J P Kinsella

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia
    John P Kinsella
    Department of Pediatrics, Divisions of Neonatology, Cardiology, and Pulmonary and Critical Care Medicine, The Children s Hospital and the University of Colorado School of Medicine, Denver, Colorado 80218 1088, USA
    J Pediatr 142:397-401. 2003
  2. ncbi request reprint Inhaled nitric oxide therapy in premature newborns
    John P Kinsella
    The Children s Hospital University of Colorado School of Medicine, Denver, Colorado 80218, USA
    Curr Opin Pediatr 18:107-11. 2006
  3. pmc Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs
    John P Kinsella
    Department of Pediatrics, Pediatric Heart Lung Center, Section of Neonatology, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Respir Crit Care Med 172:745-9. 2005
  4. pmc Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Australia
    BMC Pediatr 10:15. 2010
  5. ncbi request reprint Inhaled nitric oxide: current and future uses in neonates
    J P Kinsella
    Department of Pediatrics, and The Children s Hospital and the University of Colorado School of Medicine, Denver, CO, USA
    Semin Perinatol 24:387-95. 2000
  6. ncbi request reprint Pulmonary vasodilator therapy in congenital diaphragmatic hernia: acute, late, and chronic pulmonary hypertension
    John P Kinsella
    Department of Pediatrics, Division of Neonatology, The Children s Hospital and the University of Colorado School of Medicine, Denver, CO 80218 1088, USA
    Semin Perinatol 29:123-8. 2005
  7. ncbi request reprint Bronchopulmonary dysplasia
    John P Kinsella
    Department of Paediatrics, University of Colorado School of Medicine, Denver, USA
    Lancet 367:1421-31. 2006
  8. ncbi request reprint Early inhaled nitric oxide therapy in premature newborns with respiratory failure
    John P Kinsella
    Pediatric Heart Lung Center, University of Colorado School of Medicine, and Children s Hospital, Denver, USA
    N Engl J Med 355:354-64. 2006
  9. ncbi request reprint Inhaled nitric oxide in the premature newborn
    John P Kinsella
    Pediatric Heart Lung Center, Section of Neonatology, Denver, Colorado, USA
    J Pediatr 151:10-5. 2007
  10. doi request reprint Inhaled nitric oxide in the term newborn
    John P Kinsella
    The Children s Hospital and the University of Colorado School of Medicine, Aurora, CO 80045, USA
    Early Hum Dev 84:709-16. 2008

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia
    John P Kinsella
    Department of Pediatrics, Divisions of Neonatology, Cardiology, and Pulmonary and Critical Care Medicine, The Children s Hospital and the University of Colorado School of Medicine, Denver, Colorado 80218 1088, USA
    J Pediatr 142:397-401. 2003
    ....
  2. ncbi request reprint Inhaled nitric oxide therapy in premature newborns
    John P Kinsella
    The Children s Hospital University of Colorado School of Medicine, Denver, Colorado 80218, USA
    Curr Opin Pediatr 18:107-11. 2006
    ..The purpose of this review is to summarize the results of clinical trials of inhaled nitric oxide in premature newborns, with particular emphasis on studies published in the last 12 months...
  3. pmc Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs
    John P Kinsella
    Department of Pediatrics, Pediatric Heart Lung Center, Section of Neonatology, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Respir Crit Care Med 172:745-9. 2005
    ....
  4. pmc Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Australia
    BMC Pediatr 10:15. 2010
    ....
  5. ncbi request reprint Inhaled nitric oxide: current and future uses in neonates
    J P Kinsella
    Department of Pediatrics, and The Children s Hospital and the University of Colorado School of Medicine, Denver, CO, USA
    Semin Perinatol 24:387-95. 2000
    ..Non-ECMO centers should be able to provide iNO during transport to an ECMO center. Data suggest a possible role for iNO in preterms with hypoxemic respiratory failure and studies in this group should proceed...
  6. ncbi request reprint Pulmonary vasodilator therapy in congenital diaphragmatic hernia: acute, late, and chronic pulmonary hypertension
    John P Kinsella
    Department of Pediatrics, Division of Neonatology, The Children s Hospital and the University of Colorado School of Medicine, Denver, CO 80218 1088, USA
    Semin Perinatol 29:123-8. 2005
    ..We will also review the role of currently available pulmonary vasoactive drugs in the management of pulmonary hypertension in this population...
  7. ncbi request reprint Bronchopulmonary dysplasia
    John P Kinsella
    Department of Paediatrics, University of Colorado School of Medicine, Denver, USA
    Lancet 367:1421-31. 2006
    ..No safe and effective preventive therapy has been identified, but promising new treatments directed either at reducing lung injury or improving lung growth are under study...
  8. ncbi request reprint Early inhaled nitric oxide therapy in premature newborns with respiratory failure
    John P Kinsella
    Pediatric Heart Lung Center, University of Colorado School of Medicine, and Children s Hospital, Denver, USA
    N Engl J Med 355:354-64. 2006
    ..The safety and efficacy of early, low-dose, prolonged therapy with inhaled nitric oxide in premature newborns with respiratory failure are uncertain...
  9. ncbi request reprint Inhaled nitric oxide in the premature newborn
    John P Kinsella
    Pediatric Heart Lung Center, Section of Neonatology, Denver, Colorado, USA
    J Pediatr 151:10-5. 2007
  10. doi request reprint Inhaled nitric oxide in the term newborn
    John P Kinsella
    The Children s Hospital and the University of Colorado School of Medicine, Aurora, CO 80045, USA
    Early Hum Dev 84:709-16. 2008
    ..Its proper use and potential limitations in current clinical practice are reviewed...
  11. pmc Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus
    R L Rairigh
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80218, USA
    J Clin Invest 101:15-21. 1998
    ..We speculate that type II NOS may play a physiological role in the modulation of vascular tone in the developing fetal lung...
  12. pmc Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus
    D D Ivy
    Section of Cardiology, University of Colorado School of Medicine, Denver 80218, USA
    J Clin Invest 99:1179-86. 1997
    ..We conclude that ET(A) receptor stimulation contributes to the pathogenesis and pathophysiology of experimental perinatal pulmonary hypertension...
  13. ncbi request reprint Inhaled carbon monoxide does not cause pulmonary vasodilation in the late-gestation fetal lamb
    T R Grover
    Pediatric Heart Lung Center and Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 278:L779-84. 2000
    ....
  14. ncbi request reprint Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension
    J W Ziegler
    Department of Pediatrics, University of Colorado School of Medicine, and Children s Hospital, Denver, Colorado, USA
    Am J Respir Crit Care Med 158:1388-95. 1998
    ....
  15. ncbi request reprint NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation
    J P Zenge
    Section of Neonatology, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1157-63. 2001
    ..001). We conclude that NO has a greater role than PGs in fetal pulmonary vasoregulation during acute hemodynamic stress and that PGI(2)-induced pulmonary vasodilation is largely mediated by NO release in the fetal lung...
  16. ncbi request reprint Developmental changes in endothelial nitric oxide synthase expression and activity in ovine fetal lung
    T A Parker
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 278:L202-8. 2000
    ..We speculate that the rise in fetal lung eNOS may contribute to the marked lung growth and angiogenesis that occurs during the same period of time...
  17. ncbi request reprint Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation
    T A Parker
    The Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Heart Circ Physiol 281:H1005-14. 2001
    ..We speculate that estrogen exposure during late gestation prepares the pulmonary circulation for postnatal adaptation...
  18. ncbi request reprint Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group
    R H Clark
    Department of Pediatrics, Duke University, Durham, NC, USA
    N Engl J Med 342:469-74. 2000
    ..Inhaled nitric oxide improves gas exchange in neonates, but the efficacy of low-dose inhaled nitric oxide in reducing the need for extracorporeal membrane oxygenation has not been established...
  19. ncbi request reprint Role of inducible nitric oxide synthase in the pulmonary vascular response to birth-related stimuli in the ovine fetus
    R L Rairigh
    Pediatric Heart Lung Center and the Sections of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Circ Res 88:721-6. 2001
    ..We additionally speculate that stimulation of the airway epithelium by rhythmic distension and increased FIO(2) may activate NOS II release at birth...
  20. ncbi request reprint Developmental changes in endothelin expression and activity in the ovine fetal lung
    D D Ivy
    Pediatric Heart Lung Center, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 278:L785-93. 2000
    ..We speculate that changes in ET receptor activity play important roles in regulation of pulmonary vascular tone in the ovine fetus...
  21. ncbi request reprint Infant lung function after inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn
    E L Dobyns
    Department of Pediatrics, University of Colorado School of Medicine, USA
    Pediatr Pulmonol 28:24-30. 1999
    ..We conclude that inhaled nitric oxide therapy for the treatment of severe PPHN does not alter lung function as determined by lung volume and passive respiratory mechanics measurements during early infancy...
  22. ncbi request reprint Use of inhaled nitric oxide during interhospital transport of newborns with hypoxemic respiratory failure
    John P Kinsella
    Division of Neonatology, Department of Pediatrics, Children s Hospital and University of Colorado School of Medicine Denver, CO 80218, USA
    Pediatrics 109:158-61. 2002
  23. ncbi request reprint Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatrics
    Emily L Dobyns
    Department of Pediatrics at the Children s Hospital University of Colorado School of Medicine, Denver, USA
    Crit Care Med 30:2425-9. 2002
    ....
  24. ncbi request reprint Inhaled nitric oxide therapy in children
    John P Kinsella
    Department of Pediatrics, The Children s Hospital and the University of Colorado School of Medicine, Pediatric Heart Lung Center, Section of Neonatology, Box B 070, 1056 E 19th Ave, Denver, CO 80218 1088, USA
    Paediatr Respir Rev 6:190-8. 2005
    ..In this review, we summarise the current status of iNO therapy in the newborn and the potential role of iNO in other paediatric populations...
  25. ncbi request reprint Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus
    Vivek Balasubramaniam
    Pediatric Heart Lung Center and Section of Pediatric Pulmonary Medicine, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 284:L826-33. 2003
    ..We speculate that PDGF signaling contributes to structural vascular remodeling in perinatal PH and that selective PDGF inhibition may provide a novel therapeutic strategy for the treatment of chronic PH...
  26. ncbi request reprint Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension
    D Dunbar Ivy
    Section of Cardiology, Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine and CChildren s Hospital, Denver, Colorado 80218 1088, USA
    Am J Cardiol 92:886-90. 2003
    ..In 2 patients, NO delivered in the home using this pulsing system was well tolerated for up to 2 years. The long-term safety, efficacy, and acceptability of NO delivered in the home remains to be studied...
  27. ncbi request reprint Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor
    Jen Ruey Tang
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 287:L344-51. 2004
    ..We speculate that decreased NO production contributes to PH and decreases distal lung growth caused by impaired VEGF signaling...
  28. ncbi request reprint ABCA3 deficiency presenting as persistent pulmonary hypertension of the newborn
    Anette M Kunig
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
    J Pediatr 151:322-4. 2007
    ..When PH is prolonged and does not respond to standard therapies, genetic causes of surfactant abnormalities should be considered in the differential diagnosis...
  29. ncbi request reprint Intrauterine hypertension decreases lung VEGF expression and VEGF inhibition causes pulmonary hypertension in the ovine fetus
    Theresa R Grover
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 284:L508-17. 2003
    ..We speculate that hypertension downregulates VEGF expression in the developing lung and that impaired VEGF signaling may contribute to the pathogenesis of PPHN...
  30. ncbi request reprint Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs
    Theresa R Grover
    University of Colorado School of Medicine, Pediatric Heart Lung Center, Department of Pediatrics, and National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1345-51. 2007
    ..We speculate that early disruption of HIF and VEGF expression after preterm birth and RDS may contribute to long-term abnormalities in lung growth, leading to bronchopulmonary dysplasia...
  31. ncbi request reprint Neonatal extracorporeal life support: impact of new therapies on survival
    Paola J Fliman
    Division of Neonatology, Northwestern University, Chicago, Illinois, USA
    J Pediatr 148:595-9. 2006
    ..To evaluate the effects of pre-extracorporeal life support (ECLS) management with nitric oxide (NO), high frequency ventilation (HFV), and surfactant on mortality among neonates supported with ECLS...
  32. ncbi request reprint Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation
    Thomas A Parker
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, Colorado 80045, USA
    Am J Physiol Lung Cell Mol Physiol 289:L261-7. 2005
    ....
  33. doi request reprint Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension
    Robin H Steinhorn
    Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital, Chicago, IL 60614, USA
    J Pediatr 155:841-847.e1. 2009
    ..To evaluate the safety of intravenous (IV) sildenafil, an inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, in treating near-term and term newborns with persistent pulmonary hypertension of the newborn (PPHN)...
  34. pmc Adrenal insufficiency in newborns with congenital diaphragmatic hernia
    Beena D Kamath
    University of Colorado School of Medicine and The Children s Hospital, Aurora, CO, USA
    J Pediatr 156:495-497.e1. 2010
    ..We found that adrenal insufficiency frequently complicates the clinical course of infants with congenital diaphragmatic hernia and was associated with increased severity of illness...
  35. ncbi request reprint Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung
    Laurent Storme
    Department of Neonatology, CHRU de Lille, France
    Am J Physiol Lung Cell Mol Physiol 282:L56-66. 2002
    ..We conclude that chronic PH impairs flow-induced vasodilation and increases the myogenic response in fetal lung. We speculate that decreased NO signaling and an augmented myogenic response contributes to abnormal vasoreactivity in PH...
  36. ncbi request reprint Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats
    Yuh Jyh Lin
    Department of Pediatrics, National Cheng Kung University, Tainan, Taiwan 704
    Pediatr Res 58:22-9. 2005
    ..We conclude that neonatal hyperoxia reduced lung VEGF expression, which persisted during recovery in room air, and that inhaled NO restored distal lung growth in infant rats after neonatal hyperoxia...
  37. ncbi request reprint Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infants
    Steven H Abman
    Lancet 360:2076-7; author reply 2077. 2002
  38. ncbi request reprint Meconium aspiration syndrome: is surfactant lavage the answer?
    John P Kinsella
    Am J Respir Crit Care Med 168:413-4. 2003

Research Grants2

  1. INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASE
    John Kinsella; Fiscal Year: 2004
    ..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..