Research Topics
| Jennifer R KingSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Detail Information
Publications
Steady-state pharmacokinetics of tenofovir-based regimens in HIV-infected pediatric patientsJennifer R King
University of Alabama at Birmingham, Division of Clinical Pharmacology, 1530 3rd Avenue South, Shelby 1170, Birmingham, AL 35294 0019, USA
Antimicrob Agents Chemother 55:4290-4. 2011..Informal comparisons of treatment groups did not indicate any advantage to any combination with respect to tenofovir exposure. Further study of exposures achieved with antiretrovirals administered in combination is warranted...- Steady-state pharmacokinetics of lopinavir/ritonavir in combination with efavirenz in human immunodeficiency virus-infected pediatric patientsJennifer R King
The University of Alabama at Birmingham, Birmingham, AL, USA
Pediatr Infect Dis J 28:159-61. 2009..Our data support the current LPV/RTV dose, but EFV 350 mg/m may not be sufficient... 
Efficacy, tolerability and pharmacokinetics of two nelfinavir-based regimens in human immunodeficiency virus-infected children and adolescents: pediatric AIDS clinical trials group protocol 403Jennifer R King
University of Alabama at Birmingham, Birmingham, USA
Pediatr Infect Dis J 24:880-5. 2005..Differences in tolerability between the 2 treatment groups were not identified. Systemic exposure of these drugs was similar to that reported in other HIV-infected children and adults...
Novel methodology for antiretroviral quantitation in the female genital tractChantelle Bennetto-Hood
Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
HIV Clin Trials 10:193-9. 2009..Challenges exist regarding antiretroviral quantitation in the female genital tract. Endocervical wicking using sterile tear flow test strips is an alternative to conventional methods due to the consistent sample volume obtained...- Pharmacokinetics of antiretrovirals administered to HIV-infected children via gastrostomy tubeJennifer R King
Division of Clinical Pharmacology, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA
HIV Clin Trials 5:288-93. 2004..CONCLUSION: This pilot study suggests that administration of most PIs and NNRTIs by a g-tube to HIV-infected children provides systemic exposure comparable with that achieved after oral administration... - Evaluation of multiple drug therapy in human immunodeficiency virus-infected pediatric patientsJennifer R King
Division of Clinical Pharmacology, University of Alabama at Birmingham, 35294, USA
Pediatr Infect Dis J 22:239-44. 2003..Larger controlled clinical trials in this patient population are necessary to determine whether the benefit of this therapeutic approach outweighs potential risks... - Pharmacokinetic enhancement of protease inhibitor therapyJennifer R King
Division of Clinical Pharmacology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA
Clin Pharmacokinet 43:291-310. 2004..The following manuscript will discuss the rationale for combining protease inhibitors and will review pertinent pharmacokinetic and clinical data on these combination regimens... - Detection of nevirapine in plasma using thin-layer chromatographyJeffrey G Dubuisson
Division of Clinical Pharmacology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, USA
J Acquir Immune Defic Syndr 35:155-7. 2004.... - Zidovudine, lamivudine, and nelfinavir concentrations in amniotic fluid and maternal serumChantelle Bennetto-Hood
Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0019, USA
HIV Clin Trials 10:41-7. 2009.... - Pharmacokinetics of saquinavir with atazanavir or low-dose ritonavir administered once daily (ASPIRE I) or twice daily (ASPIRE II) in seronegative volunteersJennifer R King
PharmD, University of Alabama at Birmingham, Division of Clinical Pharmacology, 1530 3rd Avenue South, VH 116, Birmingham, AL 35294 0019, USA
J Clin Pharmacol 47:201-8. 2007..Although SQV plasma concentrations were higher when coadministered with RTV, a combination of SQV/ATV administered BID may be a viable alternative in HIV-infected, PI-naive subjects intolerant to RTV... - Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility dataEdward P Acosta
Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
Antimicrob Agents Chemother 56:5938-45. 2012.... - Tipranavir: a novel nonpeptidic protease inhibitor of HIVJennifer R King
The University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA
Clin Pharmacokinet 45:665-82. 2006..Therefore, this novel PI in combination with ritonavir represents an important new choice in the treatment of multiple-PI-experienced patients... - Single-dose pharmacokinetics of enteric-coated didanosine in HIV-infected childrenJennifer R King
The University of Alabama at Birmingham, Birmingham, Ala, USA
Antivir Ther 7:267-70. 2002.... - Persistence of nevirapine in breast milk after discontinuation of treatmentChantelle Bennetto Hood
Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0019, USA
Clin Infect Dis 45:391-4. 2007..Nevirapine was quantifiable for up to 17 days after discontinuation of therapy; total nevirapine concentrations remained above the 90% inhibitory concentration for 6 days, and no differences were observed between breasts... - Indinavir protein-free concentrations when used in indinavir/ritonavir combination therapyJennifer R King
University of Alabama at Birmingham, School of Medicine, Division of Clinical Pharmacology, Birmingham, Alabama, USA
AIDS 19:1059-63. 2005..These data suggest that RTV affects IDV protein-binding characteristics and IDV also exhibits concentration dependent binding when administered with RTV... - Effects of concentration and temperature on the stability of nevirapine in whole blood and serumChantelle J Bennetto
The University of Alabama at Birmingham, School of Medicine, Division of Clinical Pharmacology, 1530 3rd Ave. South, VH 116, Birmingham, AL 35294-0019, USA
Clin Chem 50:209-11. 2004 - Antiretroviral pharmacokinetics in the paediatric population: a reviewJennifer R King
Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA
Clin Pharmacokinet 41:1115-33. 2002..If prevention of treatment failure continues to be the goal of antiretroviral therapy, the pharmacokinetics of antiretrovirals in children need to be assessed early in the drug development process... - Methods for integration of pharmacokinetic and phenotypic information in the treatment of infection with human immunodeficiency virusEdward P Acosta
Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
Clin Infect Dis 36:373-7. 2003.... - Age-related differences in plasma and intracellular tenofovir concentrations in HIV-1-infected children, adolescents and adultsGautam Baheti
Antiviral Pharmacology Laboratory, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198 6000, USA
AIDS 27:221-5. 2013..Our objectives were to describe TFV-DP pharmacokinetics in children and adolescents and investigate the effect of age on TFV and TFV-DP concentrations... - Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatographyMichele L Turner
Division of Clinical Pharmacology, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 116, 35294-0019, Birmingham, AL, USA
J Chromatogr B Analyt Technol Biomed Life Sci 784:331-41. 2003..Recovery from plasma was consistently high (>80%). This novel HPLC methodology allows us to simultaneously determine plasma concentrations of nine antiretrovirals, including lopinavir, in HIV-infected patients on a single HPLC system... - The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracilLori K Mattison
Division of Clinical Pharmacology and Toxicology, Comprehensive Cancer Center, University of Alabama at Birmingham, 1824 6th Avenue South, Birmingham, AL 35294, USA
Clin Cancer Res 12:549-55. 2006..These pharmacokinetic data further support the future use of the UraBT as a screening test to identify DPD deficiency before 5-fluorouracil-based therapy... - Pharmacokinetic optimization of antiretroviral therapy in pregnancyKajal Buckoreelall
Division of Clinical Pharmacology, Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
Clin Pharmacokinet 51:639-59. 2012..It is necessary to consider the pharmacological characteristics of each antiretroviral when optimizing combination therapy during pregnancy to treat maternal HIV infection and prevent perinatal HIV transmission...