of race and sex discrimination as a possible influence...
BK virus infection after non-renal transplantationMartha Pavlakis
Beth Israel Deaconess Hospital, Boston, Massachusetts, USA
Adv Exp Med Biol 577:185-9. 2006..While much of the subsequent research focuses on patients after renal transplantation, we will review PV impact in patients after bone marrow transplant (BMT) and those with non-renal solid organ transplants...
