Jean King

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Progressive levels of physical dependence to tobacco coincide with changes in the anterior cingulum bundle microstructure
    Wei Huang
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e67837. 2013
  2. ncbi request reprint Sequence and seasonal effects of salivary cortisol
    J A King
    Behavioral Neuroscience Program of the Department of Psychiatry, University of Massachusetts Medical School, USA
    Behav Med 26:67-73. 2000
  3. ncbi request reprint Association of stress, hostility and plasma testosterone levels
    Jean A King
    Department of Psychiatry, University of Massachusetts Medical School, North Worcester, MA 01655, USA
    Neuro Endocrinol Lett 26:355-60. 2005
  4. pmc Procedure for minimizing stress for fMRI studies in conscious rats
    Jean A King
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    J Neurosci Methods 148:154-60. 2005
  5. ncbi request reprint Deficits in testosterone facilitate enhanced fear response
    Jean A King
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Psychoneuroendocrinology 30:333-40. 2005
  6. ncbi request reprint Neural substrates underlying impulsivity
    Jean A King
    Department of Psychiatry, Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Ann N Y Acad Sci 1008:160-9. 2003
  7. ncbi request reprint Early sexual abuse and low cortisol
    J A King
    Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
    Psychiatry Clin Neurosci 55:71-4. 2001
  8. ncbi request reprint Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs
    Jean A King
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neuropsychobiology 45:150-5. 2002
  9. ncbi request reprint Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures
    Mathew E Brevard
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA mathew brevard umassmed edu
    Epilepsia 47:745-54. 2006
  10. pmc Anticorrelated resting-state functional connectivity in awake rat brain
    Zhifeng Liang
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neuroimage 59:1190-9. 2012

Research Grants

Detail Information

Publications27

  1. pmc Progressive levels of physical dependence to tobacco coincide with changes in the anterior cingulum bundle microstructure
    Wei Huang
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e67837. 2013
    ..This study sought to determine if advancing neurophysiologic dependence as measured by the Level of PD correlates with characteristics of white matter structure measured by Fractional Anisotropy (FA)...
  2. ncbi request reprint Sequence and seasonal effects of salivary cortisol
    J A King
    Behavioral Neuroscience Program of the Department of Psychiatry, University of Massachusetts Medical School, USA
    Behav Med 26:67-73. 2000
    ..The findings in this study suggest that repeated saliva sampling and seasonal variation in cortisol levels may independently affect adrenal response and, therefore, need to be accounted for in longitudinal studies...
  3. ncbi request reprint Association of stress, hostility and plasma testosterone levels
    Jean A King
    Department of Psychiatry, University of Massachusetts Medical School, North Worcester, MA 01655, USA
    Neuro Endocrinol Lett 26:355-60. 2005
    ....
  4. pmc Procedure for minimizing stress for fMRI studies in conscious rats
    Jean A King
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    J Neurosci Methods 148:154-60. 2005
    ..The feasibility of improving the quality of fMRI data acquired in alert rats by utilizing a relatively simple technique is presented...
  5. ncbi request reprint Deficits in testosterone facilitate enhanced fear response
    Jean A King
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Psychoneuroendocrinology 30:333-40. 2005
    ..These studies suggest that testosterone decline may have a significant effect on increasing innate fear response and fear-induced enhancement of analgesia in male rats...
  6. ncbi request reprint Neural substrates underlying impulsivity
    Jean A King
    Department of Psychiatry, Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Ann N Y Acad Sci 1008:160-9. 2003
    ..As noninvasive brain imaging, neurochemical, and behavioral approaches are combined, our knowledge of the neural networks underlying impulsivity will hopefully give rise to therapeutic approaches aimed at alleviating this disorder...
  7. ncbi request reprint Early sexual abuse and low cortisol
    J A King
    Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
    Psychiatry Clin Neurosci 55:71-4. 2001
    ..The data suggest that children may have an impaired HPA axis after early trauma...
  8. ncbi request reprint Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs
    Jean A King
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neuropsychobiology 45:150-5. 2002
    ..These data provide evidence that seed finding in hamsters may serve as an animal model for screening potential anxiolytic drugs...
  9. ncbi request reprint Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures
    Mathew E Brevard
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA mathew brevard umassmed edu
    Epilepsia 47:745-54. 2006
    ....
  10. pmc Anticorrelated resting-state functional connectivity in awake rat brain
    Zhifeng Liang
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neuroimage 59:1190-9. 2012
    ..In addition, combining the neurobiological data of the IL-amygdala circuit in rodents, the finding of the present study will enable further investigation of the neurobiological basis underlying anticorrelation...
  11. ncbi request reprint Stress, social support, and cortisol: inverse associations?
    Milagros C Rosal
    University of Massachusetts Medical School, Division of Preventive and Behavioral Medicine, Department of Medicine, Worcester, 01655, USA
    Behav Med 30:11-21. 2004
    ..Both findings deserve further investigation...
  12. doi request reprint The role of 5-HT1A receptors in the behavioral responses associated with innate fear
    Jessica Shields
    University of Massachusetts Medical School, Department of Psychiatry, Center for Comparative NeuroImaging, 55 Lake Avenue North, Worcester, MA 01655, USA
    Behav Neurosci 122:611-7. 2008
    ..Taken together, these results suggest an additional anxyolitic-like effect of 8-OHDPAT in innate fear paradigms...
  13. pmc Intrinsic organization of the anesthetized brain
    Zhifeng Liang
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Neurosci 32:10183-91. 2012
    ..With the unique spatial and temporal scales of resting-state fMRI, this study has opened a new avenue for understanding the neural mechanism of (un)consciousness...
  14. doi request reprint A comparison of brain and behavioral effects of varenicline and nicotine in rats
    Jean King
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Behav Brain Res 223:42-7. 2011
    ..This study points to different effects of varenicline and nicotine on neuronal and behavioral indices...
  15. pmc Uncovering intrinsic connectional architecture of functional networks in awake rat brain
    Zhifeng Liang
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Neurosci 31:3776-83. 2011
    ....
  16. pmc Female fear: influence of estrus cycle on behavioral response and neuronal activation
    Wei Chen
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Behav Brain Res 201:8-13. 2009
    ..Taken together, these results suggest that the female's hormonal status may be correlated with alterations in both neuronal and behavioral indices of fear...
  17. pmc Activation of neural pathways associated with sexual arousal in non-human primates
    Craig F Ferris
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Magn Reson Imaging 19:168-75. 2004
    ..To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and sexual motivation...
  18. ncbi request reprint fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation
    Jeffrey R Tenney
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Epilepsia 45:1240-7. 2004
    ..A nonhuman primate model of generalized absence status epilepticus was developed for use in functional magnetic resonance imaging (fMRI) experiments to elucidate the brain mechanisms underlying this disorder...
  19. pmc FMRI of brain activation in a genetic rat model of absence seizures
    Jeffrey R Tenney
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Epilepsia 45:576-82. 2004
    ..EEG-triggered functional magnetic resonance imaging (fMRI) was used to identify areas of brain activation during spontaneous spike-and-wave discharges (SWDs) in an epileptic rat strain under awake conditions...
  20. pmc Corticothalamic modulation during absence seizures in rats: a functional MRI assessment
    Jeffrey R Tenney
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School Worcester, Massachusetts 01655, USA
    Epilepsia 44:1133-40. 2003
    ..Functional magnetic resonance imaging (fMRI) was used to identify areas of brain activation during absence seizures in an awake animal model...
  21. doi request reprint Imaging brain activation in nicotine-sensitized rats
    Zhixin Li
    Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Brain Res 1199:91-9. 2008
    ....
  22. pmc Regional cerebral blood flow and BOLD responses in conscious and anesthetized rats under basal and hypercapnic conditions: implications for functional MRI studies
    Kenneth Sicard
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, U S A
    J Cereb Blood Flow Metab 23:472-81. 2003
    ..This study also shows that perfusion and perfusion-based functional MRI can be performed in awake animals...
  23. ncbi request reprint Imaging unconditioned fear response with manganese-enhanced MRI (MEMRI)
    Wei Chen
    University of Massachusetts Medical School, Department of Psychiatry, Center for Comparative NeuroImaging, 55 Lake Avenue North, Worcester, MA 01655, USA
    Neuroimage 37:221-9. 2007
    ..Therefore the current study support the validity of MEMRI in the exploration of highly relevant complex neural circuitries associated with cognition and emotion...
  24. pmc Mapping thalamocortical networks in rat brain using resting-state functional connectivity
    Zhifeng Liang
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neuroimage 83:237-44. 2013
    ..More importantly, the present study has made it possible to non-invasively investigate the function, neuroplasticity and mutual interactions of thalamocortical networks in animal models. ..
  25. ncbi request reprint A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics
    Benjamin U Nwosu
    Division of Pediatric Endocrinology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    J Pediatr Endocrinol Metab 24:619-26. 2011
    ..Effective strategies to curb these side effects will improve the overall health of youths with psychiatric illnesses who receive SGAs. Herein we present a pilot study on the use of vitamin D in patients on treatment with SGAs...
  26. pmc Mapping resting-state brain networks in conscious animals
    Nanyin Zhang
    Center for Comparative NeuroImaging CCNI, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, United States
    J Neurosci Methods 189:186-96. 2010
    ....
  27. ncbi request reprint Confounding effects of volatile anesthesia on CBV assessment in rodent forebrain following ethanol challenge
    Feng Luo
    Experimental Imaging Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Magn Reson Imaging 26:557-63. 2007
    ..To compare and contrast the pattern and characteristics of the cerebral blood volume (CBV) response to ethanol (EtOH) in rats under awake and anesthetized conditions...

Research Grants11

  1. Roots of Mental Illness in Children
    Jean King; Fiscal Year: 2002
    ..Conference program has been organized by a committee consisting of Drs. Jean King and Craig Ferris (both of University of Massachusetts Medical School), in consultation with a steering committee ..
  2. Possible Significance of Cholinergic Influence in ADHD
    Jean A King; Fiscal Year: 2010
    ..Since ADD is a lifelong challenge these results can be potentially of use to many individuals and families. ..
  3. Imaging Nicotine-induced behavioral sensitization with fMRI
    Jean King; Fiscal Year: 2009
    ..The imaging of sensitization may provide a powerful new tool for the exploration of novel pharmacologic approaches to treating nicotine addiction, which is the largest contributor to preventable mortality in the developed world. ..
  4. Imaging Nicotine-induced behavioral sensitization with fMRI
    Jean King; Fiscal Year: 2007
    ..The imaging of sensitization may provide a powerful new tool for the exploration of novel pharmacologic approaches to treating nicotine addiction, which is the largest contributor to preventable mortality in the developed world. ..
  5. Imaging Unconditioned Fear
    Jean King; Fiscal Year: 2006
    ..Since fear experience by all animals, these studies may expand our understanding of anxiety and phobias in general. ..
  6. NMR Imaging of Prostate Cancer Using Ligands
    Jean King; Fiscal Year: 2005
    ..abstract_text> ..
  7. Imaging Unconditioned Fear
    Jean King; Fiscal Year: 2003
    ..Since fear experience by all animals, these studies may expand our understanding of anxiety and phobias in general. ..
  8. Imaging Nicotine-induced behavioral sensitization with fMRI
    Jean A King; Fiscal Year: 2010
    ..The imaging of sensitization may provide a powerful new tool for the exploration of novel pharmacologic approaches to treating nicotine addiction, which is the largest contributor to preventable mortality in the developed world. ..