Jonathan Kipnis

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    Noel C Derecki
    Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 484:105-9. 2012
  2. pmc Pro-cognitive properties of T cells
    Jonathan Kipnis
    Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 12:663-9. 2012
  3. doi request reprint Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?
    Jonathan Kipnis
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 29:455-63. 2008
  4. pmc Phagocytic activity of neuronal progenitors regulates adult neurogenesis
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22901, USA
    Nat Cell Biol 13:1076-83. 2011
  5. pmc The role of microglia in brain maintenance: implications for Rett syndrome
    Noel C Derecki
    Center for Brain Immunology and Glia and Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 34:144-50. 2013
  6. pmc Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010
  7. pmc Learning and memory ... and the immune system
    Ioana Marin
    Center for Brain Immunology and Glia BIG, Department of Neuroscience, Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Learn Mem 20:601-6. 2013
  8. pmc T cells in the central nervous system: messengers of destruction or purveyors of protection?
    James T Walsh
    School of Medicine, Center for Brain Immunology and Glia BIG, University of Virginia, Charlottesville, VA, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA
    Immunology 141:340-4. 2014
  9. pmc Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    Noel C Derecki
    Graduate Program in Neuroscience, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 25:379-85. 2011
  10. pmc Thrombospondin 1--a key astrocyte-derived neurogenic factor
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    FASEB J 24:1925-34. 2010

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    Noel C Derecki
    Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 484:105-9. 2012
    ..Our data implicate microglia as major players in the pathophysiology of this devastating disorder, and suggest that bone marrow transplantation might offer a feasible therapeutic approach for it...
  2. pmc Pro-cognitive properties of T cells
    Jonathan Kipnis
    Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 12:663-9. 2012
    ....
  3. doi request reprint Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?
    Jonathan Kipnis
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 29:455-63. 2008
    ..We discuss candidate mechanisms underlying T cell-mediated control of cognitive function in human cognitive diseases associated with immune decline, such as age- and HIV-related dementias, 'chemo-brain' and others...
  4. pmc Phagocytic activity of neuronal progenitors regulates adult neurogenesis
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22901, USA
    Nat Cell Biol 13:1076-83. 2011
    ..Collectively, these findings indicate a paradigm wherein DCX(+) neuronal precursors also serve as phagocytes, and that their phagocytic activity critically contributes to neurogenesis in the adult brain...
  5. pmc The role of microglia in brain maintenance: implications for Rett syndrome
    Noel C Derecki
    Center for Brain Immunology and Glia and Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Immunol 34:144-50. 2013
    ..Finally, we address in some detail the beneficial roles of microglia as clinical targets in Rett syndrome and other neurological disorders...
  6. pmc Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010
    ..These findings might lead to the development of new immune-based therapies for cognitive impairment associated with immune decline...
  7. pmc Learning and memory ... and the immune system
    Ioana Marin
    Center for Brain Immunology and Glia BIG, Department of Neuroscience, Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Learn Mem 20:601-6. 2013
    ..In this review we provide examples of the communication between the nervous and the immune systems in the interest of normal CNS development and function. ..
  8. pmc T cells in the central nervous system: messengers of destruction or purveyors of protection?
    James T Walsh
    School of Medicine, Center for Brain Immunology and Glia BIG, University of Virginia, Charlottesville, VA, USA Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA
    Immunology 141:340-4. 2014
    ..This cross-talk between the adaptive and innate immune systems presents potential new targets that could provide tangible benefits in pathologies that currently have few treatment options. ..
  9. pmc Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
    Noel C Derecki
    Graduate Program in Neuroscience, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 25:379-85. 2011
    ..These results might lead to development of new therapeutic approaches for cognitive pathologies associated with malfunction of adaptive immunity, such as chemo-brain, age-related dementia, HIV-dementia, and others...
  10. pmc Thrombospondin 1--a key astrocyte-derived neurogenic factor
    Zhenjie Lu
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    FASEB J 24:1925-34. 2010
    ..Our data demonstrate that TSP1 is a critical participant in maintenance of the adult NPC pool and in neuronal differentiation...
  11. pmc IL-4 in the brain: a cytokine to remember
    Sachin P Gadani
    Department of Neuroscience and Graduate Program in Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 189:4213-9. 2012
    ....
  12. pmc How do immune cells support and shape the brain in health, disease, and aging?
    Michal Schwartz
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, Neuroscience Laboratory, CHU de Qu├ębec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec G1V 4G2, Canada, and Neuroimmunology Unit, Center for Excellence in Neuromics, CRCHUM, Universite de Montreal, Montreal, Quebec H4A 2B4, Canada
    J Neurosci 33:17587-96. 2013
    ....
  13. pmc Regulatory T cells in CNS injury: the simple, the complex and the confused
    James T Walsh
    Neuroscience Graduate Program and Medical Scientist Training Program, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Trends Mol Med 17:541-7. 2011
    ..In this piece, we explore how the immunology of neurodegeneration differs from that of cancer and autoimmunity and how these differences create confusion about the role of Tregs in neurodegenerative conditions...
  14. pmc Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire
    Ali Radjavi
    Center for Brain Immunology and Glia BIG, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA Immunology Graduate Program, University of Virginia, Charlottesville, VA 22908, USA Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 35:58-63. 2014
    ....
  15. pmc Chronic mild stress eliminates the neuroprotective effect of Copaxone after CNS injury
    Igor Smirnov
    Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Brain Behav Immun 31:177-82. 2013
    ..These results may shed a light on mechanism of action of Copaxone and lead to new combined therapies for neurodegenerative and neuroinflammatory disorders...

Research Grants3

  1. Regulatory T cells in central nervous system injury
    Jonathan Kipnis; Fiscal Year: 2009
    ..In this research proposal we aim to understand the role of regulatory T-lymphocytes in CNS injury, which might help to develop new therapeutic strategies for CNS injuries based on modulation of these cells. ..
  2. Meninges-to-astrocyte communication in cognitive function
    Jonathan Kipnis; Fiscal Year: 2010
    ..This understanding has the potential to define novel therapeutic targets for several forms of cognitive decline. ..
  3. Regulatory T cells in central nervous system injury
    Jonathan Kipnis; Fiscal Year: 2010
    ..In this research proposal we aim to understand the role of regulatory T-lymphocytes in CNS injury, which might help to develop new therapeutic strategies for CNS injuries based on modulation of these cells. ..