Isabelle N King

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa
    Isabelle N King
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Biochem Biophys Res Commun 345:446-52. 2006
  2. ncbi A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity
    Isabelle N King
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 20:497-510. 2011
  3. ncbi Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism
    Irfan S Kathiriya
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 279:54937-43. 2004
  4. ncbi Mutations in NOTCH1 cause aortic valve disease
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 437:270-4. 2005
  5. ncbi A rare human sequence variant reveals myocardin autoinhibition
    Joshua F Ransom
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 283:35845-52. 2008
  6. ncbi Notch post-translationally regulates β-catenin protein in stem and progenitor cells
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Cell Biol 13:1244-51. 2011
  7. ncbi GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Rm NA8 124, Dallas, Texas 75390 9148, USA
    Nature 424:443-7. 2003

Research Grants

  1. Hairy-Related Factors in Cardiac Development and Disease
    ISABELLE KING; Fiscal Year: 2007

Collaborators

Detail Information

Publications7

  1. ncbi Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa
    Isabelle N King
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Biochem Biophys Res Commun 345:446-52. 2006
    ..These findings suggest a novel mechanism for negative feedback on Notch signaling that requires RBP-Jkappa to interact physically with Hrt and Hes...
  2. ncbi A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity
    Isabelle N King
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 20:497-510. 2011
    ..These findings illustrate the power of Drosophila-based screens to find points of intersection between miRNAs and conserved pathways in mammals...
  3. ncbi Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism
    Irfan S Kathiriya
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Biol Chem 279:54937-43. 2004
    ..These results suggest that HRT proteins may regulate specific sets of cardiac genes by modulating the function of GATA proteins and other cardiac transcriptional activators in a signal-dependent manner...
  4. ncbi Mutations in NOTCH1 cause aortic valve disease
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 437:270-4. 2005
    ..These results suggest that NOTCH1 mutations cause an early developmental defect in the aortic valve and a later de-repression of calcium deposition that causes progressive aortic valve disease...
  5. ncbi A rare human sequence variant reveals myocardin autoinhibition
    Joshua F Ransom
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 283:35845-52. 2008
    ..These findings identify a novel mechanism that regulates levels of MYOCD-dependent activation of the SRF genetic program differentially in cardiac and smooth muscle...
  6. ncbi Notch post-translationally regulates β-catenin protein in stem and progenitor cells
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Cell Biol 13:1244-51. 2011
    ..It did, however, require the endocytic adaptor protein Numb and lysosomal activity. This study reveals a previously unrecognized function of Notch in negatively titrating active β-catenin protein levels in stem and progenitor cells...
  7. ncbi GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Rm NA8 124, Dallas, Texas 75390 9148, USA
    Nature 424:443-7. 2003
    ..These results implicate GATA4 as a genetic cause of human cardiac septal defects, perhaps through its interaction with TBX5...

Research Grants2

  1. Hairy-Related Factors in Cardiac Development and Disease
    ISABELLE KING; Fiscal Year: 2007
    ..We will conduct detailed in vitro assays to identify co-factors dependent on this novel domain, and we will generate mice harboring these mutations to study their functional consequences in vivo. ..