Jonathan Kipnis

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Pro-cognitive properties of T cells
    Jonathan Kipnis
    Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 12:663-9. 2012
  2. doi request reprint Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?
    Jonathan Kipnis
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 29:455-63. 2008
  3. pmc Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli
    James C Cronk
    Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Immunity 42:679-91. 2015
  4. pmc The role of microglia in brain maintenance: implications for Rett syndrome
    Noel C Derecki
    Center for Brain Immunology and Glia and Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 34:144-50. 2013
  5. doi request reprint The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury
    Sachin P Gadani
    Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Electronic address
    Neuron 85:703-9. 2015
  6. pmc Phagocytic activity of neuronal progenitors regulates adult neurogenesis
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22901, USA
    Nat Cell Biol 13:1076-83. 2011
  7. pmc Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    Noel C Derecki
    Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 484:105-9. 2012
  8. pmc Learning and memory ... and the immune system
    Ioana Marin
    Center for Brain Immunology and Glia BIG, Department of Neuroscience, Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Learn Mem 20:601-6. 2013
  9. pmc T cells in the central nervous system: messengers of destruction or purveyors of protection?
    James T Walsh
    School of Medicine, Center for Brain Immunology and Glia BIG, University of Virginia, Charlottesville, VA, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA
    Immunology 141:340-4. 2014
  10. pmc Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    Noel C Derecki
    Graduate Program in Neuroscience, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 25:379-85. 2011

Collaborators

  • Noel C Derecki
  • Zhenjie Lu
  • Steffen Jung
  • Yang Xu
  • Ulrike Lorenz
  • Alexandre Prat
  • Michal Schwartz
  • Serge Rivest
  • James T Walsh
  • Igor Smirnov
  • Sachin P Gadani
  • James C Cronk
  • Ioana Marin
  • Antoine Louveau
  • Tajie H Harris
  • Jingjing Zheng
  • Ali Radjavi
  • Geoffrey T Norris
  • Emily Ji
  • Jacob D Eccles
  • David Castle
  • James W Mandell
  • Nathan Coddington
  • Kevin S Lee
  • Vladimir Litvak
  • Yochai Wolf
  • John R Lukens
  • Alexander L Klibanov
  • Wendy Baker
  • Aaron E Lampano
  • Timothy J Keyes
  • Alan Aderem
  • Sherin J Rouhani
  • Stephen D Turner
  • J David Peske
  • Kenneth Tung
  • Nikki Watson

Detail Information

Publications22

  1. pmc Pro-cognitive properties of T cells
    Jonathan Kipnis
    Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 12:663-9. 2012
    ....
  2. doi request reprint Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?
    Jonathan Kipnis
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 29:455-63. 2008
    ..We discuss candidate mechanisms underlying T cell-mediated control of cognitive function in human cognitive diseases associated with immune decline, such as age- and HIV-related dementias, 'chemo-brain' and others...
  3. pmc Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli
    James C Cronk
    Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Immunity 42:679-91. 2015
    ..Dysfunction of tissue-resident macrophages might contribute to the systemic pathologies observed in Rett syndrome. ..
  4. pmc The role of microglia in brain maintenance: implications for Rett syndrome
    Noel C Derecki
    Center for Brain Immunology and Glia and Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 34:144-50. 2013
    ..Finally, we address in some detail the beneficial roles of microglia as clinical targets in Rett syndrome and other neurological disorders...
  5. doi request reprint The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury
    Sachin P Gadani
    Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Electronic address
    Neuron 85:703-9. 2015
    ..These results demonstrate a novel molecular mediator contributing to immune cell recruitment to the injured CNS and may lead to new therapeutic insights in CNS injury and neurodegenerative diseases...
  6. pmc Phagocytic activity of neuronal progenitors regulates adult neurogenesis
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22901, USA
    Nat Cell Biol 13:1076-83. 2011
    ..Collectively, these findings indicate a paradigm wherein DCX(+) neuronal precursors also serve as phagocytes, and that their phagocytic activity critically contributes to neurogenesis in the adult brain...
  7. pmc Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    Noel C Derecki
    Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 484:105-9. 2012
    ..Our data implicate microglia as major players in the pathophysiology of this devastating disorder, and suggest that bone marrow transplantation might offer a feasible therapeutic approach for it...
  8. pmc Learning and memory ... and the immune system
    Ioana Marin
    Center for Brain Immunology and Glia BIG, Department of Neuroscience, Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Learn Mem 20:601-6. 2013
    ..In this review we provide examples of the communication between the nervous and the immune systems in the interest of normal CNS development and function. ..
  9. pmc T cells in the central nervous system: messengers of destruction or purveyors of protection?
    James T Walsh
    School of Medicine, Center for Brain Immunology and Glia BIG, University of Virginia, Charlottesville, VA, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA
    Immunology 141:340-4. 2014
    ..This cross-talk between the adaptive and innate immune systems presents potential new targets that could provide tangible benefits in pathologies that currently have few treatment options...
  10. pmc Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    Noel C Derecki
    Graduate Program in Neuroscience, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 25:379-85. 2011
    ..These results might lead to development of new therapeutic approaches for cognitive pathologies associated with malfunction of adaptive immunity, such as chemo-brain, age-related dementia, HIV-dementia, and others...
  11. pmc Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010
    ..These findings might lead to the development of new immune-based therapies for cognitive impairment associated with immune decline...
  12. pmc IL-4 in the brain: a cytokine to remember
    Sachin P Gadani
    Department of Neuroscience and Graduate Program in Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 189:4213-9. 2012
    ....
  13. pmc Regulatory T cells in central nervous system injury: a double-edged sword
    James T Walsh
    Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA 22908 Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908 Graduate Program in Neuroscience, University of Virginia, Charlottesville, VA 22908, Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908
    J Immunol 193:5013-22. 2014
    ....
  14. pmc Dealing with Danger in the CNS: The Response of the Immune System to Injury
    Sachin P Gadani
    Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Graduate Program in Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Neuron 87:47-62. 2015
    ..We conclude by proposing a revised interpretation of immune privilege in the brain, which takes beneficial neuro-immune communications into account. ..
  15. pmc Thrombospondin 1--a key astrocyte-derived neurogenic factor
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    FASEB J 24:1925-34. 2010
    ..Our data demonstrate that TSP1 is a critical participant in maintenance of the adult NPC pool and in neuronal differentiation...
  16. pmc How do immune cells support and shape the brain in health, disease, and aging?
    Michal Schwartz
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, Neuroscience Laboratory, CHU de Qu├ębec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec G1V 4G2, Canada, and Neuroimmunology Unit, Center for Excellence in Neuromics, CRCHUM, Universite de Montreal, Montreal, Quebec H4A 2B4, Canada
    J Neurosci 33:17587-96. 2013
    ....
  17. pmc Regulatory T cells in CNS injury: the simple, the complex and the confused
    James T Walsh
    Neuroscience Graduate Program and Medical Scientist Training Program, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Mol Med 17:541-7. 2011
    ..In this piece, we explore how the immunology of neurodegeneration differs from that of cancer and autoimmunity and how these differences create confusion about the role of Tregs in neurodegenerative conditions...
  18. pmc Microglia as a critical player in both developmental and late-life CNS pathologies
    Noel C Derecki
    Department of Neuroscience and Center for Brain Immunology and Glia BIG, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA
    Acta Neuropathol 128:333-45. 2014
    ..Here, we review the latest findings and concepts emerging from the rapidly growing body of literature exemplified for Rett syndrome and late-onset, sporadic Alzheimer's disease. ..
  19. pmc Structural and functional features of central nervous system lymphatic vessels
    Antoine Louveau
    1 Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA 2 Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature . 2015
    ....
  20. pmc Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire
    Ali Radjavi
    Center for Brain Immunology and Glia BIG, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA Immunology Graduate Program, University of Virginia, Charlottesville, VA 22908, USA Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 35:58-63. 2014
    ....
  21. pmc Chronic mild stress eliminates the neuroprotective effect of Copaxone after CNS injury
    Igor Smirnov
    Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 31:177-82. 2013
    ..These results may shed a light on mechanism of action of Copaxone and lead to new combined therapies for neurodegenerative and neuroinflammatory disorders...