Jessica Kissinger

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. pmc Genome-wide upstream motif analysis of Cryptosporidium parvum genes clustered by expression profile
    Jenna Oberstaller
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 14:516. 2013
  2. pmc Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii
    Nandita Mullapudi
    Department of Genetics, University of Georgia, East Green Street, Athens, Georgia 30602, USA
    Genome Biol 10:R34. 2009
  3. pmc Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum
    Jinling Huang
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Genome Biol 5:R88. 2004
  4. pmc piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome
    Bharath Balu
    Department of Global Health, University of South Florida, Tampa, Florida 33612, USA
    BMC Microbiol 9:83. 2009
  5. pmc Identification of putative cis-regulatory elements in Cryptosporidium parvum by de novo pattern finding
    Nandita Mullapudi
    Department of Genetics and Center for Tropical and Emerging Global Diseases, Paul D Coverdell Center, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 8:13. 2007
  6. pmc The Alveolate Perkinsus marinus: biological insights from EST gene discovery
    Sandeep J Joseph
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 11:228. 2010
  7. pmc Consistent and contrasting properties of lineage-specific genes in the apicomplexan parasites Plasmodium and Theileria
    Chih Horng Kuo
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    BMC Evol Biol 8:108. 2008
  8. pmc Genome cartography: charting the apicomplexan genome
    Jessica C Kissinger
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, USA
    Trends Parasitol 27:345-54. 2011
  9. ncbi request reprint SynView: a GBrowse-compatible approach to visualizing comparative genome data
    Haiming Wang
    Center for Tropical and Emerging Global Diseases, University of Georgia Athens, GA 30602 2606, USA
    Bioinformatics 22:2308-9. 2006
  10. ncbi request reprint A tale of three genomes: the kinetoplastids have arrived
    Jessica C Kissinger
    Department of Genetics and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30606, USA
    Trends Parasitol 22:240-3. 2006

Research Grants

Collaborators

Detail Information

Publications38

  1. pmc Genome-wide upstream motif analysis of Cryptosporidium parvum genes clustered by expression profile
    Jenna Oberstaller
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 14:516. 2013
    ..As such, very little is known about gene regulation in C. parvum...
  2. pmc Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii
    Nandita Mullapudi
    Department of Genetics, University of Georgia, East Green Street, Athens, Georgia 30602, USA
    Genome Biol 10:R34. 2009
    ..We have approached the question of gene regulation from a sequence perspective by mining the genomic sequence data to identify putative cis-regulatory elements using a de novo approach...
  3. pmc Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum
    Jinling Huang
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Genome Biol 5:R88. 2004
    ..Given the importance of gene transfers in eukaryotic evolution and the potential implications for chemotherapy, it is important to identify the complement of transferred genes in Cryptosporidium...
  4. pmc piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome
    Bharath Balu
    Department of Global Health, University of South Florida, Tampa, Florida 33612, USA
    BMC Microbiol 9:83. 2009
    ..Transposon mutagenesis has been used widely to identify gene functions in many organisms and would be extremely valuable for functional analysis of the Plasmodium genome...
  5. pmc Identification of putative cis-regulatory elements in Cryptosporidium parvum by de novo pattern finding
    Nandita Mullapudi
    Department of Genetics and Center for Tropical and Emerging Global Diseases, Paul D Coverdell Center, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 8:13. 2007
    ..parvum. To support our findings, we have established comparative real-time -PCR expression profiles for the groups of genes examined computationally...
  6. pmc The Alveolate Perkinsus marinus: biological insights from EST gene discovery
    Sandeep J Joseph
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 11:228. 2010
    ..g. parasitism) within the Alveolata. Despite intense parasite pressure, no disease-resistant oysters have been identified and no effective therapies have been developed to date...
  7. pmc Consistent and contrasting properties of lineage-specific genes in the apicomplexan parasites Plasmodium and Theileria
    Chih Horng Kuo
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    BMC Evol Biol 8:108. 2008
    ..In parasitic organisms, lineage-specific gene products are possible targets for vaccine development or therapeutics when these genes are absent from the host genome...
  8. pmc Genome cartography: charting the apicomplexan genome
    Jessica C Kissinger
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, USA
    Trends Parasitol 27:345-54. 2011
    ....
  9. ncbi request reprint SynView: a GBrowse-compatible approach to visualizing comparative genome data
    Haiming Wang
    Center for Tropical and Emerging Global Diseases, University of Georgia Athens, GA 30602 2606, USA
    Bioinformatics 22:2308-9. 2006
    ..It is in use in the PlasmoDB (http://www.PlasmoDB.org) and the CryptoDB (http://www.CryptoDB.org) projects and can be easily integrated into other cross-species comparative genome projects...
  10. ncbi request reprint A tale of three genomes: the kinetoplastids have arrived
    Jessica C Kissinger
    Department of Genetics and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30606, USA
    Trends Parasitol 22:240-3. 2006
    ....
  11. ncbi request reprint A first glimpse into the pattern and scale of gene transfer in Apicomplexa
    Jinling Huang
    Center for Tropical and Emerging Global Diseases, University of Georgia, 623 Biological Sciences, Athens, GA 30602 2606, USA
    Int J Parasitol 34:265-74. 2004
    ....
  12. pmc Gene transfer in the evolution of parasite nucleotide biosynthesis
    Boris Striepen
    Center for Tropical and Emerging Global Diseases and Departments of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 101:3154-9. 2004
    ..Taken together, these data help to explain why widely used drugs fail in the treatment of cryptosporidiosis and suggest more promising targets...
  13. ncbi request reprint Many gene and domain families have convergent fates following independent whole-genome duplication events in Arabidopsis, Oryza, Saccharomyces and Tetraodon
    Andrew H Paterson
    Plant Genome Mapping Laboratory and Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Trends Genet 22:597-602. 2006
    ..Angiosperms show more frequent polyploidization and a higher degree of duplicate gene preservation than other paleopolyploids, making them well-suited to further study of duplication-resistant genes...
  14. doi request reprint Emergence of a group 3 coronavirus through recombination
    Mark W Jackwood
    Department of Population Health, College of Veterinary Medicine, 953 College Station Road, University of Georgia, Athens, GA 30602, USA
    Virology 398:98-108. 2010
    ....
  15. pmc CryptoDB: a Cryptosporidium bioinformatics resource update
    Mark Heiges
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA
    Nucleic Acids Res 34:D419-22. 2006
    ....
  16. ncbi request reprint Genomics meets transgenics in search of the elusive Cryptosporidium drug target
    Boris Striepen
    Center for Tropical and Emerging Global Diseases, University of Georgia, 623 Biological Sciences Building, Athens, GA 30602, USA
    Trends Parasitol 20:355-8. 2004
    ..New targets for Cryptosporidium drug and vaccine development can be identified and validated based on this approach...
  17. ncbi request reprint O-glycosylation in Toxoplasma gondii: identification and analysis of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases
    Magdalena M Stwora-Wojczyk
    Department of Genetics, Center for Tropical and Emerging Global Diseases, University of Georgia, 422 Biological Sciences Building, Athens, GA 30602, USA
    Int J Parasitol 34:309-22. 2004
    ..Taken together, this information creates the basis for future studies of the function of the ppGalNAc-T gene family in the pathobiology of this apicomplexan parasite...
  18. pmc EuPathDB: a portal to eukaryotic pathogen databases
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 38:D415-9. 2010
    ..Search results are dynamically displayed as the strategy is constructed or modified, and can be downloaded, saved, revised, or shared with other database users...
  19. pmc ApiDB: integrated resources for the apicomplexan bioinformatics resource center
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, Athens, GA, USA
    Nucleic Acids Res 35:D427-30. 2007
    ..Through the ApiDB site, users may pose queries and search all available apicomplexan data and tools, or they may visit individual component organism databases...
  20. pmc GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 37:D526-30. 2009
    ..Phylogenetic relationships may also be interrogated. The ability to combine the results from independent queries, and to store queries and query results for future use facilitates complex, genome-wide mining of functional genomic data...
  21. pmc ToxoDB: accessing the Toxoplasma gondii genome
    Jessica C Kissinger
    Department of Genetics Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602 2606, USA
    Nucleic Acids Res 31:234-6. 2003
    ..the database will provide an integrated data analysis platform facilitating user-defined queries across the different data types...
  22. pmc PlasmoDB: a functional genomic database for malaria parasites
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 37:D539-43. 2009
    ..Various results can then be combined with each other on the query history page. Search results can be downloaded with associated functional data and registered users can store their query history for future retrieval or analysis...
  23. pmc TcruziDB: an integrated Trypanosoma cruzi genome resource
    Michael Luchtan
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602 2606, USA
    Nucleic Acids Res 32:D344-6. 2004
    ..As annotation, microarray and proteomic data become available, the database will incorporate and integrate these data using the GUS (http://www.gusdb. org) relational framework...
  24. pmc The Apicomplexan whole-genome phylogeny: an analysis of incongruence among gene trees
    Chih Horng Kuo
    Department of Genetics, University of Georgia, USA
    Mol Biol Evol 25:2689-98. 2008
    ..The importance of examining multiple, unlinked genes that possess a strong phylogenetic signal cannot be overstated...
  25. pmc Applied genomics: data mining reveals species-specific malaria diagnostic targets more sensitive than 18S rRNA
    Allison Demas
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30602, USA
    J Clin Microbiol 49:2411-8. 2011
    ..These novel targets provide a powerful alternative molecular diagnostic method for the detection of P. falciparum and P. vivax in conventional or multiplex PCR platforms...
  26. pmc Mining the Plasmodium genome database to define organellar function: what does the apicoplast do?
    David S Roos
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Philos Trans R Soc Lond B Biol Sci 357:35-46. 2002
    ....
  27. pmc PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data
    Amit Bahl
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 31:212-5. 2003
    ..The software used to develop PlasmoDB has been used to create a second Apicomplexan parasite genome database, ToxoDB (http://ToxoDB.org)...
  28. pmc Determining the protein repertoire of Cryptosporidium parvum sporozoites
    Sanya J Sanderson
    Departments of Pre clinical Veterinary Science and Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    Proteomics 8:1398-414. 2008
    ..For approximately half the proteome there was limited functional and structural information, highlighting the limitations in the current understanding of Cryptosporidium biology...
  29. pmc TcruziDB: an integrated, post-genomics community resource for Trypanosoma cruzi
    Fernan Aguero
    Instituto de Investigaciones Biotecnologicas, Universidad de San Martín San Martín, B 1650 KNA, Buenos Aires, Argentina
    Nucleic Acids Res 34:D428-31. 2006
    ..TcruziDB has accepted, and will continue to accept the deposition of genomic and functional genomic datasets contributed by the research community...
  30. pmc CryptoDB: the Cryptosporidium genome resource
    Daniela Puiu
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA
    Nucleic Acids Res 32:D329-31. 2004
    ..This database, like other apicomplexan parasite databases, has been built utilizing the PlasmoDB model...
  31. pmc Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database
    Li Li
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 13:443-54. 2003
    ..These genes likely mediate the novel biological features of members of the Apicomplexa and hence offer great potential for biological investigation and as possible therapeutic targets...
  32. pmc ToxoDB: an integrated Toxoplasma gondii database resource
    Bindu Gajria
    Department of Biology, Department of Genetics, Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA, USA
    Nucleic Acids Res 36:D553-6. 2008
    ..ToxoDB has matured significantly since its initial release. Here we outline the numerous updates with respect to the data and increased functionality available on the website...
  33. pmc PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished)
    Amit Bahl
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104 6018, USA
    Nucleic Acids Res 30:87-90. 2002
    ..g. by malaria researchers working in the field). The goal of PlasmoDB is to enhance utilization of the vast quantities of data emerging from genome-scale projects by the global malaria research community...
  34. ncbi request reprint Molecular phylogenetic analysis of the avian malarial parasite Plasmodium (Novyella) juxtanucleare
    Jessica C Kissinger
    Centro de Pesquisas René Rachou FIOCRUZ Avenida Augusto de Lima 1715, Barro Preto, Belo Horizonte, Minas Gerais 30190 002, Brazil
    J Parasitol 88:769-73. 2002
    ....
  35. ncbi request reprint The Plasmodium genome database
    Jessica C Kissinger
    Department of Biology and Genetics, Center for Bioinformatics and Genomics Institute, University of Pennsylvania, Philadelphia, 19104 6018, USA
    Nature 419:490-2. 2002
  36. ncbi request reprint PlasmoDB v5: new looks, new genomes
    Christian J Stoeckert
    Department of Genetics, 1415 Blockley Hall, Center for Bioinformatics, 423 Guardian Drive, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Parasitol 22:543-6. 2006
    ..This new release includes additional Plasmodium genomes and a newly designed website. The new site reflects the status of PlasmoDB as a member of a linked family of Apicomplexan databases...
  37. ncbi request reprint Adaptation of protein secretion to extremely high-salt conditions by extensive use of the twin-arginine translocation pathway
    R Wesley Rose
    Department of Biology, Leidy Laboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Microbiol 45:943-50. 2002
    ..This extensive utilization of the Tat pathway in haloarchaea suggests an evolutionary adaptation to high-salt conditions by allowing cytoplasmic folding of secreted proteins before their secretion...
  38. ncbi request reprint Analysis of the first and second internal transcribed spacer sequences of the ribosomal DNA in Biomphalaria tenagophila complex (Mollusca: Planorbidae)
    Teofânia H D A Vidigal
    Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima, 1715, 30190 002 Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 99:153-8. 2004
    ..The present results provide support for the proposal that B. tenagophila represents a complex comprising B. tenagophila, B. occidentalis and B. t. guaibensis...

Research Grants4

  1. Genome Evolution, Innovation and Adaptation in the Apicomplexa
    Jessica Kissinger; Fiscal Year: 2007
    ..The results of these studies will be shared with the larger research community via publication and deposition in community databases and Bioinformatics Resource Centers. ..
  2. Genome Evolution, Innovation and Adaptation in the Apicomplexa
    Jessica Kissinger; Fiscal Year: 2009
    ..The results of these studies will be shared with the larger research community via publication and deposition in community databases and Bioinformatics Resource Centers. ..
  3. Genome Evolution, Innovation and Adaptation in the Apicomplexa
    Jessica C Kissinger; Fiscal Year: 2010
    ..The results of these studies will be shared with the larger research community via publication and deposition in community databases and Bioinformatics Resource Centers. ..