- Can tau filaments be both physiologically beneficial and toxic?Michelle E King
Department of Biology, University of Virginia, 229 Gilmer Hall, Charlottesville, VA 22903, USA
Biochim Biophys Acta 1739:260-7. 2005..Not only do tau filaments greatly contribute to the systematic loss of neurons and the pathological presentation of memory loss, but they may represent a physiological process whose regulation may be controlled...
- Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloidMichelle E King
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
J Cell Biol 175:541-6. 2006..These results suggest that a seminal cell biological event in AD pathogenesis is acute, tau-dependent loss of microtubule integrity caused by exposure of neurons to readily diffusible Abeta...