Affiliation: University of California
- Stem-cell-based gene therapy for HIV infectionAnjie Zhen
Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Viruses 6:1-12. 2014..The first is to generate immune systems resistant to HIV infection while the second strategy involves enhancing anti-HIV immunity to eliminate HIV infected cells. ..
- In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cellsScott G Kitchen
Division of Hematology Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
PLoS Pathog 8:e1002649. 2012..These results strongly suggest that stem cell based gene therapy may be a feasible approach in the treatment of chronic viral infections and provide a foundation towards the development of this type of strategy...
- Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient miceScott G Kitchen
Division of Hematology Oncology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 4:e8208. 2009....
- CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytesMarta Epeldegui
Department of Microbiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e11448. 2010..These findings are consistent with a role for HIV in the direct stimulation of B cells, potentially leading to the accumulation of molecular lesions that have the potential to contribute to the development of NHL...
- Macrophage differentiation from embryoid bodies derived from human embryonic stem cellsAparna Subramanian
Department of Medicine, Division of Hematology Oncology
J Stem Cells 4:29-45. 2009..Furthermore, this system is amenable to genetic manipulation and may thus be used to study important mechanisms of macrophage differentiation and function...
- The Role of CD8 on CD4+ T CellsScott Kitchen; Fiscal Year: 2004..These studies combined will allow us to determine the possible effects that the appearance or loss of this subset may have on HIV disease progression and antiviral immunity. ..