Research Topics
| T E KingSummaryAffiliation: University of California Country: USA Publications
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Publications
Clinical advances in the diagnosis and therapy of the interstitial lung diseasesTalmadge E King
Department of Medicine, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, CA 94110, USA
Am J Respir Crit Care Med 172:268-79. 2005..This article highlights some of the advances and changes in clinical practice that took place in the management of patients with interstitial lung diseases over the last century...
Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortalityT E King
Department of Medicine, San Francisco General Hospital, and the University of California, San Francisco, San Francisco, California 94110, USA
Am J Respir Crit Care Med 164:1025-32. 2001..Controlling these processes, rather than stopping inflammation, appears most important in preventing progressive disease and the fatal outcome common in IPF...
Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival modelT E King
Department of Medicine, San Francisco General Hospital, and the University of California, San Francisco 94110, USA
Am J Respir Crit Care Med 164:1171-81. 2001....
Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosisTalmadge E King
Department of Medicine, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA 94110, USA
Chest 127:171-7. 2005..Idiopathic pulmonary fibrosis (IPF) is a devastating disease, yet validated, reliable criteria for evaluating patient response to therapies in clinical trials are lacking...
Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and managementTalmadge E King
Interstitial Lung Disease Center, San Francisco General Hospital, San Francisco, CA 94110, USA
Trans Am Clin Climatol Assoc 115:43-76; discussion 76-8. 2004....
Demystifying idiopathic interstitial pneumoniaHarold R Collard
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, USA
Arch Intern Med 163:17-29. 2003....
Acute interstitial pneumonitis. Case series and review of the literatureJ S Vourlekis
Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, F107, Denver, CO 80206, USA
Medicine (Baltimore) 79:369-78. 2000..Likewise, there were no features that predicted the longitudinal course in survivors. Further study to identify causal factors is required in the hope of preventing morbidity and mortality related to this disease...
Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosisJ S Lee
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Eur Respir J 39:352-8. 2012..Pepsin level was not an independent predictor of survival time. These results suggest occult aspiration may play a role in some cases of acute exacerbation of idiopathic pulmonary fibrosis...
Challenges in pulmonary fibrosis. 1: Use of high resolution CT scanning of the lung for the evaluation of patients with idiopathic interstitial pneumoniasMichael B Gotway
Department of Radiology, University of California at San Francisco, and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, USA
Thorax 62:546-53. 2007..The role of surgical lung biopsy is discussed in the diagnosis of cases when a definite HRCT diagnosis cannot be made...
Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic patternEunice J Kim
Division of Pulmonary and Critical CareMedicine, Department of Medicine, University of California at San Francisco, CA, USA
Chest 136:1397-405. 2009..In patients in whom the underlying pattern cannot be determined by HRCT scanning, surgical lung biopsy should be considered...
Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?Kevin R Flaherty
Division of Pulmonary and Critical Care Medicine, Department of Radiology, University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0360, USA
Am J Respir Crit Care Med 170:904-10. 2004..We conclude that dynamic interactions between clinicians, radiologists, and pathologists improve interobserver agreement and diagnostic confidence...
Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trialTalmadge E King
Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0120, USA
Lancet 374:222-8. 2009..We assessed whether treatment with interferon gamma-1b improved survival compared with placebo in patients with idiopathic pulmonary fibrosis and mild-to-moderate impairment of pulmonary function...
Bosentan for idiopathic pulmonary fibrosisTalmadge E King
University of California San Francisco, Department of Medicine, San Francisco, CA 94143 0120, USA
Curr Opin Investig Drugs 9:1171-9. 2008..These observations are being investigated in the ongoing BUILD-3 trial...
Current diagnosis and management of idiopathic pulmonary fibrosis: a survey of academic physiciansHarold R Collard
Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, 5K1, San Francisco, CA 94110, USA
Respir Med 101:2011-6. 2007..These results suggest there is general consensus regarding the approach to diagnosis, but that there is no consensus about medical management in IPF...
Current perspectives on the treatment of idiopathic pulmonary fibrosisNicholas Walter
San Francisco General Hospital, 1001 Potrero Avenue, Room 5H22, San Francisco, CA 94110, USA
Proc Am Thorac Soc 3:330-8. 2006..g., IFN-gamma1b, pirfenidone, N-acetylcysteine, coumadin, bosentan, or etanercept). This article examines the body of evidence supporting the current therapies and reviews the newer agents being tested in patients with IPF...
Clinical problem-solving. Anchors awayCarolyn S Calfee
Department of Medicine, University of California, San Francisco, USA
N Engl J Med 356:504-9. 2007
Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosisHarold R Collard
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Chest 125:2169-74. 2004....
Does chronic microaspiration cause idiopathic pulmonary fibrosis?Joyce S Lee
Department of Medicine, University of California, San Francisco, CA, USA
Am J Med 123:304-11. 2010..Defining the role of chronic microaspiration in idiopathic pulmonary fibrosis is essential as it has potential clinical, pathobiological, and treatment implications for this deadly disease...
Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependenceDavid G Morris
Interstitial Lung Disease Program, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94142 0854, USA
Chest 124:929-35. 2003..The chronic granulomatous inflammation of sarcoidosis has been hypothesized to depend on the CD4+ T-helper lymphocyte. HIV infection, which depletes these cells, has been reported to attenuate the manifestations of sarcoidosis...
BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosisTalmadge E King
Department of Medicine, UCSF, 505 Parnassus Avenue, Room M994, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 177:75-81. 2008..Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease lacking effective treatment...
Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung diseaseE J Kim
Dept of Medicine, University of California, San Francisco, CA 94143, USA
Eur Respir J 35:1322-8. 2010..96) were associated with better survival. A definite usual interstitial pneumonia pattern on HRCT has important prognostic implications in RA-ILD...
Quality of life and dyspnoea in patients treated with bosentan for idiopathic pulmonary fibrosis (BUILD-1)G Raghu
Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA 98195 6522, USA
Eur Respir J 35:118-23. 2010..Observations from exploratory analyses suggested benefits of bosentan on HRQoL among patients who had undergone surgical lung biopsy for diagnosis, and they merit further investigation...
Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung functionBrent W Kinder
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
Lung 188:143-9. 2010..These findings demonstrate the clinical importance of identifying UCTD in patients presenting with an "idiopathic" interstitial pneumonia...
Nonspecific interstitial pneumonitis as the sole histologic expression of hypersensitivity pneumonitisJason S Vourlekis
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Med 112:490-3. 2002
Human mast cell basic fibroblast growth factor in pulmonary fibrotic disordersY Inoue
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA
Am J Pathol 149:2037-54. 1996....
Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosisG W Hunninghake
Department of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
Am J Respir Crit Care Med 164:193-6. 2001..Lung biopsy is most helpful when clinical and radiologic data result in an uncertain diagnosis or when patients are thought not to have IPF...
A new look at the pathophysiology of asthmaT E King
Department of Medicine, San Francisco General Hospital, 1001 Potrero Ave, Room 5H22, San Francisco, CA 94110, USA
J Natl Med Assoc 91:9S-15S. 1999....
Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosisBrent W Kinder
Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Chest 133:226-32. 2008..We hypothesized that baseline BAL fluid cell count differential (ie, elevated levels of neutrophils and eosinophils, or reduced levels of lymphocytes) would predict higher mortality among persons with IPF...
Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosisHarold R Collard
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 1400 Jackson Street, Room F107, Denver, CO 80206, USA
Am J Respir Crit Care Med 168:538-42. 2003..Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone...
Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?Brent W Kinder
Department of Medicine, University of California School of Medicine, San Francisco, California, USA
Am J Respir Crit Care Med 176:691-7. 2007....
Bronchoalveolar lavage fluid D dimer levels are higher and more prevalent in black patients with pulmonary sarcoidosisRafael L Perez
Pulmonary Division, Department of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Atlanta, GA 30033, USA
Respiration 74:297-303. 2007..Abnormalities of lung coagulation and fibrinolysis in sarcoidosis are thought to play a role in the pathogenesis of this disease...
Acute exacerbations of idiopathic pulmonary fibrosisHarold R Collard
Department of Medicine, San Francisco General Hospital, University of California, USA
Am J Respir Crit Care Med 176:636-43. 2007..The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed...
Association of smoking with dsDNA autoantibody production in systemic lupus erythematosusM M Freemer
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143-0500, USA
Ann Rheum Dis 65:581-4. 2006..This information may also serve as a possible point of intervention to prevent disease or target treatment...
Neurofibromatosis-associated lung disease: a case series and literature reviewA C Zamora
Department of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
Eur Respir J 29:210-4. 2007..In conclusion, neurofibromatosis with diffuse lung disease is a definable clinical entity, characterised by upper lobe cystic and bullous disease and lower lobe fibrosis. Its relationship to smoking remains unclear...
Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosisHarold R Collard
Department of Medicine, University of California San Francisco, San Francisco, California, USA
Am J Physiol Lung Cell Mol Physiol 299:L3-7. 2010..Furthermore, they suggest that acute exacerbation of IPF has a distinct plasma biomarker profile from that of acute lung injury...
Clinical and genetic risk factors for pneumonia in systemic lupus erythematosusBrent W Kinder
Division of Rheumatology, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA
Arthritis Rheum 56:2679-86. 2007....
Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facilityMehrdad Arjomandi
Department of Medicine, University of California, San Francisco, CA, USA
J Occup Environ Med 52:647-52. 2010..To study the prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) in a cohort of workers from a nuclear weapons research and development facility...
A critical assessment of treatment options for idiopathic pulmonary fibrosisNirav R Shah
Department of Medicine, New York University School of Medicine, New York, NY, USA
Sarcoidosis Vasc Diffuse Lung Dis 22:167-74. 2005....
Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working groupRonald G Crystal
Division of Pulmonary and Critical Care Medicine, Weill Medical College of Cornell University, New York, New York, USA
Am J Respir Crit Care Med 166:236-46. 2002....
Basic fibroblast growth factor and its receptors in idiopathic pulmonary fibrosis and lymphangioleiomyomatosisYoshikazu Inoue
Division of Environmental and Occupational Health Sciences and Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Respir Crit Care Med 166:765-73. 2002..These data suggest that mast cell-derived bFGF might exert fibrogenic, proliferative effects on smooth muscle cell/myofibroblast-like cells through its receptors...
Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumoniaGary W Hunninghake
Department of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242, USA
Chest 124:1215-23. 2003..To determine which clinical and radiologic findings are independently associated with a pathologic diagnosis of usual interstitial pneumonia (UIP)...
COPD: a dust-induced disease?Carlos E Girod
Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9034, USA
Chest 128:3055-64. 2005..Further studies into the effects of kaolinite on macrophage function and the subsequent development of respiratory bronchiolitis could lead to prevention of COPD at its precursor lesion...
Classification and natural history of the idiopathic interstitial pneumoniasDong Soon Kim
Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan, 388 1 Poongnap dong, Songpa Ku, Seoul, Korea, 138 736
Proc Am Thorac Soc 3:285-92. 2006..However, there is still confusion and controversy over the relationship between idiopathic pulmonary fibrosis and fibrotic nonspecific interstitial pneumonia...
High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosisDavid A Lynch
Department of Radiology, and Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box A030, Room 2233 Denver, CO 80262, USA
Am J Respir Crit Care Med 172:488-93. 2005..High-resolution computed tomography (HRCT) is an integral aspect of the evaluation of patients with suspected idiopathic pulmonary fibrosis (IPF). However, few studies have evaluated its use in a large cohort...
A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosisGanesh Raghu
Division of Pulmonary Medicine, University of Washington, Seattle 98195, USA
N Engl J Med 350:125-33. 2004..Idiopathic pulmonary fibrosis is a progressive, fatal disease with no known efficacious therapy...
Respiratory bronchiolitis-interstitial lung disease: long-term outcomeJoshua Portnoy
National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
Chest 131:664-71. 2007..In this study, we sought to determine the outcome of RB-ILD patients with and without smoking cessation and with and without corticosteroid therapy...
Nonspecific interstitial pneumonia and systemic sclerosisTalmadge E King
Am J Respir Crit Care Med 165:1578-9. 2002
The clinical course of patients with idiopathic pulmonary fibrosisFernando J Martinez
University of Michigan, Ann Arbor, Michigan 48109, USA
Ann Intern Med 142:963-7. 2005..Prospective data defining the clinical course in idiopathic pulmonary fibrosis (IPF) are sparse...
Idiopathic interstitial pneumonias: CT featuresDavid A Lynch
Department of Radiology, University of Colorado Health Sciences Center, CB A 030, 4200 E Ninth Ave, Denver, CO 80262, USA
Radiology 236:10-21. 2005..AIP manifests as diffuse lung consolidation and ground-glass opacity. LIP is associated with a CT pattern of ground-glass opacity sometimes associated with perivascular cysts...
Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society projectWilliam D Travis
Attending Thoracic Pathologist, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Am J Respir Crit Care Med 177:1338-47. 2008..Concern was expressed that NSIP was a "wastebasket" category, difficult to distinguish from other idiopathic interstitial pneumonias...
Challenges in pulmonary fibrosis x 5: the NSIP/UIP debateRoland Du Bois
Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
Thorax 62:1008-12. 2007..The histopathological pattern of NSIP can be found in a wide variety of clinical and radiological contexts. This review addresses these and other uncertainties regarding NSIP and UIP...
Prognostic significance of bronchoalveolar lavage cellular analysis in scleroderma lung diseaseBrent W Kinder
Am J Respir Crit Care Med 177:1292-3; author reply 1293. 2008
The effect of pulmonary fibrosis on survival in patients with hypersensitivity pneumonitisJason S Vourlekis
Lung and Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Am J Med 116:662-8. 2004..01; 95% confidence interval: 1.68 to 21.45; P = 0.006). CONCLUSION: Pulmonary fibrosis is associated with diminished survival in patients with hypersensitivity pneumonitis...
Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung diseaseAna C Zamora
Hospital Universitario Dr José Eleuterio González, Monterrey, NL, Mexico
Respir Med 102:150-5. 2008..Treatment of patients with scleroderma ILD for up to 24 months with MMF was generally associated with stable pulmonary function. These data argue for a prospective trial using MMF to treat scleroderma ILD...
Anticoagulant therapy and idiopathic pulmonary fibrosisBrent W Kinder
Chest 130:302-3. 2006
Idiopathic interstitial pneumonia: do community and academic physicians agree on diagnosis?Kevin R Flaherty
University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
Am J Respir Crit Care Med 175:1054-60. 2007..Treatment and prognoses of diffuse parenchymal lung diseases (DPLDs) varies by diagnosis. Obtaining a uniform diagnosis among observers is difficult...
Racial disparities in clinical trialsTalmadge E King
N Engl J Med 346:1400-2. 2002
Research Grants
- Idiopathic Pulmonary Fibrosis Clinical Research NetworkTALMADGE KING; Fiscal Year: 2007..Protocol 2: A randomized, double blind, placebo controlled, multicenter trial of interferon gamma-1b plus pirfenidone in the treatment of IPF. (End of Abstract) ..
