Patrick F Kiser

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc A perspective on progress and gaps in HIV prevention science
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    AIDS Res Hum Retroviruses 28:1373-8. 2012
  2. ncbi request reprint State of the art in intravaginal ring technology for topical prophylaxis of HIV infection
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    AIDS Rev 14:62-77. 2012
  3. doi request reprint Design of tenofovir-UC781 combination microbicide vaginal gels
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112 5820, USA
    J Pharm Sci 101:1852-64. 2012
  4. pmc Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles
    Meredith R Clark
    Department of Bioengineering, University of Utah, Biopolymers Research Building, 20 South 2030 East, Salt Lake City, UT 84112, United States
    Int J Pharm 413:10-18. 2011
  5. pmc A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis
    Todd J Johnson
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    Antimicrob Agents Chemother 56:6272-83. 2012
  6. doi request reprint Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir
    Justin T Clark
    Department of Bioengineering, University of Utah, 20 South 2030 East, Salt Lake City, UT 84112, USA
    J Control Release 163:240-8. 2012
  7. doi request reprint Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir
    Todd J Johnson
    Department of Bioengineering, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, USA
    Eur J Pharm Sci 39:203-12. 2010
  8. pmc Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, USA
    Biomaterials 32:8343-55. 2011
  9. pmc Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings
    Todd J Johnson
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA
    Antimicrob Agents Chemother 56:1291-9. 2012
  10. pmc Activity and safety of synthetic lectins based on benzoboroxole-functionalized polymers for inhibition of HIV entry
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112 5820, United States
    Mol Pharm 8:2465-75. 2011

Research Grants

  1. Bioresponsive Microbicides for AIDS Prevention
    PATRICK KISER; Fiscal Year: 2005

Collaborators

  • David R Friend
  • Betsy C Herold
  • Eric Smith
  • Lisa C Rohan
  • Chang Won Lee
  • Charlene S Dezzutti
  • Bonnie E Lai
  • Anthony R Geonnotti
  • Thomas J Hope
  • Alamelu Mahalingam
  • Todd J Johnson
  • Kavita M Gupta
  • Meredith R Clark
  • Judit Fabian
  • Julie I Jay
  • Justin T Clark
  • Theodore H Albright
  • David F Katz
  • Anthony L Tuitupou
  • Joel S Nebeker
  • Karen M Watson
  • Robert W Buckheit
  • Festo Damian
  • Hyder A Aliyar
  • Satya Ponnapalli
  • R Tyler McCabe
  • Amy Martin
  • Janet McNicholl
  • James Smith
  • R Michael Hendry
  • Gustavo F Doncel
  • Priya Srinivasan
  • Neelima Chandra
  • Ron Otten
  • Karen Watson-Buckheit
  • Chou Pong Pau
  • Robert Buckheit
  • Lorna Rabe
  • Shweta R Ugaonkar
  • Shetha Shukair
  • Russell J Stewart
  • Adam P Simmons
  • Kristofer Langheinrich
  • Jan Balzarini
  • Mike D McRaven
  • Jennifer J Peters
  • Festo R Damian
  • Kris Langheinrich
  • David G Myszka
  • Azadeh E Poursaid
  • Mark A Mitchnik
  • Serena M Pearce
  • Patrick A Tresco
  • Rachel A Tangaro
  • Derek H Owen
  • Meredith C Roberts
  • Scott R Barnes

Detail Information

Publications16

  1. pmc A perspective on progress and gaps in HIV prevention science
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    AIDS Res Hum Retroviruses 28:1373-8. 2012
    ..This drives some of the most pressing questions in the field...
  2. ncbi request reprint State of the art in intravaginal ring technology for topical prophylaxis of HIV infection
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    AIDS Rev 14:62-77. 2012
    ....
  3. doi request reprint Design of tenofovir-UC781 combination microbicide vaginal gels
    Patrick F Kiser
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112 5820, USA
    J Pharm Sci 101:1852-64. 2012
    ..The approach described herein provides a rational schema to design and evaluate vaginal gels for use as microbicides...
  4. pmc Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles
    Meredith R Clark
    Department of Bioengineering, University of Utah, Biopolymers Research Building, 20 South 2030 East, Salt Lake City, UT 84112, United States
    Int J Pharm 413:10-18. 2011
    ..The solid phase synthesis of the crosslinkers, preparation of the particles by inverse microemulsion polymerization, HSP-triggered release of pSS and inactivation of HIV-1 studies are described...
  5. pmc A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis
    Todd J Johnson
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    Antimicrob Agents Chemother 56:6272-83. 2012
    ..In summary, the controlled release of TFV from this reservoir IVR provided elevated sheep vaginal concentrations for 90 days to merit its further evaluation as an HIV prophylactic...
  6. doi request reprint Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir
    Justin T Clark
    Department of Bioengineering, University of Utah, 20 South 2030 East, Salt Lake City, UT 84112, USA
    J Control Release 163:240-8. 2012
    ..Drug release and mechanical properties were approximated by analytical models, which may prove useful for the continuing development of IVRs for HIV prevention or other women's health indications...
  7. doi request reprint Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir
    Todd J Johnson
    Department of Bioengineering, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, USA
    Eur J Pharm Sci 39:203-12. 2010
    ..Altogether, these results suggest that multisegment polyurethane IVRs are an attractive formulation for the sustained vaginal delivery of drugs with contrasting hydrophilicity such as dapivirine and tenofovir...
  8. pmc Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 20 S 2030 E, Salt Lake City, UT 84112, USA
    Biomaterials 32:8343-55. 2011
    ....
  9. pmc Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings
    Todd J Johnson
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA
    Antimicrob Agents Chemother 56:1291-9. 2012
    ....
  10. pmc Activity and safety of synthetic lectins based on benzoboroxole-functionalized polymers for inhibition of HIV entry
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112 5820, United States
    Mol Pharm 8:2465-75. 2011
    ....
  11. pmc Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors
    Julie I Jay
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112 5820, USA
    Mol Pharm 7:116-29. 2010
    ..These polymers exhibited minimal cytotoxicity after 24 h exposure to a human vaginal cell line...
  12. doi request reprint Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions
    Festo Damian
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Int J Pharm 396:1-10. 2010
    ....
  13. doi request reprint Design of a semisolid vaginal microbicide gel by relating composition to properties and performance
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 5820, USA
    Pharm Res 27:2478-91. 2010
    ....
  14. doi request reprint Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1
    Kavita M Gupta
    Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA
    J Pharm Sci 97:4228-39. 2008
    ..These results qualify polyether urethanes for development of intravaginal rings for sustained delivery of microbicidal agents...
  15. ncbi request reprint Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles
    Kavita M Gupta
    Department of Bioengineering, University of Utah, Biopolymers Research Building, 20 S 2030 E Salt Lake City, Utah 84112, USA
    J Pharm Sci 96:670-81. 2007
    ....
  16. pmc Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1
    Alamelu Mahalingam
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 20 S 2030 E, Salt Lake City, Utah 84112, USA
    Antimicrob Agents Chemother 55:1650-60. 2011
    ..In summary, these results are encouraging and warrant further evaluation of IQP-0528 gel formulations in in vivo models, as well as the development of alternative formulations for the delivery of IQP-0528 as a microbicide...

Research Grants1

  1. Bioresponsive Microbicides for AIDS Prevention
    PATRICK KISER; Fiscal Year: 2005
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