Masashi Kitazawa

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD
    Masashi Kitazawa
    Department of Neurobiology and Behavior, University of California, Irvine, California, USA
    J Neurochem 108:1550-60. 2009
  2. doi Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model
    Masashi Kitazawa
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA
    J Immunol 187:6539-49. 2011
  3. pmc Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease
    Anumantha G Kanthasamy
    Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, USA
    Mol Brain 1:12. 2008
  4. pmc Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    Mathew Blurton-Jones
    Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13594-9. 2009
  5. ncbi Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    Salvatore Oddo
    Departments of Neurobiology and Behavior and Neurology, and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697, USA
    J Biol Chem 281:39413-23. 2006
  6. doi Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta
    Masashi Kitazawa
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697 4545, USA
    Ann Neurol 64:15-24. 2008
  7. pmc Inflammation induced by infection potentiates tau pathological features in transgenic mice
    Michael Sy
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
    Am J Pathol 178:2811-22. 2011
  8. doi Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice
    Rodrigo Medeiros
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697 4545, USA
    Am J Pathol 181:616-25. 2012
  9. pmc Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice
    Rodrigo Medeiros
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697 4545, USA
    Am J Pathol 182:1780-9. 2013
  10. pmc Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice
    Hilda Martinez-Coria
    Department of Neurobiology and Behavior, University of California, Irvine, 3400A Biological Sciences III, Irvine, CA 92697 4545, USA
    Am J Pathol 176:870-80. 2010

Research Grants

Collaborators

Detail Information

Publications25

  1. doi Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD
    Masashi Kitazawa
    Department of Neurobiology and Behavior, University of California, Irvine, California, USA
    J Neurochem 108:1550-60. 2009
    ..Taken together, our data suggest that chronic copper exposure accelerates not only amyloid pathology but also tau pathology in a mouse model of AD...
  2. doi Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model
    Masashi Kitazawa
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA
    J Immunol 187:6539-49. 2011
    ..Taken together, our results suggest that the IL-1 signaling cascade may be involved in one of the key disease mechanisms for AD...
  3. pmc Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease
    Anumantha G Kanthasamy
    Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, USA
    Mol Brain 1:12. 2008
    ..Dieldrin has been reported to be one of the environmental factors correlated with Parkinson's disease and may selectively destroy dopaminergic neurons...
  4. pmc Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    Mathew Blurton-Jones
    Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13594-9. 2009
    ..Taken together, our findings demonstrate that neural stem cells can ameliorate complex behavioral deficits associated with widespread Alzheimer disease pathology via BDNF...
  5. ncbi Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    Salvatore Oddo
    Departments of Neurobiology and Behavior and Neurology, and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697, USA
    J Biol Chem 281:39413-23. 2006
    ..Notably, reducing soluble Abeta alone did not improve the cognitive phenotype in mice with plaques and NFTs. Our results show that Abeta immunotherapy reduces soluble tau and ameliorates behavioral deficit in old transgenic mice...
  6. doi Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta
    Masashi Kitazawa
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697 4545, USA
    Ann Neurol 64:15-24. 2008
    ..Here, we address the mechanisms by which inflammation modulates Abeta and tau, two hallmark features of this disease...
  7. pmc Inflammation induced by infection potentiates tau pathological features in transgenic mice
    Michael Sy
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
    Am J Pathol 178:2811-22. 2011
    ..Taken together, infectious agents that trigger central nervous system inflammation may serve as a comorbidity for AD, leading to cognitive impairments by a mechanism that involves exacerbation of tau pathological characteristics...
  8. doi Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice
    Rodrigo Medeiros
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697 4545, USA
    Am J Pathol 181:616-25. 2012
    ..Our data provide relevant functional and molecular insights into the beneficial therapeutic effects of inhibiting calpain activation for the management of AD...
  9. pmc Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice
    Rodrigo Medeiros
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697 4545, USA
    Am J Pathol 182:1780-9. 2013
    ..Our data indicate that activating LXA4 signaling may represent a novel therapeutic approach for AD...
  10. pmc Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice
    Hilda Martinez-Coria
    Department of Neurobiology and Behavior, University of California, Irvine, 3400A Biological Sciences III, Irvine, CA 92697 4545, USA
    Am J Pathol 176:870-80. 2010
    ..These results suggest that the effects of memantine treatment on AD brain include disease modification and prevention of synaptic dysfunction...
  11. pmc Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice
    Masashi Kitazawa
    Department of Neurobiology and Behavior, 1109 Gillespie Neuroscience Facility, University of California, Irvine, Irvine, CA 92697 4545, USA
    Am J Pathol 168:1986-97. 2006
    ..The data presented here provide experimental evidence that Abeta42 plays a proximal and critical role in the muscle degenerative process...
  12. pmc Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model
    Masashi Kitazawa
    Department of Neurobiology and Behavior and Neurology, University of California, Irvine, California 92697 4545, USA
    J Neurosci 29:6132-41. 2009
    ..These findings provide support for the hypothesis that Abeta is one of the key pathogenic components in IBM pathology and subsequent skeletal muscle degeneration...
  13. pmc Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline
    Rodrigo Medeiros
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697 4545, USA
    Am J Pathol 179:980-91. 2011
    ....
  14. ncbi Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    Masashi Kitazawa
    Department of Neurobiology and Behavior, University of California Irvine, California 92697 4545, USA
    J Neurosci 25:8843-53. 2005
    ..Therefore, this study clearly demonstrates that microglial activation exacerbates key neuropathological features such as tangle formation...
  15. pmc Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice
    Carlos J Rodriguez-Ortiz
    School of Natural Sciences, University of California, Merced, California 95343, USA
    Am J Pathol 183:504-15. 2013
    ..Taken together, these results highlight an important pathologic link between VCP and cognition. ..
  16. ncbi Neural stem cells improve memory in an inducible mouse model of neuronal loss
    Tritia R Yamasaki
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 27:11925-33. 2007
    ..These results show that stem cells may have therapeutic value in diseases and conditions that result in memory loss...
  17. doi α7 nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles
    Rodrigo Medeiros
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California Department of Neurobiology and Behavior, University of California, Irvine, California
    Am J Pathol 184:520-9. 2014
    ..These novel findings indicate that activating α7 nAChR is a promising treatment for cognitive impairment in AD. ..
  18. doi Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition
    David Baglietto-Vargas
    Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697 4545, USA
    Neurobiol Dis 62:407-15. 2014
    ..These findings provide better understanding about the role of endogenous tau to Alzheimer's disease (AD) pathology and for developing new AD models. ..
  19. ncbi Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, 1109 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4545, USA
    Neurobiol Aging 24:1063-70. 2003
    ....
  20. ncbi Amyloid beta-peptide: the inside story
    Bertrand P Tseng
    Laboratory of Molecular Neuropathogenesis, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4545, USA
    Curr Alzheimer Res 1:231-9. 2004
    ..Here we review recent evidence supporting a pathogenic role for intracellular Abeta in AD, Down syndrome, and IBM...
  21. ncbi Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model
    Michael C Sugarman
    Department of Neurobiology and Behavior, University of California, 1109 Gillespie Neuroscience Facility, Irvine, CA 92697 4545, USA
    Neurobiol Aging 27:423-32. 2006
    ..These findings also highlight parallels between the MCK-betaAPP mice and the human IBM condition...
  22. ncbi Microglia as a potential bridge between the amyloid beta-peptide and tau
    Masashi Kitazawa
    Laboratory of Molecular Neuropathogenesis, Department of Neurobiology and Behavior, University of California, Irvine, 92697 4545, USA
    Ann N Y Acad Sci 1035:85-103. 2004
    ..In this review, we discuss the molecular mechanism of inflammatory responses in AD brain as well as animal models, and current therapies using NSAIDs, antioxidants, and immunotherapy as neuroprotective strategies for AD...
  23. ncbi Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions
    Masashi Kitazawa
    School of Natural Sciences, University of California, Merced, CA 95343, USA
    Curr Pharm Des 18:1131-47. 2012
    ..In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies...
  24. pmc The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology
    Angele Nalbandian
    Department of Pediatrics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 7:e46308. 2012
    ....
  25. ncbi Antipodal effects of p25 on synaptic plasticity, learning, and memory--too much of a good thing is bad
    Frank M LaFerla
    Department of Neurobiology and Behavior, University of California, Irvine, 1109 Gillespie Neuroscience Research Facility, Irvine, California 92697, USA
    Neuron 48:711-2. 2005
    ..This work demonstrates the complexity of Cdk5/p25 in neuronal function and shows that dysregulation of a factor involved in plasticity can cause neurodegeneration...

Research Grants2

  1. Pathogenic Role of Abeta, tau and Inflammation in Inclusion Body Myositis
    Masashi Kitazawa; Fiscal Year: 2007
    ..Through this application, we hope to advance the understanding of IBM as well as dementias and evaluate potential therapeutic strategies for IBM. ..