Research Topics
| J P KinsellaSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic herniaJohn P Kinsella
Department of Pediatrics, Divisions of Neonatology, Cardiology, and Pulmonary and Critical Care Medicine, The Children's Hospital and the University of Colorado School of Medicine, Denver, Colorado 80218-1088, USA
J Pediatr 142:397-401. 2003..CONCLUSIONS: Late PH occurs in a significant subset of newborn infants with CDH. Noninvasive inhaled NO treatment may reduce the duration of mechanical ventilation while safely treating late PH...
Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambsJohn P Kinsella
Department of Pediatrics, Pediatric Heart Lung Center, Section of Neonatology, University of Colorado School of Medicine, Denver, Colorado, USA
Am J Respir Crit Care Med 172:745-9. 2005....- Inhaled nitric oxide therapy in premature newbornsJohn P Kinsella
The Children s Hospital University of Colorado School of Medicine, Denver, Colorado 80218, USA
Curr Opin Pediatr 18:107-11. 2006..The purpose of this review is to summarize the results of clinical trials of inhaled nitric oxide in premature newborns, with particular emphasis on studies published in the last 12 months... - Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysisLisa M Askie
NHMRC Clinical Trials Centre, University of Sydney, Australia
BMC Pediatr 10:15. 2010.... - Inhaled nitric oxide: current and future uses in neonatesJ P Kinsella
Department of Pediatrics, and The Children s Hospital and the University of Colorado School of Medicine, Denver, CO, USA
Semin Perinatol 24:387-95. 2000..Non-ECMO centers should be able to provide iNO during transport to an ECMO center. Data suggest a possible role for iNO in preterms with hypoxemic respiratory failure and studies in this group should proceed... - Pulmonary vasodilator therapy in congenital diaphragmatic hernia: acute, late, and chronic pulmonary hypertensionJohn P Kinsella
Department of Pediatrics, Division of Neonatology, The Children s Hospital and the University of Colorado School of Medicine, Denver, CO 80218 1088, USA
Semin Perinatol 29:123-8. 2005..We will also review the role of currently available pulmonary vasoactive drugs in the management of pulmonary hypertension in this population... - Bronchopulmonary dysplasiaJohn P Kinsella
Department of Paediatrics, University of Colorado School of Medicine, Denver, USA
Lancet 367:1421-31. 2006..No safe and effective preventive therapy has been identified, but promising new treatments directed either at reducing lung injury or improving lung growth are under study... - Early inhaled nitric oxide therapy in premature newborns with respiratory failureJohn P Kinsella
Pediatric Heart Lung Center, University of Colorado School of Medicine, and Children s Hospital, Denver, USA
N Engl J Med 355:354-64. 2006..The safety and efficacy of early, low-dose, prolonged therapy with inhaled nitric oxide in premature newborns with respiratory failure are uncertain... - Inhaled nitric oxide in the premature newbornJohn P Kinsella
Pediatric Heart-Lung Center, Section of Neonatology, Denver, Colorado, USA
J Pediatr 151:10-5. 2007 
Inhaled nitric oxide in the term newbornJohn P Kinsella
The Children s Hospital and the University of Colorado School of Medicine, Aurora, CO 80045, USA
Early Hum Dev 84:709-16. 2008..Its proper use and potential limitations in current clinical practice are reviewed...- Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetusR L Rairigh
Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80218, USA
J Clin Invest 101:15-21. 1998..We speculate that type II NOS may play a physiological role in the modulation of vascular tone in the developing fetal lung... - Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetusD D Ivy
Section of Cardiology, University of Colorado School of Medicine, Denver 80218, USA
J Clin Invest 99:1179-86. 1997..We conclude that ET(A) receptor stimulation contributes to the pathogenesis and pathophysiology of experimental perinatal pulmonary hypertension... - Inhaled carbon monoxide does not cause pulmonary vasodilation in the late-gestation fetal lambT R Grover
Pediatric Heart Lung Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Am J Physiol Lung Cell Mol Physiol 278:L779-84. 2000.... - Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertensionJ W Ziegler
Department of Pediatrics, University of Colorado School of Medicine, and Children s Hospital, Denver, Colorado, USA
Am J Respir Crit Care Med 158:1388-95. 1998.... - NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulationJ P Zenge
Section of Neonatology, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Am J Physiol Lung Cell Mol Physiol 281:L1157-63. 2001..001). We conclude that NO has a greater role than PGs in fetal pulmonary vasoregulation during acute hemodynamic stress and that PGI(2)-induced pulmonary vasodilation is largely mediated by NO release in the fetal lung... - Developmental changes in endothelial nitric oxide synthase expression and activity in ovine fetal lungT A Parker
Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Am J Physiol Lung Cell Mol Physiol 278:L202-8. 2000..We speculate that the rise in fetal lung eNOS may contribute to the marked lung growth and angiogenesis that occurs during the same period of time... - Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulationT A Parker
The Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Am J Physiol Heart Circ Physiol 281:H1005-14. 2001..We speculate that estrogen exposure during late gestation prepares the pulmonary circulation for postnatal adaptation... - Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research GroupR H Clark
Department of Pediatrics, Duke University, Durham, NC, USA
N Engl J Med 342:469-74. 2000..Inhaled nitric oxide improves gas exchange in neonates, but the efficacy of low-dose inhaled nitric oxide in reducing the need for extracorporeal membrane oxygenation has not been established... - Role of inducible nitric oxide synthase in the pulmonary vascular response to birth-related stimuli in the ovine fetusR L Rairigh
Pediatric Heart Lung Center and the Sections of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
Circ Res 88:721-6. 2001..We additionally speculate that stimulation of the airway epithelium by rhythmic distension and increased FIO(2) may activate NOS II release at birth... - Developmental changes in endothelin expression and activity in the ovine fetal lungD D Ivy
Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
Am J Physiol Lung Cell Mol Physiol 278:L785-93. 2000..We speculate that changes in ET receptor activity play important roles in regulation of pulmonary vascular tone in the ovine fetus... - Infant lung function after inhaled nitric oxide therapy for persistent pulmonary hypertension of the newbornE L Dobyns
Department of Pediatrics, University of Colorado School of Medicine, USA
Pediatr Pulmonol 28:24-30. 1999..We conclude that inhaled nitric oxide therapy for the treatment of severe PPHN does not alter lung function as determined by lung volume and passive respiratory mechanics measurements during early infancy... - Use of inhaled nitric oxide during interhospital transport of newborns with hypoxemic respiratory failureJohn P Kinsella
Division of Neonatology, Department of Pediatrics, Children's Hospital and University of Colorado School of Medicine Denver, CO 80218, USA
Pediatrics 109:158-61. 2002 - Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatricsEmily L Dobyns
Department of Pediatrics at the Children's Hospital University of Colorado School of Medicine, Denver, USA
Crit Care Med 30:2425-9. 2002..We speculate that the enhanced lung recruitment by HFOV enhances the effects of low dose iNO on gas exchange... - Inhaled nitric oxide therapy in childrenJohn P Kinsella
Department of Pediatrics, The Children s Hospital and the University of Colorado School of Medicine, Pediatric Heart Lung Center, Section of Neonatology, Box B 070, 1056 E 19th Ave, Denver, CO 80218 1088, USA
Paediatr Respir Rev 6:190-8. 2005..In this review, we summarise the current status of iNO therapy in the newborn and the potential role of iNO in other paediatric populations... - Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetusVivek Balasubramaniam
Pediatric Heart Lung Center and Section of Pediatric Pulmonary Medicine, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
Am J Physiol Lung Cell Mol Physiol 284:L826-33. 2003..We speculate that PDGF signaling contributes to structural vascular remodeling in perinatal PH and that selective PDGF inhibition may provide a novel therapeutic strategy for the treatment of chronic PH... - Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertensionD Dunbar Ivy
Section of Cardiology, Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine and CChildren s Hospital, Denver, Colorado 80218 1088, USA
Am J Cardiol 92:886-90. 2003..In 2 patients, NO delivered in the home using this pulsing system was well tolerated for up to 2 years. The long-term safety, efficacy, and acceptability of NO delivered in the home remains to be studied... - Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitorJen-Ruey Tang
Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver Colorado 80218, USA
Am J Physiol Lung Cell Mol Physiol 287:L344-51. 2004..We speculate that decreased NO production contributes to PH and decreases distal lung growth caused by impaired VEGF signaling... - ABCA3 deficiency presenting as persistent pulmonary hypertension of the newbornAnette M Kunig
Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
J Pediatr 151:322-4. 2007..When PH is prolonged and does not respond to standard therapies, genetic causes of surfactant abnormalities should be considered in the differential diagnosis... - Intrauterine hypertension decreases lung VEGF expression and VEGF inhibition causes pulmonary hypertension in the ovine fetusTheresa R Grover
Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Am J Physiol Lung Cell Mol Physiol 284:L508-17. 2003..We speculate that hypertension downregulates VEGF expression in the developing lung and that impaired VEGF signaling may contribute to the pathogenesis of PPHN... - Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambsTheresa R Grover
University of Colorado School of Medicine, Pediatric Heart Lung Center, Department of Pediatrics, and National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Physiol Lung Cell Mol Physiol 292:L1345-51. 2007..We speculate that early disruption of HIF and VEGF expression after preterm birth and RDS may contribute to long-term abnormalities in lung growth, leading to bronchopulmonary dysplasia... - Neonatal extracorporeal life support: impact of new therapies on survivalPaola J Fliman
Division of Neonatology, Northwestern University, Chicago, Illinois, USA
J Pediatr 148:595-9. 2006..To evaluate the effects of pre-extracorporeal life support (ECLS) management with nitric oxide (NO), high frequency ventilation (HFV), and surfactant on mortality among neonates supported with ECLS... - Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulationThomas A Parker
Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, Colorado 80045, USA
Am J Physiol Lung Cell Mol Physiol 289:L261-7. 2005.... - Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertensionRobin H Steinhorn
Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital, Chicago, IL 60614, USA
J Pediatr 155:841-847.e1. 2009..To evaluate the safety of intravenous (IV) sildenafil, an inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, in treating near-term and term newborns with persistent pulmonary hypertension of the newborn (PPHN)... - Adrenal insufficiency in newborns with congenital diaphragmatic herniaBeena D Kamath
University of Colorado School of Medicine and The Children s Hospital, Aurora, CO, USA
J Pediatr 156:495-497.e1. 2010..We found that adrenal insufficiency frequently complicates the clinical course of infants with congenital diaphragmatic hernia and was associated with increased severity of illness... - Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lungLaurent Storme
Department of Neonatology, CHRU de Lille, France
Am J Physiol Lung Cell Mol Physiol 282:L56-66. 2002..We conclude that chronic PH impairs flow-induced vasodilation and increases the myogenic response in fetal lung. We speculate that decreased NO signaling and an augmented myogenic response contributes to abnormal vasoreactivity in PH... - Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal ratsYuh-Jyh Lin
Department of Pediatrics, National Cheng-Kung University, Tainan, Taiwan 704
Pediatr Res 58:22-9. 2005..We conclude that neonatal hyperoxia reduced lung VEGF expression, which persisted during recovery in room air, and that inhaled NO restored distal lung growth in infant rats after neonatal hyperoxia... - Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infantsSteven H Abman
Lancet 360:2076-7; author reply 2077. 2002 - Meconium aspiration syndrome: is surfactant lavage the answer?John P Kinsella
Am J Respir Crit Care Med 168:413-4. 2003
Research Grants
- INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASEJohn Kinsella; Fiscal Year: 2004..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..