C D Klaassen

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Tissue distribution, ontogeny, and chemical induction of aldo-keto reductases in mice
    Matthew Pratt-Hyatt
    Department of Internal Medicine, University of Kansas Medical Center, 1000 Hixon, MS 1063, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Drug Metab Dispos 41:1480-7. 2013
  2. pmc Hormonal and chemical regulation of paraoxonases in mice
    Xingguo Cheng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    J Pharmacol Exp Ther 342:688-95. 2012
  3. pmc Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice
    Lauren M Aleksunes
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 40:1366-79. 2012
  4. pmc Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice
    Youcai Zhang
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Drug Metab Dispos 40:1191-7. 2012
  5. pmc Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice
    Zidong Donna Fu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 40:1216-25. 2012
  6. pmc Ontogeny of novel cytochrome P450 gene isoforms during postnatal liver maturation in mice
    Julia Yue Cui
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 40:1226-37. 2012
  7. pmc Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice
    Julia Yue Cui
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Am J Physiol Gastrointest Liver Physiol 302:G979-96. 2012
  8. pmc Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene
    Kaori Nakamoto
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    BMC Genet 7:29. 2006
  9. doi request reprint Epigenetic regulation of drug processing genes
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Mech Methods 21:312-24. 2011
  10. ncbi request reprint Xenobiotic transporters: another protective mechanism for chemicals
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Int J Toxicol 21:7-12. 2002

Collaborators

Detail Information

Publications138 found, 100 shown here

  1. pmc Tissue distribution, ontogeny, and chemical induction of aldo-keto reductases in mice
    Matthew Pratt-Hyatt
    Department of Internal Medicine, University of Kansas Medical Center, 1000 Hixon, MS 1063, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Drug Metab Dispos 41:1480-7. 2013
    ..The Nrf2 activator 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) induces mRNAs of Akr1c6 and Akr1c19. Moreover, Nrf2-null and Nrf2 overexpressing mice demonstrate that this induction is Nrf2-dependent. ..
  2. pmc Hormonal and chemical regulation of paraoxonases in mice
    Xingguo Cheng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    J Pharmacol Exp Ther 342:688-95. 2012
    ..Female-predominant Pon1 expression in mouse livers is caused by the inhibitory effects of male-pattern GH secretion, and CAR activation decreases Pon1 expression...
  3. pmc Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice
    Lauren M Aleksunes
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 40:1366-79. 2012
    ..Coordinated regulation of phase I, phase II, and transport genes by activators of transcription factors can have implications in development of pharmaceuticals as well as risk assessment of environmental contaminants...
  4. pmc Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice
    Youcai Zhang
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Drug Metab Dispos 40:1191-7. 2012
    ....
  5. pmc Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice
    Zidong Donna Fu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 40:1216-25. 2012
    ..In conclusion, 51% of the 101 XPGs exhibited gender differences in liver mRNA levels across the lifespan of mice; the mRNA levels for 40% of the XPGs were lower in aged male mice and 43% were lower in aged female mice...
  6. pmc Ontogeny of novel cytochrome P450 gene isoforms during postnatal liver maturation in mice
    Julia Yue Cui
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 40:1226-37. 2012
    ....
  7. pmc Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice
    Julia Yue Cui
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Am J Physiol Gastrointest Liver Physiol 302:G979-96. 2012
    ..In conclusion, at birth, BAs from the classic pathway of synthesis trigger the induction of transporters involved in EHC of BAs in mice, through activation of the nuclear receptor FXR...
  8. pmc Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene
    Kaori Nakamoto
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    BMC Genet 7:29. 2006
    ....
  9. doi request reprint Epigenetic regulation of drug processing genes
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Mech Methods 21:312-24. 2011
    ....
  10. ncbi request reprint Xenobiotic transporters: another protective mechanism for chemicals
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Int J Toxicol 21:7-12. 2002
    ..This is due to an up-regulation of xenobiotic transporters. As a result, some microsomal enzyme inducers will enhance the elimination and decrease the toxicity of some chemicals by enhanced transport...
  11. ncbi request reprint Metallothionein: an intracellular protein to protect against cadmium toxicity
    C D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160, USA
    Annu Rev Pharmacol Toxicol 39:267-94. 1999
    ..e. storehouse for zinc and free radical scavenger)...
  12. pmc Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver
    Curtis D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 244:57-65. 2010
    ..Therefore, this review highlights the research that has contributed to the understanding of the importance of Nrf2 in toxicodynamics and toxicokinetics, especially that which pertains to the liver...
  13. pmc Metallothionein protection of cadmium toxicity
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 238:215-20. 2009
    ..Thus, MT is critical for protecting human health from Cd toxicity. There are large individual variations in MT expression, which might in turn predispose some people to Cd toxicity...
  14. pmc Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury
    C D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Environ Health Perspect 106:297-300. 1998
    ..These results indicate that MT is a part of cellular adaptive mechanisms affecting the magnitude and progression of toxic insults from metals such as Cd as well as from organic chemicals such as CCl4...
  15. pmc Xenobiotic, bile acid, and cholesterol transporters: function and regulation
    Curtis D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Pharmacol Rev 62:1-96. 2010
    ..Transporters are important transmembrane proteins that mediate the cellular entry and exit of a wide range of substrates throughout the body and thereby play important roles in human physiology, pharmacology, pathology, and toxicology...
  16. ncbi request reprint Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4)
    Ning Li
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Drug Metab Dispos 32:1265-71. 2004
    ..In contrast, LPS did not produce a significant decrease in Oatp4 mRNA levels at any time in TLR4-mutant C3H/HeJ mice. These findings demonstrate that LPS decreases Oatp4 mRNA levels in mice, and the decrease is mediated through TLR4...
  17. ncbi request reprint Regulation of hepatic transporters by xenobiotic receptors
    C D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Curr Drug Metab 6:309-28. 2005
    ..Recent studies have demonstrated that MEIs increase expression of various Oatps, Mrps, and Mdrs in liver, and some occur via activation of nuclear receptors...
  18. ncbi request reprint Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice
    David B Buckley
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 35:121-7. 2007
    ..In conclusion, marked differences in tissue- and gender-specific expression patterns of UGTs exist in mice, potentially influencing drug metabolism and pharmacokinetics...
  19. ncbi request reprint Xenobiotic transporters: ascribing function from gene knockout and mutation studies
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Building, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 101:186-96. 2008
    ....
  20. ncbi request reprint Regulation of sulfotransferase mRNA expression in male and female rats of various ages
    C D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Chem Biol Interact 109:299-313. 1998
    ..SULT-40/41 and SULT-60 mRNA expression was increased by HX in male rats and decreased by HX in female rats. (ABSTRACT TRUNCATED)..
  21. ncbi request reprint Distribution and retention of cadmium in metallothionein I and II null mice
    J Liu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160, USA
    Toxicol Appl Pharmacol 136:260-8. 1996
    ..These data support the conclusion that the persistence of Cd in the body is at least partially due to Cd binding to MT in tissues...
  22. ncbi request reprint Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2
    K Ogura
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Biochem Biophys Res Commun 281:431-9. 2001
    ..The mouse oatp2 gene consists of 17 exons, including three noncoding exons, and 16 introns. All of the introns are flanked by GT-AG splice sequences except for intron 10 that is flanked by GC-AG splice sequence...
  23. ncbi request reprint Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene
    S Choudhuri
    Department of Pharmacology, Toxicology and Therapeutics, Kansas City, Kansas 66160 7417, USA
    Biochem Biophys Res Commun 274:79-86. 2000
    ....
  24. ncbi request reprint Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats
    A L Slitt
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 34:1190-7. 2006
    ..In conclusion, in WKY rat liver, TSO increases CYP2B1/2, UGT2B1, and Mdr1b mRNA expression in a gender-dependent manner and CYP3A1, epoxide hydrolase, UGT1A6, and Mrp3 in a gender-independent manner...
  25. ncbi request reprint Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha
    J M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Biochem Pharmacol 72:512-22. 2006
    ....
  26. ncbi request reprint Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice
    J Liu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Appl Pharmacol 176:1-9. 2001
    ..Thus, this study demonstrates that it is genetic strain, not MT genotype, that is mechanistically important in determining susceptibility to Cd-induced testicular injury...
  27. ncbi request reprint Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium
    S S Habeebu
    Center for Environmental and Occupational Health, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 55:223-32. 2000
    ....
  28. ncbi request reprint Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2
    L C Rausch-Derra
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA
    Hepatology 33:1469-78. 2001
    ..These results suggest that Oatp2, but not Oatp1, is inducible by PB and PCN, which imparts the increased capacity of the liver to extract cardiac glycosides from the plasma...
  29. ncbi request reprint Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53
    H Zheng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Toxicol Appl Pharmacol 136:229-35. 1996
    ..In conclusion, these data demonstrate that Cd induces mRNA expression of the protooncogene c-jun and tumor suppressor gene p53 in liver, and that MT modulates this effect...
  30. ncbi request reprint Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity
    J Liu
    University of Kansas Medical Center, Kansas City, USA
    J Pharmacol Exp Ther 289:580-6. 1999
    ..The increased sensitivity does not appear to be due to increased acetaminophen activation, glutathione depletion, or covalent binding, but appears to be associated with the antioxidant role of MT...
  31. ncbi request reprint Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration
    Y Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA
    Toxicol Appl Pharmacol 175:253-9. 2001
    ..15% after the higher doses in both MT-null and wild-type mice. In summary, this study demonstrates that the absorption and initial distribution of orally administered Cd is dose dependent but is not influenced by MT...
  32. ncbi request reprint Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure
    J Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Toxicol Appl Pharmacol 159:98-108. 1999
    ..In conclusion, the present study demonstrates that repeated injections of Cd produces hematotoxic and immunotoxic effects, and intracellular MT protects against these chronic Cd-induced effects...
  33. ncbi request reprint trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors
    A L Slitt
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Mol Pharmacol 69:1554-63. 2006
    ..Moreover, our data demonstrate that a single compound can activate both CAR and Nrf2 transcription factors in liver...
  34. ncbi request reprint Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury
    S S Habeebu
    Center for Environmental and Occupational Health, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 56:211-9. 2000
    ....
  35. ncbi request reprint Differential expression of the metallothionein gene in liver and brain of mice and rats
    S Choudhuri
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417
    Toxicol Appl Pharmacol 119:1-10. 1993
    ..Other tissue-specific and species-specific factors controlling MT gene expression appear to be involved...
  36. ncbi request reprint Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity
    H Zheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Lett 87:139-45. 1996
    ..5-2.0 mM), suggesting that MT does not protect against MNNG-induced cytotoxicity. These results support the hypothesis that constitutive MT levels affect the sensitivity of mammalian cells to Cd and oxidative stress...
  37. ncbi request reprint Cadmium accumulation and metallothionein expression in brain of mice at different stages of development
    S Choudhuri
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Lett 84:127-33. 1996
    ..Cd distribution to brain was found to decrease with age; the brains of 7-day-old mice contained about 4-times more Cd than that of adult mice. Thus, an inverse correlation was observed between MT expression and Cd accumulation in brain...
  38. ncbi request reprint Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology
    D P Hartley
    Environmental and Occupational Medicine Center, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Drug Metab Dispos 28:608-16. 2000
    ..7-fold. Overall, these data support the use of bDNA signal amplification technology as a robust, reproducible, and efficient means of monitoring the differential expression of multiple isoforms of the CYP enzyme family...
  39. ncbi request reprint Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter
    S Choudhuri
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Biochem Biophys Res Commun 280:92-8. 2001
    ..Phylogenetic analysis reveals that mouse Oatp-5 is an ortholog of rat Oatp-5...
  40. ncbi request reprint Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity
    J Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Toxicol Appl Pharmacol 149:24-31. 1998
    ..These results demonstrate that (1) high doses of cisplatin produce hepatotoxicity, with apoptosis as the major lesion, and (2) MT protects against cisplatin-induced liver injury...
  41. ncbi request reprint Constitutive expression of metallothionein genes in mouse brain
    S Choudhuri
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160
    Toxicol Appl Pharmacol 131:144-54. 1995
    ..However, signal in ependyma was similar to that in untreated mice. Pia mater in LPS-treated, but not in untreated, mouse brain showed enhanced signal for MT-I mRNA.(ABSTRACT TRUNCATED AT 400 WORDS)..
  42. ncbi request reprint Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice
    J M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Biochem Pharmacol 71:1470-8. 2006
    ..In contrast, Mrp4 mRNA is higher in females due to repression by both DHT and MP-GH secretion in males...
  43. ncbi request reprint Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6
    J M Maher
    Department of Pharmacology, Toxicology, and Theurapeutics, University of Kansas Medical Center, Kansas City, 66160 7417, USA
    Life Sci 78:2219-25. 2006
    ....
  44. ncbi request reprint Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity
    Y Liu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 57:167-76. 2000
    ..In conclusion, this study demonstrates that lack of MT renders MT-null mice vulnerable to Cd-induced nephrotoxicity after chronic oral exposure, the primary route of human Cd exposure...
  45. ncbi request reprint Strain differences in the toxicity of cadmium to trigeminal ganglia in mice
    S S Habeebu
    Center for Environmental and Occupational Health, University of Kansas Medical Center, Kansas City, Kansas 66160-7417, USA
    Toxicol Appl Pharmacol 177:200-7. 2001
    ..This strain difference in toxicity appears to be due, at least in part, to differences in the distribution of Cd to the ganglia, but it is clearly not the only factor...
  46. ncbi request reprint Chemical modulation of metallothionein I and III mRNA in mouse brain
    H Zheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Neurochem Int 27:43-58. 1995
    ..Chemical-induced alterations of MT mRNA are non-uniform throughout the brain, and thus best studied in a region-specific manner...
  47. ncbi request reprint Protective effect of metallothionein against the toxicity of cadmium and other metals(1)
    J D Park
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA
    Toxicology 163:93-100. 2001
    ..These results suggest that MT is an important protein in the cellular defense against Cd toxicity and lethality, but it provides much less protection against the lethality of the other metals...
  48. ncbi request reprint Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor
    J Staudinger
    Department of Pharmacology and Toxicology, University of Kansas Medical Center, Breidenthal Building, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 29:1467-72. 2001
    ..Taken together, these data demonstrate a pivotal role for PXR in the regulation of drug-induced hepatomegaly and in the metabolism (CYP3A), transport (Oatp2), biosynthesis (Cyp7a1), and excretion of xenobiotics and bile acids in vivo...
  49. pmc CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes
    Scott A Reisman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 236:109-14. 2009
    ..Collectively, the present study shows that CDDO-Im pretreatment induces Nrf2-dependent cytoprotective genes and protects the liver from acetaminophen-induced hepatic injury...
  50. ncbi request reprint Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1)
    K Ogura
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Biochem Biophys Res Commun 272:563-70. 2000
    ....
  51. ncbi request reprint Characterization of metallothionein-I-transgenic mice
    M B Iszard
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Toxicol Appl Pharmacol 133:305-12. 1995
    ..Thus, MT-TG mice appear to be a good model for studying functions of MT...
  52. ncbi request reprint Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways
    M K Shelby
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 34:1772-8. 2006
    ..MEIs differentially regulate hepatic expression of individual UGT isoforms, although no one transcriptional pathway dominated. In duodenum, MEIs had minimal effects on UGT expression...
  53. ncbi request reprint Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats
    Matthew Z Dieter
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Comp Biochem Physiol C Toxicol Pharmacol 139:209-18. 2004
    ..These results suggest variation between rats and mice in regulatory mechanisms controlling ABCG5 and ABCG8 expression, and may explain some differences in lipid metabolism observed between these two species...
  54. pmc Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species
    Scott A Reisman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 108:35-47. 2009
    ..In conclusion, the present study suggests that increased activation of hepatic Nrf2 is more important for the detoxification and elimination of electrophiles than reactive oxygen species...
  55. pmc Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice
    Iván L Csanaky
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Gastrointest Liver Physiol 297:G419-33. 2009
    ..5-fold more BAs and three times more phospholipids per gram liver than the sham-operated mouse liver. Upregulation of phospholipid transport may be important in protecting the biliary tract from BA toxicity during PHx...
  56. ncbi request reprint Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Drug Metab Dispos 34:1863-7. 2006
    ..Therefore, PCN regulates the expression of some transporters, namely, Oatp1a4 and Mrp3 in liver, as well as Abca1, Cnt2, Mdr1a, and Mrp2 in small intestine via a PXR-mediated mechanism...
  57. pmc Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers
    Xingguo Cheng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:37-45. 2008
    ..In conclusion, PFOA and PFDA decrease mouse liver uptake transporters primarily via activation of PPAR-alpha...
  58. ncbi request reprint Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway
    Jonathan M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Hepatology 46:1597-610. 2007
    ....
  59. ncbi request reprint Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
    Nathan J Cherrington
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Pharmacol Exp Ther 300:97-104. 2002
    ..We conclude that rat hepatic Mrp3 is induced by CAR activators, thus enhancing the vectoral excretion of some phase II metabolites from the liver to the blood...
  60. pmc Regulation of hepatic bile acid transporters Ntcp and Bsep expression
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Biochem Pharmacol 74:1665-76. 2007
    ..In conclusion, mouse Ntcp and Bsep are regulated by age, gender, cholestyramine, and bile acid, but resistant to induction by most microsomal enzyme inducers...
  61. ncbi request reprint Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase
    Ning Li
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 83:197-203. 2005
    ..8 kb to +30). Therefore, LPS-induced down-regulation of Oatp4 appears to be independent of TNF-alpha, IL-1beta, IL-6, or iNOS...
  62. pmc Polychlorinated biphenyl congeners that increase the glucuronidation and biliary excretion of thyroxine are distinct from the congeners that enhance the serum disappearance of thyroxine
    L A Martin
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Drug Metab Dispos 40:588-95. 2012
    ..The rapid disappearance of [(125)I]T(4) from the serum of rats treated with PB-like PCBs suggests that increased tissue uptake of T(4) is an additional mechanism by which PCBs may reduce serum T(4)...
  63. ncbi request reprint Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites
    A L Slitt
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 31:1176-86. 2003
    ..In conclusion, these studies correlate increased Mrp3 protein levels in liver with increased hepatovascular excretion of AA-GLUC and suggest that induction of Mrp3 affects the route of drug excretion...
  64. pmc Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers
    L M Aleksunes
    University of Kansas Medical Center, Pharmacology, Toxicology, and Therapeutics, Kansas City, KS 66160, USA
    Xenobiotica 39:514-22. 2009
    ..The multivariate approach presented in this study should aid in predicting signalling pathways that participate either directly or indirectly in regulating hepatic drug disposition...
  65. ncbi request reprint Increased biliary excretion of thyroxine by microsomal enzyme inducers
    N R Vansell
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160-7140, USA
    Toxicol Appl Pharmacol 176:187-94. 2001
    ..Thus, it can be concluded that differential changes in serum TSH do not stem from differential increases in T(4) biliary excretion...
  66. pmc Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid
    Jonathan M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:319-28. 2008
    ..Thus, after PFDA administration, the liver mounts a compensatory hepatoprotective response via PPAR alpha and Nrf2, markedly increasing Mrp3 and Mrp4 expression, with corresponding increases in serum of known Mrp3 and Mrp4 substrates...
  67. ncbi request reprint Tissue distribution and ontogeny of sulfotransferase enzymes in mice
    Yazen Alnouti
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 93:242-55. 2006
    ..The organ-specific distribution of Sults as well as the different expression of the Sults in young animals may affect the pharmacokinetic behavior and organ-specific toxicity of xenobiotics...
  68. ncbi request reprint Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility
    Chuan Chen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Biochem Biophys Res Commun 317:46-53. 2004
    ..Mrp4 expression in liver and kidney of rats treated with six classes of microsomal enzyme inducers was examined. Mrp4 mRNA in liver was induced by two electrophile response element activators, namely ethoxyquin and oltipraz...
  69. ncbi request reprint Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis
    Angela L Slitt
    Department of Pharmacology, Toxicology, and Therapeutics University of Kansas Medical Center 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Biochim Biophys Acta 1768:637-47. 2007
    ....
  70. pmc Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice
    Yue J Cui
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 110:47-60. 2009
    ..In conclusion, FXR deficiency enhances susceptibility of mice to ANIT-induced liver injury, likely a result of impaired induction of hepatobiliary efflux transporters and subsequent hepatic accumulation of unconjugated bile acids...
  71. pmc Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice
    Scott A Reisman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 109:31-40. 2009
    ....
  72. ncbi request reprint Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
    P Rojas
    Center for Environmental and Occupational Health, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Neurosci Lett 273:113-6. 1999
    ..MT-null mice were not more sensitive than control mice to MPTP neurotoxicity. The data suggest that MT-I and -II proteins do not play a role in protecting against MPTP neurotoxicity...
  73. ncbi request reprint Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels
    A L Slitt
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
    Drug Metab Dispos 30:212-9. 2002
    ..In summary, OCT mRNA was detected primarily in kidney, and the high level of renal OCT expression may explain why the kidney is a target organ for xenobiotics with cationic properties...
  74. ncbi request reprint Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family
    M K Shelby
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160, USA
    Drug Metab Dispos 31:326-33. 2003
    ..In conclusion, some UGT isoforms were expressed in multiple tissues, whereas other UGT isoforms were predominantly expressed in a certain tissue such as nasal epithelium, liver, or GI tract...
  75. ncbi request reprint UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside. Differences in activation and induction properties in rat and mouse liver
    G A Hazelton
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66103
    Drug Metab Dispos 16:30-6. 1988
    ..In both rat and mouse, the P-450p-dependent N-ethylmorphine demethylase activity was increased 10-15-fold in PCN-pretreated animals.(ABSTRACT TRUNCATED AT 250 WORDS)..
  76. ncbi request reprint Gender-specific and developmental influences on the expression of rat organic anion transporters
    Susan C N Buist
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    J Pharmacol Exp Ther 301:145-51. 2002
    ..These data indicate that Oat mRNA expression is primarily localized to the kidney, and observed expression patterns may explain some previously recognized age- and gender-dependent toxicities associated with chemical exposure...
  77. doi request reprint NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet
    Yuji Tanaka
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    J Pharmacol Exp Ther 325:655-64. 2008
    ..Overall, these results suggest that Nrf2 inhibits lipid accumulation and oxidative stress in mouse liver after feeding a HFD, probably by interfering with lipogenic and cholesterologenic pathways...
  78. ncbi request reprint Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice
    Yuji Tanaka
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Mol Pharmacol 71:817-25. 2007
    ..Whereas renal HO-1 mRNA expression increased in wild-type mice, it was attenuated in Nrf2-null mice. These results suggest that renal HO-1 is induced via Nrf2 to protect the kidney from remote organ injury after hepatic IR...
  79. ncbi request reprint Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice
    Tamara Raphael Knight
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Toxicol Sci 100:513-24. 2007
    ..In summary, most Gst isoforms are most highly expressed in the GI tract and liver, which strongly suggests an important role of many Gst isoforms in detoxification of ingested xenobiotics...
  80. pmc Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:29-36. 2008
    ..In conclusion, PFCAs increased Cyp2B10 and 4A14 expression by activating PPAR-alpha and CAR nuclear receptors, respectively. PPAR-alpha is activated at much lower doses of PFDA than CAR...
  81. ncbi request reprint The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators
    Erik K Pacyniak
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 97:94-102. 2007
    ..In summary, our study provides the first evidence that PBDEs are activators for xenobiotic nuclear receptor...
  82. pmc Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269 3092, USA
    Toxicol Appl Pharmacol 226:74-83. 2008
    ..Thus coordinated regulation of detoxification enzymes and transporters by Nrf2 during APAP hepatotoxicity is a mechanism by which hepatocytes may limit intracellular accumulation of potentially toxic chemicals...
  83. ncbi request reprint Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport
    Jay S Petrick
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Drug Metab Dispos 35:1806-15. 2007
    ..Collectively, these studies illustrate the fact that some xenobiotic inducers may elicit their response through mechanisms involving transcription factor regulation...
  84. pmc Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver
    Julia Yue Cui
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 116:32-43. 2010
    ..76). In conclusion, this study characterized three distinct ontogenic expression signatures of the 19 Gst isoforms and examined some genetic and epigenetic mechanisms inducing their transcription during liver development...
  85. pmc Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging
    Yu Kun Jennifer Zhang
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Drug Metab Dispos 38:1122-31. 2010
    ..The hepatic transcription factors are likely to mediate the changes in hepatic DPG expression during aging and ER...
  86. ncbi request reprint Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice
    Jonathan M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 33:947-55. 2005
    ..In conclusion, marked differences in expression of the individual Mrp family members exist in various tissues, with age, and with gender...
  87. pmc ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling
    Yuji Tanaka
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 108:247-57. 2009
    ..Despite compensatory changes in Nrf2-null mice to limit ANIT toxicity, pharmacological activation of Nrf2 may represent a therapeutic option for intrahepatic cholestasis...
  88. pmc Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney
    David B Buckley
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 37:834-40. 2009
    ..In conclusion, gender differences in mouse Ugt mRNA expression were influenced by male-pattern GH secretion in liver, whereas gender differences were regulated by the effects of androgens in kidney...
  89. ncbi request reprint Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver
    Guoli Dai
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, Kansas 66160 7417, USA
    Mol Pharmacol 68:1590-6. 2005
    ..This report reveals a potential novel strategy to enhance the detoxification of APAP or other xenobiotics by manipulating Gst activity through RXRalpha-mediated pathways...
  90. ncbi request reprint Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice
    Yazen Alnouti
    Kansas Life Sciences Innovation Center, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 101:51-64. 2008
    ..Finally, in contrast to other phase-I metabolic enzymes such as CYP450 enzymes, Aldh mRNA expression seems to be generally insensitive to typical microsomal inducers except PPAR alpha ligands...
  91. pmc Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice
    Maxwell Afari Gyamfi
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 234:166-78. 2009
    ..9-fold) only in the H-RXRalpha-null mice. In conclusion, these data suggest a critical role for RXRalpha in hepatic fatty acid homeostasis and protection against MCD-induced hepatocyte injury...
  92. pmc Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys
    Xingguo Cheng
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Drug Metab Dispos 37:2178-85. 2009
    ..In conclusion, the mRNA expression of xenobiotic transporters in kidneys is determined by tissue, age, and sex hormones...
  93. ncbi request reprint The presence of xenobiotic transporters in rat placenta
    Tyra M Leazer
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 31:153-67. 2003
    ..The abundance of these mRNA transcripts in placenta suggests a role for these transporters in placental transport of xenobiotics and supports their role in the transport of endogenous substances...
  94. ncbi request reprint Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression
    Xingguo Cheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Mol Pharmacol 70:1291-7. 2006
    ..In conclusion, gender-divergent Oatp expression in liver is caused by male-pattern GH secretion pattern and androgens. In kidney, gender-divergent Oatp expression is exclusively caused by stimulation by androgens...
  95. ncbi request reprint Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake
    G L Guo
    Department of Pharmacology, Toxicology and Therapeutics, Univeristy of Kansas Medical Center, Kansas City 66160-7417, USA
    J Pharmacol Exp Ther 299:551-7. 2001
    ..In conclusion, this study indicates that rat oatp1- and oatp2-mediated uptake is subject to the short-term regulation by PKC activation, but not by PKA activation...
  96. pmc Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet
    Yu Kun Jennifer Zhang
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 245:326-34. 2010
    ..Taken together, these observations indicate that Nrf2 could decelerate the onset of fatty livers caused by the MCD diet by increasing hepatic antioxidant and detoxification capabilities...
  97. pmc Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor e
    David B Buckley
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 37:847-56. 2009
    ..In conclusion, chemical activation of AhR, CAR, PXR, PPARalpha, and Nrf2 in mouse results in induction of distinct Ugt gene sets in liver and intestine, predominantly the Ugt1a isoforms...
  98. pmc Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers
    Tamara R Knight
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:329-38. 2008
    ..Thus, the protection afforded by a ligand for one of these transcription factors will depend on the activator, as well as which Gst that detoxifies the chemicals of interest...
  99. pmc Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes
    Scott A Reisman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, 66160 7417, USA
    Biochem Pharmacol 77:1273-82. 2009
    ..Collectively, the present study demonstrates that oleanolic acid facilitates Nrf2 nuclear accumulation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity...
  100. pmc Introducing the "TCDD-inducible AhR-Nrf2 gene battery"
    Ronnie L Yeager
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 111:238-46. 2009
    ..Therefore, the present study demonstrates the novel finding that Nrf2 is required for TCDD induction of classical AhR battery genes Nqo1, Ugt1a6, and Gsta1, as well as most Ugt and Gst isoforms in livers of mice...
  101. ncbi request reprint Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2)
    Yuji Tanaka
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 101:171-8. 2008
    ..These decreases in hepatic Mrp2 may contribute to cholestasis, yet increases in kidney may protect from oxidative stress and/or inflammation after hepatic IR...

Research Grants54

  1. REGULATION OF BILIARY EXCRETION OF XENOBIOTICS BY MRP2
    Curtis Klaassen; Fiscal Year: 2004
    ....
  2. Regulation of Hepatic Excretion of Xenobiotics by Mrps
    Curtis D Klaassen; Fiscal Year: 2010
    ..Elucidation of the role of Nrf2 in the regulation of the efflux transport process will have significant ramifications in toxicology, xenobiotics disposition, drug-drug interaction, and cancer chemoprevention. ..
  3. Nuclear Receptors in Liver Health and Disease
    Curtis Klaassen; Fiscal Year: 2007
    ....
  4. Coordinate Regulation of Uptake and Efflux Transporters
    Curtis Klaassen; Fiscal Year: 2007
    ....
  5. Environmental Hormones: Effects on Thyroid Function
    Curtis Klaassen; Fiscal Year: 2005
    ..abstract_text> ..
  6. REGULATION OF HEPATIC UPTAKE OF DRUGS AND XENOBIOTICS
    Curtis Klaassen; Fiscal Year: 2003
    ..Overall, these studies will determine the significance of oatp1 and oatp2 in hepatocellular uptake. ..
  7. TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2007
    ....
  8. Regulation of Hepatic Excretion of Xenobiotics by Mrps
    Curtis Klaassen; Fiscal Year: 2007
    ..Elucidation of the role of Nrf2 in the regulation of the efflux transport process will have significant ramifications in toxicology, xenobiotics disposition, drug-drug interaction, and cancer chemoprevention. ..
  9. REGULATION OF HEPATIC UPTAKE OF DRUGS AND XENOBIOTICS
    Curtis Klaassen; Fiscal Year: 2007
    ..abstract_text> ..
  10. Regulation of Hepatic Uptake of Endogenous Signaling Molecules and Xenobiotics
    Curtis D Klaassen; Fiscal Year: 2010
    ....
  11. Nrf2 as a Master Regulator in Liver Disease Prevention and Therapy
    Curtis D Klaassen; Fiscal Year: 2010
    ..This study will determine whether this drug target will be effective against a wide-spectrum of animal models of liver disease. ..
  12. Developmental Regulation of Drug Processing Genes
    Xiao bo Zhong; Fiscal Year: 2010
    ..Thus, the findings are expected to be applicable to the improvement of efficacy and safety of pediatric pharmacology. ..
  13. Coordinate Regulation of Uptake and Efflux Transporters
    Curtis D Klaassen; Fiscal Year: 2010
    ....
  14. Regulation of Hepatic Excretion of Xenobiotics by Mrps
    Curtis Klaassen; Fiscal Year: 2009
    ..Elucidation of the role of Nrf2 in the regulation of the efflux transport process will have significant ramifications in toxicology, xenobiotics disposition, drug-drug interaction, and cancer chemoprevention. ..
  15. Nrf2 as a Master Regulator in Liver Disease Prevention and Therapy
    Curtis Klaassen; Fiscal Year: 2009
    ..This study will determine whether this drug target will be effective against a wide-spectrum of animal models of liver disease. ..
  16. HEPATOBILIARY DISPOSITION IN TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2003
    ..abstract_text> ..
  17. HEPATOBILIARY DISPOSITION IN TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 1991
    ..These studies are significant because they will provide new concepts concerning chemical-induced alteration of thyroid function, not only for one chemical but potentially for many chemicals...
  18. ENVIRONMENTAL HORMONES--EFFECTS ON THYROID FUNCTION
    Curtis Klaassen; Fiscal Year: 2000
    ..If the investigators demonstrate that TSH mediates endocrine disruptor thyroid tumor promoting activity, then as long as the promotional mechanism is prevented (increase in serum TSH), cancer would be prevented. ..